JP6170040B2 - ピルフェニドン及び選択された患者における抗線維化療法 - Google Patents
ピルフェニドン及び選択された患者における抗線維化療法 Download PDFInfo
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- JP6170040B2 JP6170040B2 JP2014512134A JP2014512134A JP6170040B2 JP 6170040 B2 JP6170040 B2 JP 6170040B2 JP 2014512134 A JP2014512134 A JP 2014512134A JP 2014512134 A JP2014512134 A JP 2014512134A JP 6170040 B2 JP6170040 B2 JP 6170040B2
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- pirfenidone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161489936P | 2011-05-25 | 2011-05-25 | |
| US61/489,936 | 2011-05-25 | ||
| US201161490057P | 2011-05-26 | 2011-05-26 | |
| US61/490,057 | 2011-05-26 | ||
| US201161523047P | 2011-08-12 | 2011-08-12 | |
| US61/523,047 | 2011-08-12 | ||
| US201161524961P | 2011-08-18 | 2011-08-18 | |
| US61/524,961 | 2011-08-18 | ||
| PCT/US2012/039538 WO2012162592A1 (en) | 2011-05-25 | 2012-05-25 | Pirfenidone and anti-fibrotic therapy in selected patients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518880A JP2014518880A (ja) | 2014-08-07 |
| JP2014518880A5 JP2014518880A5 (https=) | 2015-07-02 |
| JP6170040B2 true JP6170040B2 (ja) | 2017-07-26 |
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| JP2014512134A Expired - Fee Related JP6170040B2 (ja) | 2011-05-25 | 2012-05-25 | ピルフェニドン及び選択された患者における抗線維化療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150164874A1 (https=) |
| EP (1) | EP2713732A4 (https=) |
| JP (1) | JP6170040B2 (https=) |
| KR (1) | KR20140022048A (https=) |
| AU (1) | AU2012258575B2 (https=) |
| CA (1) | CA2835438A1 (https=) |
| HK (1) | HK1197159A1 (https=) |
| IL (1) | IL229226A0 (https=) |
| MX (1) | MX2013013752A (https=) |
| SG (1) | SG195110A1 (https=) |
| WO (1) | WO2012162592A1 (https=) |
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| WO2008157786A1 (en) | 2007-06-20 | 2008-12-24 | Auspex Pharmaceutical, Inc. | Substituted n-aryl pyridinones as fibrotic inhibitors |
| JP2014507474A (ja) * | 2011-03-08 | 2014-03-27 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 置換ｎ−アリールピリジノン |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP3782604A1 (en) * | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| EP3194446B1 (en) * | 2014-09-18 | 2022-10-26 | Cedars-Sinai Medical Center | Compositions and methods for treating fibrosis |
| ES2764840T3 (es) * | 2015-01-28 | 2020-06-04 | Univ Bordeaux | Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica |
| US20180064662A1 (en) * | 2015-03-05 | 2018-03-08 | The General Hospital Corporation | Novel compositions and uses of metformin agents |
| WO2018167103A1 (en) * | 2017-03-13 | 2018-09-20 | Genfit | Pharmaceutical compositions for combination therapy |
| AU2018322475A1 (en) * | 2017-08-22 | 2020-03-05 | Biogen Ma Inc. | Pharmaceutical compositions and dosage regimens containing anti-alpha(v)beta(6) antibodies |
| EP3969033A4 (en) * | 2019-05-17 | 2023-06-14 | The Regents of the University of California | MPS-MODIFIED PEPTIDES AND THEIR USE |
| CN112239507A (zh) | 2019-07-17 | 2021-01-19 | 鸿运华宁（杭州）生物医药有限公司 | ETA抗体与TGF-β Trap的融合蛋白质，以及其药物组合物和应用 |
| EP3821946A1 (en) * | 2019-11-12 | 2021-05-19 | Université de Strasbourg | Anti-claudin-1 monoclonal antibodies for the prevention and treatment of fibrotic diseases |
| JP7665619B2 (ja) | 2019-12-04 | 2025-04-21 | イドルシア・ファーマシューティカルズ・リミテッド | 線維性疾患の治療に使用するためのアゼチジンｌｐａ１受容体アンタゴニストのピルフェニドン及び／又はニンテダニブとの合剤 |
| CA3171622A1 (en) * | 2020-03-13 | 2021-09-16 | Puretech Lyt 100, Inc. | Methods of treating respiratory disease with deupirfenidone |
| CN114617890A (zh) * | 2020-12-08 | 2022-06-14 | 四川夏派森医药科技有限公司 | DH404在治疗SARS-CoV-2感染中的应用 |
| CN112640887B (zh) * | 2020-12-25 | 2022-05-13 | 武汉睿健医药科技有限公司 | 一种神经干细胞冻存液及其应用 |
| WO2022266370A1 (en) * | 2021-06-17 | 2022-12-22 | Aria Pharmaceuticals, Inc. | Sparsentan for treating idiopathic pulmonary fibrosis |
| CN114097807B (zh) * | 2021-11-25 | 2023-05-05 | 兰州大学 | 巴多索隆类化合物在抗农业病原真菌中的用途 |
| JP2025511066A (ja) * | 2022-03-31 | 2025-04-15 | ピュアテック・エル・ワイ・ティ・１００・インコーポレイテッド | デューピルフェニドンにより間質性肺疾患ならびに他の線維化介在性肺疾患及び障害を治療する方法 |
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| PT1258484E (pt) * | 2000-02-18 | 2009-04-03 | Kyowa Hakko Kirin Co Ltd | Novos compostos de isoxazol e de tiazol e sua utilização enquanto fármacos |
| JP2005531628A (ja) * | 2002-06-28 | 2005-10-20 | ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド | 肺線維症の処置のための４−（４−メチルピペラジン−１−イルメチル）−ｎ−［４−メチル−３−（４−ピリジン−３−イル）ピリミジン−２−イルアミノ）フェニル］−ベンズアミド |
| WO2004103296A2 (en) * | 2003-05-16 | 2004-12-02 | Intermune, Inc. | Methods of treating idiopathic pulmonary fibrosis |
| WO2005110478A2 (en) * | 2004-04-13 | 2005-11-24 | Intermune, Inc. | Combination therapy for treating fibrotic disorders |
| SG174050A1 (en) * | 2006-04-13 | 2011-09-29 | Actelion Pharmaceuticals Ltd | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| JP2010502224A (ja) * | 2006-09-08 | 2010-01-28 | アボット・ラボラトリーズ | インターロイキン１３結合タンパク質 |
| WO2008157786A1 (en) * | 2007-06-20 | 2008-12-24 | Auspex Pharmaceutical, Inc. | Substituted n-aryl pyridinones as fibrotic inhibitors |
| AP2011005824A0 (en) * | 2009-01-26 | 2011-08-31 | Intermune Inc | Methods for treating acute myocardial infarctions and associated disorders. |
| GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
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2012
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- 2012-05-25 US US14/373,276 patent/US20150164874A1/en not_active Abandoned
- 2012-05-25 WO PCT/US2012/039538 patent/WO2012162592A1/en not_active Ceased
- 2012-05-25 AU AU2012258575A patent/AU2012258575B2/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| IL229226A0 (en) | 2014-01-30 |
| JP2014518880A (ja) | 2014-08-07 |
| AU2012258575A1 (en) | 2013-11-21 |
| WO2012162592A1 (en) | 2012-11-29 |
| MX2013013752A (es) | 2014-08-01 |
| NZ617415A (en) | 2017-07-28 |
| AU2012258575B2 (en) | 2017-03-02 |
| EP2713732A1 (en) | 2014-04-09 |
| CA2835438A1 (en) | 2012-11-29 |
| US20150164874A1 (en) | 2015-06-18 |
| EP2713732A4 (en) | 2014-12-03 |
| SG195110A1 (en) | 2013-12-30 |
| HK1197159A1 (en) | 2015-01-09 |
| KR20140022048A (ko) | 2014-02-21 |
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