JP2014516080A5 - - Google Patents
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- JP2014516080A5 JP2014516080A5 JP2014514630A JP2014514630A JP2014516080A5 JP 2014516080 A5 JP2014516080 A5 JP 2014516080A5 JP 2014514630 A JP2014514630 A JP 2014514630A JP 2014514630 A JP2014514630 A JP 2014514630A JP 2014516080 A5 JP2014516080 A5 JP 2014516080A5
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- JP
- Japan
- Prior art keywords
- particles
- poly
- pharmaceutically active
- composition
- particle diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002245 particle Substances 0.000 claims description 86
- 239000000203 mixture Substances 0.000 claims description 56
- 229920000642 polymer Polymers 0.000 claims description 45
- 239000013543 active substance Substances 0.000 claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- 239000000843 powder Substances 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 23
- 238000000576 coating method Methods 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 229920002959 polymer blend Polymers 0.000 claims description 12
- 238000013270 controlled release Methods 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 239000012736 aqueous medium Substances 0.000 claims description 4
- 238000009826 distribution Methods 0.000 claims description 4
- 239000006186 oral dosage form Substances 0.000 claims description 4
- -1 poly (ethylene) Polymers 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- OZCMOJQQLBXBKI-UHFFFAOYSA-N 1-ethenoxy-2-methylpropane Chemical compound CC(C)COC=C OZCMOJQQLBXBKI-UHFFFAOYSA-N 0.000 claims description 2
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 2
- 229920008347 Cellulose acetate propionate Polymers 0.000 claims description 2
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 claims description 2
- 229920002284 Cellulose triacetate Polymers 0.000 claims description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920001305 Poly(isodecyl(meth)acrylate) Polymers 0.000 claims description 2
- 229920002319 Poly(methyl acrylate) Polymers 0.000 claims description 2
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 2
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- 229920006217 cellulose acetate butyrate Polymers 0.000 claims description 2
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 2
- 229920006218 cellulose propionate Polymers 0.000 claims description 2
- 230000009918 complex formation Effects 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 claims description 2
- 229920001483 poly(ethyl methacrylate) polymer Polymers 0.000 claims description 2
- 229920000212 poly(isobutyl acrylate) Polymers 0.000 claims description 2
- 229920000205 poly(isobutyl methacrylate) Polymers 0.000 claims description 2
- 229920000196 poly(lauryl methacrylate) Polymers 0.000 claims description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 2
- 229920000184 poly(octadecyl acrylate) Polymers 0.000 claims description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 2
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 2
- 229920000129 polyhexylmethacrylate Polymers 0.000 claims description 2
- 229920000197 polyisopropyl acrylate Polymers 0.000 claims description 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 2
- 229920000182 polyphenyl methacrylate Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 230000002441 reversible effect Effects 0.000 claims description 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 239000011236 particulate material Substances 0.000 claims 1
- 239000013618 particulate matter Substances 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494659P | 2011-06-08 | 2011-06-08 | |
| US61/494,659 | 2011-06-08 | ||
| PCT/US2012/041331 WO2012170676A1 (en) | 2011-06-08 | 2012-06-07 | Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094634A Division JP2017137354A (ja) | 2011-06-08 | 2017-05-11 | 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014516080A JP2014516080A (ja) | 2014-07-07 |
| JP2014516080A5 true JP2014516080A5 (cg-RX-API-DMAC7.html) | 2015-05-28 |
Family
ID=47296440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514630A Withdrawn JP2014516080A (ja) | 2011-06-08 | 2012-06-07 | 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 |
| JP2017094634A Pending JP2017137354A (ja) | 2011-06-08 | 2017-05-11 | 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017094634A Pending JP2017137354A (ja) | 2011-06-08 | 2017-05-11 | 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10463611B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2717860A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2014516080A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2835293C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012170676A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| US20110020423A1 (en) | 2009-07-22 | 2011-01-27 | Puretech Ventures | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| WO2012170676A1 (en) * | 2011-06-08 | 2012-12-13 | Sti Pharma, Llc | Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration |
| TWI649100B (zh) * | 2013-06-17 | 2019-02-01 | 地平線罕見醫學製藥有限責任公司 | 延遲釋放型半胱胺珠粒調配物，以及其製備及使用方法 |
| US9452181B2 (en) | 2013-07-22 | 2016-09-27 | Duchesnay Inc. | Composition for the management of nausea and vomiting |
| PL3024466T3 (pl) | 2013-07-22 | 2018-08-31 | Duchesnay Inc. | Kompozycja do kontrolowania nudności i wymiotów |
| WO2016077832A2 (en) | 2014-11-14 | 2016-05-19 | Gemphire Therapeutics Inc. | PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS |
| WO2017055935A1 (en) * | 2015-09-30 | 2017-04-06 | Symed Labs Limited | Amorphous co-precipitates of flibanserin |
| US10143665B2 (en) | 2015-11-17 | 2018-12-04 | Horizon Orphan Llc | Methods for storing cysteamine formulations and related methods of treatment |
| CN106866546A (zh) * | 2015-12-10 | 2017-06-20 | 常州爱诺新睿医药技术有限公司 | 氟班色林或其药学上可接受的盐与药用辅料的固体分散体及其制备方法 |
| WO2018047002A1 (en) * | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
| AU2017322544B2 (en) * | 2016-09-12 | 2022-06-02 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3H-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
| KR102658015B1 (ko) | 2016-09-12 | 2024-05-21 | 에스티 아이피 홀딩 아게 | 4-메틸-5-(피라진-2-일)-3h-1,2-디티올-3-티온의 제제, 및 그의 제조 및 사용 방법 |
| WO2018047013A1 (en) * | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same |
| JP7053590B2 (ja) * | 2016-09-27 | 2022-04-12 | バイエル・ファルマ・アクティエンゲゼルシャフト | カルコブトロールの変態ａの結晶形態を製造する方法 |
| EP3518910A4 (en) | 2016-09-30 | 2020-11-04 | Xenamed Corporation | COMPOSITIONS OF MIDODRINE AND THEIR METHODS OF USE |
| US20180297929A1 (en) | 2017-04-18 | 2018-10-18 | Gemphire Therapeutics Inc. | Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor |
| EP3727347A4 (en) | 2017-12-22 | 2021-10-20 | Xenamed Corp. | LONG-RELEASE MIDODRINE HYDROCHLORIDE COMPOSITIONS AND METHODS OF USE |
| US10933020B2 (en) | 2018-09-28 | 2021-03-02 | Karuna Therapeutics, Inc. | Compositions and methods for treating disorders ameliorated by muscarinic receptor activation |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| WO2021013861A1 (en) * | 2019-07-22 | 2021-01-28 | Nanomi, B.V. | Sustained release trepostinil-compound microparticle compositions |
| CR20220506A (es) * | 2020-03-09 | 2023-01-17 | Sushma Paul Berlia | Formulaciones de liberación controlada que comprenden drotaverina o sal de la misma |
| US11135220B1 (en) | 2020-04-08 | 2021-10-05 | St Ip Holding Ag | Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione |
| KR20220048341A (ko) * | 2020-10-12 | 2022-04-19 | 뉴지랩테라퓨틱스 주식회사 | 나파모스타트 또는 이의 약제학적으로 허용가능한 염을 함유하는 방출 조절 제형 및 이의 제조방법 |
| AU2022234218A1 (en) * | 2021-03-09 | 2023-09-07 | Ensysce Biosciences Inc. | Modified release compositions of nafamostat and methods of using same |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS521867A (en) | 1975-06-24 | 1977-01-08 | Tonichi Kotsu Consultant:Kk | Rotary vertical garrage |
| JPS6327424A (ja) * | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | 徐放性製剤およびその製造法 |
| GB8618811D0 (en) | 1986-08-01 | 1986-09-10 | Approved Prescription Services | Sustained release ibuprofen formulation |
| GB8724763D0 (en) | 1987-10-22 | 1987-11-25 | Aps Research Ltd | Sustained-release formulations |
| US4971805A (en) * | 1987-12-23 | 1990-11-20 | Teysan Pharmaceuticals Co., Ltd. | Slow-releasing granules and long acting mixed granules comprising the same |
| ES2091211T3 (es) * | 1989-06-23 | 1996-11-01 | Syntex Inc | Ranolazina y piperazinas relacionadas utilizadas en el tratamiento de tejidos que sufren una lesion fisica o quimica. |
| IE66933B1 (en) * | 1990-01-15 | 1996-02-07 | Elan Corp Plc | Controlled absorption naproxen formulation for once-daily administration |
| US5431922A (en) * | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
| KR100221695B1 (ko) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
| US5376384A (en) * | 1992-12-23 | 1994-12-27 | Kinaform Technology, Inc. | Delayed, sustained-release pharmaceutical preparation |
| DK66493D0 (da) | 1993-06-08 | 1993-06-08 | Ferring A S | Praeparater, isaer til brug ved behandling af inflammatoriske tarmsygdomme eller til at opnaa forbedret saarheling |
| US5558879A (en) | 1995-04-28 | 1996-09-24 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water soluble drugs in which a passageway is formed in situ |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| AU6283299A (en) | 1998-10-01 | 2000-04-17 | Elan Pharma International Limited | Controlled release nanoparticulate compositions |
| US6528090B2 (en) * | 1998-12-18 | 2003-03-04 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
| FR2796790B1 (fr) | 1999-07-23 | 2002-11-29 | Sagem | Procedes de transmission et de diffusion de paquets de donnees et recepteurs pour la mise en oeuvre des procedes |
| EP2260837A1 (en) * | 2001-06-01 | 2010-12-15 | Pozen, Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| US7101573B2 (en) * | 2001-09-28 | 2006-09-05 | Mcneil-Pcc, Inc. | Simethicone solid oral dosage form |
| US20040224020A1 (en) * | 2002-12-18 | 2004-11-11 | Schoenhard Grant L. | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
| MXPA05010636A (es) | 2003-04-04 | 2005-12-12 | Pharmacia Corp | Comprimidos de multiparticulas preparados por compresion de liberacion oral prolongada. |
| US20040219210A1 (en) | 2003-05-01 | 2004-11-04 | Jian-Hwa Guo | Controlled release solid dosage nifedipine formulations |
| SI21638A (sl) | 2003-11-12 | 2005-06-30 | LEK farmacevtska dru�ba d.d. | Farmacevtska oblika z nadzorovanim sproščanjem ketoprofena |
| US8389032B2 (en) * | 2005-05-23 | 2013-03-05 | Kraft Foods Global Brands Llc | Delivery system for active components as part of an edible composition having selected particle size |
| US9161918B2 (en) * | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| JP4936420B2 (ja) | 2005-08-02 | 2012-05-23 | 塩野義製薬株式会社 | 徐放性顆粒剤 |
| WO2007078895A2 (en) * | 2005-12-30 | 2007-07-12 | Biovail Laboratories International S.R.L. | Modified release formulations of tramadol and uses thereof |
| US20070160667A1 (en) | 2006-01-11 | 2007-07-12 | Nava Shterman | Controlled release formulation of divalproex sodium |
| CA2690379A1 (en) * | 2007-06-13 | 2008-12-24 | Auspex Pharmaceuticals, Inc. | Substituted piperazines |
| US20100008986A1 (en) | 2008-07-14 | 2010-01-14 | Glenmark Generics, Ltd. | Pharmaceutical compositions comprising sumatriptan and naproxen |
| US20110313009A1 (en) * | 2008-07-17 | 2011-12-22 | Horizon Pharma Usa, Inc. | Nsaid dose unit formulations with h2-receptor antagonists and methods of use |
| US20100255082A1 (en) * | 2008-07-31 | 2010-10-07 | Ishwar Chauhan | Functionally Coated Breakable Tablets |
| US20100305163A1 (en) | 2009-05-20 | 2010-12-02 | Pramod Dattatray Yedurkar | Pharmaceutical formulations comprising nsaid and proton pump inhibitor drugs |
| WO2012170676A1 (en) | 2011-06-08 | 2012-12-13 | Sti Pharma, Llc | Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration |
-
2012
- 2012-06-07 WO PCT/US2012/041331 patent/WO2012170676A1/en not_active Ceased
- 2012-06-07 JP JP2014514630A patent/JP2014516080A/ja not_active Withdrawn
- 2012-06-07 EP EP12797656.1A patent/EP2717860A4/en active Pending
- 2012-06-07 US US14/119,387 patent/US10463611B2/en active Active
- 2012-06-07 CA CA2835293A patent/CA2835293C/en active Active
-
2017
- 2017-05-11 JP JP2017094634A patent/JP2017137354A/ja active Pending
-
2019
- 2019-09-13 US US16/570,411 patent/US11191719B2/en active Active
-
2021
- 2021-10-29 US US17/515,022 patent/US20220047505A1/en active Pending
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