JP2014518219A5 - - Google Patents
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- Publication number
- JP2014518219A5 JP2014518219A5 JP2014516091A JP2014516091A JP2014518219A5 JP 2014518219 A5 JP2014518219 A5 JP 2014518219A5 JP 2014516091 A JP2014516091 A JP 2014516091A JP 2014516091 A JP2014516091 A JP 2014516091A JP 2014518219 A5 JP2014518219 A5 JP 2014518219A5
- Authority
- JP
- Japan
- Prior art keywords
- difluoro
- difluorophenyl
- tetrazol
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC*(C1)C1C1CCCCC1 Chemical compound CCC*(C1)C1C1CCCCC1 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498571P | 2011-06-19 | 2011-06-19 | |
| US61/498,571 | 2011-06-19 | ||
| US201161505949P | 2011-07-08 | 2011-07-08 | |
| US61/505,949 | 2011-07-08 | ||
| US201261611880P | 2012-03-16 | 2012-03-16 | |
| US61/611,880 | 2012-03-16 | ||
| PCT/US2012/043101 WO2012177608A1 (en) | 2011-06-19 | 2012-06-19 | Metalloenzyme inhibitor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518219A JP2014518219A (ja) | 2014-07-28 |
| JP2014518219A5 true JP2014518219A5 (https=) | 2015-07-30 |
| JP6122846B2 JP6122846B2 (ja) | 2017-04-26 |
Family
ID=47391258
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516090A Expired - Fee Related JP6159318B2 (ja) | 2011-06-19 | 2012-06-19 | 金属酵素阻害化合物 |
| JP2014516091A Active JP6122846B2 (ja) | 2011-06-19 | 2012-06-19 | 金属酵素阻害剤化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516090A Expired - Fee Related JP6159318B2 (ja) | 2011-06-19 | 2012-06-19 | 金属酵素阻害化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8809378B2 (https=) |
| EP (2) | EP2721020B1 (https=) |
| JP (2) | JP6159318B2 (https=) |
| KR (2) | KR20140040235A (https=) |
| CN (2) | CN103764646A (https=) |
| AR (1) | AR086988A1 (https=) |
| AU (2) | AU2012273166A1 (https=) |
| BR (1) | BR102012015199A2 (https=) |
| CA (2) | CA2839769A1 (https=) |
| CL (1) | CL2013003639A1 (https=) |
| CO (1) | CO6940433A2 (https=) |
| CR (1) | CR20140024A (https=) |
| EA (2) | EA201490038A1 (https=) |
| EC (1) | ECSP14013153A (https=) |
| HK (1) | HK1198651A1 (https=) |
| IN (1) | IN2014MN00093A (https=) |
| MX (1) | MX2013015160A (https=) |
| PH (1) | PH12013502624A1 (https=) |
| UY (1) | UY34146A (https=) |
| WO (2) | WO2012177603A2 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014MN00093A (https=) | 2011-06-19 | 2015-06-19 | Viamet Pharmaceuticals Inc | |
| WO2012177635A1 (en) * | 2011-06-19 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EA025266B1 (ru) | 2011-06-23 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| HRP20180913T1 (hr) | 2011-07-08 | 2018-07-27 | H. Lundbeck A/S | Pozitivni alosterni modulatori receptora nikotinskog acetilkolina |
| EP3351541A1 (en) | 2011-12-11 | 2018-07-25 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| ES2774267T3 (es) * | 2012-01-20 | 2020-07-20 | Mycovia Pharmaceuticals Inc | Compuestos inhibidores de metaloenzimas |
| WO2013135674A1 (en) * | 2012-03-12 | 2013-09-19 | Syngenta Participations Ag | Insecticidal 2-aryl-acetamide compounds |
| US20150246898A1 (en) * | 2012-09-12 | 2015-09-03 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds |
| CN105102443B (zh) * | 2013-02-04 | 2017-07-28 | 先正达参股股份有限公司 | 新颖的杀微生物剂 |
| EP2984080B1 (en) * | 2013-04-12 | 2017-08-30 | Bayer CropScience Aktiengesellschaft | Novel triazolinthione derivatives |
| BR112015025679A8 (pt) * | 2013-04-12 | 2020-02-11 | Bayer Cropscience Ag | novos derivados de triazol |
| JP6397482B2 (ja) * | 2013-04-12 | 2018-09-26 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 新規トリアゾール誘導体 |
| HK1223093A1 (zh) * | 2013-05-28 | 2017-07-21 | Viamet Pharmaceuticals (NC), Inc. | 杀真菌组合物 |
| US9688671B2 (en) | 2013-06-12 | 2017-06-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| JP6572234B2 (ja) | 2014-03-19 | 2019-09-04 | ヴィアメット ファーマスーティカルズ(エヌシー),インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231226B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942972A1 (en) | 2014-03-19 | 2015-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antifungal compound process |
| JP6633539B2 (ja) * | 2014-03-19 | 2020-01-22 | ダウ アグロサイエンシィズ エルエルシー | 2−(2,4−ジフルオロフェニル)−1,1−ジフルオロ−1−(5−置換−ピリジン−2−イル)−3−(1h−テトラゾール−1−イル)プロパン−2−オールおよびその調製工程 |
| ES2800905T3 (es) * | 2014-03-19 | 2021-01-05 | Mycovia Pharmaceuticals Inc | Procedimiento para compuesto antifúngico |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP2017512777A (ja) | 2014-03-19 | 2017-05-25 | ヴィアメット ファーマスーティカルズ,インコーポレイテッド | 抗真菌化合物の調製方法 |
| CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| BR112016021257B1 (pt) | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| CA2942231A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| US9944664B2 (en) * | 2014-04-15 | 2018-04-17 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds as fungicides |
| CA3135263A1 (en) | 2014-07-02 | 2016-01-07 | Ralco Nutrition, Inc. | Agricultural compositions and applications utilizing essential oils |
| US20170303540A1 (en) | 2014-10-02 | 2017-10-26 | Bayer Cropscience Aktiengesellschaft | Novel triazole derivatives |
| US20180339976A1 (en) * | 2015-04-02 | 2018-11-29 | Bayer Cropscience Aktiengesellschaft | Novel triazole derivatives |
| AU2016265932B2 (en) | 2015-05-18 | 2020-10-08 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compounds |
| JP6847458B2 (ja) | 2015-09-18 | 2021-03-24 | マイコヴィア ファーマシューティカルズ,インコーポレイテッド | 抗真菌化合物のプロセス |
| AR106729A1 (es) | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación |
| US20180370946A1 (en) | 2015-11-17 | 2018-12-27 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| EP3795563B1 (en) | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| SMT202100573T1 (it) | 2016-12-22 | 2021-11-12 | Calithera Biosciences Inc | Composizioni e metodi per l'inibizione dell'attivita' dell'arginasi |
| CN106866575A (zh) * | 2017-03-21 | 2017-06-20 | 苏州汉德创宏生化科技有限公司 | 2‑(1‑哌啶基)‑5‑溴噻唑的合成方法 |
| CN107056690A (zh) * | 2017-03-22 | 2017-08-18 | 上海康鹏科技有限公司 | 一种6‑溴吡啶‑3‑甲醛的制备方法 |
| US11213031B2 (en) * | 2017-11-13 | 2022-01-04 | Bayer Aktiengesellschaft | Tetrazolylpropyl derivatives and their use as fungicides |
| CN108358871B (zh) * | 2018-02-01 | 2020-05-22 | 浙江扬帆新材料股份有限公司 | 一种2-苄基-2-二甲基氨基-1-(4-吗啉苯基)丁酮的合成方法 |
| CN116528855B (zh) * | 2020-10-16 | 2026-03-13 | 米拉洛克斯有限责任公司 | 用于治疗癌症、阿尔茨海默病、血色沉着病和其它病症的金属酶抑制剂 |
| CN117069697A (zh) * | 2022-05-16 | 2023-11-17 | 上海济煜医药科技有限公司 | 一类含杂环结构化合物的制备方法及作为抗菌剂的应用 |
| CN117069693A (zh) * | 2022-05-16 | 2023-11-17 | 上海济煜医药科技有限公司 | 一类含胺基结构化合物的制备方法及作为抗菌剂的应用 |
| CN115007323B (zh) * | 2022-06-17 | 2024-01-23 | 中南大学 | 一种抑制矿物中黄铁矿浮选的方法 |
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| GB8301699D0 (en) * | 1983-01-21 | 1983-02-23 | Pfizer Ltd | Antifungal agents |
| GB8304282D0 (en) * | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| DE3313073A1 (de) * | 1983-04-12 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | 1-azolyl-3-pyrazolyl-2-propanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| EP0149426B1 (de) | 1983-12-20 | 1988-05-04 | Ciba-Geigy Ag | Mikrobizide |
| GB8506619D0 (en) * | 1985-03-14 | 1985-04-17 | Pfizer Ltd | Triazole antifungal agents |
| US4738851A (en) | 1985-09-27 | 1988-04-19 | University Of Iowa Research Foundation, Inc. | Controlled release ophthalmic gel formulation |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US4882150A (en) | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
| US5206364A (en) * | 1988-08-13 | 1993-04-27 | Pfizer Inc. | Triazole antifungal agents |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| US5521222A (en) | 1989-09-28 | 1996-05-28 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| EP0431519B1 (en) | 1989-12-04 | 1994-06-15 | G.D. Searle & Co. | System for transdermal albuterol administration |
| US5077033A (en) | 1990-08-07 | 1991-12-31 | Mediventures Inc. | Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| GB9121456D0 (en) * | 1991-10-10 | 1991-11-27 | Pfizer Ltd | Triazole antifungal agents |
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| ES2094688B1 (es) | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| GB9512961D0 (en) | 1995-06-26 | 1995-08-30 | Pfizer Ltd | Antifungal agents |
| CN1189162A (zh) | 1995-06-26 | 1998-07-29 | 辉瑞研究开发公司 | 三唑抗真菌剂 |
| FI102788B (fi) * | 1995-09-14 | 1999-02-15 | Nokia Telecommunications Oy | Yhteisen levydatan hallinta kahdennetussa tietokoneyksikössä |
| IT1283911B1 (it) | 1996-02-05 | 1998-05-07 | Farmigea Spa | Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo |
| GB9605705D0 (en) * | 1996-03-19 | 1996-05-22 | Pfizer Ltd | Therapeutic agents |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
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| CN100422153C (zh) | 2005-02-06 | 2008-10-01 | 沈阳化工研究院 | N-(2-取代苯基)-n-甲氧基氨基甲酸酯类化合物及其制备与应用 |
| BRPI0501146A (pt) * | 2005-03-16 | 2006-10-31 | Fmc Quimica Do Brasil Ltda | composição fungicida/inseticida/herbicida/nematicida, uso de derivados de imidazóis e/ou trazóis no combate de pragas agrìcolas, método para preparação da referida composição, bem como método para controle de doenças/insetos/ácaros/nematóides e plantas daninhas, particularmente de doenças foliares e/ou de solos |
| EP2073741A4 (en) | 2006-10-18 | 2013-07-24 | Bnl Biotech Co Ltd | ENDODONTIC INSTRUMENT FOR SHUTDOWN OF RADICULAR CHANNEL AND HEATED END SUITABLE FOR THIS INSTRUMENT |
| CA2669887A1 (en) | 2006-11-21 | 2008-05-29 | Viamet Pharmaceuticals, Inc. | Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties |
| WO2008124131A1 (en) * | 2007-04-05 | 2008-10-16 | The John Hopkins University | Antifungal agents as neuroprotectants |
| US8221057B2 (en) | 2008-06-25 | 2012-07-17 | General Electric Company | Method, system and controller for establishing a wheel space temperature alarm in a turbomachine |
| AU2011242562B2 (en) * | 2010-04-24 | 2016-10-13 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| WO2011134911A2 (en) | 2010-04-28 | 2011-11-03 | Bayer Cropscience Ag | Fungicide hydroximoyl-tetrazole derivatives |
| EP2522683B1 (en) | 2011-05-10 | 2013-12-11 | Hüttenes-Albertus Chemische-Werke GmbH | Silicic ester modified phenol/formaldehyde novolaks and their use for the production of resin coated substrates |
| IN2014MN00093A (https=) | 2011-06-19 | 2015-06-19 | Viamet Pharmaceuticals Inc | |
| WO2012177635A1 (en) * | 2011-06-19 | 2012-12-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| EA025266B1 (ru) * | 2011-06-23 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
| EP3351541A1 (en) * | 2011-12-11 | 2018-07-25 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| ES2774267T3 (es) * | 2012-01-20 | 2020-07-20 | Mycovia Pharmaceuticals Inc | Compuestos inhibidores de metaloenzimas |
| US20150246898A1 (en) * | 2012-09-12 | 2015-09-03 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds |
-
2012
- 2012-06-19 IN IN93MUN2014 patent/IN2014MN00093A/en unknown
- 2012-06-19 US US13/527,387 patent/US8809378B2/en not_active Expired - Fee Related
- 2012-06-19 HK HK14112183.6A patent/HK1198651A1/xx unknown
- 2012-06-19 WO PCT/US2012/043094 patent/WO2012177603A2/en not_active Ceased
- 2012-06-19 CN CN201280039384.7A patent/CN103764646A/zh active Pending
- 2012-06-19 EA EA201490038A patent/EA201490038A1/ru unknown
- 2012-06-19 CA CA2839769A patent/CA2839769A1/en not_active Abandoned
- 2012-06-19 US US13/527,402 patent/US8901121B2/en not_active Expired - Fee Related
- 2012-06-19 KR KR1020147001294A patent/KR20140040235A/ko not_active Withdrawn
- 2012-06-19 AR ARP120102183A patent/AR086988A1/es unknown
- 2012-06-19 KR KR1020147001273A patent/KR101912850B1/ko not_active Expired - Fee Related
- 2012-06-19 CA CA2838909A patent/CA2838909A1/en not_active Abandoned
- 2012-06-19 PH PH1/2013/502624A patent/PH12013502624A1/en unknown
- 2012-06-19 JP JP2014516090A patent/JP6159318B2/ja not_active Expired - Fee Related
- 2012-06-19 BR BR102012015199-5A patent/BR102012015199A2/pt not_active Application Discontinuation
- 2012-06-19 AU AU2012273166A patent/AU2012273166A1/en not_active Abandoned
- 2012-06-19 EP EP12801966.8A patent/EP2721020B1/en not_active Not-in-force
- 2012-06-19 AU AU2012273161A patent/AU2012273161B9/en not_active Ceased
- 2012-06-19 JP JP2014516091A patent/JP6122846B2/ja active Active
- 2012-06-19 CN CN201280039383.2A patent/CN103842355A/zh active Pending
- 2012-06-19 EA EA201490036A patent/EA024385B1/ru not_active IP Right Cessation
- 2012-06-19 EP EP12802388.4A patent/EP2721021B1/en active Active
- 2012-06-19 WO PCT/US2012/043101 patent/WO2012177608A1/en not_active Ceased
- 2012-06-19 MX MX2013015160A patent/MX2013015160A/es unknown
- 2012-06-20 UY UY0001034146A patent/UY34146A/es not_active Application Discontinuation
-
2013
- 2013-12-18 CL CL2013003639A patent/CL2013003639A1/es unknown
-
2014
- 2014-01-15 CO CO14006566A patent/CO6940433A2/es not_active Application Discontinuation
- 2014-01-16 EC ECSP14013153 patent/ECSP14013153A/es unknown
- 2014-01-16 CR CR20140024A patent/CR20140024A/es unknown
- 2014-08-12 US US14/457,620 patent/US9221791B2/en not_active Expired - Fee Related
- 2014-12-01 US US14/557,117 patent/US9556143B2/en not_active Expired - Fee Related
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