JP2014518274A5 - - Google Patents
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- Publication number
- JP2014518274A5 JP2014518274A5 JP2014519082A JP2014519082A JP2014518274A5 JP 2014518274 A5 JP2014518274 A5 JP 2014518274A5 JP 2014519082 A JP2014519082 A JP 2014519082A JP 2014519082 A JP2014519082 A JP 2014519082A JP 2014518274 A5 JP2014518274 A5 JP 2014518274A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- epigenetic
- use according
- unit dose
- spb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 14
- VPZRWNZGLKXFOE-UHFFFAOYSA-M sodium phenylbutyrate Chemical compound [Na+].[O-]C(=O)CCCC1=CC=CC=C1 VPZRWNZGLKXFOE-UHFFFAOYSA-M 0.000 claims 14
- 229960002232 sodium phenylbutyrate Drugs 0.000 claims 13
- 230000001973 epigenetic effect Effects 0.000 claims 12
- 239000003607 modifier Substances 0.000 claims 12
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 7
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 7
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 7
- 229960001285 quercetin Drugs 0.000 claims 7
- 235000005875 quercetin Nutrition 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- VRYALKFFQXWPIH-PBXRRBTRSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC=O VRYALKFFQXWPIH-PBXRRBTRSA-N 0.000 claims 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- PMMURAAUARKVCB-UHFFFAOYSA-N alpha-D-ara-dHexp Natural products OCC1OC(O)CC(O)C1O PMMURAAUARKVCB-UHFFFAOYSA-N 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 4
- 235000006708 antioxidants Nutrition 0.000 claims 4
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 230000034659 glycolysis Effects 0.000 claims 4
- 229940094952 green tea extract Drugs 0.000 claims 4
- 235000020688 green tea extract Nutrition 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 238000010253 intravenous injection Methods 0.000 claims 4
- 239000007800 oxidant agent Substances 0.000 claims 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 238000001647 drug administration Methods 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108010016076 Octreotide Proteins 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 229930003268 Vitamin C Natural products 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 229960005215 dichloroacetic acid Drugs 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052732 germanium Inorganic materials 0.000 claims 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 229960003646 lysine Drugs 0.000 claims 2
- 229960002700 octreotide Drugs 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229960002429 proline Drugs 0.000 claims 2
- 229960003080 taurine Drugs 0.000 claims 2
- 235000019154 vitamin C Nutrition 0.000 claims 2
- 239000011718 vitamin C Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 1
- 230000004049 epigenetic modification Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505393P | 2011-07-07 | 2011-07-07 | |
| US61/505,393 | 2011-07-07 | ||
| US201161507950P | 2011-07-14 | 2011-07-14 | |
| US61/507,950 | 2011-07-14 | ||
| PCT/US2012/045821 WO2013006821A1 (en) | 2011-07-07 | 2012-07-06 | Systems, methods, and formulations for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017009055A Division JP6401317B2 (ja) | 2011-07-07 | 2017-01-23 | がんを治療するためのシステム、方法、および製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518274A JP2014518274A (ja) | 2014-07-28 |
| JP2014518274A5 true JP2014518274A5 (OSRAM) | 2015-08-13 |
| JP6082737B2 JP6082737B2 (ja) | 2017-02-15 |
Family
ID=47437478
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519082A Active JP6082737B2 (ja) | 2011-07-07 | 2012-07-06 | がんを治療するためのシステム、方法、および製剤 |
| JP2017009055A Active JP6401317B2 (ja) | 2011-07-07 | 2017-01-23 | がんを治療するためのシステム、方法、および製剤 |
| JP2018166950A Pending JP2018203767A (ja) | 2011-07-07 | 2018-09-06 | がんを治療するためのシステム、方法、および製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017009055A Active JP6401317B2 (ja) | 2011-07-07 | 2017-01-23 | がんを治療するためのシステム、方法、および製剤 |
| JP2018166950A Pending JP2018203767A (ja) | 2011-07-07 | 2018-09-06 | がんを治療するためのシステム、方法、および製剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20130011488A1 (OSRAM) |
| EP (2) | EP3326625A1 (OSRAM) |
| JP (3) | JP6082737B2 (OSRAM) |
| KR (2) | KR102020939B1 (OSRAM) |
| CN (2) | CN109675041A (OSRAM) |
| AU (2) | AU2012278813B2 (OSRAM) |
| CA (1) | CA2839727C (OSRAM) |
| ES (1) | ES2630306T3 (OSRAM) |
| IN (1) | IN2014DN00195A (OSRAM) |
| MX (1) | MX354383B (OSRAM) |
| PL (1) | PL2729008T3 (OSRAM) |
| RU (1) | RU2644635C2 (OSRAM) |
| WO (1) | WO2013006821A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8933078B2 (en) | 2011-07-14 | 2015-01-13 | Research Cancer Institute Of America | Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances |
| EP2804857A1 (en) * | 2012-01-18 | 2014-11-26 | Concert Pharmaceuticals Inc. | Deuterated alpha-lipoic acid |
| CN103877066B (zh) * | 2014-02-21 | 2016-08-24 | 中国人民解放军第二军医大学 | 载多西他赛和莱菔硫烷的自组装纳米粒的制备方法与应用 |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US11890292B2 (en) | 2017-02-27 | 2024-02-06 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| US11369585B2 (en) * | 2017-03-17 | 2022-06-28 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| WO2019071229A1 (en) * | 2017-10-06 | 2019-04-11 | Research Cancer Institute Of America | COMPOSITIONS, METHODS, SYSTEMS AND / OR KITS FOR PREVENTING AND / OR TREATING NEOPLASMS |
| EP3710434A4 (en) | 2017-11-17 | 2021-07-28 | Research Cancer Institute of America | COMPOSITIONS, METHODS, SYSTEMS AND / OR KITS FOR THE PREVENTION AND / OR TREATMENT OF NEOPLASMS |
| WO2020061254A1 (en) * | 2018-09-19 | 2020-03-26 | Virginia Tech Intellectual Properties, Inc. | Brca1 modulating compounds, formulations thereof, and uses thereof |
| US20230008508A1 (en) * | 2019-12-10 | 2023-01-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Combination therapies for the treatment of cancer |
| CN112336716A (zh) * | 2020-11-25 | 2021-02-09 | 四川大学华西医院 | 维生素c和双硫仑在制备抗肿瘤联合用药物中的用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4569836A (en) * | 1981-08-27 | 1986-02-11 | Gordon Robert T | Cancer treatment by intracellular hyperthermia |
| JP2514500B2 (ja) * | 1991-09-14 | 1996-07-10 | 呉羽化学工業株式会社 | 多剤耐性抑制剤及び発現阻害剤 |
| WO1997047317A1 (en) * | 1996-06-11 | 1997-12-18 | Novartis Ag | Combination of a somatostatin analogue and a rapamycin |
| US5865722A (en) | 1997-04-04 | 1999-02-02 | Numotech, Incorporated | Shape-adaptable topical hyperbaric oxygen chamber |
| US6299925B1 (en) * | 1999-06-29 | 2001-10-09 | Xel Herbaceuticals, Inc. | Effervescent green tea extract formulation |
| US6376525B1 (en) * | 2000-09-15 | 2002-04-23 | Qingzhong Kong | Method and composition for treating cancer using cellular organelle crystallizing agents |
| US7008633B2 (en) * | 2000-12-18 | 2006-03-07 | Board Of Regents, The University Of Texas System | Local regional chemotherapy and radiotherapy using in situ hydrogel |
| WO2003012085A1 (en) * | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
| US7435725B2 (en) * | 2001-11-06 | 2008-10-14 | The Quigly Corporation | Oral compositions and methods for prevention, reduction and treatment of radiation injury |
| US20030105104A1 (en) * | 2001-11-27 | 2003-06-05 | Burzynski Stanislaw R. | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy |
| US6572897B1 (en) * | 2002-07-03 | 2003-06-03 | Vitacost.Com, Inc. | Insulin sensitivity maintenance and blood sugar level maintenance formulation for the prevention and treatment of diabetes |
| CN1964714B (zh) * | 2003-08-29 | 2011-09-28 | Hdac默克研究有限责任公司 | 辛二酰苯胺异羟肟酸和吉西他滨在制备用于治疗癌症的药物中的用途 |
| EP1571225A1 (en) * | 2004-03-02 | 2005-09-07 | PrimaGen Holding B.V. | Diagnosis of a disease and monitoring of therapy using the AC133 gene |
| JP2008511611A (ja) * | 2004-08-30 | 2008-04-17 | ルナメツド・インコーポレーテツド | 治療用４−フェニル酪酸制御放出製剤 |
| JP2006298781A (ja) * | 2005-04-15 | 2006-11-02 | Geno Membrane:Kk | エストロン３硫酸トランスポーター活性阻害剤 |
| JP2009532346A (ja) * | 2006-03-31 | 2009-09-10 | イラスマス・ユニバーシティ・メディカル・センター・ロッテルダム | 腫瘍増殖制御のための新規組成物 |
| EP1847274A1 (en) * | 2006-04-21 | 2007-10-24 | CIPROSA LLC - Corporate Creations Network, Inc. | Association of phenylbutyrate, ATRA and cytidine and its use in anti-tumour therapy |
| EP2040708B1 (en) * | 2006-07-17 | 2018-03-14 | Thomas Christian Lines | Quercetin-containing compositions |
| US9408816B2 (en) * | 2006-12-26 | 2016-08-09 | Pharmacyclics Llc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
| US20080305096A1 (en) * | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
| US20110104100A1 (en) * | 2007-10-04 | 2011-05-05 | Medistem Laboratories, Inc. | Compositions and methods of stem cell therapy for autism |
| WO2009105230A2 (en) * | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
| AU2009270886A1 (en) * | 2008-07-18 | 2010-01-21 | Novartis Ag | Use of HDAC inhibitors for the treatment of Hodgkin's disease |
| US20100316733A1 (en) * | 2009-06-15 | 2010-12-16 | Locklear Kenneth R | Hyperbaric Oxygen Therapy and Treatment Method |
-
2012
- 2012-07-06 PL PL12806902T patent/PL2729008T3/pl unknown
- 2012-07-06 JP JP2014519082A patent/JP6082737B2/ja active Active
- 2012-07-06 WO PCT/US2012/045821 patent/WO2013006821A1/en not_active Ceased
- 2012-07-06 KR KR1020147003161A patent/KR102020939B1/ko active Active
- 2012-07-06 ES ES12806902.8T patent/ES2630306T3/es active Active
- 2012-07-06 EP EP17163492.6A patent/EP3326625A1/en not_active Withdrawn
- 2012-07-06 AU AU2012278813A patent/AU2012278813B2/en active Active
- 2012-07-06 CN CN201910036937.7A patent/CN109675041A/zh active Pending
- 2012-07-06 KR KR1020197026111A patent/KR20190107166A/ko not_active Withdrawn
- 2012-07-06 CN CN201280033815.9A patent/CN103796514A/zh active Pending
- 2012-07-06 CA CA2839727A patent/CA2839727C/en active Active
- 2012-07-06 EP EP12806902.8A patent/EP2729008B1/en active Active
- 2012-07-06 US US13/543,563 patent/US20130011488A1/en not_active Abandoned
- 2012-07-06 MX MX2014000150A patent/MX354383B/es active IP Right Grant
- 2012-07-06 RU RU2014101261A patent/RU2644635C2/ru active
-
2014
- 2014-01-09 IN IN195DEN2014 patent/IN2014DN00195A/en unknown
-
2016
- 2016-03-21 US US15/076,371 patent/US20170014376A1/en not_active Abandoned
- 2016-12-08 AU AU2016269491A patent/AU2016269491B2/en active Active
-
2017
- 2017-01-23 JP JP2017009055A patent/JP6401317B2/ja active Active
-
2018
- 2018-09-06 JP JP2018166950A patent/JP2018203767A/ja active Pending
-
2019
- 2019-02-05 US US16/268,279 patent/US20200206183A1/en not_active Abandoned
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