|
US4916135A
(en)
|
1989-05-08 |
1990-04-10 |
Hoechst Roussel Pharmaceuticals Inc. |
N-heteroaryl-4-quinolinamines
|
|
US5710158A
(en)
|
1991-05-10 |
1998-01-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
PT100905A
(pt)
|
1991-09-30 |
1994-02-28 |
Eisai Co Ltd |
Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
|
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
JP2994165B2
(ja)
*
|
1992-06-26 |
1999-12-27 |
ゼネカ・リミテッド |
キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
|
|
GB9510757D0
(en)
*
|
1994-09-19 |
1995-07-19 |
Wellcome Found |
Therapeuticaly active compounds
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US6046206A
(en)
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
|
|
JP4386967B2
(ja)
|
1996-07-13 |
2009-12-16 |
グラクソ、グループ、リミテッド |
プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物
|
|
AU3969697A
(en)
|
1996-08-01 |
1998-02-25 |
Dow Agrosciences Llc |
Quinolinium derivatives having fungicidal activity
|
|
WO1998013350A1
(en)
|
1996-09-25 |
1998-04-02 |
Zeneca Limited |
Qinoline derivatives inhibiting the effect of growth factors such as vegf
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
GB9800569D0
(en)
*
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
DK1117653T3
(da)
|
1998-10-01 |
2003-05-26 |
Astrazeneca Ab |
Quinolin- og quinazolinderivater og deres anvendelse som inhibitorer af cykokin-merierede sygdomme
|
|
GB2345486A
(en)
|
1999-01-11 |
2000-07-12 |
Glaxo Group Ltd |
Heteroaromatic protein tyrosine kinase inhibitors
|
|
CN1391562A
(zh)
|
1999-09-21 |
2003-01-15 |
阿斯特拉曾尼卡有限公司 |
用作药物的喹唑啉衍生物
|
|
JP2003520855A
(ja)
|
2000-01-28 |
2003-07-08 |
アストラゼネカ アクチボラグ |
化学的化合物
|
|
MXPA02007957A
(es)
|
2000-02-17 |
2002-11-29 |
Amgen Inc |
Inhibidores de cinasas.
|
|
US6521618B2
(en)
|
2000-03-28 |
2003-02-18 |
Wyeth |
3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
|
|
US6589758B1
(en)
*
|
2000-05-19 |
2003-07-08 |
Amgen Inc. |
Crystal of a kinase-ligand complex and methods of use
|
|
JP2004505964A
(ja)
|
2000-08-09 |
2004-02-26 |
アストラゼネカ アクチボラグ |
Ｖｅｇｆ阻害活性を有するキノリン誘導体
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
GB0025782D0
(en)
|
2000-10-20 |
2000-12-06 |
Pfizer Ltd |
Use of inhibitors
|
|
GB0104422D0
(en)
|
2001-02-22 |
2001-04-11 |
Glaxo Group Ltd |
Quinoline derivative
|
|
PE20020958A1
(es)
|
2001-03-23 |
2002-11-14 |
Bayer Corp |
Inhibidores de la rho-quinasa
|
|
TWI261055B
(en)
|
2001-03-23 |
2006-09-01 |
Bayer Corp |
Rho-Kinase Inhibitors
|
|
SE0101675D0
(sv)
|
2001-05-11 |
2001-05-11 |
Astrazeneca Ab |
Novel composition
|
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
WO2003026665A1
(en)
|
2001-09-26 |
2003-04-03 |
Bayer Pharmaceuticals Corporation |
2-phenylamino-4-(5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
|
|
ES2333702T3
(es)
|
2001-12-24 |
2010-02-26 |
Astrazeneca Ab |
Derivados de quinazolina sustituidos que actuan como unhibidores de cinasas aurora.
|
|
US7645878B2
(en)
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
|
AU2003255482A1
(en)
*
|
2002-10-02 |
2004-04-23 |
Merck Patent Gmbh |
Use of 4 amino-quinazolines as anti cancer agents
|
|
US7262200B2
(en)
|
2002-10-25 |
2007-08-28 |
Vertex Pharmaceuticals Incorporated |
Indazolinone compositions useful as kinase inhibitors
|
|
US20040122161A1
(en)
|
2002-12-21 |
2004-06-24 |
Paul Charles W. |
Hot melt adhesive based on acrylic block copolymers
|
|
PT1847539E
(pt)
|
2002-12-24 |
2009-10-06 |
Astrazeneca Ab |
Derivados de quinazolina
|
|
TWI328009B
(en)
|
2003-05-21 |
2010-08-01 |
Glaxo Group Ltd |
Quinoline derivatives as phosphodiesterase inhibitors
|
|
JP2007501854A
(ja)
|
2003-05-27 |
2007-02-01 |
ファイザー・プロダクツ・インク |
受容体型チロシンキナーゼ阻害薬としてのキナゾリン類およびピリド［３，４−ｄ］ピリミジン類
|
|
CN1984660B
(zh)
|
2003-07-03 |
2010-12-15 |
美瑞德生物工程公司 |
作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
|
|
MXPA06002964A
(es)
|
2003-09-16 |
2006-06-14 |
Astrazeneca Ab |
Derivados de quinazolina como inhibidores de cinasa de tirosina.
|
|
EP2392565B1
(en)
|
2003-09-26 |
2014-03-19 |
Exelixis, Inc. |
c-Met modulators and methods of use
|
|
KR100807920B1
(ko)
|
2003-12-23 |
2008-02-27 |
화이자 인코포레이티드 |
신규한 퀴놀린 유도체
|
|
US7687502B2
(en)
|
2004-03-23 |
2010-03-30 |
Banyu Pharmaceutical Co., Ltd. |
Substituted quinazoline or pyridopyrimidine derivative
|
|
WO2005115145A2
(en)
|
2004-05-20 |
2005-12-08 |
Wyeth |
Quinone substituted quinazoline and quinoline kinase inhibitors
|
|
CA2567080A1
(en)
|
2004-05-27 |
2005-12-15 |
Vertex Pharmaceuticals Incorporated |
Ice inhibitors for the treatment of autoinflammatory diseases
|
|
US7452887B2
(en)
|
2004-06-04 |
2008-11-18 |
Amphora Discovery Corporation |
Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
|
|
FR2873695A1
(fr)
|
2004-07-30 |
2006-02-03 |
Palumed Sa |
Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
|
|
BRPI0519267A2
(pt)
|
2004-12-22 |
2009-01-06 |
Bayer Schering Pharma Ag |
derivado de quinolina, seu uso, produÇço e medicamento contendo o mesmo
|
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
CA2603748A1
(en)
|
2005-04-06 |
2006-10-12 |
Exelixis, Inc. |
C-met modulators and methods of use
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
EP1746096A1
(en)
|
2005-07-15 |
2007-01-24 |
4Sc Ag |
2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
|
|
ITMI20052008A1
(it)
|
2005-10-21 |
2007-04-22 |
Ctg Pharma S R L |
Nuovi antimalarici derivati della 4-aminochinolina
|
|
FR2902100A1
(fr)
|
2006-06-13 |
2007-12-14 |
Sanofi Aventis Sa |
Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
|
|
US7511063B2
(en)
|
2006-08-16 |
2009-03-31 |
Schering Corporation |
High affinity quinoline-based kinase ligands
|
|
JP2008063278A
(ja)
|
2006-09-07 |
2008-03-21 |
Fujifilm Finechemicals Co Ltd |
１−ピリジン−４−イル−インドール類の製造方法
|
|
EP2061469B8
(en)
|
2006-09-11 |
2014-02-26 |
Curis, Inc. |
Quinazoline based egfr inhibitors
|
|
JP5580592B2
(ja)
|
2006-09-11 |
2014-08-27 |
キュリス，インコーポレイテッド |
亜鉛結合部分を含むキナゾリン系ｅｇｆｒインヒビター
|
|
CA2662937A1
(en)
|
2006-09-11 |
2008-03-20 |
Curis, Inc. |
Multi-functional small molecules as anti-proliferative agents
|
|
TW200829555A
(en)
|
2006-11-10 |
2008-07-16 |
Astrazeneca Ab |
Chemical compounds
|
|
US8163923B2
(en)
|
2007-03-14 |
2012-04-24 |
Advenchen Laboratories, Llc |
Spiro substituted compounds as angiogenesis inhibitors
|
|
US8148532B2
(en)
|
2007-03-14 |
2012-04-03 |
Guoqing Paul Chen |
Spiro substituted compounds as angiogenesis inhibitors
|
|
US20080234267A1
(en)
|
2007-03-20 |
2008-09-25 |
Karen Elizabeth Lackey |
Compounds and Methods of Treatment
|
|
WO2008119771A2
(en)
|
2007-03-30 |
2008-10-09 |
Clanotech Ab |
Quinoline-s-carboxylic acid derivatives as tyrosine kinase inhibitors
|
|
WO2008128647A1
(en)
|
2007-04-23 |
2008-10-30 |
Sanofi-Aventis |
Quinoline-carboxamide derivatives as p2y12 antagonists
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
MX2009013069A
(es)
|
2007-06-01 |
2010-03-17 |
Wyeth Llc |
Tratamiento de leucemia resistente al imatinib.
|
|
CN101362719B
(zh)
|
2007-08-06 |
2012-04-18 |
北京师范大学 |
喹啉类衍生物以及包含其的组合物
|
|
US7939546B2
(en)
|
2007-10-12 |
2011-05-10 |
Supergen, Inc. |
Quinoline derivatives for modulating DNA methylation
|
|
US7790746B2
(en)
|
2007-10-12 |
2010-09-07 |
Supergen, Inc. |
Quinoline derivatives for modulating DNA methylation
|
|
WO2009073746A1
(en)
|
2007-12-07 |
2009-06-11 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Apparatus for countercurrent chromatography
|
|
EP2072502A1
(de)
*
|
2007-12-20 |
2009-06-24 |
Bayer Schering Pharma Aktiengesellschaft |
Sulfoximid-substituierte Chinolin- und Chinazolinderivate als Kinase-Inhibitoren
|
|
GB0801416D0
(en)
|
2008-01-25 |
2008-03-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
KR20100135780A
(ko)
|
2008-03-06 |
2010-12-27 |
제넨테크, 인크. |
Ｃ-ｍｅｔ 및 ｅｇｆｒ 길항제로의 조합 요법
|
|
KR20110069092A
(ko)
*
|
2008-10-17 |
2011-06-22 |
제넨테크, 인크. |
치료 방법
|
|
DE102008062566A1
(de)
|
2008-12-16 |
2010-06-17 |
Bayer Schering Pharma Aktiengesellschaft |
Aminosäureester-Prodrugs und ihre Verwendung
|
|
PH12012500097A1
(en)
|
2009-07-21 |
2011-01-27 |
Shanghai Inst Organic Chem |
Potent small molecule inhibitors of autophagy, and methods of use thereof
|
|
WO2011112588A2
(en)
*
|
2010-03-08 |
2011-09-15 |
Case Western Reserve University |
Compositions and methods for treating inflammatory disorders
|
|
JP2013523657A
(ja)
|
2010-03-26 |
2013-06-17 |
グラクソ グループ リミテッド |
キナーゼ阻害剤としてのインダゾリル‐ピリミジン
|
|
US20130023534A1
(en)
|
2010-03-26 |
2013-01-24 |
Casillas Linda N |
Pyrazolyl-pyrimidines as kinase inhibitors
|
|
EP2552208A4
(en)
|
2010-03-31 |
2014-07-09 |
Glaxo Group Ltd |
IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
|
|
JP2013526484A
(ja)
|
2010-05-07 |
2013-06-24 |
グラクソ グループ リミテッド |
キナーゼ阻害剤としてのアミノ‐キノリン
|
|
UY33549A
(es)
|
2010-08-10 |
2012-01-31 |
Glaxo Group Ltd |
Quinolil aminas como agentes inhibidores de las quinasas
|
|
US8609672B2
(en)
|
2010-08-27 |
2013-12-17 |
University Of The Pacific |
Piperazinylpyrimidine analogues as protein kinase inhibitors
|
|
MY181439A
(en)
|
2011-02-28 |
2020-12-22 |
Sunshine Lake Pharma Co Ltd |
Substituted quinoline compounds and methods of use
|
|
KR101940340B1
(ko)
|
2011-03-04 |
2019-01-18 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
키나제 억제제로서의 아미노-퀴놀린
|
|
TWI547494B
(zh)
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
AR092529A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
AR092530A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
BR112015019624A2
(pt)
|
2013-02-21 |
2017-07-18 |
Glaxosmithkline Ip Dev Ltd |
quinazolinas como inibidores de quinase
|