MX2016003240A - Berbinas sustituidas y su sintesis. - Google Patents

Berbinas sustituidas y su sintesis.

Info

Publication number
MX2016003240A
MX2016003240A MX2016003240A MX2016003240A MX2016003240A MX 2016003240 A MX2016003240 A MX 2016003240A MX 2016003240 A MX2016003240 A MX 2016003240A MX 2016003240 A MX2016003240 A MX 2016003240A MX 2016003240 A MX2016003240 A MX 2016003240A
Authority
MX
Mexico
Prior art keywords
substituted
synthesis
berbines
bischler
napieralski
Prior art date
Application number
MX2016003240A
Other languages
English (en)
Inventor
Christopher W Grote
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of MX2016003240A publication Critical patent/MX2016003240A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención provee berbinas sustituidas, procesos para la síntesis de compuestos de berbina sustituida preferentemente mediante una ciclación Bischler-Napieralski seguido por reducción, así como también intermedios usados en la síntesis de compuestos de berbina sustituida. El precursor de amida para la reacción Bischler-Napieralski podría obtenerse tratando la amina libre con haluros de ácido, fuentes de formiato o aldehídos. También se proveen métodos para usar las berbinas sustituidas para inhibir el crecimiento de células cancerosas.
MX2016003240A 2013-10-04 2014-10-02 Berbinas sustituidas y su sintesis. MX2016003240A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361886695P 2013-10-04 2013-10-04
PCT/US2014/058806 WO2015051106A1 (en) 2013-10-04 2014-10-02 Substituted berbines and their synthesis

Publications (1)

Publication Number Publication Date
MX2016003240A true MX2016003240A (es) 2016-06-07

Family

ID=52779136

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016003240A MX2016003240A (es) 2013-10-04 2014-10-02 Berbinas sustituidas y su sintesis.

Country Status (9)

Country Link
EP (1) EP3055307B1 (es)
JP (1) JP6654568B2 (es)
AU (1) AU2014329531B2 (es)
BR (1) BR112016006865B1 (es)
CA (1) CA2923760C (es)
ES (1) ES2774775T3 (es)
MX (1) MX2016003240A (es)
PL (1) PL3055307T3 (es)
WO (1) WO2015051106A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9495155B2 (en) 2013-08-06 2016-11-15 Intel Corporation Methods, apparatus, instructions and logic to provide population count functionality for genome sequencing and alignment
JP6733449B2 (ja) * 2016-09-15 2020-07-29 株式会社ツムラ ベルベリン型アルカロイドの製造方法
CN109232557B (zh) * 2018-11-14 2021-01-29 常州大学 一种9-o-芳基取代小檗碱衍生物的合成和用途
CN114989162A (zh) * 2021-02-02 2022-09-02 江苏康缘药业股份有限公司 一种化合物晶型及其制备方法和应用
CN113735847B (zh) * 2021-09-10 2022-06-07 四川大学 一种盐酸小檗碱的合成制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272707A (en) * 1964-07-17 1966-09-13 Smith Kline French Lab Pharmaceutical compositions and methods for their use
US3420834A (en) * 1964-11-13 1969-01-07 Roussel Uclaf 2,3-dimethoxy-berbines substituted in the 10 position and process
US4013666A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto
US4052389A (en) * 1976-03-23 1977-10-04 Bristol-Myers Company Derivatives of 9,10-dihydroxy-1-(p-alkoxybenzyl)-perhydroisoquinoline oxazine-3-one
WO2009002873A1 (en) * 2007-06-22 2008-12-31 Cvi Pharmaceuticals Limited Compounds, compositions and methods for reducing lipid levels
EP2014651A1 (en) * 2007-07-12 2009-01-14 Exonhit Therapeutics SA Compounds and methods for modulating Rho GTPases
JP5551711B2 (ja) * 2008-12-23 2014-07-16 シーブイアイ ファーマシューティカルズ リミテッド 脂質レベルを減少させるための化合物、組成物および方法
WO2010127307A1 (en) * 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Antimicrobial agents
JP6577491B2 (ja) * 2014-06-11 2019-09-18 スペックジーエックス エルエルシー ベルビンの酸化的脱芳香族化

Also Published As

Publication number Publication date
ES2774775T3 (es) 2020-07-22
WO2015051106A1 (en) 2015-04-09
JP2016533396A (ja) 2016-10-27
AU2014329531A1 (en) 2016-04-14
BR112016006865A2 (pt) 2017-08-01
CA2923760A1 (en) 2015-04-09
PL3055307T3 (pl) 2020-07-27
EP3055307A1 (en) 2016-08-17
CA2923760C (en) 2021-07-27
JP6654568B2 (ja) 2020-02-26
EP3055307B1 (en) 2019-12-04
EP3055307A4 (en) 2017-08-02
AU2014329531B2 (en) 2018-04-05
BR112016006865B1 (pt) 2023-05-09

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FG Grant or registration