JP2014524465A5 - - Google Patents
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- Publication number
- JP2014524465A5 JP2014524465A5 JP2014526601A JP2014526601A JP2014524465A5 JP 2014524465 A5 JP2014524465 A5 JP 2014524465A5 JP 2014526601 A JP2014526601 A JP 2014526601A JP 2014526601 A JP2014526601 A JP 2014526601A JP 2014524465 A5 JP2014524465 A5 JP 2014524465A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- bacteriochlorophyll
- nrr
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 bacteriochlorophyll compound Chemical class 0.000 claims 35
- 108010003118 Bacteriochlorophylls Proteins 0.000 claims 19
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 19
- 229930002875 chlorophyll Natural products 0.000 claims 12
- 235000019804 chlorophyll Nutrition 0.000 claims 12
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 11
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 claims 8
- 150000001768 cations Chemical class 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052763 palladium Inorganic materials 0.000 claims 8
- 230000004962 physiological condition Effects 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 230000002378 acidificating effect Effects 0.000 claims 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000004036 bacteriochlorins Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000524 functional group Chemical group 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002428 photodynamic therapy Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 239000003513 alkali Substances 0.000 claims 2
- 150000001447 alkali salts Chemical class 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 229920001222 biopolymer Polymers 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000004087 cornea Anatomy 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 150000002772 monosaccharides Chemical class 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 150000002892 organic cations Chemical class 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 108010013121 palladium-bacteriopheophorbide Proteins 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 210000003786 sclera Anatomy 0.000 claims 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 1
- 125000004530 1,2,4-triazinyl group Chemical group N1=NC(=NC=C1)* 0.000 claims 1
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 claims 1
- 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims 1
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- 206010054760 Corneal thinning Diseases 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-O Pyrazolium Chemical compound C1=CN[NH+]=C1 WTKZEGDFNFYCGP-UHFFFAOYSA-O 0.000 claims 1
- 229920002305 Schizophyllan Polymers 0.000 claims 1
- 229910052769 Ytterbium Inorganic materials 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- VUEDNLCYHKSELL-UHFFFAOYSA-N arsonium Chemical compound [AsH4+] VUEDNLCYHKSELL-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical group N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 1
- 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229940125904 compound 1 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-O hydron;1,3-oxazole Chemical compound C1=COC=[NH+]1 ZCQWOFVYLHDMMC-UHFFFAOYSA-O 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-O hydron;pyrimidine Chemical compound C1=CN=C[NH+]=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-O 0.000 claims 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-O isoquinolin-2-ium Chemical compound C1=[NH+]C=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-O 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 108010049593 padeliporfin Proteins 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- SBMSLRMNBSMKQC-UHFFFAOYSA-N pyrrolidin-1-amine Chemical group NN1CCCC1 SBMSLRMNBSMKQC-UHFFFAOYSA-N 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161526414P | 2011-08-23 | 2011-08-23 | |
| US61/526,414 | 2011-08-23 | ||
| PCT/IL2012/050325 WO2013027222A1 (en) | 2011-08-23 | 2012-08-23 | (bacterio)chlorophyll photosensitizers for treatment of eye diseases and disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524465A JP2014524465A (ja) | 2014-09-22 |
| JP2014524465A5 true JP2014524465A5 (cg-RX-API-DMAC7.html) | 2015-10-01 |
| JP6215203B2 JP6215203B2 (ja) | 2017-10-18 |
Family
ID=46889394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526601A Active JP6215203B2 (ja) | 2011-08-23 | 2012-08-23 | 眼疾患および障害の治療用の（バクテリオ）クロロフィル光増感剤 |
Country Status (20)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| US9566301B2 (en) | 2012-03-29 | 2017-02-14 | Cxl Ophthalmics, Llc | Compositions and methods for treating or preventing diseases associated with oxidative stress |
| EP2830627B1 (en) | 2012-03-29 | 2024-05-01 | Epion Therapeutics, Inc. | Ocular treatment solutions, delivery devices and delivery augmentation methods |
| RU2635185C2 (ru) * | 2013-12-17 | 2017-11-09 | Иван Дмитриевич Захаров | Фармацевтический препарат для профилактики и лечения прогрессирующей близорукости |
| US11207410B2 (en) | 2015-07-21 | 2021-12-28 | Avedro, Inc. | Systems and methods for treatments of an eye with a photosensitizer |
| CN106620893B (zh) * | 2015-07-23 | 2021-07-30 | 爱博诺德(北京)医疗科技股份有限公司 | 用于眼部疾病光治疗的材料 |
| US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
| CN105601638B (zh) * | 2016-01-28 | 2018-10-26 | 东北林业大学 | 一种叶绿酸衍生物及其制备方法、作为光敏抑菌剂及光敏杀虫剂的应用 |
| US10342697B2 (en) | 2016-04-13 | 2019-07-09 | Avedro, Inc. | Systems and methods for delivering drugs to an eye |
| US20170319329A1 (en) * | 2016-05-05 | 2017-11-09 | David Muller | Corneal Implant Systems and Methods |
| AU2017390276A1 (en) * | 2017-01-03 | 2019-06-27 | Vitrean, Inc. | Methods and devices for treating a retinal detachment |
| JP7364552B2 (ja) * | 2017-08-02 | 2023-10-18 | ザ ユニバーシティ オブ シカゴ | Ｘ線誘起光線力学療法、放射線療法、放射線力学療法、化学療法、免疫療法、及びそれらの任意の組み合わせのための、ナノスケール金属有機層及び金属有機ナノプレート |
| CN109091685A (zh) * | 2018-08-10 | 2018-12-28 | 北京市眼科研究所 | 一种对角膜炎提取细菌病原体的灭活方法 |
| US11702546B2 (en) | 2018-10-24 | 2023-07-18 | California Institute Of Technology | Near-infrared heptamethine dyes for generation of singlet oxygen |
| CN113286788A (zh) * | 2018-10-24 | 2021-08-20 | 加州理工学院 | 使用单线态氧治疗近视和其他眼病症 |
| US20220041563A1 (en) * | 2018-12-04 | 2022-02-10 | Avedro, Inc. | Compounds and Compositions for Eye Treatments |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| IL133253A0 (en) * | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| RU2201219C2 (ru) * | 2001-04-24 | 2003-03-27 | Макаров Константин Алексеевич | Фармакологическая композиция пролонгированного действия |
| US20040266748A1 (en) * | 2001-10-03 | 2004-12-30 | Robinson Byron C | Photosensitizing carbamate derivatives |
| IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| ES2602460T3 (es) * | 2004-06-07 | 2017-02-21 | Yeda Research And Development Co., Ltd. | Derivados de bacterioclorofila catiónicos y usos de los mismos |
| EP2061512B1 (en) * | 2006-08-23 | 2019-10-02 | Yeda Research And Development Co. Ltd. | Conjugates of rgd peptides and (bacterio)chlorophyll photosensitizers and their uses |
| KR101502632B1 (ko) | 2006-10-24 | 2015-03-17 | 캘리포니아 인스티튜트 오브 테크놀로지 | 신체 조직의 물리적 및/또는 화학적 성질에 영향을 주는 광화학적 요법 |
| RU2404768C1 (ru) * | 2009-10-28 | 2010-11-27 | Федеральное агентство по науке и инновациям | Глазные капли |
| JPWO2011099602A1 (ja) * | 2010-02-12 | 2013-06-17 | 学校法人日本大学 | ポルフィリン誘導体および放射線力学療法におけるその使用 |
-
2012
- 2012-08-23 BR BR112014004306A patent/BR112014004306A2/pt not_active IP Right Cessation
- 2012-08-23 HK HK14113090.6A patent/HK1199412A1/xx unknown
- 2012-08-23 ES ES12762405T patent/ES2856698T3/es active Active
- 2012-08-23 EP EP12762405.4A patent/EP2747763B1/en active Active
- 2012-08-23 US US14/240,328 patent/US9452172B2/en active Active
- 2012-08-23 JP JP2014526601A patent/JP6215203B2/ja active Active
- 2012-08-23 PT PT127624054T patent/PT2747763T/pt unknown
- 2012-08-23 PE PE2014000246A patent/PE20141183A1/es not_active Application Discontinuation
- 2012-08-23 DK DK12762405.4T patent/DK2747763T3/da active
- 2012-08-23 WO PCT/IL2012/050325 patent/WO2013027222A1/en not_active Ceased
- 2012-08-23 RU RU2014110784A patent/RU2632439C2/ru active
- 2012-08-23 KR KR1020147007481A patent/KR101962991B1/ko active Active
- 2012-08-23 CA CA2846011A patent/CA2846011C/en active Active
- 2012-08-23 MX MX2014002107A patent/MX360683B/es active IP Right Grant
- 2012-08-23 CN CN201280045801.9A patent/CN103930108B/zh active Active
- 2012-08-23 IN IN2153CHN2014 patent/IN2014CN02153A/en unknown
- 2012-08-23 HU HUE12762405A patent/HUE053321T2/hu unknown
- 2012-08-23 AU AU2012298156A patent/AU2012298156B2/en not_active Ceased
-
2014
- 2014-02-21 CL CL2014000432A patent/CL2014000432A1/es unknown
- 2014-03-20 ZA ZA2014/02056A patent/ZA201402056B/en unknown
-
2016
- 2016-08-18 US US15/240,221 patent/US20160354468A1/en not_active Abandoned
-
2018
- 2018-11-20 US US16/196,537 patent/US11058772B2/en active Active
-
2021
- 2021-07-08 US US17/370,743 patent/US20210330792A1/en not_active Abandoned
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