JP2014525412A5 - - Google Patents

Info

Publication number

JP2014525412A5

JP2014525412A5 JP2014526228A JP2014526228A JP2014525412A5 JP 2014525412 A5 JP2014525412 A5 JP 2014525412A5 JP 2014526228 A JP2014526228 A JP 2014526228A JP 2014526228 A JP2014526228 A JP 2014526228A JP 2014525412 A5 JP2014525412 A5 JP 2014525412A5

Authority

JP

Japan

Prior art keywords

fragment

antibody

tumor

antagonist

medicament

Prior art date

2012-08-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims 67
• 239000012634 fragment Substances 0.000 claims 48
• 206010028980 Neoplasm Diseases 0.000 claims 44
• 102000013691 Interleukin-17 Human genes 0.000 claims 40
• 108050003558 Interleukin-17 Proteins 0.000 claims 40
• 239000005557 antagonist Substances 0.000 claims 38
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 12
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 12
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 12
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 10
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 229960000397 bevacizumab Drugs 0.000 claims 6
• 210000005259 peripheral blood Anatomy 0.000 claims 6
• 239000011886 peripheral blood Substances 0.000 claims 6
• 238000002591 computed tomography Methods 0.000 claims 4
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 3
• 102100022338 Integrin alpha-M Human genes 0.000 claims 3
• 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 3
• 210000004204 blood vessel Anatomy 0.000 claims 3
• 210000000481 breast Anatomy 0.000 claims 3
• 238000002512 chemotherapy Methods 0.000 claims 3
• 210000001072 colon Anatomy 0.000 claims 3
• 230000003247 decreasing effect Effects 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 230000002401 inhibitory effect Effects 0.000 claims 3
• 210000004185 liver Anatomy 0.000 claims 3
• 210000004072 lung Anatomy 0.000 claims 3
• 238000012544 monitoring process Methods 0.000 claims 3
• 210000001672 ovary Anatomy 0.000 claims 3
• 210000002307 prostate Anatomy 0.000 claims 3
• 238000001959 radiotherapy Methods 0.000 claims 3
• 102000005962 receptors Human genes 0.000 claims 3
• 108020003175 receptors Proteins 0.000 claims 3
• 210000000664 rectum Anatomy 0.000 claims 3
• 238000002179 total cell area Methods 0.000 claims 3
• 238000002595 magnetic resonance imaging Methods 0.000 claims 2
• 238000002600 positron emission tomography Methods 0.000 claims 2
• 238000002603 single-photon emission computed tomography Methods 0.000 claims 2
• 230000005747 tumor angiogenesis Effects 0.000 claims 2
• 230000004614 tumor growth Effects 0.000 claims 2