MX370344B - Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas. - Google Patents
Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas.Info
- Publication number
- MX370344B MX370344B MX2016004994A MX2016004994A MX370344B MX 370344 B MX370344 B MX 370344B MX 2016004994 A MX2016004994 A MX 2016004994A MX 2016004994 A MX2016004994 A MX 2016004994A MX 370344 B MX370344 B MX 370344B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- morphinan
- ols
- ones
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En la presente se describen métodos de recipiente único para preparar morfinan-6-oles N-alquilo a partir de morfinan-6-onas. En particular, los métodos comprenden poner en contacto una morfinan-6-ona con un agente reductor basado en boro y ya sea un compuesto carbonilo, un agente de acilación o un agente de alquilación. En la presente se describen métodos de recipiente único donde el grupo NH se trata con un compuesto carbonilo, como aldehído o cetona, y un agente reductor, y donde el grupo 6-ceto se reduce a un grupo 6-hidroxi; métodos de recipiente único donde el grupo NH se trata con un agente de alquilación y una base, generando así un grupo N-alquilo, y donde el grupo 6-ceto se reduce a un grupo 6-hidroxi por la adición de un agente reductor; y métodos donde el grupo NH se acila con un agente de acilación y una base, generando así un grupo N-acilo, y donde el grupo 6-ceto se reduce a un grupo 6-hidroxi por la adición de un agente reductor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898634P | 2013-11-01 | 2013-11-01 | |
| PCT/US2014/063372 WO2015066443A1 (en) | 2013-11-01 | 2014-10-31 | Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016004994A MX2016004994A (es) | 2016-08-01 |
| MX370344B true MX370344B (es) | 2019-12-10 |
Family
ID=53005176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016004994A MX370344B (es) | 2013-11-01 | 2014-10-31 | Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9499556B2 (es) |
| EP (1) | EP3063152B1 (es) |
| JP (1) | JP2016534991A (es) |
| AU (1) | AU2014342096B2 (es) |
| CA (1) | CA2926726C (es) |
| ES (1) | ES2749157T3 (es) |
| MX (1) | MX370344B (es) |
| PL (1) | PL3063152T3 (es) |
| WO (1) | WO2015066443A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015066443A1 (en) | 2013-11-01 | 2015-05-07 | Mallinckrodt Llc | Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| CN111116597A (zh) * | 2018-10-31 | 2020-05-08 | 扬子江药业集团江苏紫龙药业有限公司 | 一种纳布啡游离碱的制备方法 |
| CN110330500B (zh) * | 2019-07-12 | 2021-11-23 | 宜昌人福药业有限责任公司 | 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法 |
| CN117083277A (zh) * | 2021-03-15 | 2023-11-17 | 苏州恩华生物医药科技有限公司 | 一种纳布啡癸二酸酯及其中间体的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69507697T2 (de) | 1994-05-31 | 1999-06-10 | Mallinckrodt Chemical Inc | Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält |
| GB0421687D0 (en) | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
| US7238791B1 (en) | 2005-12-16 | 2007-07-03 | Roche Diagnostics Operations, Inc. | 6-monoacetylmorphine derivatives useful in immunoassay |
| AU2007267362B2 (en) | 2006-05-25 | 2011-08-11 | Alpharma (Bermuda) Investments Ltd | Process useful in the preparation of morphinan antagonists |
| EP2180000B1 (en) * | 2007-05-04 | 2013-03-27 | Mallinckrodt LLC | Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
| WO2010132570A1 (en) | 2009-05-12 | 2010-11-18 | Board Of Regents The University Of Texas System | Synthesis of morphine and related derivatives |
| GB0914338D0 (en) | 2009-08-17 | 2009-09-30 | Johnson Matthey Plc | Improved process |
| CA2840643C (en) | 2011-06-29 | 2017-11-21 | Alkermes, Inc. | Peripherally acting opioid compounds |
| WO2015066443A1 (en) | 2013-11-01 | 2015-05-07 | Mallinckrodt Llc | Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones |
-
2014
- 2014-10-31 WO PCT/US2014/063372 patent/WO2015066443A1/en active Application Filing
- 2014-10-31 JP JP2016522102A patent/JP2016534991A/ja active Pending
- 2014-10-31 MX MX2016004994A patent/MX370344B/es active IP Right Grant
- 2014-10-31 US US14/529,368 patent/US9499556B2/en active Active
- 2014-10-31 PL PL14858224T patent/PL3063152T3/pl unknown
- 2014-10-31 EP EP14858224.0A patent/EP3063152B1/en active Active
- 2014-10-31 CA CA2926726A patent/CA2926726C/en active Active
- 2014-10-31 AU AU2014342096A patent/AU2014342096B2/en active Active
- 2014-10-31 ES ES14858224T patent/ES2749157T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014342096B2 (en) | 2018-05-10 |
| WO2015066443A1 (en) | 2015-05-07 |
| EP3063152A1 (en) | 2016-09-07 |
| ES2749157T3 (es) | 2020-03-19 |
| US20150126741A1 (en) | 2015-05-07 |
| JP2016534991A (ja) | 2016-11-10 |
| PL3063152T3 (pl) | 2020-01-31 |
| MX2016004994A (es) | 2016-08-01 |
| EP3063152B1 (en) | 2019-08-07 |
| US9499556B2 (en) | 2016-11-22 |
| AU2014342096A1 (en) | 2016-05-05 |
| CA2926726A1 (en) | 2015-05-07 |
| EP3063152A4 (en) | 2017-06-28 |
| CA2926726C (en) | 2020-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: SPECGX LLC |
|
| FG | Grant or registration |