JP2014525735A5 - - Google Patents
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- Publication number
- JP2014525735A5 JP2014525735A5 JP2014516358A JP2014516358A JP2014525735A5 JP 2014525735 A5 JP2014525735 A5 JP 2014525735A5 JP 2014516358 A JP2014516358 A JP 2014516358A JP 2014516358 A JP2014516358 A JP 2014516358A JP 2014525735 A5 JP2014525735 A5 JP 2014525735A5
- Authority
- JP
- Japan
- Prior art keywords
- single variable
- variable domain
- immunoglobulin single
- protein
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108060003951 Immunoglobulin Proteins 0.000 claims 33
- 102000018358 immunoglobulin Human genes 0.000 claims 33
- 108091006027 G proteins Proteins 0.000 claims 15
- 102000030782 GTP binding Human genes 0.000 claims 15
- 108091000058 GTP-Binding Proteins 0.000 claims 15
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 12
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 5
- 108020003175 receptors Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 102000034345 heterotrimeric G proteins Human genes 0.000 claims 1
- 108091006093 heterotrimeric G proteins Proteins 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000007781 signaling event Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161571159P | 2011-06-21 | 2011-06-21 | |
| US61/571,159 | 2011-06-21 | ||
| EP11181357 | 2011-09-15 | ||
| EP11181357.2 | 2011-09-15 | ||
| PCT/EP2012/062036 WO2012175643A2 (en) | 2011-06-21 | 2012-06-21 | Binding domains directed against gpcr:g protein complexes and uses derived thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017026632A Division JP2017127306A (ja) | 2011-06-21 | 2017-02-16 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014525735A JP2014525735A (ja) | 2014-10-02 |
| JP2014525735A5 true JP2014525735A5 (enExample) | 2015-08-13 |
| JP6164535B2 JP6164535B2 (ja) | 2017-07-19 |
Family
ID=47423019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516358A Active JP6164535B2 (ja) | 2011-06-21 | 2012-06-21 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
| JP2017026632A Pending JP2017127306A (ja) | 2011-06-21 | 2017-02-16 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017026632A Pending JP2017127306A (ja) | 2011-06-21 | 2017-02-16 | Ｇｐｃｒ：ｇタンパク質複合体に対して作製された結合ドメインおよびそれに由来する使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9695227B2 (enExample) |
| EP (3) | EP3345919B1 (enExample) |
| JP (2) | JP6164535B2 (enExample) |
| CN (2) | CN107857810A (enExample) |
| AU (1) | AU2012273987B2 (enExample) |
| CA (1) | CA2839834A1 (enExample) |
| DK (1) | DK2723764T3 (enExample) |
| ES (1) | ES2662372T3 (enExample) |
| HR (1) | HRP20180443T1 (enExample) |
| HU (1) | HUE036982T2 (enExample) |
| NO (1) | NO2723764T3 (enExample) |
| PL (1) | PL2723764T3 (enExample) |
| PT (1) | PT2723764T (enExample) |
| WO (1) | WO2012175643A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| WO2012175643A2 (en) | 2011-06-21 | 2012-12-27 | Vib Vzw | Binding domains directed against gpcr:g protein complexes and uses derived thereof |
| WO2014001557A1 (en) | 2012-06-28 | 2014-01-03 | Ucb Pharma S.A. | A method for identifying compounds of therapeutic interest |
| TWI707038B (zh) | 2013-08-05 | 2020-10-11 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| EP3164415B1 (en) * | 2014-07-04 | 2024-10-30 | INSERM - Institut National de la Santé et de la Recherche Médicale | Anti- mglur2 conformational single domain antibodies and uses thereof |
| WO2016067094A2 (en) | 2014-10-27 | 2016-05-06 | King Abdullah University Of Science And Technology | Methods and systems for identifying ligand-protein binding sites |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| CN108698012A (zh) | 2015-09-22 | 2018-10-23 | 特韦斯特生物科学公司 | 用于核酸合成的柔性基底 |
| WO2017095958A1 (en) | 2015-12-01 | 2017-06-08 | Twist Bioscience Corporation | Functionalized surfaces and preparation thereof |
| CN105802970A (zh) * | 2016-05-30 | 2016-07-27 | 东北师范大学 | 靶向沉默Gβ1的shRNA |
| KR102212257B1 (ko) | 2016-08-22 | 2021-02-04 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 핵산 라이브러리 |
| WO2018057526A2 (en) | 2016-09-21 | 2018-03-29 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CN107037116B (zh) * | 2016-12-01 | 2019-04-23 | 白波 | 检测gpcr之间相互作用及其交界面的方法 |
| EP3554514A4 (en) | 2016-12-16 | 2020-08-05 | Twist Bioscience Corporation | BANKS OF VARIANTS OF IMMUNOLOGICAL SYNAPSE AND THEIR SYNTHESIS |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| AU2018234629A1 (en) | 2017-03-15 | 2019-10-17 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| JP7169999B2 (ja) | 2017-06-12 | 2022-11-11 | ツイスト バイオサイエンス コーポレーション | シームレス核酸アセンブリのための方法 |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| AU2018328847A1 (en) * | 2017-09-11 | 2020-04-23 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| WO2019079769A1 (en) | 2017-10-20 | 2019-04-25 | Twist Bioscience Corporation | HEATED NANOWELLS FOR THE SYNTHESIS OF POLYNUCLEOTIDES |
| EP4635987A3 (en) | 2017-10-31 | 2026-01-14 | Vib Vzw | Novel antigen-binding chimeric proteins and methods and uses thereof |
| SG11202001226PA (en) * | 2017-12-21 | 2020-03-30 | Firmenich & Cie | Method for identifying positive allosteric modulators for odorant receptors |
| EP4715681A2 (en) | 2018-01-04 | 2026-03-25 | Atlas Data Storage, Inc. | Dna-based digital information storage |
| WO2019155041A1 (en) * | 2018-02-12 | 2019-08-15 | Vib Vzw | Gβγ COMPLEX ANTIBODIES AND USES THEREOF |
| CN108586620B (zh) * | 2018-05-10 | 2021-11-23 | 山东大学 | 筛选昆虫性信息素受体的配体的传感器分子以及筛选方法 |
| IL278771B2 (en) | 2018-05-18 | 2025-09-01 | Twist Bioscience Corp | Polynucleotides, reagents and methods for nucleic acid hybridization |
| FR3084365B1 (fr) | 2018-07-27 | 2020-10-23 | Cisbio Bioassays | Anticorps a domaine unique qui se lient a la proteine g alpha |
| US20220064245A1 (en) * | 2018-12-21 | 2022-03-03 | Vib Vzw | Fusion proteins comprising a cytokine and scaffold protein |
| WO2020139871A1 (en) | 2018-12-26 | 2020-07-02 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| FR3092172B1 (fr) * | 2019-01-30 | 2021-02-12 | Cisbio Bioassays | Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP |
| AU2020227802A1 (en) | 2019-02-26 | 2021-10-14 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| WO2020176678A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
| CN114041057A (zh) | 2019-04-29 | 2022-02-11 | 康福治疗有限公司 | 嵌合蛋白和筛选与gpcr结合的化合物和配体的方法 |
| US12123814B1 (en) * | 2019-06-14 | 2024-10-22 | Pierce Biotechnology, Inc. | G- protein coupled receptor extraction formulations |
| US12565537B2 (en) | 2019-06-18 | 2026-03-03 | Musc Foundation For Research Development | Compositions and methods targeting the nucleotide free state of RAS to block oncogenic signaling and transformation |
| CA3144644A1 (en) | 2019-06-21 | 2020-12-24 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| EP4034564A4 (en) | 2019-09-23 | 2023-12-13 | Twist Bioscience Corporation | VARIANT NUCLEIC ACID LIBRARIES FOR SINGLE-DOMAIN ANTIBODIES |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| BR112022011235A2 (pt) | 2019-12-09 | 2022-12-13 | Twist Bioscience Corp | Bibliotecas de variantes de ácido nucleico para receptores de adenosina |
| FR3106830B1 (fr) | 2020-01-30 | 2022-02-11 | Cisbio Bioassays | Anticorps anti-protéine G alpha |
| US12391762B2 (en) | 2020-08-26 | 2025-08-19 | Twist Bioscience Corporation | Methods and compositions relating to GLP1R variants |
| US20230340461A1 (en) * | 2022-02-14 | 2023-10-26 | Twist Bioscience Corporation | Combinatorial dna assembly for multispecific antibodies |
| WO2023159144A2 (en) * | 2022-02-17 | 2023-08-24 | The Regents Of The University Of Michigan | G-protein coupled receptor assay |
| CN114702570B (zh) * | 2022-03-23 | 2022-12-06 | 山东大学 | aGPCR拮抗剂 |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
| US11862295B1 (en) | 2022-11-08 | 2024-01-02 | United Arab Emirates University | Method of classifying conformers |
| CN116425888B (zh) * | 2023-04-24 | 2024-11-05 | 徐州医科大学 | 一种多肽tat-v2r1c及其应用 |
| US12176075B1 (en) | 2023-11-14 | 2024-12-24 | United Arab Emirates University | Method of matching conformers of different molecules |
| WO2025129064A1 (en) * | 2023-12-15 | 2025-06-19 | Eve Bio, Llc | Spliced rna barcodes for multiplexed cell-based high throughput screening |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| EP4620523A1 (en) * | 2024-03-22 | 2025-09-24 | Genome Research Limited | Mutants of the beta2-adrenergic receptor with altered activity and their use in disease treatment. |
| JP2025167890A (ja) * | 2024-04-26 | 2025-11-07 | 国立大学法人 東京大学 | 標的タンパク質に付加されるためのタンパク質 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| WO1999037681A2 (en) | 1998-01-26 | 1999-07-29 | Unilever Plc | Method for producing antibody fragments |
| AU2291700A (en) | 1999-01-19 | 2000-08-07 | Unilever Plc | Method for producing antibody fragments |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US7208279B2 (en) | 2001-03-14 | 2007-04-24 | Caden Biosciences, Inc. | Method for identifying inhibitors of G protein coupled receptor signaling |
| US7294472B2 (en) * | 2001-03-14 | 2007-11-13 | Caden Biosciences | Method for identifying modulators of G protein coupled receptor signaling |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| WO2004035614A1 (en) * | 2001-07-11 | 2004-04-29 | Karo Bio Ab | Synthetic or partially purified peptides which can bind to specific subunits of g proteins and uses thereof |
| US7371849B2 (en) | 2001-09-13 | 2008-05-13 | Institute For Antibodies Co., Ltd. | Methods of constructing camel antibody libraries |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| JP4490290B2 (ja) | 2002-12-31 | 2010-06-23 | ネクター セラピューティクス アラバマ，コーポレイション | 加水分解安定性マレイミド末端ポリマー |
| WO2006086883A1 (en) | 2005-02-16 | 2006-08-24 | Universite De Montreal | Biosensors for monitoring receptor-mediated g-protein activation |
| CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| US7947807B2 (en) * | 2007-10-15 | 2011-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3) |
| NZ589036A (en) * | 2008-05-16 | 2012-07-27 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
| WO2009147196A1 (en) | 2008-06-04 | 2009-12-10 | Vib Vzw | Hiv-rev-multimerization inhibiting nanobodies |
| WO2010043650A2 (en) * | 2008-10-14 | 2010-04-22 | Ablynx Nv | Amino acid sequences directed against cellular receptors for viruses and bacteria |
| CA2749558C (en) | 2008-12-08 | 2019-01-15 | Complix Nv | Single-chain antiparallel coiled coil proteins |
| GB201014715D0 (en) * | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| US8765414B2 (en) | 2011-03-15 | 2014-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | GPCR fusion protein containing an N-terminal autonomously folding stable domain, and crystals of the same |
| WO2012175643A2 (en) | 2011-06-21 | 2012-12-27 | Vib Vzw | Binding domains directed against gpcr:g protein complexes and uses derived thereof |
-
2012
- 2012-06-21 WO PCT/EP2012/062036 patent/WO2012175643A2/en not_active Ceased
- 2012-06-21 EP EP17209368.4A patent/EP3345919B1/en active Active
- 2012-06-21 US US14/129,100 patent/US9695227B2/en active Active
- 2012-06-21 HR HRP20180443TT patent/HRP20180443T1/hr unknown
- 2012-06-21 ES ES12730478.0T patent/ES2662372T3/es active Active
- 2012-06-21 HU HUE12730478A patent/HUE036982T2/hu unknown
- 2012-06-21 EP EP23193788.9A patent/EP4282882A3/en active Pending
- 2012-06-21 CA CA2839834A patent/CA2839834A1/en active Pending
- 2012-06-21 EP EP12730478.0A patent/EP2723764B1/en active Active
- 2012-06-21 DK DK12730478.0T patent/DK2723764T3/en active
- 2012-06-21 CN CN201710728087.8A patent/CN107857810A/zh active Pending
- 2012-06-21 NO NO12730478A patent/NO2723764T3/no unknown
- 2012-06-21 JP JP2014516358A patent/JP6164535B2/ja active Active
- 2012-06-21 CN CN201280040585.9A patent/CN104053667B/zh active Active
- 2012-06-21 PL PL12730478T patent/PL2723764T3/pl unknown
- 2012-06-21 AU AU2012273987A patent/AU2012273987B2/en active Active
- 2012-06-21 PT PT127304780T patent/PT2723764T/pt unknown
-
2017
- 2017-02-16 JP JP2017026632A patent/JP2017127306A/ja active Pending
- 2017-05-01 US US15/583,540 patent/US10626154B2/en active Active
-
2020
- 2020-04-17 US US16/852,235 patent/US12252521B2/en active Active
-
2024
- 2024-11-26 US US18/960,784 patent/US20250171510A1/en active Pending
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