JP2014515039A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014515039A5 JP2014515039A5 JP2014510928A JP2014510928A JP2014515039A5 JP 2014515039 A5 JP2014515039 A5 JP 2014515039A5 JP 2014510928 A JP2014510928 A JP 2014510928A JP 2014510928 A JP2014510928 A JP 2014510928A JP 2014515039 A5 JP2014515039 A5 JP 2014515039A5
- Authority
- JP
- Japan
- Prior art keywords
- polylactide
- oligo
- peg
- polypeptide
- chains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166241.7 | 2011-05-16 | ||
| EP11166241 | 2011-05-16 | ||
| EP11166942 | 2011-05-20 | ||
| EP11166942.0 | 2011-05-20 | ||
| US201161515458P | 2011-08-05 | 2011-08-05 | |
| US201161515432P | 2011-08-05 | 2011-08-05 | |
| EP11176736 | 2011-08-05 | ||
| EP11176741.4 | 2011-08-05 | ||
| EP11176736.4 | 2011-08-05 | ||
| EP11176741 | 2011-08-05 | ||
| US61/515,432 | 2011-08-05 | ||
| US61/515,458 | 2011-08-05 | ||
| EP11192577 | 2011-12-08 | ||
| EP11192572.3 | 2011-12-08 | ||
| EP11192577.2 | 2011-12-08 | ||
| EP11192572 | 2011-12-08 | ||
| PCT/IB2012/052445 WO2012156918A1 (en) | 2011-05-16 | 2012-05-16 | Bio-orthogonal drug activation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515039A JP2014515039A (ja) | 2014-06-26 |
| JP2014515039A5 true JP2014515039A5 (https=) | 2017-03-02 |
| JP6215194B2 JP6215194B2 (ja) | 2017-10-18 |
Family
ID=47176369
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510929A Active JP5993940B2 (ja) | 2011-05-16 | 2012-05-16 | 生体直交型薬物活性化 |
| JP2014510928A Active JP6215194B2 (ja) | 2011-05-16 | 2012-05-16 | 生体直交型薬物活性化 |
| JP2014510930A Active JP6482273B2 (ja) | 2011-05-16 | 2012-05-16 | 生体直交型薬物活性化 |
| JP2016161617A Ceased JP2017014262A (ja) | 2011-05-16 | 2016-08-22 | 生体直交型薬物活性化 |
| JP2018000737A Active JP6608467B2 (ja) | 2011-05-16 | 2018-01-05 | 生体直交型薬物活性化 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510929A Active JP5993940B2 (ja) | 2011-05-16 | 2012-05-16 | 生体直交型薬物活性化 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510930A Active JP6482273B2 (ja) | 2011-05-16 | 2012-05-16 | 生体直交型薬物活性化 |
| JP2016161617A Ceased JP2017014262A (ja) | 2011-05-16 | 2016-08-22 | 生体直交型薬物活性化 |
| JP2018000737A Active JP6608467B2 (ja) | 2011-05-16 | 2018-01-05 | 生体直交型薬物活性化 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US20160151505A1 (https=) |
| EP (4) | EP2709666B1 (https=) |
| JP (5) | JP5993940B2 (https=) |
| CN (4) | CN103732257A (https=) |
| AU (3) | AU2012257418B2 (https=) |
| CA (3) | CA2836338C (https=) |
| DK (1) | DK2709667T3 (https=) |
| ES (1) | ES2920373T3 (https=) |
| WO (3) | WO2012156918A1 (https=) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2836338C (en) * | 2011-05-16 | 2022-05-03 | Koninklijke Philips N.V. | Tetrazine derivatives used in bio-orthogonal drug activation |
| AU2013302756C1 (en) | 2012-08-14 | 2018-05-17 | 10X Genomics, Inc. | Microcapsule compositions and methods |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2014065860A1 (en) * | 2012-10-24 | 2014-05-01 | The General Hospital Corporation | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions |
| WO2014081300A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Channel protein activatable liposomes |
| FI2922574T3 (fi) * | 2012-11-22 | 2023-08-11 | Tagworks Pharmaceuticals B V | Kemiallisesti pilkkoutuva ryhmä |
| WO2014081299A1 (en) * | 2012-11-22 | 2014-05-30 | Tagworks Pharmaceuticals B.V. | Activatable liposomes |
| US20150297741A1 (en) * | 2012-11-22 | 2015-10-22 | Tagworks Pharmaceuticals B.V. | Bio-orthogonal drug activation |
| WO2014133620A2 (en) * | 2012-12-07 | 2014-09-04 | University Of Washington Through Its Center For Commercialization | Thermally-activated self-immolative materials |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| KR20200140929A (ko) | 2013-02-08 | 2020-12-16 | 10엑스 제노믹스, 인크. | 폴리뉴클레오티드 바코드 생성 |
| PT3611180T (pt) | 2013-03-15 | 2022-03-15 | Biomolecular Holdings Llc | Imunoglobulina híbrida que contém uma ligação não peptídica |
| JP6847388B2 (ja) | 2013-03-15 | 2021-03-31 | レゲネロン ファーマシューティカルス，インコーポレーテッド | 生物活性分子、そのコンジュゲート、及び治療用途 |
| US20150087043A1 (en) * | 2013-04-11 | 2015-03-26 | Coferon, Inc | Monomers capable of multimerizing in an aqueous solution that employ bioorthogonal chemistries, and methods of using same |
| ES2966631T3 (es) | 2013-06-19 | 2024-04-23 | Univ California | Estructuras químicas para el suministro localizado de agentes terapéuticos |
| BR112016004023A2 (pt) | 2013-08-26 | 2022-11-16 | Regeneron Pharma | Composição, métodos para preparar uma composição e para tratar uma doença, e, composto |
| NZ718283A (en) | 2013-09-25 | 2022-05-27 | Cytomx Therapeutics Inc | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
| US9562073B2 (en) * | 2014-01-31 | 2017-02-07 | Cytomx Therapeutics, Inc. | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
| CN106659796B (zh) | 2014-03-14 | 2021-04-30 | 加利福尼亚大学董事会 | Tco缀合物和治疗剂递送方法 |
| KR102587838B1 (ko) | 2014-03-14 | 2023-10-12 | 바이오몰레큘러 홀딩스 엘엘씨 | 비-펩티드 결합을 함유하는 하이브리드 면역글로불린 |
| US20170119892A1 (en) * | 2014-04-04 | 2017-05-04 | President And Fellows Of Harvard College | Refillable drug delivery devices and methods of use thereof |
| WO2015200893A2 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Methods of analyzing nucleic acids from individual cells or cell populations |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| MX379365B (es) | 2014-06-30 | 2025-03-11 | Tarveda Therapeutics Inc | Conjugados y partículas direccionados y formulaciones de estos. |
| WO2016025480A1 (en) * | 2014-08-11 | 2016-02-18 | The General Hospital Corporation | Cyclooctenes for bioorthogonol reactions |
| CN104356110B (zh) * | 2014-11-19 | 2018-01-23 | 西北大学 | 一种硫诱导3,6‑芳香杂环不对称取代‑1,2,4,5‑四嗪化合物及其合成方法 |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| BR112017020149A8 (pt) | 2015-03-27 | 2023-05-02 | Regeneron Pharma | Derivados de maitansinoide, conjugados dos mesmos e métodos de uso |
| US20160331852A1 (en) * | 2015-05-11 | 2016-11-17 | Memorial Sloan Kettering Cancer Center | Radioligands for pretargeted pet imaging and methods of their therapeutic use |
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| WO2017044983A1 (en) | 2015-09-10 | 2017-03-16 | Shasqi, Inc. | Bioorthogonal compositions |
| GB201516480D0 (en) | 2015-09-17 | 2015-11-04 | Univ Edinburgh | Tetrazine as a trigger to release caged cargo |
| EP3153155B1 (en) * | 2015-10-08 | 2021-03-03 | President and Fellows of Harvard College | Refillable drug delivery devices and methods of use thereof |
| US11160871B2 (en) | 2015-10-28 | 2021-11-02 | Tarveda Therapeutics, Inc. | SSTR-targeted conjugates and particles and formulations thereof |
| WO2017106427A1 (en) * | 2015-12-15 | 2017-06-22 | Joseph Fox | Methods for inducing bioorthogonal reactivity |
| BR112018014759B1 (pt) | 2016-01-25 | 2024-02-27 | Regeneron Pharmaceuticals, Inc | Compostos derivados de maitasinoide e seus conjugados, composição compreendendo os mesmos, seus métodos de fabricação e uso |
| US11690825B2 (en) | 2016-03-09 | 2023-07-04 | Board Of Regents, The University Of Texas System | 20-HETE receptor (GPR75) antagonists and methods of use |
| BR112018070537B1 (pt) * | 2016-04-06 | 2022-11-01 | Sumitomo Chemical Company, Limited | Composto heterocíclico, composição compreendendo o mesmo e seus usos |
| WO2018004338A1 (en) | 2016-06-27 | 2018-01-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| HUE057849T2 (hu) | 2017-01-11 | 2022-06-28 | Alkermes Inc | Hiszton deacetiláz biciklusos gátlói |
| EP3385779A1 (en) * | 2017-04-05 | 2018-10-10 | Koninklijke Philips N.V. | Multi-view display device and method |
| AU2018250312C1 (en) | 2017-04-07 | 2024-08-22 | Tambo, Inc. | Bioorthogonal compositions |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| CN107281204A (zh) * | 2017-05-04 | 2017-10-24 | 北京大学 | 一种非对称的1，2，4，5‑四嗪分子的应用 |
| WO2019014549A1 (en) | 2017-07-14 | 2019-01-17 | The Penn State Research Foundation | Compositions and methods for targeted delivery of therapeutic and/or diagnostic species |
| LT3664802T (lt) | 2017-08-07 | 2022-06-27 | Alkermes, Inc. | Bicikliniai histonų deacetilazės inhibitoriai |
| US10590244B2 (en) | 2017-10-04 | 2020-03-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
| US10837047B2 (en) * | 2017-10-04 | 2020-11-17 | 10X Genomics, Inc. | Compositions, methods, and systems for bead formation using improved polymers |
| WO2019084323A1 (en) | 2017-10-25 | 2019-05-02 | Georgia State University Research Foundation, Inc. | CHEMICAL RELEASE SYSTEM DELIVERED BY ENRICHMENT |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| AU2019251767B2 (en) * | 2018-04-11 | 2024-07-11 | Clarity Pharmaceuticals Ltd | Targeting compounds and methods for their production |
| US12522587B2 (en) | 2018-05-04 | 2026-01-13 | Remedy Plan, Inc. | Cancer treatments targeting cancer stem cells |
| CA3099421C (en) * | 2018-05-04 | 2025-05-06 | Tagworks Pharmaceuticals B.V. | COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY |
| AU2019262520B2 (en) | 2018-05-04 | 2025-07-10 | Tagworks Pharmaceuticals B.V. | Tetrazines for high click conjugation yield in vivo and high click release yield |
| KR102011772B1 (ko) * | 2018-05-31 | 2019-08-19 | (주)스파크바이오파마 | 신규한 형광체-테트라진 화합물 및 이의 용도 |
| WO2019231016A1 (ko) | 2018-05-31 | 2019-12-05 | (주)스파크바이오파마 | 신규한 형광체-테트라진 화합물 및 이의 용도 |
| CR20210175A (es) | 2018-09-18 | 2021-06-01 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2) |
| SG11202103393XA (en) * | 2018-10-10 | 2021-04-29 | Tambo Inc | Processes for preparing functionalized cyclooctenes |
| CA3120327A1 (en) | 2018-12-06 | 2020-06-11 | Cytomx Therapeutics, Inc. | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| WO2020123882A1 (en) * | 2018-12-12 | 2020-06-18 | The General Hospital Corporation | Prodrugs with a tridentate self-immolative linker |
| CN112010817A (zh) * | 2019-05-31 | 2020-12-01 | 四川大学华西医院 | 一种制备四嗪类化合物的方法及其应用 |
| AU2020295308B2 (en) | 2019-06-17 | 2024-07-04 | Tagworks Pharmaceuticals B.V. | Agents for cleaving labels from biomolecules in vivo |
| IL289094A (en) * | 2019-06-17 | 2022-02-01 | Tagworks Pharmaceuticals B V | Tetrazines for increasing the speed and yield of the "click release" reaction |
| DK3983363T3 (da) * | 2019-06-17 | 2024-06-24 | Tagworks Pharmaceuticals B V | Forbindelser til hurtig og effektiv klikfrigivelse |
| EP4055008A1 (en) | 2019-11-06 | 2022-09-14 | Remedy Plan, Inc. | Cancer treatments targeting cancer stem cells |
| CN113321698B (zh) * | 2020-02-28 | 2022-08-23 | 国家纳米科学中心 | 一种单甲基澳瑞他汀e前药及其制备方法和应用 |
| CN113321702B (zh) * | 2020-02-28 | 2022-08-05 | 国家纳米科学中心 | 一种单甲基澳瑞他汀f甲酯前药及其制备方法和应用 |
| CN113354657B (zh) * | 2020-03-05 | 2022-10-21 | 国家纳米科学中心 | 一种Mytoxin A前药及其制备方法和应用 |
| EP3909944A1 (en) * | 2020-05-14 | 2021-11-17 | Rigshospitalet | Nuclide labelled h-tetrazines and use thereof for pet and spect pretargeted imaging and radionuclide therapy |
| CN116056765A (zh) * | 2020-08-07 | 2023-05-02 | 坦伯公司 | 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途 |
| US20230301988A1 (en) | 2020-08-27 | 2023-09-28 | The Texas A&M University System | Inhibitors of sars cov-2 infection and uses thereof |
| WO2022072949A2 (en) * | 2020-10-02 | 2022-04-07 | The General Hospital Corporation | Bioorthogonal linkers and reactions |
| WO2022197877A1 (en) | 2021-03-19 | 2022-09-22 | Genentech, Inc. | Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents |
| KR20240083175A (ko) * | 2021-08-25 | 2024-06-11 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 항체-약물-접합체를 사용하는 방법 |
| US20250009890A1 (en) * | 2021-11-05 | 2025-01-09 | Tambo, Inc. | Trans-cyclooctene-modified bispecific antibodies |
| DK4186529T3 (da) * | 2021-11-25 | 2025-08-25 | Veraxa Biotech Gmbh | Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse |
| US20250114489A1 (en) | 2022-02-15 | 2025-04-10 | Tagworks Pharmaceuticals B.V. | Masked il12 protein |
| CN114652857B (zh) * | 2022-03-31 | 2023-10-20 | 成都大学 | 一种用于修复内皮糖萼受损的靶向药物递送系统及其制备方法 |
| CN115974892B (zh) * | 2022-12-27 | 2023-09-08 | 四川大学华西医院 | 三氮唑四嗪类化合物及其制备方法、应用 |
| CN121127267A (zh) * | 2023-02-15 | 2025-12-12 | 泰克沃尔科斯制药有限公司 | 具有改进性质的四嗪 |
| CN116370650B (zh) * | 2023-04-14 | 2024-03-22 | 四川大学华西医院 | 基于四嗪连接子的多肽药物偶联物及其制备方法、应用 |
| CN116675664B (zh) * | 2023-04-21 | 2025-06-24 | 苏州大学 | 一种生物正交断键反应体系及前药与应用 |
| WO2025043219A1 (en) * | 2023-08-24 | 2025-02-27 | The Regents Of The University Of California | Methods for uncaging tetrazines |
| WO2025166249A1 (en) * | 2024-01-31 | 2025-08-07 | Oregon State University | Tetrazine amino acids and methods for their production and use |
| CN117700394B (zh) * | 2024-02-06 | 2024-05-28 | 南京大学 | 一类可与非张力烯基硼酸快速环加成反应的四嗪类化合物及其生物医药应用 |
| WO2025174248A1 (en) * | 2024-02-16 | 2025-08-21 | Tagworks Pharmaceuticals B.V. | Trans-cyclooctenes with "or gate" release |
| CN117752824A (zh) * | 2024-02-21 | 2024-03-26 | 中国医学科学院医学实验动物研究所 | 预靶向肿瘤免疫探针、生物正交制剂、试剂盒及应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826964A (en) | 1982-07-20 | 1989-05-02 | Sri International | Bridged oxygen analogs of daunorubcin and doxorubicin |
| US4486414A (en) | 1983-03-21 | 1984-12-04 | Arizona Board Of Reagents | Dolastatins A and B cell growth inhibitory substances |
| US4486444A (en) | 1983-06-20 | 1984-12-04 | Merck & Co., Inc. | (Hydroxybenzoyl)thiophenesulfonamide and acyl derivatives thereof for the topical treatment of elevated intraocular pressure |
| US4879278A (en) | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| US4986988A (en) | 1989-05-18 | 1991-01-22 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13 |
| US5138036A (en) | 1989-11-13 | 1992-08-11 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14 |
| US5198560A (en) | 1990-04-27 | 1993-03-30 | Bristol-Myers Squibb Company | Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US6034065A (en) | 1992-12-03 | 2000-03-07 | Arizona Board Of Regents | Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10 |
| US5410024A (en) | 1993-01-21 | 1995-04-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| US5530097A (en) | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5504191A (en) | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
| US5521284A (en) | 1994-08-01 | 1996-05-28 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide amides and esters |
| US5599902A (en) | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| CA2253204A1 (en) | 1996-05-03 | 1997-11-13 | Roger S. Cubicciotti | Prodrug compositions and drug delivery methods using synthetic receptors |
| WO1998036765A1 (en) | 1997-02-25 | 1998-08-27 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18 |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US8236949B2 (en) * | 2007-07-17 | 2012-08-07 | University Of Delaware | Tetrazine-based bio-orthogonal coupling reagents and methods |
| WO2009109998A1 (en) | 2008-03-03 | 2009-09-11 | Lupin Limited | Novel protein tyrosine phosphatase - ib inhibitors |
| US8900549B2 (en) * | 2008-10-31 | 2014-12-02 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
| GB0906379D0 (en) * | 2009-04-14 | 2009-05-20 | Kencryst Ltd | Reduced sodium salt |
| CN102395380B (zh) * | 2009-04-16 | 2015-05-20 | 皇家飞利浦电子股份有限公司 | 预靶向试剂盒、方法和其中使用的试剂 |
| RU2011146362A (ru) * | 2009-04-16 | 2013-05-27 | Конинклейке Филипс Электроникс Н.В. | Набор для предварительного таргетинга, способ и средства, используемые в нем |
| US10434197B2 (en) | 2010-07-23 | 2019-10-08 | University Of Delaware | Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes |
| US9463256B2 (en) * | 2010-10-14 | 2016-10-11 | Koninklijke Philips N.V. | Pretargeting kit, method and agents used therein |
| JP5992435B2 (ja) | 2010-12-21 | 2016-09-14 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 循環からの生体分子の除去剤 |
| EP2522369A1 (en) * | 2011-05-09 | 2012-11-14 | Koninklijke Philips Electronics N.V. | Pretargeting kit, method and agents used therein |
| CA2836338C (en) | 2011-05-16 | 2022-05-03 | Koninklijke Philips N.V. | Tetrazine derivatives used in bio-orthogonal drug activation |
| WO2014065860A1 (en) | 2012-10-24 | 2014-05-01 | The General Hospital Corporation | Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions |
| US20150297741A1 (en) | 2012-11-22 | 2015-10-22 | Tagworks Pharmaceuticals B.V. | Bio-orthogonal drug activation |
| FI2922574T3 (fi) | 2012-11-22 | 2023-08-11 | Tagworks Pharmaceuticals B V | Kemiallisesti pilkkoutuva ryhmä |
| WO2016025480A1 (en) | 2014-08-11 | 2016-02-18 | The General Hospital Corporation | Cyclooctenes for bioorthogonol reactions |
| WO2018004338A1 (en) | 2016-06-27 | 2018-01-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| AU2019262520B2 (en) * | 2018-05-04 | 2025-07-10 | Tagworks Pharmaceuticals B.V. | Tetrazines for high click conjugation yield in vivo and high click release yield |
| CA3099421C (en) * | 2018-05-04 | 2025-05-06 | Tagworks Pharmaceuticals B.V. | COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY |
| IL289094A (en) * | 2019-06-17 | 2022-02-01 | Tagworks Pharmaceuticals B V | Tetrazines for increasing the speed and yield of the "click release" reaction |
| AU2020295308B2 (en) * | 2019-06-17 | 2024-07-04 | Tagworks Pharmaceuticals B.V. | Agents for cleaving labels from biomolecules in vivo |
| DK3983363T3 (da) * | 2019-06-17 | 2024-06-24 | Tagworks Pharmaceuticals B V | Forbindelser til hurtig og effektiv klikfrigivelse |
-
2012
- 2012-05-16 CA CA2836338A patent/CA2836338C/en active Active
- 2012-05-16 AU AU2012257418A patent/AU2012257418B2/en active Active
- 2012-05-16 AU AU2012257416A patent/AU2012257416B8/en active Active
- 2012-05-16 EP EP12725514.9A patent/EP2709666B1/en active Active
- 2012-05-16 US US14/117,125 patent/US20160151505A1/en not_active Abandoned
- 2012-05-16 CN CN201280035091.1A patent/CN103732257A/zh active Pending
- 2012-05-16 WO PCT/IB2012/052445 patent/WO2012156918A1/en not_active Ceased
- 2012-05-16 JP JP2014510929A patent/JP5993940B2/ja active Active
- 2012-05-16 AU AU2012257417A patent/AU2012257417B2/en active Active
- 2012-05-16 WO PCT/IB2012/052446 patent/WO2012156919A1/en not_active Ceased
- 2012-05-16 CN CN201280035096.4A patent/CN103889459B/zh active Active
- 2012-05-16 US US14/117,246 patent/US9421274B2/en active Active
- 2012-05-16 JP JP2014510928A patent/JP6215194B2/ja active Active
- 2012-05-16 ES ES12725515T patent/ES2920373T3/es active Active
- 2012-05-16 JP JP2014510930A patent/JP6482273B2/ja active Active
- 2012-05-16 EP EP12725515.6A patent/EP2709667B1/en active Active
- 2012-05-16 CA CA2836361A patent/CA2836361C/en active Active
- 2012-05-16 EP EP21208293.7A patent/EP3973993A1/en active Pending
- 2012-05-16 US US14/117,655 patent/US9931408B2/en active Active
- 2012-05-16 DK DK12725515.6T patent/DK2709667T3/da active
- 2012-05-16 CN CN201280024028.8A patent/CN103732256A/zh active Pending
- 2012-05-16 CA CA2836365A patent/CA2836365C/en active Active
- 2012-05-16 EP EP12725516.4A patent/EP2709668A1/en not_active Withdrawn
- 2012-05-16 CN CN201810251663.9A patent/CN108524510A/zh active Pending
- 2012-05-16 WO PCT/IB2012/052447 patent/WO2012156920A1/en not_active Ceased
-
2015
- 2015-12-30 US US14/983,858 patent/US10376594B2/en active Active
-
2016
- 2016-08-22 JP JP2016161617A patent/JP2017014262A/ja not_active Ceased
- 2016-11-23 US US15/233,283 patent/US10004810B2/en active Active
-
2018
- 2018-01-05 JP JP2018000737A patent/JP6608467B2/ja active Active
-
2019
- 2019-07-15 US US16/512,038 patent/US10967069B2/en active Active
-
2021
- 2021-02-05 US US17/169,217 patent/US11857636B2/en active Active
-
2023
- 2023-10-30 US US18/497,645 patent/US20240091371A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014515039A5 (https=) | ||
| IL284154A (en) | Analogues of oligonucleotides containing inter-subunit bonds and/or terminal groups, preparations containing them and their uses | |
| JP2012520430A5 (https=) | ||
| WO2014176373A3 (en) | Interleukin-10 compositions and uses thereof | |
| EP4357355A3 (en) | Virus purification | |
| JP2014009322A5 (https=) | ||
| JP2012501986A5 (https=) | ||
| WO2014145932A3 (en) | Specific multivalent virus-like particle vaccines and uses thereof | |
| JP2013001794A5 (https=) | ||
| JP2010529364A5 (https=) | ||
| JP2016540019A5 (https=) | ||
| WO2015010791A3 (en) | Novel antibodies for the diagnosis and treatment of rheumatoid arthritis | |
| JP2016509026A5 (https=) | ||
| WO2015066135A3 (en) | Metal ligand-containing prepolymers, methods of synthesis, and compositions thereof | |
| JP2011125841A5 (https=) | ||
| WO2015044434A3 (de) | FLUOR-9-METHYL-ß-CARBOLINE | |
| WO2016027160A3 (en) | Nasal composition comprising mixture of hyaluronic acids and saline solution | |
| JP2014520972A5 (https=) | ||
| JP2013160948A5 (https=) | ||
| Khutoryanskiy | Showcasing research by Michael T. Cook, Sarah L. Smith and Vitaliy V. Khutoryanskiy from the University of Reading and University of Hertfordshire, UK | |
| RU2012133422A (ru) | Полимерная композиция | |
| CN302151609S (zh) | 酒瓶（丰谷窖藏） | |
| 王亮云 | Self-Healing Materials via Supramolecular Force | |
| CN302203826S (zh) | 除湿机（12-10） | |
| TH113943S (th) | ถุงบรรจุ |