JP2014524444A5 - - Google Patents
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- Publication number
- JP2014524444A5 JP2014524444A5 JP2014526240A JP2014526240A JP2014524444A5 JP 2014524444 A5 JP2014524444 A5 JP 2014524444A5 JP 2014526240 A JP2014526240 A JP 2014526240A JP 2014526240 A JP2014526240 A JP 2014526240A JP 2014524444 A5 JP2014524444 A5 JP 2014524444A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- pharmaceutically acceptable
- pharmaceutical composition
- amino acid
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 132
- 239000008194 pharmaceutical composition Substances 0.000 claims description 75
- 235000002639 sodium chloride Nutrition 0.000 claims description 65
- 150000003839 salts Chemical class 0.000 claims description 62
- 150000001413 amino acids Chemical group 0.000 claims description 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 35
- 108010024409 linaclotide Proteins 0.000 claims description 32
- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 claims description 32
- 229960000812 linaclotide Drugs 0.000 claims description 32
- 235000001014 amino acid Nutrition 0.000 claims description 16
- 229940024606 amino acid Drugs 0.000 claims description 16
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 14
- 102100034605 Atrial natriuretic peptide receptor 3 Human genes 0.000 claims description 12
- 101000924488 Homo sapiens Atrial natriuretic peptide receptor 3 Proteins 0.000 claims description 12
- 206010010774 Constipation Diseases 0.000 claims description 11
- 150000003141 primary amines Chemical class 0.000 claims description 10
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- 239000011777 magnesium Substances 0.000 claims description 9
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 239000011572 manganese Substances 0.000 claims description 8
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
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- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 6
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
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- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 3
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 3
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- CPSYWNLKRDURMG-UHFFFAOYSA-L hydron;manganese(2+);phosphate Chemical compound [Mn+2].OP([O-])([O-])=O CPSYWNLKRDURMG-UHFFFAOYSA-L 0.000 claims description 3
- 208000003243 intestinal obstruction Diseases 0.000 claims description 3
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| UA119335C2 (uk) * | 2013-12-11 | 2019-06-10 | Айронвуд Фармасьютикалз, Інк. | Композиції лінаклотиду з затриманим вивільненням |
| WO2016125064A1 (en) * | 2015-02-02 | 2016-08-11 | Aurobindo Pharma Ltd | Stable compositions comprising linaclotide |
| CN105176304A (zh) * | 2015-09-17 | 2015-12-23 | 安徽温禾新材料科技股份有限公司 | 一种木塑地板加工用底漆 |
| JP7132128B2 (ja) * | 2016-04-25 | 2022-09-06 | ジェレシス，エルエルシー | 便秘の治療方法 |
| CN117257800A (zh) | 2016-11-02 | 2023-12-22 | 诺华股份有限公司 | Fgfr4抑制剂和胆汁酸螯合剂的组合 |
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| CN114206324A (zh) * | 2019-06-10 | 2022-03-18 | 硬木药品公司 | 治疗与腹泻占主导的肠易激综合征相关的腹部疼痛 |
| US20230226143A1 (en) * | 2020-06-30 | 2023-07-20 | Ocvirk, Soren | Pharmaceutical composition comprising a combination of a guanylate cyclase c (gucy2c) agonist and a short-chain fatty acid or prodrug thereof |
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- 2012-08-17 EP EP12753313.1A patent/EP2776055B1/en not_active Revoked
- 2012-08-17 DK DK12753313.1T patent/DK2776055T3/en active
- 2012-08-17 PL PL12753313T patent/PL2776055T3/pl unknown
- 2012-08-17 WO PCT/US2012/051289 patent/WO2013025969A1/en not_active Ceased
- 2012-08-17 CN CN201280050874.7A patent/CN104053449B/zh not_active Ceased
-
2017
- 2017-10-11 JP JP2017197493A patent/JP2018002740A/ja not_active Withdrawn
-
2018
- 2018-02-27 US US15/906,744 patent/US20180186835A1/en not_active Abandoned
- 2018-10-26 US US16/171,524 patent/US20190062376A1/en not_active Abandoned
-
2019
- 2019-02-05 JP JP2019018657A patent/JP2019085415A/ja not_active Withdrawn
-
2020
- 2020-05-25 JP JP2020090285A patent/JP2020128424A/ja not_active Withdrawn
- 2020-10-09 US US17/066,802 patent/US20210032292A1/en not_active Abandoned
-
2021
- 2021-11-12 JP JP2021184756A patent/JP2022010265A/ja not_active Withdrawn
- 2021-12-30 US US17/566,241 patent/US20220119452A1/en not_active Abandoned
-
2023
- 2023-05-05 US US18/143,892 patent/US20230272007A1/en not_active Abandoned
- 2023-12-05 JP JP2023205346A patent/JP2024015204A/ja active Pending
-
2025
- 2025-06-05 JP JP2025094194A patent/JP2025116257A/ja active Pending
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