JP2014515035A - ストレプトコッカス・ニューモニエに対するワクチン - Google Patents

ストレプトコッカス・ニューモニエに対するワクチン Download PDF

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Publication number
JP2014515035A
JP2014515035A JP2014510771A JP2014510771A JP2014515035A JP 2014515035 A JP2014515035 A JP 2014515035A JP 2014510771 A JP2014510771 A JP 2014510771A JP 2014510771 A JP2014510771 A JP 2014510771A JP 2014515035 A JP2014515035 A JP 2014515035A
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JP
Japan
Prior art keywords
immunogenic composition
composition according
phtd
mpl
pneumolysin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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JP2014510771A
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English (en)
Japanese (ja)
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JP2014515035A5 (cg-RX-API-DMAC7.html
Inventor
ドノエル，フィリップ
プールマン，ジャン
ヴェルラント，ヴィンセント
ワッレマック，ユーグ
Original Assignee
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from GBGB1108256.7A external-priority patent/GB201108256D0/en
Priority claimed from GBGB1121647.0A external-priority patent/GB201121647D0/en
Application filed by グラクソスミスクライン バイオロジカルズ ソシエテ アノニム filed Critical グラクソスミスクライン バイオロジカルズ ソシエテ アノニム
Publication of JP2014515035A publication Critical patent/JP2014515035A/ja
Publication of JP2014515035A5 publication Critical patent/JP2014515035A5/ja
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2014510771A 2011-05-17 2012-05-15 ストレプトコッカス・ニューモニエに対するワクチン Ceased JP2014515035A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1108256.7A GB201108256D0 (en) 2011-05-17 2011-05-17 Vaccine
GB1108256.7 2011-05-17
GB1121647.0 2011-12-16
GBGB1121647.0A GB201121647D0 (en) 2011-12-16 2011-12-16 Vaccine
PCT/EP2012/058987 WO2012156391A1 (en) 2011-05-17 2012-05-15 Vaccine against streptococcus pneumoniae

Publications (2)

Publication Number Publication Date
JP2014515035A true JP2014515035A (ja) 2014-06-26
JP2014515035A5 JP2014515035A5 (cg-RX-API-DMAC7.html) 2015-06-25

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JP2014510771A Ceased JP2014515035A (ja) 2011-05-17 2012-05-15 ストレプトコッカス・ニューモニエに対するワクチン

Country Status (17)

Country Link
US (1) US20140072622A1 (cg-RX-API-DMAC7.html)
EP (1) EP2709658A1 (cg-RX-API-DMAC7.html)
JP (1) JP2014515035A (cg-RX-API-DMAC7.html)
KR (1) KR20140033127A (cg-RX-API-DMAC7.html)
CN (1) CN103533953A (cg-RX-API-DMAC7.html)
AR (1) AR086405A1 (cg-RX-API-DMAC7.html)
AU (1) AU2012257771C1 (cg-RX-API-DMAC7.html)
BR (1) BR112013029514A2 (cg-RX-API-DMAC7.html)
CA (1) CA2834834A1 (cg-RX-API-DMAC7.html)
EA (1) EA201391456A1 (cg-RX-API-DMAC7.html)
IL (1) IL229051A0 (cg-RX-API-DMAC7.html)
MX (1) MX339058B (cg-RX-API-DMAC7.html)
SG (1) SG194733A1 (cg-RX-API-DMAC7.html)
TW (1) TW201309327A (cg-RX-API-DMAC7.html)
UY (1) UY34073A (cg-RX-API-DMAC7.html)
WO (1) WO2012156391A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201308537B (cg-RX-API-DMAC7.html)

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GB201218660D0 (en) 2012-10-17 2012-11-28 Glaxosmithkline Biolog Sa Immunogenic composition
JP6236086B2 (ja) * 2012-10-17 2017-11-22 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム １種以上の肺炎球菌莢膜糖類コンジュゲートとインフルエンザ菌由来のタンパク質Ｅおよび／またはＰｉｌＡを含むタンパク質成分とを含む免疫原性組成物
EP4001290A1 (en) 2015-11-06 2022-05-25 Adjuvance Technologies, Inc. Triterpene saponin analogues
EP3562838A2 (en) * 2016-12-28 2019-11-06 Henriques Normark, Birgitta Microparticles from streptococcus pneumoniae as vaccine antigens
EP3630957A4 (en) * 2017-05-23 2021-10-06 Emulate, Inc. ADVANCED PULMONARY MODELS
CN111212846B (zh) * 2017-10-16 2023-05-26 佐剂技术公司 三萜皂苷类似物
CA3219814A1 (en) * 2021-05-27 2022-12-01 James M. Rolke Mpla compositions and methods of use
CN116212012A (zh) * 2021-12-02 2023-06-06 上海泽润生物科技有限公司 复合佐剂以及包含它的疫苗制剂
WO2025229688A1 (en) * 2024-05-03 2025-11-06 Kumar Samal Shailesh Method for producing anti-phosphorylcholine antibodies and vaccine composition thereof
CN118702827B (zh) * 2024-08-27 2025-03-07 南京澄实生物医药科技有限公司 一种预防肺炎链球菌感染的融合蛋白及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004508417A (ja) * 2000-09-15 2004-03-18 グラクソスミスクライン・バイオロジカルス・ソシエテ・アノニム ワクチン
JP2009519309A (ja) * 2005-12-13 2009-05-14 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニンアジュバントを含むワクチン組成物
JP2009520759A (ja) * 2005-12-22 2009-05-28 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 肺炎球菌多糖類コンジュゲートワクチン

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UY34073A (es) 2013-01-03
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WO2012156391A1 (en) 2012-11-22
US20140072622A1 (en) 2014-03-13
EA201391456A1 (ru) 2014-05-30
ZA201308537B (en) 2015-08-26
AU2012257771A1 (en) 2013-04-04
EP2709658A1 (en) 2014-03-26
AU2012257771B2 (en) 2015-01-15
KR20140033127A (ko) 2014-03-17
SG194733A1 (en) 2013-12-30
CN103533953A (zh) 2014-01-22
AU2012257771C1 (en) 2015-12-03
AR086405A1 (es) 2013-12-11
BR112013029514A2 (pt) 2019-09-24
TW201309327A (zh) 2013-03-01

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