|
JPS63107966A
(ja)
|
1986-05-22 |
1988-05-12 |
Fujisawa Pharmaceut Co Ltd |
ピリミジン誘導体
|
|
KR0166088B1
(ko)
|
1990-01-23 |
1999-01-15 |
. |
수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
|
|
US5376645A
(en)
|
1990-01-23 |
1994-12-27 |
University Of Kansas |
Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
|
|
US5272158A
(en)
|
1991-10-29 |
1993-12-21 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
|
US5238950A
(en)
|
1991-12-17 |
1993-08-24 |
Schering Corporation |
Inhibitors of platelet-derived growth factor
|
|
GB9518953D0
(en)
|
1995-09-15 |
1995-11-15 |
Pfizer Ltd |
Pharmaceutical formulations
|
|
GB9711643D0
(en)
|
1997-06-05 |
1997-07-30 |
Janssen Pharmaceutica Nv |
Glass thermoplastic systems
|
|
AU1507199A
(en)
|
1997-12-15 |
1999-07-05 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel pyrimidine-5-carboxamide derivatives
|
|
WO1999032479A1
(en)
|
1997-12-23 |
1999-07-01 |
Alcon Laboratories, Inc. |
Phthalimide-piperidine, -pyrrolidine and -azepine derivatives, their preparation and their use as muscarinic receptor (ant-)agonists
|
|
AU5107900A
(en)
|
1999-06-09 |
2000-12-28 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel heterocyclic carboxamide derivatives
|
|
GB9918035D0
(en)
|
1999-07-30 |
1999-09-29 |
Novartis Ag |
Organic compounds
|
|
AU1929801A
(en)
|
1999-12-16 |
2001-06-25 |
Alcon Inc. |
Inhibitors of adenosine kinase for the treatment of optic nerve and retinal damage
|
|
ATE322494T1
(de)
|
2000-01-07 |
2006-04-15 |
Universitaire Instelling Antwe |
Purin derivate, ihre herstellung und verwendung
|
|
CA2398956A1
(en)
|
2000-02-14 |
2001-08-16 |
Japan Tobacco Inc. |
A pharmaceutical composition for prophylaxis or therapy of a postoperative stress
|
|
JP2001302667A
(ja)
|
2000-04-28 |
2001-10-31 |
Bayer Ag |
イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
US7105667B2
(en)
|
2001-05-01 |
2006-09-12 |
Bristol-Myers Squibb Co. |
Fused heterocyclic compounds and use thereof
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
GB0115109D0
(en)
|
2001-06-21 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
US20040235867A1
(en)
|
2001-07-24 |
2004-11-25 |
Bilodeau Mark T. |
Tyrosine kinase inhibitors
|
|
US20030158195A1
(en)
|
2001-12-21 |
2003-08-21 |
Cywin Charles L. |
1,6 naphthyridines useful as inhibitors of SYK kinase
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
MXPA05001804A
(es)
|
2002-08-14 |
2005-05-27 |
Vertex Pharma |
Inhibidores de proteinas cinasas y usos de los mismos.
|
|
AU2003286711A1
(en)
|
2002-10-25 |
2004-05-13 |
Vertex Pharmaceuticals Incorporated |
Indazolinone compositions useful as kinase inhibitors
|
|
EP1560824A1
(en)
|
2002-11-05 |
2005-08-10 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of jak and other protein kinases
|
|
US20040235834A1
(en)
|
2003-03-25 |
2004-11-25 |
Farmer Luc J. |
Thiazoles useful as inhibitors of protein kinases
|
|
ATE396731T1
(de)
|
2003-03-25 |
2008-06-15 |
Vertex Pharma |
Thiazole zur verwendung als inhibitoren von protein-kinasen
|
|
US7550590B2
(en)
|
2003-03-25 |
2009-06-23 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
BRPI0413018B8
(pt)
|
2003-07-30 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, e, uso de um composto
|
|
US7320992B2
(en)
|
2003-08-25 |
2008-01-22 |
Amgen Inc. |
Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use
|
|
US20050182061A1
(en)
|
2003-10-02 |
2005-08-18 |
Jeremy Green |
Phthalimide compounds useful as protein kinase inhibitors
|
|
WO2005056524A2
(en)
|
2003-12-09 |
2005-06-23 |
Euro-Celtique S.A. |
Therapeutic agents useful for treating pain
|
|
US8057815B2
(en)
|
2004-04-19 |
2011-11-15 |
Portola Pharmaceuticals, Inc. |
Methods of treatment with Syk inhibitors
|
|
JP2008511659A
(ja)
|
2004-09-01 |
2008-04-17 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
2,4−ピリミジンジアミン化合物の合成
|
|
EP1814878B1
(en)
|
2004-11-24 |
2012-01-04 |
Rigel Pharmaceuticals, Inc. |
Spiro-2, 4-pyrimidinediamine compounds and their uses
|
|
US20060128710A1
(en)
|
2004-12-09 |
2006-06-15 |
Chih-Hung Lee |
Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
|
|
RU2007140733A
(ru)
|
2005-04-06 |
2009-05-20 |
Айрм Ллк (Bm) |
Диариламинсодержащие соединения и композиции, и их применение в качестве модуляторов ядерных рецепторов стероидного гормона
|
|
WO2006112479A1
(ja)
*
|
2005-04-19 |
2006-10-26 |
Kyowa Hakko Kogyo Co., Ltd. |
含窒素複素環化合物
|
|
WO2006129100A1
(en)
|
2005-06-03 |
2006-12-07 |
Glaxo Group Limited |
Novel compounds
|
|
US20070049559A1
(en)
|
2005-06-28 |
2007-03-01 |
Bruce Pfeffer |
Preparations comprising arylazine substituted with a carbonylic moiety to increase the activity of Gelatinase A in ocular cells
|
|
US20070185063A1
(en)
|
2005-08-23 |
2007-08-09 |
Idenix Pharmaceuticals, Inc. |
Seven-membered ring nucleosides
|
|
WO2007023382A2
(en)
|
2005-08-25 |
2007-03-01 |
Pfizer Inc. |
Pyrimidine amino pyrazole compounds, potent kinase inhibitors
|
|
US20070117775A1
(en)
|
2005-10-31 |
2007-05-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and Methods For Treating Inflammatory Disorders
|
|
JP5400388B2
(ja)
|
2005-12-15 |
2014-01-29 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
キナーゼインヒビターおよびその利用
|
|
CN102532133A
(zh)
|
2006-01-17 |
2012-07-04 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的吖吲哚类
|
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
|
JPWO2008047831A1
(ja)
|
2006-10-17 |
2010-02-25 |
協和発酵キリン株式会社 |
Jak阻害剤
|
|
ATE543819T1
(de)
|
2006-10-19 |
2012-02-15 |
Signal Pharm Llc |
Heteroarylverbindungen, zusammensetzungen daraus und behandlungsverfahren damit
|
|
WO2008057402A2
(en)
|
2006-11-02 |
2008-05-15 |
Cytovia, Inc. |
N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof
|
|
EP2420505A1
(en)
|
2006-11-21 |
2012-02-22 |
Rigel Pharmaceuticals, Inc. |
Prodrug salts of 2, 4- pyrimidinediamine compounds and their uses
|
|
US20100298557A1
(en)
|
2006-12-28 |
2010-11-25 |
Taisho Pharmaceutical Co., Ltd |
Pyrazolopyrimidine compound
|
|
US20100104534A1
(en)
|
2007-03-23 |
2010-04-29 |
Srikanth Venkatraman |
Hydrazido-peptides as inhibitors of hcv ns3-protease
|
|
SG185285A1
(en)
|
2007-06-03 |
2012-11-29 |
Univ Vanderbilt |
Benzamide mglur5 positive allosteric modulators and methods of making and using same
|
|
WO2009026107A1
(en)
|
2007-08-17 |
2009-02-26 |
Portola Pharmaceuticals, Inc. |
Protein kinase inhibitors
|
|
JP2009067729A
(ja)
|
2007-09-14 |
2009-04-02 |
Kyowa Hakko Kirin Co Ltd |
Hsp90ファミリー蛋白質阻害剤
|
|
US20100331297A1
(en)
|
2007-11-07 |
2010-12-30 |
Foldrx Pharmaceuticals, Inc. |
Modulation of protein trafficking
|
|
EP2234986A2
(en)
|
2007-12-20 |
2010-10-06 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
JP5496915B2
(ja)
|
2008-02-13 |
2014-05-21 |
シージーアイ ファーマシューティカルズ,インコーポレーテッド |
6−アリール−イミダゾ[1,2−a]ピラジン誘導体、その製造方法、及びその使用方法
|
|
PL2252300T3
(pl)
|
2008-02-22 |
2017-04-28 |
Rigel Pharmaceuticals, Inc. |
Zastosowanie 2,4-pirymidynodiamin do leczenia miażdżycy
|
|
US8436005B2
(en)
|
2008-04-03 |
2013-05-07 |
Abbott Laboratories |
Macrocyclic pyrimidine derivatives
|
|
EA024109B1
(ru)
|
2008-04-16 |
2016-08-31 |
Портола Фармасьютиклз, Инк. |
Ингибиторы протеинкиназ
|
|
SG2014015085A
(en)
|
2008-04-16 |
2014-06-27 |
Portola Pharm Inc |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
|
|
AU2009256574A1
(en)
|
2008-06-13 |
2009-12-17 |
Novartis Ag |
2,4'-bipyridinyl compounds as protein kinase D inhibitors useful for the treatment of IA heart failure and cancer
|
|
JP5754568B2
(ja)
|
2008-08-05 |
2015-07-29 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
4−ジメチルアミノ−フェニルで置換されているナフチリジン、及び医薬としてのその使用
|
|
JP2011529932A
(ja)
|
2008-08-05 |
2011-12-15 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
置換ナフチリジン及び医薬としてのその使用
|
|
TWI453207B
(zh)
|
2008-09-08 |
2014-09-21 |
Signal Pharm Llc |
胺基三唑并吡啶,其組合物及使用其之治療方法
|
|
EA021293B1
(ru)
|
2008-12-08 |
2015-05-29 |
Джилид Коннектикут, Инк. |
ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
|
EP2443106A1
(en)
|
2009-06-18 |
2012-04-25 |
Cellzome Limited |
Heterocyclylaminopyrimidines as kinase inhibitors
|
|
US8735417B2
(en)
|
2009-12-17 |
2014-05-27 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as Syk inhibitors
|
|
WO2011075517A1
(en)
|
2009-12-17 |
2011-06-23 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
|
SG181857A1
(en)
*
|
2009-12-23 |
2012-07-30 |
Takeda Pharmaceutical |
Fused heteroaromatic pyrrolidinones as syk inhibitors
|
|
GB201007203D0
(en)
|
2010-04-29 |
2010-06-16 |
Glaxo Group Ltd |
Novel compounds
|