JP2014517848A5 - - Google Patents
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- Publication number
- JP2014517848A5 JP2014517848A5 JP2014512959A JP2014512959A JP2014517848A5 JP 2014517848 A5 JP2014517848 A5 JP 2014517848A5 JP 2014512959 A JP2014512959 A JP 2014512959A JP 2014512959 A JP2014512959 A JP 2014512959A JP 2014517848 A5 JP2014517848 A5 JP 2014517848A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- independently
- der
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 6
- 101000604110 Homo sapiens Palmitoleoyl-protein carboxylesterase NOTUM Proteins 0.000 claims 5
- 102100038424 Palmitoleoyl-protein carboxylesterase NOTUM Human genes 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- -1 nitro, sulfanyl Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 4
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 4
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000004202 carbamide Substances 0.000 claims 2
- 235000013877 carbamide Nutrition 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 206010065687 Bone loss Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490839P | 2011-05-27 | 2011-05-27 | |
| US61/490,839 | 2011-05-27 | ||
| PCT/US2012/039087 WO2012166458A1 (en) | 2011-05-27 | 2012-05-23 | 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014517848A JP2014517848A (ja) | 2014-07-24 |
| JP2014517848A5 true JP2014517848A5 (OSRAM) | 2015-07-02 |
| JP6166718B2 JP6166718B2 (ja) | 2017-07-19 |
Family
ID=46201840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512959A Expired - Fee Related JP6166718B2 (ja) | 2011-05-27 | 2012-05-23 | ＮＯＴＵＭペクチンアセチルエステラーゼの４Ｈ−チエノ［３，２−ｃ］クロメン系阻害剤及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120302562A1 (OSRAM) |
| EP (1) | EP2714675B1 (OSRAM) |
| JP (1) | JP6166718B2 (OSRAM) |
| CN (1) | CN103649072A (OSRAM) |
| AU (1) | AU2012262748B2 (OSRAM) |
| CA (1) | CA2837084C (OSRAM) |
| DK (1) | DK2714675T3 (OSRAM) |
| ES (1) | ES2715832T3 (OSRAM) |
| HU (1) | HUE043221T2 (OSRAM) |
| PL (1) | PL2714675T3 (OSRAM) |
| PT (1) | PT2714675T (OSRAM) |
| WO (1) | WO2012166458A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2714675B1 (en) * | 2011-05-27 | 2019-01-02 | Lexicon Pharmaceuticals, Inc. | 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use |
| EP4183853B1 (en) | 2016-04-15 | 2024-10-02 | Beckman Coulter, Inc. | Photoactive macromolecules and uses thereof |
| SG11202001514XA (en) * | 2017-08-31 | 2020-03-30 | Daiichi Sankyo Co Ltd | Novel method for producing antibody-drug conjugate |
| CN108948011A (zh) * | 2018-08-14 | 2018-12-07 | 华南农业大学 | 一种普拉多沙星的制备方法 |
| GB201814151D0 (en) * | 2018-08-31 | 2018-10-17 | Ucl Business Plc | Compounds |
| CN109134493A (zh) * | 2018-09-19 | 2019-01-04 | 浙江师范大学 | 一种具有抗菌活性的2-氧代色烯并噻吩衍生物及其合成方法和应用 |
| CN112094182B (zh) * | 2020-09-22 | 2021-11-12 | 中国海洋大学 | 一种医药中间体苯并环己酮化合物的绿色合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1917601C3 (de) * | 1969-04-05 | 1980-09-25 | Bayer Ag, 5090 Leverkusen | Benzoxazolyl-(2)-dihydronaphtho [4,5-b] thiophene und deren Verwendung als optische Aufheller |
| DE2628878A1 (de) * | 1976-06-26 | 1978-01-05 | Bayer Ag | Beschichtungszusammensetzung |
| US4487778A (en) * | 1983-01-27 | 1984-12-11 | Fmc Corporation | Insecticidal esters derived from benzocycloalkane-thiophenemethyl compounds |
| GB8504702D0 (en) * | 1985-02-23 | 1985-03-27 | Zyma Sa | Tricyclic compounds |
| US6080576A (en) | 1998-03-27 | 2000-06-27 | Lexicon Genetics Incorporated | Vectors for gene trapping and gene activation |
| FR2790959B1 (fr) | 1999-03-15 | 2003-06-27 | Pf Medicament | Utilisation de fractions membranaires bacteriennes a effet adjuvant, leurs procedes de preparation et composition pharmaceutique les contenant |
| UY26026A1 (es) * | 1999-03-16 | 2000-10-31 | Smithkline Beecham Corportion | Inhibidores de proteasas |
| GB0012362D0 (en) * | 2000-05-22 | 2000-07-12 | Aventis Pharma Ltd | Chemical compounds |
| US20040082602A1 (en) | 2002-07-19 | 2004-04-29 | Hagen Timothy J. | Substituted thiophene carboxamide compounds for the treatment of inflammation |
| JPWO2005012284A1 (ja) * | 2003-07-31 | 2007-09-27 | 大正製薬株式会社 | ４，５−ジヒドロナフト［１，２−ｂ］チオフェン誘導体 |
| WO2006080439A1 (ja) * | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | 三環性化合物 |
| WO2006080406A1 (ja) * | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | 三環性化合物 |
| WO2009123971A1 (en) * | 2008-03-31 | 2009-10-08 | Genentech, Inc. | Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use |
| EP2714675B1 (en) * | 2011-05-27 | 2019-01-02 | Lexicon Pharmaceuticals, Inc. | 4h-thieno[3,2-c]chromene-based inhibitors of notum pectinacetylesterase and methods of their use |
-
2012
- 2012-05-23 EP EP12725227.8A patent/EP2714675B1/en active Active
- 2012-05-23 CA CA2837084A patent/CA2837084C/en active Active
- 2012-05-23 HU HUE12725227A patent/HUE043221T2/hu unknown
- 2012-05-23 ES ES12725227T patent/ES2715832T3/es active Active
- 2012-05-23 WO PCT/US2012/039087 patent/WO2012166458A1/en not_active Ceased
- 2012-05-23 PL PL12725227T patent/PL2714675T3/pl unknown
- 2012-05-23 DK DK12725227.8T patent/DK2714675T3/en active
- 2012-05-23 JP JP2014512959A patent/JP6166718B2/ja not_active Expired - Fee Related
- 2012-05-23 AU AU2012262748A patent/AU2012262748B2/en not_active Ceased
- 2012-05-23 US US13/478,529 patent/US20120302562A1/en not_active Abandoned
- 2012-05-23 PT PT12725227T patent/PT2714675T/pt unknown
- 2012-05-23 CN CN201280025844.0A patent/CN103649072A/zh active Pending
-
2014
- 2014-05-21 US US14/284,106 patent/US9624238B2/en not_active Expired - Fee Related
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