JP2014516088A5 - - Google Patents
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- Publication number
- JP2014516088A5 JP2014516088A5 JP2014514934A JP2014514934A JP2014516088A5 JP 2014516088 A5 JP2014516088 A5 JP 2014516088A5 JP 2014514934 A JP2014514934 A JP 2014514934A JP 2014514934 A JP2014514934 A JP 2014514934A JP 2014516088 A5 JP2014516088 A5 JP 2014516088A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- rvwf
- vwf
- subject
- von willebrand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100036537 von Willebrand factor Human genes 0.000 claims description 73
- 238000000034 method Methods 0.000 claims description 35
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 32
- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 26
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 26
- 229960001134 von willebrand factor Drugs 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 21
- 108010054218 Factor VIII Proteins 0.000 claims description 18
- 102000001690 Factor VIII Human genes 0.000 claims description 18
- 229960000301 factor viii Drugs 0.000 claims description 18
- 230000002947 procoagulating effect Effects 0.000 claims description 8
- 201000003542 Factor VIII deficiency Diseases 0.000 claims description 6
- 208000009292 Hemophilia A Diseases 0.000 claims description 6
- 208000027276 Von Willebrand disease Diseases 0.000 claims description 6
- 208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 claims description 6
- 238000004113 cell culture Methods 0.000 claims description 4
- 241000699802 Cricetulus griseus Species 0.000 claims description 2
- 102000004961 Furin Human genes 0.000 claims description 2
- 108090001126 Furin Proteins 0.000 claims description 2
- 208000010287 Type 3 von Willebrand Disease Diseases 0.000 claims description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 34
- 229940124597 therapeutic agent Drugs 0.000 claims 34
- 208000015316 von Willebrand disease 3 Diseases 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161495884P | 2011-06-10 | 2011-06-10 | |
| US61/495,884 | 2011-06-10 | ||
| US201161511901P | 2011-07-26 | 2011-07-26 | |
| US61/511,901 | 2011-07-26 | ||
| US201161523790P | 2011-08-15 | 2011-08-15 | |
| US61/523,790 | 2011-08-15 | ||
| PCT/US2012/041957 WO2012171031A1 (en) | 2011-06-10 | 2012-06-11 | Treatment of coagulation disease by administration of recombinant vwf |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137381A Division JP6527114B2 (ja) | 2011-06-10 | 2016-07-12 | 組換えフォンウィルブランド因子の投与による凝固疾患の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516088A JP2014516088A (ja) | 2014-07-07 |
| JP2014516088A5 true JP2014516088A5 (enExample) | 2015-07-30 |
| JP6347468B2 JP6347468B2 (ja) | 2018-06-27 |
Family
ID=46321496
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514934A Active JP6347468B2 (ja) | 2011-06-10 | 2012-06-11 | 組換えフォンウィルブランド因子の投与による凝固疾患の治療 |
| JP2016137381A Active JP6527114B2 (ja) | 2011-06-10 | 2016-07-12 | 組換えフォンウィルブランド因子の投与による凝固疾患の治療 |
| JP2018246475A Pending JP2019048892A (ja) | 2011-06-10 | 2018-12-28 | 組換えフォンウィルブランド因子の投与による凝固疾患の治療 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137381A Active JP6527114B2 (ja) | 2011-06-10 | 2016-07-12 | 組換えフォンウィルブランド因子の投与による凝固疾患の治療 |
| JP2018246475A Pending JP2019048892A (ja) | 2011-06-10 | 2018-12-28 | 組換えフォンウィルブランド因子の投与による凝固疾患の治療 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9272021B2 (enExample) |
| EP (3) | EP3858375B1 (enExample) |
| JP (3) | JP6347468B2 (enExample) |
| KR (3) | KR20190041032A (enExample) |
| CN (3) | CN108210889A (enExample) |
| AR (1) | AR086904A1 (enExample) |
| AU (5) | AU2012267458A1 (enExample) |
| BR (1) | BR112013031795A2 (enExample) |
| CA (1) | CA2838845C (enExample) |
| DK (3) | DK3412305T3 (enExample) |
| ES (3) | ES2860450T3 (enExample) |
| FI (1) | FI3858375T3 (enExample) |
| HK (1) | HK1257436A1 (enExample) |
| HR (1) | HRP20180962T1 (enExample) |
| HU (1) | HUE039317T2 (enExample) |
| LT (1) | LT2717905T (enExample) |
| MX (2) | MX350582B (enExample) |
| PL (3) | PL3858375T3 (enExample) |
| PT (3) | PT2717905T (enExample) |
| RU (2) | RU2680402C2 (enExample) |
| SG (2) | SG10201604684WA (enExample) |
| SI (1) | SI2717905T1 (enExample) |
| TR (1) | TR201808823T4 (enExample) |
| WO (1) | WO2012171031A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210889A (zh) * | 2011-06-10 | 2018-06-29 | 百深有限责任公司 | 通过施用重组vwf治疗凝血疾病 |
| CN102776260B (zh) * | 2012-07-26 | 2015-04-29 | 上海泰龙生物医药科技有限公司 | 一种高效表达重组人凝血八因子的方法 |
| DK2796145T3 (da) | 2013-04-22 | 2018-01-29 | Csl Ltd | Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro |
| NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| FR3034669B1 (fr) | 2015-04-07 | 2020-02-14 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Nouvelle utilisation du facteur von willebrand |
| SG11201808475XA (en) | 2016-04-15 | 2018-10-30 | Baxalta Inc | Method and apparatus for providing a pharmacokinetic drug dosing regiment |
| US10896749B2 (en) | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
| AU2018298232B2 (en) * | 2017-07-07 | 2025-04-03 | Takeda Pharmaceutical Company Limited | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant VWF |
| US10632176B2 (en) | 2017-07-07 | 2020-04-28 | Baxalta Incorporated | Treatment of gastrointestinal bleeding in patients with severe von Willebrand disease by administration of recombinant VWF |
| MY204220A (en) | 2018-02-06 | 2024-08-16 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
| MX2020009788A (es) * | 2018-03-21 | 2020-12-09 | Takeda Pharmaceuticals Co | Separación de factor de von willebrand (vwf) y propéptido de factor de von willebrand (vwf) por métodos cromatográficos. |
| KR20210134642A (ko) * | 2019-02-01 | 2021-11-10 | 다케다 야쿠힌 고교 가부시키가이샤 | 재조합 vwf (rvwf)를 이용한 예방 치료 방법 |
| US20220401524A1 (en) * | 2019-09-11 | 2022-12-22 | Takeda Pharmaceutical Company Limited | Methods of treatment related to complexes of von willebrand factor and complement c1q |
| AR121268A1 (es) | 2020-02-04 | 2022-05-04 | Takeda Pharmaceuticals Co | Tratamiento de la menorragia en pacientes con enfermedad de von willebrand grave mediante la administración de vwf recombinante |
| IL303089A (en) * | 2020-11-24 | 2023-07-01 | Band Therapeutics Llc | Compositions and methods for treatment of bleeding disorders |
| WO2024124136A1 (en) * | 2022-12-09 | 2024-06-13 | Vega Therapeutics, Inc. | Von willebrand disease animal models |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4638028A (en) | 1985-04-08 | 1987-01-20 | Goodyear Tire & Rubber Company | Rubber polymerases and methods for their production and use |
| WO1986006096A1 (en) | 1985-04-11 | 1986-10-23 | The Children's Medical Center Corporation | Von willebrand factor |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| AT406373B (de) * | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
| AT405403B (de) * | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
| US6531577B1 (en) | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
| US6864403B1 (en) | 1998-10-15 | 2005-03-08 | E. I. Du Pont De Nemours And Company | Plant protein disulfide isomerases |
| US20040014657A1 (en) * | 2001-11-05 | 2004-01-22 | Jan Ohrstrom | Use of blood coagulation factor XIII for treating haemophilia A |
| WO2005012354A1 (en) * | 2003-07-31 | 2005-02-10 | Zlb Behring Gmbh | Method for extending the half-life of fviii |
| EP1593388A1 (en) * | 2004-05-05 | 2005-11-09 | ZLB Behring GmbH | Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers |
| US20060094104A1 (en) | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
| KR20070092754A (ko) * | 2004-12-27 | 2007-09-13 | 백스터 인터내셔널 인코포레이티드 | 중합체 - 폰 빌레브란트 인자 - 접합체 |
| ES2474573T3 (es) | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
| JP2010529155A (ja) * | 2007-06-13 | 2010-08-26 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 出血性疾患の治療及び予防的処置における血管外投与のためのｖｗｆ安定化ｆｖｉｉｉ製剤及びｆｖｉｉｉなしのｖｗｆ製剤の使用 |
| BRPI0820271A2 (pt) | 2007-11-09 | 2015-05-26 | Baxter Int | Métodos de aumentar a sobrevivência de uma proteína de coagulação pela inibição da interação com um receptor de depuração, de aumentar a sobrevivência de fator viii que inibe receptores de depruração de proteína de coagulação, de tratar um indivíduo com uma doença de coagulação sanguínea, e de tratar uma doença que tem por característica uma deficiência de fator viii em um indivíduo, e, proteína de ...métodos de aumentar a sobrevivência de uma proteína de coagulação pela inibição da interação com um receptor de depuração, de aumentar a sobrevivência de fator viii pela inibição da interação com um receptor de depuração, de preparar uma composição que inibe receptores de depuração de proteína de coagulação, de tratar um indivíduo com uma doença de coagulação sanguínea, e de tratar uma doença que tem por característica uma deficiência de fator viii em um indivíduo, e, proteína de coagulação modificada. |
| JP2009127455A (ja) | 2007-11-20 | 2009-06-11 | Bando Kiko Co Ltd | 往復動エンジン |
| NZ586383A (en) * | 2007-12-28 | 2012-11-30 | Baxter Int | Recombinant vwf formulations |
| ES2298096B1 (es) * | 2008-01-08 | 2009-01-01 | Grifols, S.A. | Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos. |
| CN103739712B (zh) | 2008-06-24 | 2016-10-05 | 德国杰特贝林生物制品有限公司 | 具有延长的体内半衰期的因子viii、冯·维勒布兰德因子或它们的复合物 |
| TWI670072B (zh) * | 2008-10-21 | 2019-09-01 | 美商巴克斯歐塔公司 | 凍乾的重組ｖｗｆ調配物 |
| JP2013500743A (ja) * | 2009-08-04 | 2013-01-10 | バクスター・インターナショナル・インコーポレイテッド | Ｆｖｉｉｉおよびｖｗｆがノックアウトされた遺伝子導入マウス−血友病ａモデル |
| ES3037386T3 (en) | 2010-07-08 | 2025-10-01 | Takeda Pharmaceuticals Co | Method of producing recombinant high molecular weight vwf in cell culture |
| US20120006800A1 (en) | 2010-07-09 | 2012-01-12 | Illinois Tool Works Inc. | Weld bead feature communication systems and devices |
| CN108210889A (zh) * | 2011-06-10 | 2018-06-29 | 百深有限责任公司 | 通过施用重组vwf治疗凝血疾病 |
-
2012
- 2012-06-11 CN CN201810079423.5A patent/CN108210889A/zh active Pending
- 2012-06-11 CN CN201280038870.7A patent/CN103732244A/zh active Pending
- 2012-06-11 HU HUE12728919A patent/HUE039317T2/hu unknown
- 2012-06-11 SI SI201231321T patent/SI2717905T1/sl unknown
- 2012-06-11 CN CN201611071108.5A patent/CN107412743B/zh active Active
- 2012-06-11 FI FIEP20216368.9T patent/FI3858375T3/fi active
- 2012-06-11 WO PCT/US2012/041957 patent/WO2012171031A1/en not_active Ceased
- 2012-06-11 EP EP20216368.9A patent/EP3858375B1/en active Active
- 2012-06-11 AU AU2012267458A patent/AU2012267458A1/en not_active Abandoned
- 2012-06-11 JP JP2014514934A patent/JP6347468B2/ja active Active
- 2012-06-11 PL PL20216368.9T patent/PL3858375T3/pl unknown
- 2012-06-11 PT PT127289197T patent/PT2717905T/pt unknown
- 2012-06-11 MX MX2013014543A patent/MX350582B/es active IP Right Grant
- 2012-06-11 KR KR1020197010327A patent/KR20190041032A/ko not_active Ceased
- 2012-06-11 LT LTEP12728919.7T patent/LT2717905T/lt unknown
- 2012-06-11 DK DK18173179.5T patent/DK3412305T3/da active
- 2012-06-11 ES ES18173179T patent/ES2860450T3/es active Active
- 2012-06-11 ES ES20216368T patent/ES2976169T3/es active Active
- 2012-06-11 SG SG10201604684WA patent/SG10201604684WA/en unknown
- 2012-06-11 EP EP18173179.5A patent/EP3412305B1/en active Active
- 2012-06-11 RU RU2017102679A patent/RU2680402C2/ru active
- 2012-06-11 KR KR1020147000709A patent/KR101969515B1/ko active Active
- 2012-06-11 SG SG10202002591QA patent/SG10202002591QA/en unknown
- 2012-06-11 US US13/493,926 patent/US9272021B2/en active Active
- 2012-06-11 KR KR1020207020667A patent/KR102319868B1/ko active Active
- 2012-06-11 AR ARP120102073A patent/AR086904A1/es not_active Application Discontinuation
- 2012-06-11 PT PT202163689T patent/PT3858375T/pt unknown
- 2012-06-11 EP EP12728919.7A patent/EP2717905B1/en active Active
- 2012-06-11 BR BR112013031795A patent/BR112013031795A2/pt active IP Right Grant
- 2012-06-11 CA CA2838845A patent/CA2838845C/en active Active
- 2012-06-11 HR HRP20180962TT patent/HRP20180962T1/hr unknown
- 2012-06-11 PL PL12728919T patent/PL2717905T3/pl unknown
- 2012-06-11 TR TR2018/08823T patent/TR201808823T4/tr unknown
- 2012-06-11 ES ES12728919.7T patent/ES2682249T3/es active Active
- 2012-06-11 PL PL18173179T patent/PL3412305T3/pl unknown
- 2012-06-11 PT PT181731795T patent/PT3412305T/pt unknown
- 2012-06-11 DK DK20216368.9T patent/DK3858375T3/da active
- 2012-06-11 RU RU2014100107A patent/RU2628537C2/ru active
- 2012-06-11 DK DK12728919.7T patent/DK2717905T3/en active
-
2013
- 2013-12-10 MX MX2020000083A patent/MX2020000083A/es unknown
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2015
- 2015-12-30 US US14/985,212 patent/US20160184403A1/en not_active Abandoned
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2016
- 2016-04-13 AU AU2016202299A patent/AU2016202299B2/en active Active
- 2016-07-12 JP JP2016137381A patent/JP6527114B2/ja active Active
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2017
- 2017-07-20 AU AU2017206235A patent/AU2017206235B2/en active Active
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2018
- 2018-12-27 HK HK18116648.2A patent/HK1257436A1/zh unknown
- 2018-12-28 JP JP2018246475A patent/JP2019048892A/ja active Pending
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2020
- 2020-01-02 AU AU2020200026A patent/AU2020200026A1/en not_active Abandoned
-
2022
- 2022-03-04 AU AU2022201518A patent/AU2022201518B2/en active Active
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