JP2014520810A5 - - Google Patents
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- Publication number
- JP2014520810A5 JP2014520810A5 JP2014519138A JP2014519138A JP2014520810A5 JP 2014520810 A5 JP2014520810 A5 JP 2014520810A5 JP 2014519138 A JP2014519138 A JP 2014519138A JP 2014519138 A JP2014519138 A JP 2014519138A JP 2014520810 A5 JP2014520810 A5 JP 2014520810A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- pain
- neuralgia
- aryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 208000004296 neuralgia Diseases 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000001931 aliphatic group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 206010029240 Neuritis Diseases 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000004663 dialkyl amino group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 208000000094 Chronic Pain Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 206010019233 Headaches Diseases 0.000 claims 3
- 208000005298 acute pain Diseases 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010054048 Postoperative ileus Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000010247 contact dermatitis Diseases 0.000 claims 2
- 206010013663 drug dependence Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 206010003399 Arthropod bite Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010007882 Cellulitis Diseases 0.000 claims 1
- 206010008334 Cervicobrachial syndrome Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 208000022497 Cocaine-Related disease Diseases 0.000 claims 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010063057 Cystitis noninfective Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 208000004232 Enteritis Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000021965 Glossopharyngeal Nerve disease Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 208000035154 Hyperesthesia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- 206010049949 Intercostal neuralgia Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000002472 Morton Neuroma Diseases 0.000 claims 1
- 208000020059 Morton neuralgia Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 1
- 206010029279 Neurogenic bladder Diseases 0.000 claims 1
- 206010060860 Neurological symptom Diseases 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010068106 Occipital neuralgia Diseases 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 208000026251 Opioid-Related disease Diseases 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
- 206010068319 Oropharyngeal pain Diseases 0.000 claims 1
- 206010034464 Periarthritis Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 206010036105 Polyneuropathy Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- 206010038678 Respiratory depression Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 206010040744 Sinus headache Diseases 0.000 claims 1
- 208000004078 Snake Bites Diseases 0.000 claims 1
- 208000026137 Soft tissue injury Diseases 0.000 claims 1
- 208000003589 Spider Bites Diseases 0.000 claims 1
- 206010042496 Sunburn Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000009692 acute damage Effects 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 230000008499 blood brain barrier function Effects 0.000 claims 1
- 210000001218 blood-brain barrier Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 201000001352 cholecystitis Diseases 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 201000006145 cocaine dependence Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 208000012790 cranial neuralgia Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 201000005442 glossopharyngeal neuralgia Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 208000008384 ileus Diseases 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000007803 itching Effects 0.000 claims 1
- 210000003127 knee Anatomy 0.000 claims 1
- 208000037805 labour Diseases 0.000 claims 1
- 230000001617 migratory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002756 mu opiate receptor agonist Substances 0.000 claims 1
- 239000002623 mu opiate receptor antagonist Substances 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000009985 neuronitis Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000005040 opiate dependence Diseases 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 208000019629 polyneuritis Diseases 0.000 claims 1
- 208000037821 progressive disease Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000001738 temporomandibular joint Anatomy 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502721P | 2011-06-29 | 2011-06-29 | |
| US61/502,721 | 2011-06-29 | ||
| PCT/US2012/044928 WO2013003720A1 (en) | 2011-06-29 | 2012-06-29 | Peripherally acting opioid compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520810A JP2014520810A (ja) | 2014-08-25 |
| JP2014520810A5 true JP2014520810A5 (cg-RX-API-DMAC7.html) | 2015-08-27 |
| JP5981992B2 JP5981992B2 (ja) | 2016-08-31 |
Family
ID=47391264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519138A Expired - Fee Related JP5981992B2 (ja) | 2011-06-29 | 2012-06-29 | 末梢作用オピオイド化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8962646B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2725908B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5981992B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012275181B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2840643C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2725908T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2638329T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20171251T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE034326T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2725908T (cg-RX-API-DMAC7.html) |
| PL (1) | PL2725908T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2725908T (cg-RX-API-DMAC7.html) |
| RS (1) | RS56181B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2725908T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201700400T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013003720A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2725908B1 (en) * | 2011-06-29 | 2017-05-31 | Alkermes, Inc. | Peripherally acting opioid compounds |
| MX370344B (es) | 2013-11-01 | 2019-12-10 | SpecGx LLC | Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas. |
| WO2015183780A1 (en) * | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| JP6360915B2 (ja) * | 2014-06-13 | 2018-07-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザモルフィナン誘導体及びその使用 |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| CN113573711A (zh) * | 2019-01-04 | 2021-10-29 | 伊瑟治疗公司 | 治疗药物或酒精依赖性的方法 |
| US12397060B2 (en) | 2019-01-28 | 2025-08-26 | University Of Rhode Island Board Of Trustees | pHLIP®-mediated intracellular delivery of immuno-stimulatory compounds |
| BR112022025037A2 (pt) | 2020-06-10 | 2023-02-14 | Aligos Therapeutics Inc | Compostos antivirais para tratar infecções por coronavírus, picornavírus e norovírus |
| AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES252980A1 (es) | 1958-10-30 | 1960-11-01 | Boehringer Sohn Ingelheim | Procedimiento para la obtencion de nuevas sales cuaternarias, terapéuticamente valiosas, de la normorfina y de sus derivados |
| CH581624A5 (cg-RX-API-DMAC7.html) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| DE2254298A1 (de) | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| US4032529A (en) | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4176186A (en) | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| FR2514644A1 (fr) | 1981-10-19 | 1983-04-22 | Sanofi Sa | Composition pharmaceutique a action antagoniste peripherique des opiaces |
| US4374139A (en) | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US4929622A (en) | 1987-09-24 | 1990-05-29 | Hoechst-Roussel Pharmaceuticals, Inc. | 2,6-Methanopyrrolo-3-benzazocines |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| EP0632041A1 (en) | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| NZ326331A (en) | 1996-01-10 | 2000-01-28 | Smithkline Beecham Spa | Heterocycle-condensed morphinoid derivatives and medicaments |
| ES2121553B1 (es) | 1996-12-23 | 1999-06-16 | Univ Santiago Compostela | Nuevos endoperoxidos morfinicos funcionalizados en posiciones c-6 y c-14 del anillo c y procedimiento para su obtencion. |
| GB9709972D0 (en) | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| CA2380814A1 (en) | 1999-08-13 | 2001-02-22 | Southern Research Institute | Pyridomorphinans, thienomorphinans and use thereof |
| JP2003528819A (ja) | 1999-11-29 | 2003-09-30 | アドラー コーポレーション | オピオイドおよびそのアンタゴニストに関する新規方法および組成物 |
| DE60109960T2 (de) | 2000-10-31 | 2006-02-16 | Rensselaer Polytechnic Institute | 8-substituierte 2,6-methano-3-benzazocine und 3-substituierte morphinane als opioidrezeptorbindende agenzien |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| ES2249722T3 (es) | 2002-05-30 | 2006-04-01 | Eli Lilly And Company | Antagonistas de receptor de opioides. |
| DE10229842A1 (de) | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
| WO2004007449A1 (en) | 2002-07-16 | 2004-01-22 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| JP4202319B2 (ja) | 2002-07-29 | 2008-12-24 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ベンゾジオキソール |
| WO2004045562A2 (en) | 2002-11-18 | 2004-06-03 | The Mclean Hospital Corporation | Mixed kappa/mu opioids and uses thereof |
| US20080009478A1 (en) | 2003-10-22 | 2008-01-10 | Arena Pharmaceuticals, Inc. | Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases |
| EA200700403A1 (ru) | 2004-08-05 | 2007-08-31 | Янссен Фармацевтика Н.В. | ТРИЦИКЛИЧЕСКИЕ δ-ОПИОИДНЫЕ МОДУЛЯТОРЫ |
| US20060063792A1 (en) | 2004-09-17 | 2006-03-23 | Adolor Corporation | Substituted morphinans and methods of their use |
| EP1817291A1 (en) | 2004-11-05 | 2007-08-15 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphans |
| AU2005319060A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| CA2600350C (en) | 2005-03-07 | 2015-02-10 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
| ATE490251T1 (de) | 2005-06-16 | 2010-12-15 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
| ES2480390T3 (es) | 2005-07-21 | 2014-07-28 | Rensselaer Polytechnic Institute | 2,6-metano-3-benzazocinas 8-carboxamido sustituidas y morfanos 3-carboxamido sustituidos como ligandos de los receptores opioides |
| EP1928881A2 (en) | 2005-08-19 | 2008-06-11 | Pharmacofore, Inc. | Prodrugs of active agents |
| WO2008144394A2 (en) | 2007-05-16 | 2008-11-27 | Rensselaer Polytechnic Institute | Fused-ring heterocycle opioids |
| KR101519682B1 (ko) * | 2007-08-09 | 2015-05-19 | 렌슬러 폴리테크닉 인스티튜트 | 4급 오피오이드 카르복스아미드 |
| AU2009274147B2 (en) | 2008-07-21 | 2014-09-04 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
| CN101646168B (zh) * | 2009-08-24 | 2012-01-25 | 华为终端有限公司 | 数据加密方法、解密方法及移动终端 |
| US8436175B2 (en) * | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| EP2725908B1 (en) * | 2011-06-29 | 2017-05-31 | Alkermes, Inc. | Peripherally acting opioid compounds |
-
2012
- 2012-06-29 EP EP12805087.9A patent/EP2725908B1/en active Active
- 2012-06-29 RS RS20170823A patent/RS56181B1/sr unknown
- 2012-06-29 US US13/537,544 patent/US8962646B2/en active Active
- 2012-06-29 SI SI201231033T patent/SI2725908T1/sl unknown
- 2012-06-29 PL PL12805087T patent/PL2725908T3/pl unknown
- 2012-06-29 DK DK12805087.9T patent/DK2725908T3/en active
- 2012-06-29 SM SM20170400T patent/SMT201700400T1/it unknown
- 2012-06-29 WO PCT/US2012/044928 patent/WO2013003720A1/en not_active Ceased
- 2012-06-29 CA CA2840643A patent/CA2840643C/en not_active Expired - Fee Related
- 2012-06-29 ES ES12805087.9T patent/ES2638329T3/es active Active
- 2012-06-29 LT LTEP12805087.9T patent/LT2725908T/lt unknown
- 2012-06-29 JP JP2014519138A patent/JP5981992B2/ja not_active Expired - Fee Related
- 2012-06-29 HR HRP20171251TT patent/HRP20171251T1/hr unknown
- 2012-06-29 AU AU2012275181A patent/AU2012275181B2/en not_active Ceased
- 2012-06-29 PT PT128050879T patent/PT2725908T/pt unknown
- 2012-06-29 HU HUE12805087A patent/HUE034326T2/en unknown
-
2015
- 2015-01-16 US US14/598,678 patent/US9415045B2/en not_active Expired - Fee Related
-
2016
- 2016-07-12 US US15/207,731 patent/US9775840B2/en not_active Expired - Fee Related
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