JP6072810B2 - 第ｖｉｉｉ因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用 - Google Patents
第ｖｉｉｉ因子の生物学的利用能を改善するための硫酸化グリコサミノグリカンの使用 Download PDFInfo
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Engineering & Computer Science (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP11185648.0 | 2011-10-18 | ||
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| EP11185648 | 2011-10-18 | ||
| PCT/EP2012/070615 WO2013057167A1 (en) | 2011-10-18 | 2012-10-18 | Use of sulfated glycosaminoglycans for improving the bioavailability of factor viii |
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| JP2014530246A JP2014530246A (ja) | 2014-11-17 |
| JP2014530246A5 JP2014530246A5 (enExample) | 2015-11-26 |
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| EP (1) | EP2768522B1 (enExample) |
| JP (1) | JP6072810B2 (enExample) |
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| DK (1) | DK2768522T3 (enExample) |
| ES (1) | ES2600081T3 (enExample) |
| WO (1) | WO2013057167A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9511123B2 (en) | 2011-10-18 | 2016-12-06 | Csl Behring Gmbh | Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor VIII |
| AU2015270394B2 (en) | 2014-06-06 | 2017-12-21 | Octapharma Ag | Preparation comprising Factor VIII and Von Willebrand factor peptides |
| EP3191524A4 (en) * | 2014-09-12 | 2018-05-30 | The Regents of The University of California | Macropinocytosing human anti-cd46 antibodies and targeted cancer therapeutics |
| CA2975734C (en) | 2015-02-06 | 2025-02-18 | Univ North Carolina Chapel Hill | OPTIMIZED GENE EXPRESSION CASSETTES FOR HUMAN COAGULATION FACTOR VIII AND THEIR USE |
| SE539575C2 (en) * | 2015-07-30 | 2017-10-17 | Tx Medic Ab | Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| CA1341174C (en) | 1985-04-12 | 2001-01-30 | John J. Toole Jr. | Procoagulant proteins derived from factor viii: c |
| FR2673632A1 (fr) | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| IL113010A (en) | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| ATE319817T1 (de) | 1996-04-24 | 2006-03-15 | Univ Michigan | Gegen inaktivierung resistenter faktor viii |
| WO2000024759A1 (en) | 1998-10-23 | 2000-05-04 | The Trustees Of The University Of Pennsylvania | Systemic delivery of gene products via skin |
| US20040192599A1 (en) | 2001-06-15 | 2004-09-30 | Schuh Andre C | Gene therapy for hemophilia a |
| US7041635B2 (en) | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
| SI1624891T2 (sl) | 2003-05-06 | 2013-09-30 | Biogen Idec Hemophilia Inc. | Strjevalni faktor-FC himerni proteini za zdravljenje hemofilije |
| JP2011503101A (ja) * | 2007-11-09 | 2011-01-27 | バクスター・インターナショナル・インコーポレイテッド | 修飾された組換え第ｖｉｉｉ因子およびフォンウィルブランド因子ならびにその使用方法 |
| EP2626079A3 (en) | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Conjungated factor VIII molecules |
| AU2010284977A1 (en) * | 2009-08-20 | 2012-03-29 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| WO2011095604A1 (en) | 2010-02-04 | 2011-08-11 | Octapharma Biopharmaceuticals Gmbh | Half-life prolongation of proteins |
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2012
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- 2012-10-18 CA CA2852397A patent/CA2852397A1/en not_active Abandoned
- 2012-10-18 JP JP2014536225A patent/JP6072810B2/ja not_active Expired - Fee Related
- 2012-10-18 WO PCT/EP2012/070615 patent/WO2013057167A1/en not_active Ceased
- 2012-10-18 AU AU2012318279A patent/AU2012318279B2/en not_active Ceased
- 2012-10-18 KR KR1020147013300A patent/KR20140083036A/ko not_active Withdrawn
- 2012-10-18 US US14/352,540 patent/US9393289B2/en not_active Expired - Fee Related
- 2012-10-18 CN CN201280051236.7A patent/CN103889445A/zh active Pending
- 2012-10-18 DK DK12777895.9T patent/DK2768522T3/en active
- 2012-10-18 ES ES12777895.9T patent/ES2600081T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140083036A (ko) | 2014-07-03 |
| JP2014530246A (ja) | 2014-11-17 |
| US20140315815A1 (en) | 2014-10-23 |
| AU2012318279B2 (en) | 2015-06-04 |
| EP2768522A1 (en) | 2014-08-27 |
| EP2768522B1 (en) | 2016-07-27 |
| CA2852397A1 (en) | 2013-04-25 |
| CN103889445A (zh) | 2014-06-25 |
| WO2013057167A1 (en) | 2013-04-25 |
| US9393289B2 (en) | 2016-07-19 |
| DK2768522T3 (en) | 2016-11-14 |
| AU2012318279A1 (en) | 2013-05-02 |
| ES2600081T3 (es) | 2017-02-07 |
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