JP2014530246A5 - - Google Patents

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Publication number
JP2014530246A5
JP2014530246A5 JP2014536225A JP2014536225A JP2014530246A5 JP 2014530246 A5 JP2014530246 A5 JP 2014530246A5 JP 2014536225 A JP2014536225 A JP 2014536225A JP 2014536225 A JP2014536225 A JP 2014536225A JP 2014530246 A5 JP2014530246 A5 JP 2014530246A5
Authority
JP
Japan
Prior art keywords
factor viii
sulfated glycosaminoglycan
administered
dose
sulfated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014536225A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014530246A (ja
JP6072810B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/070615 external-priority patent/WO2013057167A1/en
Publication of JP2014530246A publication Critical patent/JP2014530246A/ja
Publication of JP2014530246A5 publication Critical patent/JP2014530246A5/ja
Application granted granted Critical
Publication of JP6072810B2 publication Critical patent/JP6072810B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2014536225A 2011-10-18 2012-10-18 第viii因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用 Expired - Fee Related JP6072810B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161548606P 2011-10-18 2011-10-18
EP11185648 2011-10-18
EP11185648.0 2011-10-18
US61/548,606 2011-10-18
PCT/EP2012/070615 WO2013057167A1 (en) 2011-10-18 2012-10-18 Use of sulfated glycosaminoglycans for improving the bioavailability of factor viii

Publications (3)

Publication Number Publication Date
JP2014530246A JP2014530246A (ja) 2014-11-17
JP2014530246A5 true JP2014530246A5 (enExample) 2015-11-26
JP6072810B2 JP6072810B2 (ja) 2017-02-01

Family

ID=48140372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014536225A Expired - Fee Related JP6072810B2 (ja) 2011-10-18 2012-10-18 第viii因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用

Country Status (10)

Country Link
US (1) US9393289B2 (enExample)
EP (1) EP2768522B1 (enExample)
JP (1) JP6072810B2 (enExample)
KR (1) KR20140083036A (enExample)
CN (1) CN103889445A (enExample)
AU (1) AU2012318279B2 (enExample)
CA (1) CA2852397A1 (enExample)
DK (1) DK2768522T3 (enExample)
ES (1) ES2600081T3 (enExample)
WO (1) WO2013057167A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2768521B1 (en) 2011-10-18 2016-07-13 CSL Behring GmbH Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii
BR112016026842A2 (pt) 2014-06-06 2017-12-12 Octapharma Ag preparação compreendendo fator viii e peptídeos de fator de von willebrand
EP3191524A4 (en) * 2014-09-12 2018-05-30 The Regents of The University of California Macropinocytosing human anti-cd46 antibodies and targeted cancer therapeutics
KR102554850B1 (ko) * 2015-02-06 2023-07-13 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 최적화된 인간 응고 인자 viii 유전자 발현 카세트 및 그의 용도
SE539575C2 (en) * 2015-07-30 2017-10-17 Tx Medic Ab Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
MX9203440A (es) 1985-04-12 1992-07-01 Genetics Inst Proteinas procoagulantes novedosas.
FR2673632A1 (fr) 1991-03-08 1992-09-11 Lille Transfusion Sanguine Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique.
SE504074C2 (sv) 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
IL113010A0 (en) 1994-03-31 1995-10-31 Pharmacia Ab Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
DE4435485C1 (de) 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
PT1754718E (pt) 1996-04-24 2011-07-13 Univ Michigan Factor viii resistente à inactivação
WO2000024759A1 (en) 1998-10-23 2000-05-04 The Trustees Of The University Of Pennsylvania Systemic delivery of gene products via skin
CA2450125A1 (en) 2001-06-15 2002-12-27 Andre C. Schuh Gene therapy for hemophilia a
US7041635B2 (en) 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
SI1624891T2 (sl) 2003-05-06 2013-09-30 Biogen Idec Hemophilia Inc. Strjevalni faktor-FC himerni proteini za zdravljenje hemofilije
AU2008323768A1 (en) * 2007-11-09 2009-05-14 Baxter Healthcare S.A. Modified recombinant Factor VIII and von Willebrand Factor and methods of use
US20130189239A1 (en) * 2008-02-27 2013-07-25 Novo Nordisk A/S Conjugated Factor VIII Molecules
EP2467166A2 (en) * 2009-08-20 2012-06-27 CSL Behring GmbH Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
WO2011095604A1 (en) * 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins

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