|
US4916135A
(en)
|
1989-05-08 |
1990-04-10 |
Hoechst Roussel Pharmaceuticals Inc. |
N-heteroaryl-4-quinolinamines
|
|
US5710158A
(en)
|
1991-05-10 |
1998-01-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
PT100905A
(pt)
|
1991-09-30 |
1994-02-28 |
Eisai Co Ltd |
Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
|
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
JP2994165B2
(ja)
*
|
1992-06-26 |
1999-12-27 |
ゼネカ・リミテッド |
キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
|
|
GB9510757D0
(en)
*
|
1994-09-19 |
1995-07-19 |
Wellcome Found |
Therapeuticaly active compounds
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US6046206A
(en)
|
1995-06-07 |
2000-04-04 |
Cell Pathways, Inc. |
Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
|
|
WO1998002434A1
(en)
|
1996-07-13 |
1998-01-22 |
Glaxo Group Limited |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
|
AU3969697A
(en)
|
1996-08-01 |
1998-02-25 |
Dow Agrosciences Llc |
Quinolinium derivatives having fungicidal activity
|
|
EP0929526B1
(en)
|
1996-09-25 |
2005-07-27 |
AstraZeneca AB |
Qinoline derivatives inhibiting the effect of growth factors such as vegf
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
RS49779B
(sr)
*
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
NZ510210A
(en)
|
1998-10-01 |
2003-06-30 |
Astrazeneca Ab |
4-phenylamino substituted quinazoline or quinoline derivatives useful for treating cytokine mediated diseases or conditions
|
|
GB2345486A
(en)
|
1999-01-11 |
2000-07-12 |
Glaxo Group Ltd |
Heteroaromatic protein tyrosine kinase inhibitors
|
|
WO2001021596A1
(en)
|
1999-09-21 |
2001-03-29 |
Astrazeneca Ab |
Quinazoline derivatives and their use as pharmaceuticals
|
|
US6977259B2
(en)
|
2000-01-28 |
2005-12-20 |
Astrazeneca Ab |
Quinoline derivatives and their use as aurora 2 kinase inhibitors
|
|
WO2001060816A1
(en)
|
2000-02-17 |
2001-08-23 |
Amgen Inc. |
Kinase inhibitors
|
|
US6521618B2
(en)
|
2000-03-28 |
2003-02-18 |
Wyeth |
3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
|
|
US6589758B1
(en)
|
2000-05-19 |
2003-07-08 |
Amgen Inc. |
Crystal of a kinase-ligand complex and methods of use
|
|
MXPA03000252A
(es)
|
2000-08-09 |
2003-06-06 |
Astrazeneca Ab |
Derivados de quinolina que tienen actividad de inhibicion de fcev.
|
|
GB0025782D0
(en)
|
2000-10-20 |
2000-12-06 |
Pfizer Ltd |
Use of inhibitors
|
|
US6548508B2
(en)
|
2000-10-20 |
2003-04-15 |
Pfizer, Inc. |
Use of PDE V inhibitors for improved fecundity in mammals
|
|
GB0104422D0
(en)
|
2001-02-22 |
2001-04-11 |
Glaxo Group Ltd |
Quinoline derivative
|
|
DK1370552T3
(da)
|
2001-03-23 |
2007-05-07 |
Bayer Pharmaceuticals Corp |
Rho-kinase-inhibitorer
|
|
CA2441492C
(en)
|
2001-03-23 |
2011-08-09 |
Bayer Corporation |
Rho-kinase inhibitors
|
|
SE0101675D0
(sv)
|
2001-05-11 |
2001-05-11 |
Astrazeneca Ab |
Novel composition
|
|
US7115617B2
(en)
|
2001-08-22 |
2006-10-03 |
Amgen Inc. |
Amino-substituted pyrimidinyl derivatives and methods of use
|
|
WO2003026666A1
(en)
|
2001-09-26 |
2003-04-03 |
Bayer Pharmaceuticals Corporation |
2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors
|
|
PL211694B1
(pl)
|
2001-12-24 |
2012-06-29 |
Astrazeneca Ab |
Podstawiona pochodna chinazoliny, jej zastosowania oraz jej kompozycja farmaceutyczna
|
|
US7645878B2
(en)
|
2002-03-22 |
2010-01-12 |
Bayer Healthcare Llc |
Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
|
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
|
WO2004030672A1
(en)
*
|
2002-10-02 |
2004-04-15 |
Merck Patent Gmbh |
Use of 4 amino-quinazolines as anti cancer agents
|
|
WO2004037814A1
(en)
|
2002-10-25 |
2004-05-06 |
Vertex Pharmaceuticals Incorporated |
Indazolinone compositions useful as kinase inhibitors
|
|
US20040122161A1
(en)
|
2002-12-21 |
2004-06-24 |
Paul Charles W. |
Hot melt adhesive based on acrylic block copolymers
|
|
EP1578755B1
(en)
|
2002-12-24 |
2007-08-22 |
AstraZeneca AB |
Phosphonooxy quinazoline derivatives and their pharmaceutical use
|
|
TWI328009B
(en)
|
2003-05-21 |
2010-08-01 |
Glaxo Group Ltd |
Quinoline derivatives as phosphodiesterase inhibitors
|
|
CA2527017A1
(en)
|
2003-05-27 |
2004-12-09 |
Pfizer Products Inc. |
Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors
|
|
WO2005003100A2
(en)
|
2003-07-03 |
2005-01-13 |
Myriad Genetics, Inc. |
4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
|
|
DK1667991T3
(da)
|
2003-09-16 |
2008-08-18 |
Astrazeneca Ab |
Quinazolinderivater som tyrosinkinaseinhibitorer
|
|
SI2392564T1
(sl)
|
2003-09-26 |
2014-02-28 |
Exelixis, Inc. |
c-Met modulatorji in postopki uporabe
|
|
AU2004309166B2
(en)
|
2003-12-23 |
2008-02-21 |
Pfizer Inc. |
Novel quinoline derivatives
|
|
WO2005090332A1
(ja)
|
2004-03-23 |
2005-09-29 |
Banyu Pharmaceutical Co., Ltd |
置換キナゾリン又はピリドピリミジン誘導体
|
|
WO2005115145A2
(en)
|
2004-05-20 |
2005-12-08 |
Wyeth |
Quinone substituted quinazoline and quinoline kinase inhibitors
|
|
EP1778221A2
(en)
|
2004-05-27 |
2007-05-02 |
Vertex Pharmaceuticals Incorporated |
Ice inhibitors for the treatment of autoinflammatory diseases
|
|
JP2008501696A
(ja)
|
2004-06-04 |
2008-01-24 |
アンフォラ ディスカバリー コーポレーション |
Ａｔｐ利用酵素阻害活性を示すキノリンおよびイソキノリン系化合物、ならびにその組成物および使用
|
|
FR2873695A1
(fr)
|
2004-07-30 |
2006-02-03 |
Palumed Sa |
Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
|
|
BRPI0519267A2
(pt)
|
2004-12-22 |
2009-01-06 |
Bayer Schering Pharma Ag |
derivado de quinolina, seu uso, produÇço e medicamento contendo o mesmo
|
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
EP1874759A4
(en)
|
2005-04-06 |
2009-07-15 |
Exelixis Inc |
C-MET MODULATORS MODULATORS AND METHODS OF USE
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
EP1746096A1
(en)
|
2005-07-15 |
2007-01-24 |
4Sc Ag |
2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer
|
|
ITMI20052008A1
(it)
|
2005-10-21 |
2007-04-22 |
Ctg Pharma S R L |
Nuovi antimalarici derivati della 4-aminochinolina
|
|
FR2902100A1
(fr)
|
2006-06-13 |
2007-12-14 |
Sanofi Aventis Sa |
Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique
|
|
US7511063B2
(en)
|
2006-08-16 |
2009-03-31 |
Schering Corporation |
High affinity quinoline-based kinase ligands
|
|
JP2008063278A
(ja)
|
2006-09-07 |
2008-03-21 |
Fujifilm Finechemicals Co Ltd |
１−ピリジン−４−イル−インドール類の製造方法
|
|
JP2010502743A
(ja)
|
2006-09-11 |
2010-01-28 |
キュリス，インコーポレイテッド |
抗増殖薬剤としての多機能性低分子
|
|
AU2007296745B2
(en)
|
2006-09-11 |
2011-12-01 |
Curis, Inc. |
Quinazoline based EGFR inhibitors
|
|
KR20090067169A
(ko)
|
2006-09-11 |
2009-06-24 |
쿠리스 인코퍼레이션 |
아연 결합 부분을 함유한 퀴나졸린 계열 ｅｇｆｒ 억제제
|
|
TW200829555A
(en)
|
2006-11-10 |
2008-07-16 |
Astrazeneca Ab |
Chemical compounds
|
|
US8148532B2
(en)
|
2007-03-14 |
2012-04-03 |
Guoqing Paul Chen |
Spiro substituted compounds as angiogenesis inhibitors
|
|
US8163923B2
(en)
|
2007-03-14 |
2012-04-24 |
Advenchen Laboratories, Llc |
Spiro substituted compounds as angiogenesis inhibitors
|
|
US20080234267A1
(en)
|
2007-03-20 |
2008-09-25 |
Karen Elizabeth Lackey |
Compounds and Methods of Treatment
|
|
WO2008119771A2
(en)
|
2007-03-30 |
2008-10-09 |
Clanotech Ab |
Quinoline-s-carboxylic acid derivatives as tyrosine kinase inhibitors
|
|
EP2148871A1
(en)
|
2007-04-23 |
2010-02-03 |
Sanofi-Aventis |
Quinoline-carboxamide derivatives as p2y12 antagonists
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
AU2008260070B9
(en)
|
2007-06-01 |
2012-01-19 |
Wyeth Llc |
Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles
|
|
CN101362719B
(zh)
|
2007-08-06 |
2012-04-18 |
北京师范大学 |
喹啉类衍生物以及包含其的组合物
|
|
US7939546B2
(en)
|
2007-10-12 |
2011-05-10 |
Supergen, Inc. |
Quinoline derivatives for modulating DNA methylation
|
|
US7790746B2
(en)
|
2007-10-12 |
2010-09-07 |
Supergen, Inc. |
Quinoline derivatives for modulating DNA methylation
|
|
WO2009073746A1
(en)
|
2007-12-07 |
2009-06-11 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Apparatus for countercurrent chromatography
|
|
EP2072502A1
(de)
*
|
2007-12-20 |
2009-06-24 |
Bayer Schering Pharma Aktiengesellschaft |
Sulfoximid-substituierte Chinolin- und Chinazolinderivate als Kinase-Inhibitoren
|
|
GB0801416D0
(en)
|
2008-01-25 |
2008-03-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
SG188802A1
(en)
|
2008-03-06 |
2013-04-30 |
Genentech Inc |
Combination therapy with c-met and egfr antagonists
|
|
KR20110069092A
(ko)
*
|
2008-10-17 |
2011-06-22 |
제넨테크, 인크. |
치료 방법
|
|
DE102008062566A1
(de)
|
2008-12-16 |
2010-06-17 |
Bayer Schering Pharma Aktiengesellschaft |
Aminosäureester-Prodrugs und ihre Verwendung
|
|
PH12012500097A1
(en)
|
2009-07-21 |
2011-01-27 |
Shanghai Inst Organic Chem |
Potent small molecule inhibitors of autophagy, and methods of use thereof
|
|
US20130005726A1
(en)
|
2010-03-08 |
2013-01-03 |
Derek Abbott |
Compositions and methods for treating inflammatory disorders
|
|
EP2552211A4
(en)
|
2010-03-26 |
2013-10-23 |
Glaxo Group Ltd |
INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
|
|
WO2011120026A1
(en)
|
2010-03-26 |
2011-09-29 |
Glaxo Group Limited |
Pyrazolyl-pyrimidines as kinase inhibitors
|
|
US20130018039A1
(en)
|
2010-03-31 |
2013-01-17 |
Bodmer Vera Q |
Imidazolyl-imidazoles as kinase inhibitors
|
|
US20130053375A1
(en)
|
2010-05-07 |
2013-02-28 |
Glaxo Group Limited |
Amino-quinolines as kinase inhibitors
|
|
UY33549A
(es)
|
2010-08-10 |
2012-01-31 |
Glaxo Group Ltd |
Quinolil aminas como agentes inhibidores de las quinasas
|
|
WO2012027495A1
(en)
|
2010-08-27 |
2012-03-01 |
University Of The Pacific |
Piperazinylpyrimidine analogues as protein kinase inhibitors
|
|
AU2012223639B2
(en)
|
2011-02-28 |
2015-03-19 |
Sunshine Lake Pharma Co., Ltd. |
Substituted quinoline compounds and methods of use
|
|
JP6026441B2
(ja)
|
2011-03-04 |
2016-11-16 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ |
キナーゼ阻害剤としてのアミノキノリン
|
|
TWI547494B
(zh)
*
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
TW201425307A
(zh)
|
2012-09-13 |
2014-07-01 |
Glaxosmithkline Llc |
作為激酶抑制劑之胺基－喹啉類
|
|
TWI592417B
(zh)
|
2012-09-13 |
2017-07-21 |
葛蘭素史克智慧財產發展有限公司 |
胺基喹唑啉激酶抑制劑之前藥
|
|
ES2654100T3
(es)
|
2013-02-21 |
2018-02-12 |
Glaxosmithkline Intellectual Property Development Limited |
Quinazolinas como inhibidores de quinasa
|