JP2014518880A5 - - Google Patents
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- JP2014518880A5 JP2014518880A5 JP2014512134A JP2014512134A JP2014518880A5 JP 2014518880 A5 JP2014518880 A5 JP 2014518880A5 JP 2014512134 A JP2014512134 A JP 2014512134A JP 2014512134 A JP2014512134 A JP 2014512134A JP 2014518880 A5 JP2014518880 A5 JP 2014518880A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- inhibitors
- pirfenidone
- fvc
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003112 inhibitor Substances 0.000 claims description 38
- 239000003795 chemical substances by application Substances 0.000 claims description 35
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- 230000000694 effects Effects 0.000 claims description 23
- 229960003073 pirfenidone Drugs 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 13
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- 108060006698 EGF receptor Proteins 0.000 claims description 12
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- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 11
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- -1 PF-4480682 Chemical compound 0.000 claims description 10
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- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 9
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- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 9
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- 230000003472 neutralizing effect Effects 0.000 claims description 8
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-
2012
- 2012-05-25 CA CA2835438A patent/CA2835438A1/en not_active Abandoned
- 2012-05-25 KR KR1020137028921A patent/KR20140022048A/ko not_active Ceased
- 2012-05-25 EP EP12788732.1A patent/EP2713732A4/en not_active Withdrawn
- 2012-05-25 US US14/373,276 patent/US20150164874A1/en not_active Abandoned
- 2012-05-25 WO PCT/US2012/039538 patent/WO2012162592A1/en not_active Ceased
- 2012-05-25 AU AU2012258575A patent/AU2012258575B2/en not_active Ceased
- 2012-05-25 HK HK14109929.1A patent/HK1197159A1/xx unknown
- 2012-05-25 MX MX2013013752A patent/MX2013013752A/es not_active Application Discontinuation
- 2012-05-25 SG SG2013086541A patent/SG195110A1/en unknown
- 2012-05-25 JP JP2014512134A patent/JP6170040B2/ja not_active Expired - Fee Related
-
2013
- 2013-11-04 IL IL229226A patent/IL229226A0/en unknown
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