|
US2699808A
(en)
|
1944-10-06 |
1955-01-18 |
Mark W Lowe |
Apparatus for peeling tomatoes
|
|
US4534899A
(en)
|
1981-07-20 |
1985-08-13 |
Lipid Specialties, Inc. |
Synthetic phospholipid compounds
|
|
US4426330A
(en)
|
1981-07-20 |
1984-01-17 |
Lipid Specialties, Inc. |
Synthetic phospholipid compounds
|
|
US5354844A
(en)
|
1989-03-16 |
1994-10-11 |
Boehringer Ingelheim International Gmbh |
Protein-polycation conjugates
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US5227170A
(en)
|
1989-06-22 |
1993-07-13 |
Vestar, Inc. |
Encapsulation process
|
|
EP0420081A1
(en)
|
1989-09-26 |
1991-04-03 |
Takeda Chemical Industries, Ltd. |
Monoclonal antibody against an acidic FGF protein, its production and use
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5356633A
(en)
|
1989-10-20 |
1994-10-18 |
Liposome Technology, Inc. |
Method of treatment of inflamed tissues
|
|
US5527528A
(en)
|
1989-10-20 |
1996-06-18 |
Sequus Pharmaceuticals, Inc. |
Solid-tumor treatment method
|
|
US5580575A
(en)
|
1989-12-22 |
1996-12-03 |
Imarx Pharmaceutical Corp. |
Therapeutic drug delivery systems
|
|
US5469854A
(en)
|
1989-12-22 |
1995-11-28 |
Imarx Pharmaceutical Corp. |
Methods of preparing gas-filled liposomes
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US6582908B2
(en)
|
1990-12-06 |
2003-06-24 |
Affymetrix, Inc. |
Oligonucleotides
|
|
JP3220180B2
(ja)
|
1991-05-23 |
2001-10-22 |
三菱化学株式会社 |
薬剤含有タンパク質結合リポソーム
|
|
US5521291A
(en)
|
1991-09-30 |
1996-05-28 |
Boehringer Ingelheim International, Gmbh |
Conjugates for introducing nucleic acid into higher eucaryotic cells
|
|
NZ244306A
(en)
|
1991-09-30 |
1995-07-26 |
Boehringer Ingelheim Int |
Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
|
|
US20040006005A1
(en)
|
2002-07-02 |
2004-01-08 |
Sanjay Bhanot |
Use of integrin-linked kinase inhibitors for treating insulin resistance, hyperglycemia and diabetes
|
|
US5583020A
(en)
|
1992-11-24 |
1996-12-10 |
Ribozyme Pharmaceuticals, Inc. |
Permeability enhancers for negatively charged polynucleotides
|
|
EP0673559A1
(en)
|
1992-12-14 |
1995-09-27 |
Honeywell Inc. |
Motor system with individually controlled redundant windings
|
|
EP0677055A1
(en)
|
1992-12-31 |
1995-10-18 |
Texas Biotechnology Corporation |
Antisense molecules directed against a fibroflast growth factor receptor gene family
|
|
JP3351476B2
(ja)
|
1993-01-22 |
2002-11-25 |
三菱化学株式会社 |
リン脂質誘導体及びそれを含有するリポソーム
|
|
US5395619A
(en)
|
1993-03-03 |
1995-03-07 |
Liposome Technology, Inc. |
Lipid-polymer conjugates and liposomes
|
|
US5462854A
(en)
|
1993-04-19 |
1995-10-31 |
Beckman Instruments, Inc. |
Inverse linkage oligonucleotides for chemical and enzymatic processes
|
|
US5534259A
(en)
|
1993-07-08 |
1996-07-09 |
Liposome Technology, Inc. |
Polymer compound and coated particle composition
|
|
US5543158A
(en)
|
1993-07-23 |
1996-08-06 |
Massachusetts Institute Of Technology |
Biodegradable injectable nanoparticles
|
|
US5417978A
(en)
|
1993-07-29 |
1995-05-23 |
Board Of Regents, The University Of Texas System |
Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
US5543152A
(en)
|
1994-06-20 |
1996-08-06 |
Inex Pharmaceuticals Corporation |
Sphingosomes for enhanced drug delivery
|
|
US5591721A
(en)
|
1994-10-25 |
1997-01-07 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US5512295A
(en)
|
1994-11-10 |
1996-04-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Synthetic liposomes for enhanced uptake and delivery
|
|
US20050053976A1
(en)
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
DE69829760T3
(de)
|
1997-09-12 |
2016-04-14 |
Exiqon A/S |
Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US20030228597A1
(en)
|
1998-04-13 |
2003-12-11 |
Cowsert Lex M. |
Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
|
|
DE69900847T2
(de)
|
1998-04-17 |
2002-09-12 |
Tufts College |
Map kinase-inhibitoren zur behandlung von durch tnf-alpha induzierte lipolyse- verursachte krankheiten
|
|
DK199800393U1
(da)
|
1998-10-21 |
1998-10-21 |
R E Beton A S Betonelementfabr |
Tagelement
|
|
US6153432A
(en)
|
1999-01-29 |
2000-11-28 |
Zen-Bio, Inc |
Methods for the differentiation of human preadipocytes into adipocytes
|
|
AU776362B2
(en)
|
1999-05-04 |
2004-09-09 |
Roche Innovation Center Copenhagen A/S |
L-ribo-LNA analogues
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
ES2258459T3
(es)
|
1999-05-21 |
2006-09-01 |
Bristol-Myers Squibb Company |
Pirrolotriazinas inhibidoras de quinasas.
|
|
ES2264929T3
(es)
|
1999-09-08 |
2007-02-01 |
Genentech, Inc. |
Acidos nucleicos y polipeptidos del factor 19 de crecimiento fibroblastico (fgf-19) y procedimientos de utilizacion para el tratamiento de la obesidad.
|
|
WO2001049849A1
(en)
|
2000-01-05 |
2001-07-12 |
Zymogenetics, Inc. |
Novel fgf homolog zfgf11
|
|
US6287860B1
(en)
|
2000-01-20 |
2001-09-11 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of MEKK2 expression
|
|
EP1268793A2
(en)
|
2000-03-22 |
2003-01-02 |
Amgen, Inc. |
Fibroblast growth factor receptor-like molecules and uses thereof
|
|
AU5056501A
(en)
|
2000-03-31 |
2001-10-08 |
Nobuyuki Itoh |
Fibroblast growth factor-like molecules and uses thereof
|
|
AU6459801A
(en)
|
2000-05-12 |
2001-11-26 |
Mark T Keating |
Compositions and methods for cell dedifferentiation and tissue regeneration
|
|
EP1202065A1
(en)
|
2000-10-25 |
2002-05-02 |
Aventis Pharma S.A. |
Net, a transcription factor of the TCF family, as regulator of angiogenic expression.
|
|
CA2452458A1
(en)
|
2001-07-03 |
2003-01-16 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
|
DE10152147A1
(de)
|
2001-10-25 |
2003-05-15 |
Chemogenix Gmbh |
Verfahren zum Aufbringen von Nukleosiden und/oder Nukleotiden auf funktionalisierten Oberflächen sowie Verfahren zur Bestimmung von Kopplungsausbeuten bei der Synthese von Nukleotiden
|
|
MXPA04003954A
(es)
|
2001-10-26 |
2004-11-29 |
Aventis Pharma Inc |
Bencimidazoles.
|
|
US7655397B2
(en)
|
2002-04-25 |
2010-02-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers
|
|
NZ537155A
(en)
|
2002-05-23 |
2006-09-29 |
Cytopia Pty Ltd |
Protein kinase inhibitors
|
|
TW200401638A
(en)
|
2002-06-20 |
2004-02-01 |
Bristol Myers Squibb Co |
Heterocyclic inhibitors of kinases
|
|
EP2267117A3
(en)
|
2002-06-27 |
2011-07-13 |
Verva Pharmaceuticals Pty Ltd |
Differentiation modulating agents and uses therefor
|
|
AU2003232412A1
(en)
|
2002-07-08 |
2004-01-23 |
Koninklijke Philips Electronics N.V. |
Reflective stereoscopic display
|
|
AU2003286757B2
(en)
|
2002-11-01 |
2009-06-04 |
Merck Sharp & Dohme Corp. |
Carbonylamino-benzimidazole derivatives as androgen receptor modulators
|
|
AU2003295387A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
EP1562971B1
(en)
|
2002-11-05 |
2014-02-12 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US8090542B2
(en)
|
2002-11-14 |
2012-01-03 |
Dharmacon Inc. |
Functional and hyperfunctional siRNA
|
|
US7250289B2
(en)
*
|
2002-11-20 |
2007-07-31 |
Affymetrix, Inc. |
Methods of genetic analysis of mouse
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
US20050048494A1
(en)
|
2003-08-28 |
2005-03-03 |
Yixin Wang |
Colorectal cancer prognostics
|
|
DK1661905T3
(da)
|
2003-08-28 |
2012-07-23 |
Takeshi Imanishi |
Hidtil ukendte syntetiske nukleinsyrer af N-O-krydsbindingstype
|
|
AU2004274021B2
(en)
|
2003-09-18 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
|
SI1680140T1
(sl)
|
2003-10-16 |
2011-08-31 |
Imclone Llc |
Inhibitorji receptorja-1 za fibroblastni rastni faktor in metode za zdravljenje z le-temi
|
|
EP1697420A2
(en)
|
2003-12-19 |
2006-09-06 |
Five Prime Therapeutics, Inc. |
Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
|
|
US20090247604A1
(en)
|
2004-02-05 |
2009-10-01 |
Intradigm Corporation |
RNAi Therapeutics for Treatment of Eye Neovascularization Diseases
|
|
CA2555531A1
(en)
|
2004-02-05 |
2005-08-25 |
Intradigm Corporation |
Methods and compositions for combination rnai therapeutics
|
|
CA2582464A1
(en)
|
2004-10-13 |
2006-04-27 |
Sanjay Bhanot |
Antisense modulation of ptp1b expression
|
|
CA2640171C
(en)
|
2006-01-27 |
2014-10-28 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
JP5441688B2
(ja)
|
2006-05-11 |
2014-03-12 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
５’修飾二環式核酸類似体
|
|
EP1918376A1
(en)
*
|
2006-11-03 |
2008-05-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
|
|
WO2008101157A1
(en)
|
2007-02-15 |
2008-08-21 |
Isis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2008109369A2
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting tnf gene expression and uses thereof
|
|
WO2008109372A2
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting pdgf gene expression and uses thereof
|
|
EP2170917B1
(en)
|
2007-05-30 |
2012-06-27 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
ES2386492T3
(es)
|
2007-06-08 |
2012-08-21 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos carbocíclicos
|
|
CN101796062B
(zh)
|
2007-07-05 |
2014-07-30 |
Isis制药公司 |
6-双取代双环核酸类似物
|
|
MX2010003606A
(es)
*
|
2007-10-01 |
2010-07-02 |
Isis Pharmaceuticals Inc |
Modulacion antisentido de la expresion del receptor del factor de crecimiento fibroblastico 4.
|
|
US8323891B2
(en)
*
|
2008-08-01 |
2012-12-04 |
Claflin University |
miRNA triplex formations for the downregulation of viral replication
|
|
NZ599032A
(en)
*
|
2009-09-11 |
2014-09-26 |
Isis Pharmaceuticals Inc |
Modulation of huntingtin expression
|
|
US9984408B1
(en)
|
2012-05-30 |
2018-05-29 |
Amazon Technologies, Inc. |
Method, medium, and system for live video cooperative shopping
|