BR112014004306A2 - fotossensibilizadores de (bacterio)clorofila para tratamento de doenças e distúrbios do olho - Google Patents
fotossensibilizadores de (bacterio)clorofila para tratamento de doenças e distúrbios do olhoInfo
- Publication number
- BR112014004306A2 BR112014004306A2 BR112014004306A BR112014004306A BR112014004306A2 BR 112014004306 A2 BR112014004306 A2 BR 112014004306A2 BR 112014004306 A BR112014004306 A BR 112014004306A BR 112014004306 A BR112014004306 A BR 112014004306A BR 112014004306 A2 BR112014004306 A2 BR 112014004306A2
- Authority
- BR
- Brazil
- Prior art keywords
- bacterio
- photosensitizers
- chlorophyll
- disorders
- eye diseases
- Prior art date
Links
- 229930002875 chlorophyll Natural products 0.000 title 1
- 235000019804 chlorophyll Nutrition 0.000 title 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 208000030533 eye disease Diseases 0.000 title 1
- 239000003504 photosensitizing agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161526414P | 2011-08-23 | 2011-08-23 | |
| PCT/IL2012/050325 WO2013027222A1 (en) | 2011-08-23 | 2012-08-23 | (bacterio)chlorophyll photosensitizers for treatment of eye diseases and disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014004306A2 true BR112014004306A2 (pt) | 2017-03-28 |
Family
ID=46889394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014004306A BR112014004306A2 (pt) | 2011-08-23 | 2012-08-23 | fotossensibilizadores de (bacterio)clorofila para tratamento de doenças e distúrbios do olho |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9452172B2 (pt) |
| EP (1) | EP2747763B1 (pt) |
| JP (1) | JP6215203B2 (pt) |
| KR (1) | KR101962991B1 (pt) |
| CN (1) | CN103930108B (pt) |
| AU (1) | AU2012298156B2 (pt) |
| BR (1) | BR112014004306A2 (pt) |
| CA (1) | CA2846011C (pt) |
| CL (1) | CL2014000432A1 (pt) |
| DK (1) | DK2747763T3 (pt) |
| ES (1) | ES2856698T3 (pt) |
| HK (1) | HK1199412A1 (pt) |
| HU (1) | HUE053321T2 (pt) |
| IN (1) | IN2014CN02153A (pt) |
| MX (1) | MX360683B (pt) |
| PE (1) | PE20141183A1 (pt) |
| PT (1) | PT2747763T (pt) |
| RU (1) | RU2632439C2 (pt) |
| WO (1) | WO2013027222A1 (pt) |
| ZA (1) | ZA201402056B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
| EP3494974B1 (en) | 2011-07-08 | 2023-10-18 | The University of North Carolina at Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| EP2830637A4 (en) | 2012-03-29 | 2016-03-16 | Cxl Ophthalmics Llc | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES RELATED TO OXIDATIVE STRESS |
| WO2013148896A1 (en) | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular treatment solutions, delivery devices and delivery augmentation methods |
| RU2635185C2 (ru) * | 2013-12-17 | 2017-11-09 | Иван Дмитриевич Захаров | Фармацевтический препарат для профилактики и лечения прогрессирующей близорукости |
| US11207410B2 (en) | 2015-07-21 | 2021-12-28 | Avedro, Inc. | Systems and methods for treatments of an eye with a photosensitizer |
| CN106620893B (zh) | 2015-07-23 | 2021-07-30 | 爱博诺德(北京)医疗科技股份有限公司 | 用于眼部疾病光治疗的材料 |
| US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
| CN105601638B (zh) * | 2016-01-28 | 2018-10-26 | 东北林业大学 | 一种叶绿酸衍生物及其制备方法、作为光敏抑菌剂及光敏杀虫剂的应用 |
| WO2017180851A1 (en) | 2016-04-13 | 2017-10-19 | Avedro, Inc. | Systems and methods for delivering drugs to an eye |
| EP4335419A3 (en) * | 2016-05-05 | 2024-04-03 | David Muller | Corneal implant systems and methods |
| WO2018128876A1 (en) * | 2017-01-03 | 2018-07-12 | Vitrean, Inc. | Methods and devices for treating a retinal detachment |
| WO2019028250A1 (en) * | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
| CN109091685A (zh) * | 2018-08-10 | 2018-12-28 | 北京市眼科研究所 | 一种对角膜炎提取细菌病原体的灭活方法 |
| JP2022503941A (ja) * | 2018-10-24 | 2022-01-12 | カリフォルニア インスティチュート オブ テクノロジー | 近赤外線照射により活性化された染料から生成した一重項酸素を用いた、近視および他の眼の状態の治療 |
| US11702546B2 (en) | 2018-10-24 | 2023-07-18 | California Institute Of Technology | Near-infrared heptamethine dyes for generation of singlet oxygen |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| IL133253A0 (en) * | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| RU2201219C2 (ru) * | 2001-04-24 | 2003-03-27 | Макаров Константин Алексеевич | Фармакологическая композиция пролонгированного действия |
| EP1450790A4 (en) * | 2001-10-03 | 2005-10-26 | Miravant Pharm Inc | PHOTOSENSIBILIZING CARBAMATE DERIVATIVES |
| IL152900A0 (en) | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| WO2005120573A2 (en) * | 2004-06-07 | 2005-12-22 | Yeda Research And Development Co. Ltd. | Cationic bacteriochlorophyll derivatives and uses thereof |
| HUE047789T2 (hu) * | 2006-08-23 | 2020-05-28 | Yeda Res & Dev | RGD peptidek és (bakterio)klorofill fényérzékenyítõk konjugátumai, valamint ezek alkalmazásai |
| KR101502632B1 (ko) | 2006-10-24 | 2015-03-17 | 캘리포니아 인스티튜트 오브 테크놀로지 | 신체 조직의 물리적 및/또는 화학적 성질에 영향을 주는 광화학적 요법 |
| RU2404768C1 (ru) * | 2009-10-28 | 2010-11-27 | Федеральное агентство по науке и инновациям | Глазные капли |
| JPWO2011099602A1 (ja) * | 2010-02-12 | 2013-06-17 | 学校法人日本大学 | ポルフィリン誘導体および放射線力学療法におけるその使用 |
-
2012
- 2012-08-23 IN IN2153CHN2014 patent/IN2014CN02153A/en unknown
- 2012-08-23 PT PT127624054T patent/PT2747763T/pt unknown
- 2012-08-23 HU HUE12762405A patent/HUE053321T2/hu unknown
- 2012-08-23 MX MX2014002107A patent/MX360683B/es active IP Right Grant
- 2012-08-23 BR BR112014004306A patent/BR112014004306A2/pt not_active IP Right Cessation
- 2012-08-23 KR KR1020147007481A patent/KR101962991B1/ko active IP Right Grant
- 2012-08-23 WO PCT/IL2012/050325 patent/WO2013027222A1/en active Application Filing
- 2012-08-23 DK DK12762405.4T patent/DK2747763T3/da active
- 2012-08-23 JP JP2014526601A patent/JP6215203B2/ja active Active
- 2012-08-23 CA CA2846011A patent/CA2846011C/en active Active
- 2012-08-23 EP EP12762405.4A patent/EP2747763B1/en active Active
- 2012-08-23 US US14/240,328 patent/US9452172B2/en active Active
- 2012-08-23 ES ES12762405T patent/ES2856698T3/es active Active
- 2012-08-23 AU AU2012298156A patent/AU2012298156B2/en not_active Ceased
- 2012-08-23 PE PE2014000246A patent/PE20141183A1/es not_active Application Discontinuation
- 2012-08-23 RU RU2014110784A patent/RU2632439C2/ru active
- 2012-08-23 CN CN201280045801.9A patent/CN103930108B/zh active Active
-
2014
- 2014-02-21 CL CL2014000432A patent/CL2014000432A1/es unknown
- 2014-03-20 ZA ZA2014/02056A patent/ZA201402056B/en unknown
- 2014-12-31 HK HK14113090.6A patent/HK1199412A1/xx unknown
-
2016
- 2016-08-18 US US15/240,221 patent/US20160354468A1/en not_active Abandoned
-
2018
- 2018-11-20 US US16/196,537 patent/US11058772B2/en active Active
-
2021
- 2021-07-08 US US17/370,743 patent/US20210330792A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP6215203B2 (ja) | 2017-10-18 |
| AU2012298156A1 (en) | 2014-04-10 |
| CN103930108B (zh) | 2017-05-24 |
| AU2012298156B2 (en) | 2017-08-17 |
| DK2747763T3 (da) | 2021-03-29 |
| KR20140088514A (ko) | 2014-07-10 |
| PT2747763T (pt) | 2021-02-22 |
| WO2013027222A1 (en) | 2013-02-28 |
| EP2747763B1 (en) | 2020-12-30 |
| CN103930108A (zh) | 2014-07-16 |
| RU2632439C2 (ru) | 2017-10-04 |
| ES2856698T3 (es) | 2021-09-28 |
| RU2014110784A (ru) | 2015-09-27 |
| US11058772B2 (en) | 2021-07-13 |
| MX360683B (es) | 2018-11-13 |
| IN2014CN02153A (pt) | 2015-05-29 |
| CL2014000432A1 (es) | 2014-11-28 |
| KR101962991B1 (ko) | 2019-03-27 |
| HK1199412A1 (en) | 2015-07-03 |
| US20140378888A1 (en) | 2014-12-25 |
| PE20141183A1 (es) | 2014-10-05 |
| US20160354468A1 (en) | 2016-12-08 |
| EP2747763A1 (en) | 2014-07-02 |
| CA2846011A1 (en) | 2013-02-28 |
| HUE053321T2 (hu) | 2021-06-28 |
| US20210330792A1 (en) | 2021-10-28 |
| ZA201402056B (en) | 2015-11-25 |
| US9452172B2 (en) | 2016-09-27 |
| CA2846011C (en) | 2019-10-15 |
| MX2014002107A (es) | 2015-04-16 |
| US20190231874A1 (en) | 2019-08-01 |
| JP2014524465A (ja) | 2014-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2634 DE 29-06-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |