JP2014514415A - セリンプロテアーゼ変異体を含む組成物及び方法 - Google Patents
セリンプロテアーゼ変異体を含む組成物及び方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38681—Chemically modified or immobilised enzymes
Abstract
Description
別途記載のない限り、本発明の調製は、当該技術分野内の分子生物学、タンパク質工学、微生物学及び組み換えDNAにおいて通常使用される従来技術を伴う。このような技術は当業者に既知のものであり、当業者に広く知られている数多くの文献及び参考文献に記載されている。本明細書で引用される全ての特許、特許出願、論文及び刊行物は、参照により明示的に本案件に組み込まれる。
本発明は、1つ以上のプロテアーゼ変異体、すなわち新規ポリペプチドを含み、これを集合的に「本発明に使用されるポリペプチド」と呼んでもよい。本発明に使用されるポリペプチドとしては、酵素活性(例えばタンパク質分解活性)を有する、例えばサブチリシン変異体のような、単離された、組換え型の、実質的に純粋な、又は非天然の変異型プロテアーゼポリペプチドが挙げられる。一部の実施形態では、サブチリシン変異体、又は配列番号2の配列を有するGG36の変異体のようなポリペプチドは、その親、例えば配列番号2の配列を有するGG36プロテアーゼと比較して、改善されたクリーニング性能を有する。一部の実施形態では、上記ポリぺプチドは、クリーニング用途に有用であり、クリーニングする必要のある物品又は表面(例えば、物品の表面の)をクリーニングする方法に有用なクリーニング組成物中に組み込まれてもよい。
AQSVPWGISRVQAPAAHNRGLTGSGVKVAVLDTGISTHPDLNIRGGASFVPGEPSTQDGNGHGTHVAGTIAALNNSIGVLGVAPSAELYAVKVLGASGSGSVSSIAQGLEWAGNNGMHVANLSLGSPSPSATLEQAVNSATSRGVLVVAASGNSGAGSISYPARYANAMAVGATDQNNNRASFSQYGAGLDIVAPGVNVQSTYPGSTYASLNGTSMATPHVAGAAALVKQKNPSWSNVQIRNHLKNTATSLGSTNLYGSGLVNAEAATR(配列番号2)である。
AQSVPYGVSQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLKVAGGASMVPSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASLYAVKVLGADGSGQYSWIINGIEWAIANNMDVINMSLGGPSGSAALKAAVDKAVASGVVVVAAAGNEGTSGSSSTVGYPGKYPSVIAVGAVDSSNQRASFSSVGPELDVMAPGVSIQSTLPGNKYGAYNGTSMASPHVAGAAALILSKHPNWTNTQVRSSLENTTTKLGDSFYYGKGLINVQAAAQ(配列番号1)である。
S103A+S188D+N248D+E271F,T022A+V104I+S188D+E271F,T022A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+Q245R+E271F,S103A+V104I+S188D+A232V+N248D,V104I+S188D+N248D+E271F,S188D+A232V+E271F,T022A+S103A+V104I+S188D+E271F,T022A+S103A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+N248D+E271F,S103A+S188D+A232V+E271F,V104I+S188D+A232V+E271F,T022A+S188D+A232V+Q245R,T022A+S188D+Q245R+E271F,T022A+S188D+N248D+E271F,S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+Q245R,S188D+A232V+Q245R+N248D,S188D+Q245R+N248D+E271F,T022A+S188D+A232V+N248D,T022A+S103A+S188D+Q245R+E271F,T022A+S103A+S188D+N248D+E271F,T022A+V104I+S188D+A232V+Q245R,S103A+S188D+A232V+Q245R+N248D,S103A+S188D+Q245R+N248D+E271F,T022A+S103A+S188D+A232V+N248D,T022A+V104I+S188D+N248D+E271F,T022A+V104I+S188D+Q245R+E271F,S188D+A232V+Q245R+E271F,S188D+A232V+N248D+E271F,T022A+S103A+V104I+S188D+A232V+Q245R,V104I+S188D+A232V+Q245R+N248D,T022A+V104I+S188D+A232V+N248D,V104I+S188D+Q245R+N248D+E271F,T022A+S188D+A232V+E271F,T022A+S103A+V104I+S188D+Q245R+E271F,T022A+S103A+V104I+S188D+N248D+E271F,T022A+S188D+Q245R+N248D+E271F,S103A+S188D+A232V+Q245R+E271F,S103A+S188D+A232V+N248D+E271F,S103A+V104I+S188D+Q245R+N248D+E271F,T022A+S103A+V104I+S188D+A232V+N248D,S103A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+A232V+E271F,V104I+S188D+A232V+N248D+E271F,V104I+S188D+A232V+Q245R+E271F,T022A+S103A+S188D+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+E271F,T022A+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D,S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+Q245R+N248D+E271F,S103A+V104I+S188D+A232V+N248D+E271F,S103A+V104I+S188D+A232V+Q245R+E271F,T022A+S188D+A232V+Q245R+E271F,T022A+S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+N248D+E271F,T022A+S103A+S188D+A232V+Q245R+N248D,S103A+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+A232V+Q245R+E271F,T022A+V104I+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D+E271F,V104I+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+E271F,G159D+S188D+Q245R+N248D,T022A+G159D+S188D,T022A+S103A+G159D+S188D,T022A+V104I+G159D+S188D,T022A+S103A+V104I+G159D+S188D,S103A+G159D+S188D+Q245R,V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+Q245R,S103A+G159D+S188D+N248D,V104I+G159D+S188D+N248D,S103A+V104I+G159D+S188D+N248D,G159D+S188D+A232V,S103A+G159D+S188D+A232V,V104I+G159D+S188D+A232V,S103A+V104I+G159D+S188D+A232V,T022A+G159D+S188D+Q245R,G159D+S188D+E271F,T022A+S103A+G159D+S188D+Q245R,S103A+G159D+S188D+E271F,T022A+V104I+G159D+S188D+Q245R,V104I+G159D+S188D+E271F,T022A+S103A+V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+E271F,T022A+G159D+S188D+N248D,T022A+S103A+G159D+S188D+N248D,T022A+V104I+G159D+S188D+N248D,S103A+G159D+S188D+Q245R+N248D,T022A+S103A+V104I+G159D+S188D+N248D,V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+N248D,T022A+G159D+S188D+A232V,T022A+S103A+G159D+S188D+A232V,T022A+V104I+G159D+S188D+A232V,G159D+S188D+A232V+Q245R,T022A+S103A+V104I+G159D+S188D+A232V,S103A+G159D+S188D+A232V+Q245R,G159D+S188D+Q245R+E271F,V104I+G159D+S188D+A232V+Q245R,G159D+S188D+A232V+N248D,T022A+G159D+S188D+E271F,S103A+G159D+S188D+Q245R+E271F,G159D+S188D+N248D+E271F,S103A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+A232V+N248D,T022A+G159D+S188D+Q245R+N248D,T022A+S103A+G159D+S188D+E271F,
V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+E271F,V104I+G159D+S188D+A232V+N248D,S103A+G159D+S188D+N248D+E271F,T022A+S103A+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+E271F,V104I+G159D+S188D+N248D+E271F,G159D+S188D+A232V+E271F,T022A+S103A+V104I+G159D+S188D+E271F,S103A+V104I+G159D+S188D+A232V+N248D,T022A+V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+N248D+E271F,S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+E271F,T022A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+Q245R,T022A+G159D+S188D+Q245R+E271F,S103A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+Q245R+N248D+E271F,T022A+S103A+G159D+S188D+A232V+Q245R,T022A+S103A+G159D+S188D+Q245R+E271F,T022A+S103A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+N248D,G159D+S188D+A232V+Q245R+N248D,T022A+V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+N248D+E271F,T022A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+Q245R+N248D+E271F,G159D+S188D+A232V+Q245R+E271F,G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+N248D,V104I+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+N248D,T022A+G159D+S188D+A232V+E271F,T022A+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+E271F,T022A+V104I+G159D+S188D+A232V+N248D,V104I+G159D+S188D+A232V+Q245R+N248D,S103A+G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+Q245R+E271F,V104I+G159D+S188D+A232V+N248D+E271F,T022A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+A232V+Q245R+N248D+E271F,T022A+G159D+S188D+A232V+N248D+E271F,T022A+G159D+S188D+A232V+Q245R+E271F,T022A+G159D+S188D+A232V+Q245R+N248D,S101G+S103A+S188D,S101G+V104I+S188D,S101G+S103A+V104I+S188D(リスト9)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
T022A+S103A+V104I+S188D+Q245R+N248D,T022A+S103A+V104I+S188D+A232V+Q245R,T022A+S103A+V104I+S188D+Q245R+E271F,T022A+S103A+V104I+S188D+N248D+E271F,S103A+V104I+S188D+Q245R+N248D+E271F,T022A+S103A+V104I+S188D+A232V+N248D,S103A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+Q245R+N248D+E271F,T022A+V104I+S188D+Q245R+N248D+E271F,S103A+V104I+S188D+A232V+N248D+E271F,S103A+V104I+S188D+A232V+Q245R+E271F,T022A+S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+N248D+E271F,T022A+S103A+S188D+A232V+Q245R+N248D,S103A+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+A232V+Q245R+E271F,T022A+V104I+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D+E271F,V104I+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+E271F,T022A+S103A+V104I+G159D+S188D+Q245R,T022A+S103A+V104I+G159D+S188D+N248D,S103A+V104I+G159D+S188D+Q245R+N248D,T022A+S103A+V104I+G159D+S188D+A232V,S103A+V104I+G159D+S188D+A232V+Q245R,T022A+S103A+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+E271F,T022A+S103A+V104I+G159D+S188D+E271F,S103A+V104I+G159D+S188D+A232V+N248D,T022A+V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+N248D+E271F,S103A+V104I+G159D+S188D+A232V+E271F,T022A+S103A+G159D+S188D+A232V+Q245R,T022A+S103A+G159D+S188D+Q245R+E271F,T022A+S103A+G159D+S188D+N248D+E271F,T022A+V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+N248D+E271F,T022A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+Q245R+N248D+E271F,T022A+S103A+G159D+S188D+A232V+N248D,V104I+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+N248D,T022A+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+E271F,T022A+V104I+G159D+S188D+A232V+N248D,V104I+G159D+S188D+A232V+Q245R+N248D,S103A+G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+Q245R+E271F,V104I+G159D+S188D+A232V+N248D+E271F,T022A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+A232V+Q245R+N248D+E271F,T022A+G159D+S188D+A232V+N248D+E271F,T022A+G159D+S188D+A232V+Q245R+E271F,又はT022A+G159D+S188D+A232V+Q245R+N248D(リスト10)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
S103A+V104I+S188D+A232V+Q245R,T022A+S103A+V104I+S188D+Q245R,T022A+S103A+V104I+S188D+N248D,S103A+V104I+S188D+Q245R+N248D,T022A+S103A+V104I+S188D+A232V,T022A+S103A+S188D+Q245R+N248D,T022A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+Q245R+E271F,S103A+V104I+S188D+A232V+N248D,T022A+S103A+V104I+S188D+E271F,S103A+V104I+S188D+N248D+E271F,S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+Q245R,T022A+S103A+S188D+Q245R+E271F,T022A+S103A+S188D+N248D+E271F,T022A+V104I+S188D+A232V+Q245R,S103A+S188D+A232V+Q245R+N248D,S103A+S188D+Q245R+N248D+E271F,T022A+S103A+S188D+A232V+N248D,T022A+V104I+S188D+N248D+E271F,T022A+V104I+S188D+Q245R+E271F,V104I+S188D+A232V+Q245R+N248D,T022A+V104I+S188D+A232V+N248D,V104I+S188D+Q245R+N248D+E271F,T022A+S188D+Q245R+N248D+E271F,S103A+S188D+A232V+Q245R+E271F,S103A+S188D+A232V+N248D+E271F,T022A+S103A+S188D+A232V+E271F,V104I+S188D+A232V+N248D+E271F,V104I+S188D+A232V+Q245R+E271F,T022A+V104I+S188D+A232V+E271F,T022A+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D,S188D+A232V+Q245R+N248D+E271F,T022A+S188D+A232V+Q245R+E271F,T022A+S103A+V104I+G159D+S188D,S103A+V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+N248D,S103A+V104I+G159D+S188D+A232V,T022A+S103A+G159D+S188D+Q245R,T022A+V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+E271F,T022A+S103A+G159D+S188D+N248D,T022A+V104I+G159D+S188D+N248D,S103A+G159D+S188D+Q245R+N248D,V104I+G159D+S188D+Q245R+N248D,T022A+S103A+G159D+S188D+A232V,T022A+V104I+G159D+S188D+A232V,S103A+G159D+S188D+A232V+Q245R,V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+Q245R+E271F,S103A+G159D+S188D+A232V+N248D,T022A+G159D+S188D+Q245R+N248D,T022A+S103A+G159D+S188D+E271F,V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+E271F,V104I+G159D+S188D+A232V+N248D,S103A+G159D+S188D+N248D+E271F,V104I+G159D+S188D+N248D+E271F,S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+E271F,T022A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+Q245R,T022A+G159D+S188D+Q245R+E271F,G159D+S188D+Q245R+N248D+E271F,T022A+G159D+S188D+A232V+N248D,G159D+S188D+A232V+Q245R+N248D,G159D+S188D+A232V+Q245R+E271F,G159D+S188D+A232V+N248D+E271F,又はT022A+G159D+S188D+A232V+E271F(リスト11)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
−S188D−Q245R,T022A−G118R−A158E−S166D,G020R−S024R−N062E−S078D−G118S−G159D−S188D−Q245R−N248D,T022A−S024R−G118R−S166D−S188D,N062E−S078G−G118S−G159D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271H,G020R−S024R−N062E−S078G−G118D−Q245R−N248D,S024R−T033S−N116L−A158E−S166D,S024R−N062E−S078G−G118D−P129E−G159D−Q245R,G020R−N062E−S078D−G118S−Q245R,T022A−S024R−N062E−N116L−A158E,G020R−N062E−S078G−G118D−P129E,S024R−T033S−N062E−N116L−G118R−S188D,G020R−N062E−S078G−G118D−P129E−G159D−S188D−H249R,S024R−S078G−G118S−P129E−G159D−Q245R−N248D,G020R−N062E−S078G−G118D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245T−N248D−E271T,S078G−G118S−P129E−G159D−S188D−Q245R−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248H−E271T,G020R−S024R−S078D−G118S−G159D−S188D−H249R,G020R−S078D−G118S−P129E−G159D−Q245R−N248D−H249R,S024R−N062E−N116L−G118R,T022A−S024R−N116L−G118R−A158E−S188D,S024R−N062E−S078G−G118S−P129E−Q245R,S024R−N062E−G118R−A158E,G020R−N062E−S078G−G118S−G159D−S188D,G020R−S024R−S078D−G118S−G159D−S188D−Q245R−N248D−H249R,S024R−S078D−G118S−P129E−G159D−Q245R,A098Q−S099T−G102A−S103G,T022A−G118R−S166D−S188D,S024R−S078D−G118S−G159D−S188D−H249R,T022A−S024R−N116L−G118R−S166D−S188D,T022A−N062E−G118R−A158E,G020R−S078G−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118D−G159D−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271F,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271F,G020R−N062E−S078G−G118S−P129E−N248D−H249R,S024R−N116L−G118R−S128I−S166D−S188D,G020R−S024R−N062E−S078G−G118D−P129E−G159D−S188D−H249R,G020R−S024R−N062E−S078G−G118D−G159D−S188D−N248D,G020R−S024R−S078G−G118D−P129E−S188D−Q245R−N248D,S024R−N062E−S078D−G118S−S188D−H249R,T033S−N062E−G118R,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271H,T033S−G118R−A158E−S166D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248H,G020R−S024R−S078D−G118D−S188D−Q245R−N248D−H249R,T022A−S024R−N062E,G020R−S024R−N062E−S078D−G118D−G159D−S188D−R247L,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248E−E271T,G020R−N062E−S078G−G118S−P129E
−G159D−Q245R−N248D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248H,P014S−G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248E−E271L,G020R−S078D−G118D−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248D−E271T,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248E−E271L,S024R−N062E−S078D−G118S−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248E−E271H,G020R−S078D−G118S−P129E−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248H−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248H−E271H,S024F−T033S−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,S024F−S101G−S103A−V104I−N116L−S128N−Y209V−G211Q−T213A−A232V,S024R−S078G−G118S−G159D−S188D−Q245R−N248D,G020R−S024R−S078G−G118S−S188D−Q245R,G020R−S024R−N062E−S078D−G118D−P129E−G159D−Q245R,S024R−S078D−G118D−G159D−S188D−H249R,G020R−S078G−G118S−G159D−S188D−H249R,G020R−S024R−N062E−S078G−G118S−S188D−N248D,S078D−G118S−G159D−Q245R,G020R−S024R−N062E−S078G−G118D−P129E−G159D−N248D−H249R,S024R−N062E−S078G−G118S−P129E−Q245R−N248D,G020R−S078G−G118S−P129E−S188D−Q245R−N248D,S024R−N062E−S078G−G118S−G159D−Q245R,G020R−N062E−S078D−G118D−P129E−Q245R,T022A−S101G−S103A−V104I−G159D−S188E−P210L−A232T−Q245T−N248D−E271T,G020R−S024R−N062E−S078G−G118S−P129E,G020R−S024R−N062E−S078G−G118D−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248D−E271L,A016S−T022A−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248H−E271H,G020R−N062E−S078G−G118D−P129E−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248E,G020R−S024R−S078G−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118S−G159D−Q245R
−N248D,G020R−S078G−G118S−G159D−S188D−Q245R,S024R−N062E−S078G−G118S−G159D−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248H−E271H,G020R−S024R−N062E−S078G−G118D−G159D,T022A−S101G−S103A−V104I−G159D−S188D−A232T−V244A−Q245R−N248H−E271H,S024R−S078G−G118S−P129E−G159D−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248D−E271F,G020R−S024R−N062E−S078G−G118D−G159D−S188D−Q245R,T022A−S024R−N062E−S128I−A158E,G020R−S024R−S078G−G118D−N248D−H249R,S024R−S078G−G118D−P129E−Q245R−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q236K−Q245T−N248E,N062E−S078G−G118S−G159D−Q245R−N248D,T033S−G118R−S166D,G020R−S024R−S078G−G118D−P129E−S188D−N248D,G020R−S078G−G118S−P129E−G159D−S188D−Q245R−N248D,A016S−T022A−S101G−S103A−V104I−L111V,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271H,S024R−N116L−G118R−S128I−A158E−S188D−V199I,G020R−S024R−S078D−G118D−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271T,G020R−S024R−S078D−G118S−S188D−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271T,G020R−S024R−S078G−G118D−P129E−S188D−H249R,S024R−N062E−S078G−G118S−S188D−N248D,T022A−S101G−S103A−V104I−N116L−S128N−Y209A−G211Q−T213A−A232V,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271L,S024R−A048V−S078G−G118D−G159D−S188D−H249R,G020R−S024R−N062E−S078D−G118D,G102A−S103G−V104I,G020R−S024R−S078D−G118D−G159D−Q245R−N248D−H249R,T022A−T033S−G118R−A158E,T022A−S024R−N116L−S128I−S188D,G020R−S024R−S078D−G118D−P129E−G159D−Q245R−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248E−E271F,S024R−N062E−S078G−G118S−S188D−Q245R,S024R−N062E−S078G−G118D−G159D,G020R−S024R−N062E−S078D−G118S−P129E−G159D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E−E271T,G020R−S078G−G118D−S188D−N248D−H249R,T022A−S024R−N062E−N116L−G118R−A158E−S166D−S188D,S078G
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−P129E−N248D,N155W,A016S−S024F−S101G−S103A−V104I−N116A−S128N−Y209V−G211Q−T213A−A232V,G020R−N062E−S078D−G118D−P129E−Q245R−N248D,G020R−S078D−G118D−P129E−S188D−Q236R−N248D−H249R,T022A−S024R−N116L−A158E−S188D,S101G−S103A−V104I−N116A−S128N−Y209V−G211Q−T213A−A232V,S078D−G118S−S188D−Q245R−N248D,T022L−S024F−S078N−L217E,S099A−S101A−G102A,G020R−S078D−G118D−G159D−N248D−H249R,T022A−N076D−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T033S−N116L−G118R−S166D−S188D,S024R−G118R−S128I−A158E−S166D−S188D,G020R−S024R−N062E−S078G−G118S−P129E−G159D−Q245R−N248D−H249R,N062E−S078G−G118D−N248D−H249R,N062E−S078R−P129E−S188D−Q245R−N248D,S024R−N062E−G159D−S188D−Q245R,G020R−N062E−G118R−S188D−N248D−H249R,N062E−S078R−P129E−G159D,G020R−S024R−N062E−P129E−S188D−N248D,N062E−S078R−G118R−G159D−S188D−P210L−N248D,N062E−S078R−Q245R−N248D,G020R−G159D−S188D−H249R,G020R−G118R−G159D−S188D−N248D,G118R−P129E−G159D−S188D−H249R,N062E−S078R−G118R−P129E−N248D,N062E−S078R−G159D,N062E−G118R−P129E−S188D−Q245R,G020R−S024R−P129E−G159D−S188D−N248D,S024R−N062E−S078R−G159D−N248D,G020R−P129E−S188D−H249R,G020R−P129E−G159D−S188D−Q245R,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S188D−Y209V−T213A−A232V,G020R−G159D−S188D−Q245R−N248D,G118R−P129E−G159D−Q245R−N248D,G020R−N062E−S078R−P129E−S188D−N248D,G020R−P129E−S188D−Q245R,S024R−N062E−S188D−N248D,S078R−L111I−N185I−I198L−L217E,G020R−P129E−S188D−N248D−H249R,G020R−N062E−G118R−G159D−N248D,G020K−T022L−G118R−P129E−S188D,G020R−G118R−P129E−S188D,G020R−P129E−G159D−Q245R−N248D,G020R−S024R−P129E−G159D,G020R−P129E−G159D−Q245R−N248D−H249R,S024R−P129E−G159D−S188D−Q245R−N248D−H249R,G020R−P129E−Q245R−N248D,N062E−S078R−G159D−N248D,S024R−G118R−P129E−G159D−S188D−Q245R−N248D−H249R,G020R−G061W−P129E−G159D−S188D−Q245R,T022A−S101G−S103A−V104I−G159D−S188D−M222S−A232V−Q245R−N248D−A270V−E271F,N062E−G159D−S188D−H249R,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S130D−Y209V−T213A−A232V,G020R−S024R−P129E−G159D−N248D−H249R,P129E−G159D−S188D−H249R,G118R−P129E−G159D−S188D−K237R−N248D−H249R,G020R−G159D−S188D−Q245R,G020R−S188D−Q245R−N248D−H249R,T022A−S101G−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S078R−G118R−P129E−S188D−N248D,G020R−S024R−G118R−G159D−S188D−Q245R−N248D,G020R−G118R−P129E−G159D−S188D,G020R−G159D−S188D,G020R−G118R−P129E−S188D−N248D,A016S−S024R−S101G−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,G020K−N062E−S188D−T213A−M222S,A016S−S024F−S101D−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,S024G−S078N−S101N−Q109G−S128A−L217Q,T022A−G097S−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−M222S−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−M222S−A232V−Q245R−N248D−E271F,G020R−P129E−Q245R,S024R−P129E−G159D−Q245R−N248D,S024R−G118R−S188D−N248D,G020R−P129E−H249R,S024R−P129E−Q245R−N248D,T022A−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−S078R−P129E
−G159D−S188D−H249R,T022A−S101G−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,G118R−P129E−H249R,G020R−N062E−G118R,G020R−G118R−P129E−G159D−Q245R−N248D,T022A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,S024R−S078R−G118R−P129E−G159D−S188D,P129E−Q245R−N248D−H249R,S024G−G061S−S078N−S101N−Q109G−S128A−L217Q−N243V,S078R−V084A−P129E−Q245R,S024R−G118R−G159D−S188D−N248D,G020R−G118R−P129E−G159D−H249R,S078R−P129E−G159D,G061P−S078N−G097A−S101N−S128A−V203Y−L217Q,P086S−S087G−A088V−G097A−N117S−S128A−L217Q,S024R−S078R−G159D−S188D−Q245R−N248D−H249R,S078R−G118R−P129E,S024G−S078N−S101N−S128A−L217Q−N243V,S024R−S078R−G159D−S188D,G020R−G118R−P129E,G020R−S024R−P129E−G159D−S188D−H249R,S024R−G118R−G159D−S188D,S024R−G118R−P129E−G159D−S188D−Q245R−N248D,S024G−S078N−S101N−S128A−L217Q,S024R−G159D−S188D−Q245R,S024G−S078N−S101N−Q109G−L217Q−N243V−N248A,G020R−S078R−G159D−S188D−Q245R−N248D,S078R−G118R−P129E−S188D−N248D,S024R−S188D−Q245R−N248D,G020R−S024R−S101A−P210I−G211Q,G020R−G159D−N248D−H249R,G020R−P129E,G020K−N062E−N116L−T213A−M222S,S024G−S078N−A088T−S101N−Q109G−N116T−S128A−A158S−L217Q−N218S−L257G,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S166D−Y209V−T213A−A232V,S024R−N062E−S078R−P129E−H249R,N018K−G020R−S024R−R045T−S101A−P210I−G211Q−T213A,G020R−S024R−G118R−P129E−G159D−S188D−N248D−H249R,G020R−S024R−P129E−H249R,G020R−G118R−S188D−Q245R−N248D−H249R,G020R−S024R−N062E−S078G−G118S−Q245R,G020R−S024R−G118R−P129E−G159D−N248D,S024G−S078N−S101N−Q109G−S128A−L217Q−S256R,S024G−S078N−S101N−S128A−A158S−L217Q−L257G,G020R−S024R−G118R−S188D−N248D,G020R−G118R−G159D−S188D−Q245R−N248D−H249R,G159D−S188D−Q245R−N248D,S078N−G118R−S166D−L217E−M222S,G020R−G118R−P129E−G159D−Q245R−N248D−H249R,T022A−S101Q−S103A−V104I−L124V−S128A−P129S−A232V−Q245R,S024R−N062E−Q245R,S188D−Q245R−N248D,S024R−G118R−P129E−S188D−H249R,T022A−G097A−S101Q−S103A−V104I−P129S−A232V−Q245R,G020R−G118R−S188D−Q245R−N248D,S024G−S078N−S101N−Q109G−N116T−S128A−L217Q−N243V−S256R,G020R−G118R,G020R−S024R−S188D,N062E−P129E−G159D−S188D−Q245R,G020R−G159D−Q245R−N248D,G020R−N043R−S101A−P210I−G211Q,G097A−S101N−S128A−L217Q,G020R−G118R−S188D−N248D,S024R−S188D−N248D,G020R−S024R−S188D−Q245R−N248D,G020R−S024R−G118R−P129E−G159D−N248D−H249R,G020R−P129E−N248D,G159D−S188D,P129E−G159D,G020R−S188D−H249R,P129E−G159D−Q245R−N248D,G020R−G118R−G159D−N248D−H249R,G118R−S188D−N248D−H249R,G020K−S101D−G102A−L217E−S240R,N043R−G102A−L217E,N062E−S078N−S101D−S240R,G102A−L217E,G020K−S128L−L217E−S240R,G020K−N062E−S078N−L217E−S240R,N043R−S101D−S128L−L217E−S240R,G020K−S078N−S101D−G102A−P210L,N043R−S101D−L217E,G020K−G100S−L217E−S240R,S078N−G100S,G020K−N043R−S101D−G102A−L217E,G100S−S240R,G020K−G102A−L217E,G020K−S024G−N062E−S078N−S101N−Q109N−N116L−S128A−S188D,G020K−L217E−S240R,N043R−S101D,N043R−S078N−S101D−S128L−S240R,N043R−S078N−S101D−L217E−S240R,G020K−S078N−S101D,N043R−S128L−S240R,G020K−N062E−N116L−N123G−T213A,G020K−N062E−G097S−S101G−Q109G−N116L−S128A,G020K−N062E−S078N−G097A
−S101N−Q109N−N116L−S188D,N043R−S078N−S101D−G102A−L217E,G020K−S078N−S099G−S128L−L217E,G020K−N062E−S101D,G020K−S128L−L217E,G020K−S024G−N062E−S078N−G097S−S101G−Q109G−N116L−L217Q,N043R−G097A−S101D−S128L,G020K−S024G−N062E−S101Q−Q109N−N116L−S128A,G020K−S024G−N062E−S078N−S101N−N116L−S128A−L217Q,S078N−G102A−S240R,N043R−S078N−G100S−L217E−S240R,G020K−S078N−S128L−L217E−S240R,G020K−N062E−N116L−S128Q,G020K−S101G−L217E−S240R,G020K−S024G−N062E−S101N−Q109G−N116L−S128A−L217Q,G020K−N062E−S078N−G097S−S101N−N116L−L217Q,G020K−N062E−G097S−S101N−Q109G−N116L−L217Q,G020K−S024G−N062E−S078N−G097A−S101Q−Q109N−N116L−M222S,G020K−S024G−N062E−S078N−G097S−S101Q−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S078N−S101N−Q109G−N116L−S188D−L217Q,又はG020K−N062E−S105G−N116L−S128L−T213A(リスト14)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
S024R−T033S−N116L−S128I−A158E,A016V−G020R−S024R−S078D−G118D−P129E−Q245R−N248D,S099G−S101A−G102A−S103G−V104I,A016S−T022A−S101A−V104L−S128N−L148I,G020R−S024R−S078G−G118S−P129E−S188D,S259W,S259H,T022A−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,N018D−S101G−S103A−V104I−N116A−Y209A−G211Q−T213A−A232V,G020K−S024F−S078N−S166D−T213A,N076D−S101A−S103A−V104I−S188D−A232V−Q245R,S078D−G118D−P129E−G159D−H249R,S024R−S078G−G118D−P129E−G159D−N248D,S024R−N062E−S101A−S103A−V104I−S188D−A232V−Q245R,E271R,G020R−S024R−S078D−G118D−P129E−G159D−S188D,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,G020R−N062E−S078D−G118S−G159D−S188D−Q245R−H249R,Q012R−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,G020R−S078G−G118D−P129E−G159D−S188D−Q245R−N248D,G020R−N062E−S078G−G118S−P129E−G159D−S188D−Q245R−H249R,T022A−S101G−S103A−V104I−G118R−S128L−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S078D−G118D−G159D−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,G020R−S024R−N062E−S078D−G118S−P129E−S188D−Q245R−N248D−H249R,G020R−S078G−G118S−G159D−H249R,G020K−T022L−S024F−G118R−S128D−S166D,T022A−S024R−N062E−N116L−G118R−S128I−A158E−S166D,A016S−S103G−V104L,A016S−T033S−S101G−S103A−V104I−N116L−Y209A−A232V,G020R−S024R−N062E−S078D−G118S−P129E−S188D−N248D,G020K−T022L−S078N−G118R−S166D,G020K−T213A−L217E,S024R−N062E−S078D−G118S−P129E−G159D−S188D−Q245R−N248D−H249R,S078N−S166D−T213A−L217E,S078D−G118S−P129E−G159D−Q245R−H249R,T022A−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,G020K−T022L−G118R−L217E,T022A−V104L−L111V,T022A−S101G−S103A−V104I−S128A−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−N062E−S078G−G118S−P129E−S188D−N248D,G020R−S024R−S078D−G118D−G159D−S188D−N248D,T022L−S078N−L217E,G020R−S024R−S078G−G118S−S188D,S024F−S101G−S103A−V104I−N116L−Y209V−G211Q−T213A−A232V,T022A−N116L−G118R−A158E−S166D,G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D−H249R,T022A−V104I−S128N,S024R−S078G−G118D−Q245R,N062E−S078G−G118S−P129E−G159D−S188D−H249R,T022A−S101G−S103A−V104I−I107V−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,S024R−N062E−S078D−G118S−P129E−G159D−Q245R−N248D−H249R,T022A−T033S−G118R−A158E−S188D,T022A−S078N−G097A−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−S166D−S188D,A016S−S024F−T033S−S101G−S103A−V104I−N116L−Y209A−A232V,T022A−T033S−S128I−A158E,S024R−T033S−N116L−S188D,N062E−N076D−S101A−S103A−V104I−P210I−A232V−Q245R,T022A−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,S130D,G020K−T022L−S024F−S078N−G118R−S166D−L217E,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E,S024R−T033S−N116L−S166D−S188D,S024R−S078D−G118S−S188D−Q245R−H249R,T022A−S024R−T033S−A158E−S166D−S188D,G020K−T022L−S024F−S166D−T213A−L217E,T022A−N062E−N116L−G118R−S188D,G020R−S078G−G118D−Q245R−N248D−H249R,T022A−N116L−G118R−S128I,T022L−S078N−S166D,T022L−G118R−S128D,G097P−S099A,
T022L−S024F−G118R−S128D,S242K,N062E−S078D−G118S−G159D,A016S−S103G−S128N−L148I,G097P−A098Q−S101A,T022A−S103A−V104L−S128N−L148I,T022A−S101G−S103A−V104I−G118R−G159D−S188D−T213A−A232V−Q245R−N248D−E271F,S099G−S101G−G102A,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245T−N248D,G100S−S101G−V104I,S078D−G118S−G159D−Q245R−N248D,A016S−S024F−T033S−S101G−S103A−V104I−N116A−Y209V−G211Q−T213A−A232V,T022A−S024R−T033S−N116L−A158E,T022A−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024R−N116L−S128I−S166D,S101G−S103A−V104I−N116L−S128N−Y209V−A232V,S024F−S101G−S103A−V104I−N116L−Y209A−A232V,G020R−S078G−G118D−G159D−S188D−N248D,G020R−S078D−G118D−S188D−Q245R−N248D,S024F−S078N−G118R−S128D,T022L−S024F−S078N−G118R−S166D,G020R−S024R−S078D−G118S−P129E−G159D−S188D−Q245R−H249R,S103A−V104L−S128N,T022A−S024R−N062E−N116L−S128I,T022A−N062E−N116L−G118R−A158E−S188D,T022A−S024G−G097S−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−N062E−S078D−G118D−G159D−S188D−Q245R−H249R,N062E−S078D−G118S−S188D−Q245R−N248D,T022A−S103A−L148I,T022A−S024R−N116L−S128I−A158E−S188D,G097P−S099T−S101G−V104I,S166D−T213A−L217E,A016S−T033S−S101G−S103A−V104I−N116L−Y209V−A232V,N062E−S078D−G118S−P129E−G159D−S188D−Q245R,T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209A−G211Q−A232V,G020K−T022L−S078N−G118R−S128D−S166D−L217E,T033S−S188D,T033S−N116L−G118R−A158E,T022A−S024G−N076D−V093I−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−S078D−G118S−P129E−Q245R−H249R,T022A−S024R−A158E−S166D−S188D,G020K−T022L−S078N−G118R−S128D,G020R−S024R−S078D−G118D−P129E−S188D,S099T−G102A,S024R−N116L−G118R−A158E−S188D,T033S−N116L−G118R−S166D,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245V−N248H,S078D−G118D−Q245R,G020K−S078N−G118R−S166D−T213A−L217E−A272D,A016S−T022A−V104L−L111V−L148I,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245V−N248H,N062E−N116L−G118R−S166D,N062E−S166D,T022A−S024R−N062E−G118R−A158E−S188D,T022A−S024F−S101G−S103A−V104I−N116A−Y209V−A232V,T022A−S024R−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,G020R−S024R−N062E−S078G−G118D−Q245R,S024R−N116L−S128I−A158E−S188D,S024R−N062E−S101A−S103A−V104I−P210I−A232V−Q245R,A114T,T022L−S024F−S078N−G118R−S128D,S024R−N116L−G118R−S166D,N062E−S078G−G118D−P129E,A016S−T022A−S101G−S103A−V104I−N116L−Y209A−G211Q−A232V,G020K−T022L−S078N−S166D,G020R−S024R−N062E−S078G−G118S−P129E−S188D−Q245R−N248D−H249R,T022A−S078N−G097A−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103G,A016S−S024F−S101G−S103A−V104I−N116L−S128N−Y209A−G211Q−S212L−A232V,S024F−G118R−S166D−T213A,G100S−S101G,A016S−T022A−S103A−V104L−S128N,G020K−S024F−S078N−G118R−S166D,S099T−G102A−S103G,G020K−S024F−S128D−L217E,S078D−G118D−G159D−H249R,N062E−S078G−G118D−S188D,N076D−S101A−S103A−V104I−P210I−A232V−Q245R,S024R−S078G−G118D−P129E−N248D,S078G−G118S−G159D−S188D,A016S−S101G−S103A−V104I−N116L−S128N−Y209V−G211Q−T213A−A232V,G020K−S078N−G118R−S166D−T213A−L217E,T022A−S101N−S103A−V104I−L124V−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−P129S−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−S078D−G118D−P129E,G020K−S024F−S128D−T213A,T022A−T033S−A158E−S188D,G020K−S024F−S128D−S166D−T274A,S024R−N062E−N116L−G118R−S128I−A158E−S166D−S188D,S078G−G118S−P129E−S188D,T022A−S024R−S128I−A158E−S188D,T022A−S024R−G118R−S128I−A158E,T022A−N116L−S166D,G020K−G118R−S128D−S166D,G020K−T022L−S024F−S078N−G118R−S128D−L217E,G020R−S024R−S078D−G118D−P129E−S188D−N248D,G020K−T022L−G118R−S128D−L217E,S024F−S078N−G118R−S128D−T213A,
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T022A−G118R−S128I−A158E,G097P−S101A−V104L,S103G−V104I−S128N−L148I,G020R−N062E−S078G−G118D−P129E−S188D,V026W,G020R−N062E−S078D−G118D−P129E−G159D,T022A−N076D−S101G−S103A−V104I−I107V−N123S−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,S103G−S128N−L148I,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S078N−G097S−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,N062E−S078D−G118S−G159D−S188D−Q245R−H249R,S024R−N076D−S101A−S103A−V104I−A232V−Q245R,T022L−S078N,A016S−T022A−S024F−S101G−S103A−V104I−N116L−Y209V−T213A−A232V,G020K−T022L−S128D−T213A,N062E−G118R−S128I−S188D,S024R−N116L−S128I−S166D−S188D,T022A−S101N−S103A−V104I−S128A−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−T033S−N116L−G118R−A158E,T022A−N076D−G097A−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022L−S024F−S166D−L217E,S024R−S078D−G118S−G159D−N248D−H249R,T022A−S101Q−S103A−V104I−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,A016S−T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209A−A232V,S078G−G118D−P129E−Q245R−N248D,G020R−S078G−G118D−G159D−N248D,G020K−T022L−G118R−S128D−S166D,T022A−S024G−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−G097A−S101G−S103A−V104I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248D,G020R−N062E−S078G−G118D−S188D−Q245R−H249R,S024F−S101G−S103A−V104I−N116L−Y209A−T213A−A232V,S024R−N062E−N076D−S101A−S103A−V104I−A232V−Q245R,T022A−S024R−N116L−G118R−S128I−A158E,A098Q−S099T−S101A−V104L,T022A−S024G−G097S−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S099G−G102A,T022A−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,T022A−S078N−G097S−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−G159E−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101G−S103A−V104I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,
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Q245R−N248D,S099G−S103G−V104I,T022A−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,N062E−N116L−A158E,T022A−S024G−N076D−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022L−S024F−S078N−S166D−T213A−L217E,T022A−S101G−S103A−V104I−G159E−S188D−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,S024R−N062E−N116L−G118R−S128I−A158E−S188D,A016S−S024F−S101G−S103A−V104I−N116L−Y209V−G211Q−A232V,T022A−S024R−S101G−S103A−V104I−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F−A272V,T022A−S024G−N076D−G097A−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N062Q−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−N062E−A158E−S166D−S188D,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248E,N062E−N116L−G118R−S128I,T033S−N062E−N116L−G118R−A158E−S166D,G020R−N062E−S078G−G118D−P129E−S188D−Q245R−H249R,T022A−N076D−S078N−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S078N−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−S166D−T213A,T022A−S024G−N076D−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T033S−N116L−G118R−A158E−S166D−S188D,S024R−S078D−G118S−P129E−S188D−N248D,S024R−N062E−S078G−G118D−G159D−N248D,T022A−G097A−S101N−S103A−V104I−L124V−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022L−S024F−S078N−S166D−T213A,G020R−S024R−S078G−G118D−S188D−H249R,T022A−G097A−S101Q−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,A016S−T022A−V104I−L111V,T022A−S078N−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024F−T033S−S101G−S103A−V104I−N116L−Y209V−A232V,T022A−S101G−S103A−V104I−P129E−A158E−G159E−S188D−A232V−Q245R−N248D−E271F,T022A−N062E−N116L−G118R,T022A−N076D−G097S−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,A016S−T022A−S101G−V104I−L111V−L148I,S024R−N116L−S128I−A158E,T022A−S024F−S101G−S103A−V104I−N116A−Y209A−A232V,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,N062E−S078D−G118S−G159D−S188D−K235R−Q245R,T022A−S101Q−S103A−V104I−S128A−P129S−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097S−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,
T022A−S103G−V104I−S128N−L148I,T022A−N076D−S078N−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097S−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−G097S−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L124V−S128A−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024F−S101G−S103A−V104I−N116L−Y209V−G211Q−T213A−A232V,N076D−S101A−S103A−V104I−A232V−Q245R,T022A−S101Q−S103A−V104I−L124V−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T033S−S166D,T022A−S024G−S078N−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−G097S−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,A114L,G020R−S024R−S078D−G118S−P129E−G159D−K237E−N248D−H249R,G020K−T022L−S024F−G118R−S128D−T213A−L217E,A016S−S101A−S103A−V104L−S128N−L148I,T022A−N076D−S078N−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097S−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101N−S103A−V104I−L124V−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−S101Q−S103A−V104I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,A016S−T022A−S101G−S103A−V104I−N116L−Y209V−A232V,T022A−G097A−S101N−S103A−V104I−L124V−S128A−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−T033S−G118R−S188D,T022A−T033S−N116L−G118R−S128I−S188D,T022A−S024R−T033S−S128I−A158E−S188D,T022A−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,A016S−T022A−S103A−L148I,T022A−N076D−S078N−G097A−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,N018S−T022A−S024G−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097A−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T066V,T022A−G097A−S101N−S103A−V104I−S128A−P129S−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S099T−S101A−S103G,T253L,N076D−S101A−S103A−V104I−P210I−M222S−A232V−Q245R,S099G−S101A−G102A,T022A−G097A−S101N−S103A−V104I−L124V−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,T022A−S024G−G097A−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−S078D−G118D−S188D−Q245R,T022A−S103G−V104L−S128N,S024R−N116L−G118R,T022A−N076D−S101G−S103A−V104I−I107V−N123S−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−A270V−E271F,T022A−N076D−S078N−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097S−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N043R−N076D−S101G−S103A−V104I−P129E−A158E−G159E−S188D−A232V−Q245R−N248D−E271F−A272V,
T022A−S024G−N076D−S078N−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T033S−N062E,T022A−N076D−S101G−S103A−V104I−A158E−S188D−A232V−Q245R−N248D−E271F−A272V,A098Q−S099A−G102A,G118R−S128I−A158E−S188D,T022A−S024G−N076D−G097A−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097S−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S103A−V104L−S128N,T022A−S101N−S103A−V104I−S128A−P129S−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−T033S−A158E,S024R−S188D,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245V−N248H−E271T,S024R−T033S−N062E,S024R−T033S−S166D,T022A−T033S−S101G−S103A−V104I−G118R−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N062E−A158E−S166D−S188D,T022A−N076D−G097A−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−G097S−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−S101A−S103A−V104I−S188D−P210I−M222S−A232V−Q245R,T022A−N076D−G097S−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022L−G118R−S128D−T213A,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245V−N248E,T022A−N076D−G097S−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−G097A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−P129E−A158E−S188D−A232V−Q245R−N248D−E271F,S056G,G020R−N062E−S078D−G118S−P129E−S188D−Q245R−N248D−H249R,T022A−N076D−G097S−S101Q−S103A−V104I−Q109G−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−S078D−G118S−P129E−S188D−Q245R−H249R,T022A−N076D−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−L124V−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−R275H,T022A−S024G−S078N−G097A−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−R045S−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,T022A−S101G−S103A−V104I−L126I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N062D−S101G−S103A−V104I−N116L−G159D−S188D−T213A−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−G097S−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,S024R−N062E−S078G−G118D−P129E−Q245R−H249R,T022A−S101G−S103A−S128N,G020R−S024R−S078G−G118D−P129E−N248D−H249R,N116L−G118R−P129E−S188D,T022A−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−L126I−S128A−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S078D−G118S−P129E−G159D−S188D,T022A−T033S−G118R−S166D−S188D,S078G−G118D−P129E−G159D−S188D,T022A−S024G−G097S−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S103A−V104I−L111V,T022A−S024G−S078N−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−A085T−S101G−S103A−V104I−A158E−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−E089G−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−Q109N−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L124V−S128A−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097A−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,
T022A−G097A−S101Q−S103A−V104I−S128A−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,S101G−S103A,L196S,T022A−S024G−S078N−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097A−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−S101N−S103A−V104I−Q109N−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−L124V−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,E271S,A098Q−S099T−G100S−S101A,T022A−S024G−N076D−G097A−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−Q109N−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−Q109N−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097S−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−P129E−G159E−S188D−A232V−Q245R−N248D−E271F,R019H−T022A−N043R−N076D−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024G−N076D−S078N−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022L−S078N−S166D−T213A,G020R−S024R−S078D−G118D−Q245R−N248D,N269K,T022A−S101N−S103A−V104I−Q109G−G159D−S188D−A232V−Q245R−N248D−E271F,
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N062E−S078N−G097S−S101N−Q109N−N116L−S128A,S024G−S078N−G097S−S101G−S128A−S188D−L217Q,S024G−S078N−G097A−S101N−Q109G−S128A−S188D−L217Q,G020K−N043R−G102A−S128L,G020K−S078N−S101D−G102A−L217E−S240R,G020K−N062E−G100S,S078N−S128L−L217E−E271L,S128Q−L217E−E271L,G020K−S024G−N062E−S078N−G097A−S101N−N116L−S128A−L217Q,G020K−S024G−N062E−S078N−G097S−S101G−N116L−S128A−L217Q,G020K−S078N−S101D−G102A−L217E,G020K−N062E−S128L,G020K−N062E−S078N−S101G−Q109N−N116L,G020K−S024G−N062E−S078N−G097S−S101Q−N116L−S128A−L217Q,S078N−S128L−L217E−S240R,S101D−S128Q−L217E−S240R−E271L,N043R−G102A−S240R,G020K−N062E−S078N−S101N−Q109N−N116L−M222S,G020K−N062E−S101N−Q109G−N116L−S128A−L217Q,G020K−S024G−N062E−S078N−G097A−S101G−N116L−L217Q,G020K−N062E−S101G−N116L−S188D,G020K−N062E−G097S−S101Q−Q109N−N116L−S128A−S188D,G020K−I035V−G100S−S128L−L217E,N043R−S101D−G102A−S240R,N062E−S078N−G100S,G020K−N043R−N062E−A215T,N062E−S240R,N043R−S128L−L217E−S240R,N062E−S101D−S240R,G020K−S101D−N116L−T213A,G020K−S101D−N116L−S128Q−P210S−T213A,G020K−S101D−T213A,G020K−S024G−N062E−S078N−G097S−S101Q−Q109N−N116L−S128A,G020K−N062E−S078N−G097S−S101Q−N116L−S128A−L217Q,S024G−G097S−S101N−Q109G−S188D−L217Q,G020K−S024G−N062E−S101N−Q109G−N116L−L217Q,L217E−S240R,S101D−L217E−S240R−E271L,N043R−N062E−S101D−S128L−S240R,G097A−S101N−S128A−S188D−L217Q,G020K−N062E−S078N−S101N−N116L−S128A−L217Q,G020K−N062E−S078N−G097S−S101G−Q109N−N116L−L217Q,G020K−S024G−N062E−G097S−S1
01N−Q109G−N116L−S128A−L217Q,G020K−S024G−N062E−G097S−S101G−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−S101N−Q109N−N116L−S128A−S188D,S078N−G097S−S101N−Q109N−S128A−S188D−L217Q−W241L,G020K−N043R−N062E−S078N−S101D,G020K−N062E−S101D−S240R,G020K−S101D−S128Q,G020K−N116L−S128Q−Y209H−T213A,G020K−N043R−S078N−G100S−L217E−N218D,S024G−S101N−Q109G−S128A−S188D−L217Q,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S128A−S188D,S078N−S101N−Q109G−S188D−L217Q,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S188D−L217Q,G020K−N062E−S078N−S101Q−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S101G−Q109G−N116L,G020K−S024G−N062E−G097S−S101N−Q109G−N116L−S128A−S188D−M222S,S024G−G097A−S101G−S188D−L217Q,S024G−S078N−G097A−S101G−S128A−S188D,G097S−S101N−Q109G−S128A−S188D,G020K−S078N−S101D−I246T,N043R−S128L−L217E,G020K−S101D−L217E−S240R,S128L−L217E−T224A−E271L,G020K−S078N−S101D−S128Q−L217E−E271L,N062E−S078N−S101D−L217E−S240R,G020K−S101D−L217E−E271L,G020K−S078N−S128Q−L217E−S240R,G020K−N062E−S101D−N116L−T213A,G100S−S101D,S078N−G097S−S101G−S128A−L217Q,G020K−N062E−G097S−S101N−N116L−S128A−L217Q,G020K−N062E−G097S−S101N−N116L−L217Q,S101N−Q109G−S188D,G020K−S024G−N062E−G097S−S101Q−Q109N−N116L−S128A−L217Q,G020K−S024G−N062E−G097S−S101N−N116L,G020K−S024G−N062E−S101N−N116L−S128A,G020K−S024G−N062E−S078N−S101Q−Q109N−N116L−S128A,G020K−N062E−S078N−S101N−Q109G−N116L−S188D,G020K−N062E−S078N−S101N−Q109G−N116L−S128A,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S128A−M222S,G020K−S024G−N062E−S078N−G097S−S101G−N116L−S128A,S024G−S078N−G097S−S101Q−Q109G−S128A−S188D−L217Q,S024G−S078N−S101G−Q109N−S188D−L217Q,S024G−S078N−G097A−S101G−Q109G−S188D,S078N−S101D−S128Q−L217E−S240R−E271L,G020K−S128Q−L217E,S128Q−L217E−S240R−E271L,G020K−S078N−S101D−L217E,G020K−S078N−S101D−L217E−E271L,G020K−N116L−S128Q−T213A,G020K−N116L−N123G,S101G−S188D−L217Q,G020K−S024G−N062E−S078N−S101G−N116L−L217Q,S078N−G097A−S101G−Q109N−S128A−S188D,G020K−S078N−S128L−L217E−E271L,G020K−N062E−S101Q−Q109G−N116L,G020K−S101D−L217E,S024G−
G097A−S101N−Q109N−S128A,G020K−S078N−S101D−S128L−L217E−S240R,G097A−S101G−L217Q,S024G−S101Q−Q109G−S128A−L217Q,G020K−S024G−N062E−T071A−S078N−G097S−S101G−N116L−L217Q,G020K−S024G−N062E−S078N−S101G−N116L−S128A,G020K−S024G−N062E−S078N−G097A−S101N−N116L,G020K−N062E−G097A−S101N−N116L,G020K−S024G−N062E−G097A−S101N−Q109G−N116L−S128A,G020K−S024G−N062E−S078N−G097S−S101G−Q109N−N116L,G020K−N062E−S078N−G097S−S101Q−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−S101N−Q109G−N116L−L217Q,G020K−S024G−N062E−G097A−S101N−Q109G−N116L−S188D−L217Q,G020K−S024G−N062E−S101G−N116L,S078N−G097S−S101N−Q109G−G159D−L217Q,S024G−G097A−S101N−Q109G−S188D,S078N−S101G−S128A−L217Q,S078N−G097A−S101N−S128A−S188D−L217Q,S024G−G097S−S101G−S128A−S188D−L217Q,S024G−S078N−G097S−S101Q−Q109G−S128A−S188D−L217Q−V227A,G020K−N062E−S078N,S078N−S128L−L217E−S240R−E271L,G020K−N062E−I072N−S101D−N116L−S128Q,G020K−T057P−N062E−N116L−S128Q−T213A,G020K−N043R−S078N−S101D−S240R,S078N−G097S−S101N−Q109N−S128A−S188D−L217Q,S024G−S101N−Q109N−S128A−S188D,G020K−S024G−N062E−G097S−S101Q−N116L−S128A,S024G−S078N−G097S−S101N−Q109N−S128A−S188D,N043R−G100S,G020K−N062E−S078N−S101Q−Q109G−N116L−S128A,S078N−S101Q−Q109N−S188D−L217Q,G020K−N116L−S128L−T213A,G020K−S078N−S101D−L217E−S240R,G020K−N062E−S101N−Q109N−N116L−M222S,G020K−S024G−N062E−G097A−S101Q−Q109N−N116L−S128A,S078N−G097S−S101G−S128A−S188D,G097S−S101G−Q109N−S128A−M222S,S024G−S078N−G097A−S101Q−S128A−M222S,G097A−S101G−Q109N−L217Q,S024G−S078N−S101G−S128A−S188D−L217Q,S024G−G097A−S101N−Q109G−S128A−S188D,G097S−S101N−Q109G−S128A,S078N−G097A−S101Q−L217Q,G020K−N043R−S078N−S101D,G020K−N043R−E054D−N062E−S078N−S240R,G020K−S101D−S240R,S128Q−L217E−S240R,G020K−S128Q−L217E−V244A−E271L,G020K−L217E−E271L,G020K−S078N−S128L−L217E,S078N−S101D−S128Q−L217E−E271L,G020K−N062E−L217E−E271L,G020K−N062E−S101D−N116L−S128Q−T213A,G020K−N062E−S078N−N116L−S128I,G020K−N062E−S078N−S128Q−T213A,S024G−G097A−S101G−Q109G−S128A,S024G−G097S−S101N−Q109N−S128A−L217Q,G020K−S024G−N062E−S078N−S101N−N116L−S128A−S188D−L217Q,G020K−S101D,G020K−N062E−S078N−G097S−S101Q−N116L−S128A,G020K−N062E−G097S−S101G−N116L−S188D,N043R−S078N−G100S−S128L−S240R,G097S−S101N−Q109N−S188D,G097S−S101Q−Q109N−S128A−L217Q,G020K−N062E−S101N−Q109G−N116L−S128A−S188D−M222S,G020K−S024G−N062E−S078N−G097S−S101Q−Q109G−N116L,G020K−N062E−M222S,G097S−S101Q−Q109G−S188D,G020K−S078N−L217E−S240R,G020K−N062E−S078N−G097A−S101N−Q109G−N116L−S188D,G020K−S024G−N062E−G097S−S101Q−Q109G−N116L−S188D,G020K−N062E−S078N−G097A−S101Q−N116L−S128A−M222S,G020K−N062E−S078N−S101N−N116L−S188D,G020K−S024G−N062E−S078N−S101G−N116L,G020K−N062E−S078N−S101N−N116L−S128A−S188D,G020K−S024G−N062E−G097S−S101N−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−G097S−S101N−Q109N−N116L,G020K−N062E−S101G−N116L−S188D−L217Q,G097A−S101N−S128A,S101G−Q109N−S128A−M222S,S024G−G097S−S101Q−Q109G−S188D−L217Q,G097S−S101Q−Q109N−S128A−S188D,S024G−S078N−G097A−S101Q−S188D−L217Q,S024G−S078N−S101G−Q109G−S128A−L217Q,G020K−N062E−S128L−S240R,N062E−S078N−S128L−S240R,N043R−G102A−S128L−L217E−S240R,N062E−S078N−L217E−S240R−E271L,S078N−S128Q−L217E−N269S,G020K−N062E−N123G−T213A,G020K−N062E−S078N−S099G−N116L−S128Q−T213A−L217N,G020K−N062E−S078N−S128I−L217N,G097A−S101Q−S128A−S188D−L217Q,G020K−N062E−S078N−G097S−S101N−Q109G−N116L,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S188D,G020K−N043R−S128L−S240R,S024G−S078N−G097A−S101N−Q109N−S128A,G020K−N062E−G097S−S101Q−N116L−L217Q,G020K−N062E−S078N−S128I,G020K−S024G−N062E−L090V−G097A−S101Q−N116
L−M222S,G020K−N062E−S078N−S101Q−Q109G−N116L−S188D−L217Q,G020K−S024G−N062E−G097A−S101G−N116L−S128A−S188D−L217Q,G020K−N062E−G097S−S101N−Q109N−N116L−S188D−L217Q,G020K−S024G−A048V−N062E−S078N−G097A−S101N−N116L−S128A−L217Q,G020K−N062E−S078N−S101Q−Q109G−N116L,G020K−S024G−N062E−G097S−S101N−Q109N−N116L−S128A,G020K−N062E−S078N−G097A−S101Q−Q109G−N116L−S188D,G020K−N062E−S078N−G097A−S101N−Q109N−N116L−N218D,S024G−S101N−Q109G−S128A−S188D−M222S,S024G−G097A−S101Q−Q109N−S188D−L217Q,S024G−S078N−G097S−S101Q−Q109N−S128A−S188D,S101N−Q109G−M222S,S024G−I072V−G097S−S101N−S128A−L217Q,S101G−S128A,N043R−S078N−G102A−A215G,G020K−S101D−S128L−L217E−S240R,S078N−S101D−S128Q−L217E−S240R,G020K−N116L−S128L−M222S,G020K−N062E−S078N−N116L−T213A−M222S,G020K−N062E−S078N−N116L−S128Q,G020K−N062E−T213A,又はG020K−N062E−S078N−N116L−N123G−M222S(リスト15)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
S078G−G118D−P129E−G159D−S188D−Q236R−Q245R−N248D,T022A−N076D−S078N−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F−A272V,T022A−N076D−N077D−S078N−G097S−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N043R−N076D−S101G−S103A−V104I−P129E−A158E−S188D−A232V−Q245R−N248D−A270V−E271F,S099G−S101A−G102A−S103A,A016S−T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,T022A−S024G−G097A−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−S024R−S078D−G118S−P129E−Q245R,S056C,S024R−T033S−N062E−N116L,T022A−S024G−N076D−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T033S−S101G−S103A−V104I−N116L−S128N−Y209A−T213A−A232V,A098Q−S099A−G100S−S101G−V104I,T022A−S078N−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−Q245R−N248D−A270V−E271F−A272V,T022A−N076D−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−S101N−S103A−V104I−Q109N−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−L090I−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−N062E−S078G−G118D−P129E−G159D−S188D−N248D−H249R,A016S−T033S−S101G−S103A−V104I−N116L−S128N−Y209V−T213A−A232V,G020R−S078G−G118D−N248D−H249R,T022A−N062Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−N062E−N116L−A158E−S166D−S188D,T022A−S024G−N076D−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,T022A−N062Q−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−G097A−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−I107V−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N116L−G118R,T022A−S024R−T033S−N062E−N116L−G118R−S128I−A158E−S188D,T022A−N076D−G097S−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−T033S−N062E−N116L−S128I−S188D,T022A−S024G−N076D−G097S−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,S240V,N062E−G118R,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248E,S024R−N062E−S078G−G118D−P129E−S188D−Q245R−N248D,A016S−S103A−V104I,A088P,T022A−S101N−S103A−V104I−Q109N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L126I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G097P−A098F−V104L,T022A−G097S−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101N−S103A−V104I−Q1
09N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−T022L−S128D,T022A−S024G−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−S024R−N062E−S078D−G118D−P129E−G159D−S188D−N248D−H249R,S024F−S078N−G118R−L217E,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−A158E−G159E−S188D−A232V−Q245R−N248D−E271F−A272V,S024R−N062E−N116L−G118R−S128I−S188D,G118R−S128D−S166D−T213A,T022A−G097A−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−T033S−S101G−S103A−V104I−N116L−S128L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−S101Q−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097S−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101N−S103A−V104I−Q109N−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−G097A−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−L126I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S078G−G118S−S188D−H249R,T022A−S024G−N076D−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101A−S103A,T022A−N076D−S101G−S103A−V104I−P129E−G159E−S188D−A232V−Q245R−N248D,S024R−S078D−G118D−S188D−N248D−H249R,S099A−V104I,T022A−G097S−S101Q−S103A−V104I−Q109N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−S078G−G118D−G159D−N248D,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−P129E−G159E−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−L124V−S128A−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−L124V−G159D−S188D−A232V−Q245R−N248D−E271F,S078G−G118D−P129E,S212W,T022A−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−A270V−E271F−A272V,T022A−S078N−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S101G−V104L,T022A−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024G−G097A−S101Q−S103A−V104I−Q109N−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−P129E−A158E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−T033S−S101G−S103A−V104I−N116L−N117S−Y209A−G211Q−T213A−A232V,S101G−S103A−V104I−N116L−G118V−Y209A−G211Q−A232V,T022A−N062E−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024F−T213A,T022A−S024G−N076D−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−S078D−G118S−P129E−G159D−Q245R−H249R,T022A−N076D−S101Q−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S078N−G097A−S099G−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−G159D−S188D−L217Q−N218S−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S101N−S103A−V104I−Q109N−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−S078D−G118D−Q245R,T022A−S078N−I079V−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N116L−G118R−S128I−A158E−S166D,S078G−G118D−S188D,G097P−A098Q−S099G−G102A,S099A−S103G,S078D−G118D−P129E−Q245R−N248D,T022A−S024G−S078N−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S078N−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097S−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N116L−S128I−A158E−S166D−S188D,A016S−T022A−S101A−S103G−V104I,T022A−G097S−S101N−S103A−V104I−S128A−G159D−R186H−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L126I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−L126I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−G097S−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N043R−N076D−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024R−T033S−N062E−N116L−S128I−S188D,T022A−S024G−S078N−G097S−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022L−S078N−G118R−S128D−T213A,T022A−N076D−G097A−A098T−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,S103A−V104L,G020R−S024R−S078D−G118D−P129E−Q245R−H249R,S024R−S078G−G118D−P129E−G159D−S188D−N248
D,T022A−S024R−N043R−S101G−S103A−V104I−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−G061W−N076D−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F,G020R−N062E−S078D−G118S−S188D−N248D,T022A−S101G−S103A−V104I−A158E−G159E−S188D−A232V−Q245R−N248D−E271F,G100S−V104I,T022A−S024G−N076D−S078N−G097S−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G097P−A098F−S103A,T022A−G097S−S101Q−S103A−V104I−Q109G−G159D−S188D−A232V−Q245R−N248D−E271F,S024F−S078N−G118R−S128D−L217E,T022A−S101Q−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−T033S−N116L−S128I−A158E−S166D,T022L−S024F−S128D,T022A−S101G−S103A−V104L,T022A−N043R−S101G−S103A−V104I−A158E−G159E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−N076D−S101G−S103A−V104I−I107V−G159D−S188D−A232V−Q245R−N248D−E271F,T022L−S024F−S078N,T022A−N062E−A158E−S188D,G020K−T022L−S166D−T213A,T022A−S024G−T071A−S078N−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,A016S−T022A−S101G−S103A−V104I−L148I,S078D−G118S−S188D−Q245R−N248D−H249R,G020K−T022L−S128D−S166D,T022A−S024G−N076D−G097S−S101N−S103A−V104I−Q109N−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N062E−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F,G020R−N062E−S078G−G118D−P129E−Q245R−H249R,G020R−S078G−G118D−P129E−S188D−N248D,G020K−T022L−S024F−S078N−G118R−S128D−S166D,T022A−N076D−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−L126I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T255G,T022A−G097A−S101N−S103A−V104I−L126I−S128A−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F,S024R−T033S−N062E−G118R−S166D−S188D,T022A−G097A−S101Q−S103A−V104I−S128A−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−N062E−S078D−G118S−P129E−G159D−S188D−Q245R−H249R,T022A−S024G−S101Q−S103A−V104I−Q109N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,A098Q−G102A,T022A−S024R−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−A270V−E271F,T022A−S024G−S078N−G097A−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−S101N−S103A−V104I−Q109G−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−N116L,T022A−S101G−S103A−V104I−L126I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−S078N−S128D,T022A−S024G−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−G159D−S188D−T213A−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L126I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−G097A−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−G097A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−T033S−N062E−N116L−S166D,T022A−S024G−N076D−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,A016S−S024F−S101G−S103A−V104I−N116L−Y209V−A232V,G020K−S024F−S078N−S128D−S166D,G025A,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F,G097P−S099T−V104I,T022A−N076D−S078N−G097A−S101N−S103A−V104I−Q109G−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−S078G−G118S−G159D−Q245R−N248D−H249R,T022A−S024G−S078N−S101Q−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097S−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−G097S−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−G097S−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,D041K,T022A−S024G−G097A−S101G−S103A−V104I−S128A−
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T213A−M222S,S078N−L217E,G020K−N062E−S128I−L217N,G020K−N062E−S078N−S128Q−L217N,G097S−S101N−Q109G−S128A−S188D−M222S,G020K−S024G−N062E−S101Q−Q109N−N116L−S188D,G020K−N062E−S078N−N116L−S128I−L217N,S024G−S078N−G097A−S101N−Q109G−S188D,S024G−G097A−S101Q−Q109N−L217Q,G020K−S101D−S128L,S101N−Q109G−S128A,S078N−S101D−L217E,S024G−S078N−S101N−S128A−M222S,G020K−S024G−N062E−G097A−S101Q−N116L−S128A−S188D,S024G−S078N−G097A−S101N−Q109N−S128A−M222S,G020K−N062E−S078N−G097A−S101N−N116L−S128A−S188D−L217Q,G020K−S024G−N062E−S078N−G097S−S101Q−N116L−S188D,G020K−N062E−S078N−G097S−S101G−N116L−M222S,G020K−S024G−N062E−S078N−S101N−N116L−M222S,G020K−S024G−N062E−G097S−S101Q−N116L,G020K−S024G−N062E−S101Q−Q109G−N116L−S128A−S188D,G020K−S024G−N062E−G097S−S101N−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S078N−G097S−S101N−N116L,S024G−S078N−S101G−Q109G−M222S,S078N−G097A−S101G−Q109G−S128A,S078N−G097S−S101N−Q109N−S128A,S078N−G097A−S101N−Q109N−S188D,S024G−S101N−S128A−S188D−M222S,S101Q−Q109N−S188D−M222S,S101D−G102A−L217E,G020K−N062E−S078N−S101D−L217E,G020K−S078N−S101D−I107T−S128L−S240R,G020K−S078N−G100S−L217E−N218D,G020K−N043R−S101D,N043R−G100S−S128L−L217E,G020K−S078N−S101D−S128L−L217E−E271L,G020K−S101D−S128L−E271L,G020K−S101D−N116L−S128L−T213A,G020K−N062E−S078N−T213A−L217N,G020K−N062E−N116L−L217N,G020K−N062E−S128I−T213A,N062E−S101D−S128L−S240R,G097S−S101N−S128A,G020K−N062E−S078N−N116L−T213A−L217N,G020K−S101D−M222S,S024G−S101G−Q109G,G097A−S101Q−Q109G,G097S−S101Q−Q109N−S188D,G020K−N062E−G097S−S101N−N116L−S128A−S188D−L217Q,S078N−S101Q−S128A−M222S,S078N−G097A−S101Q−Q109N,S024G−S078N−G097A−S101Q−S128A−S188D,S078N−S101D−G102A,G020K−N062E−S078N−G097S−S101Q−Q109G−N116L−S128A−S188D−M222S,G020K−S024G−N062E−S078N−G097S−S101N−Q109N−N116L−S188D−L217Q−M222S,G020K−N062E−G097S−S101Q−N116L−S128A,G020K−S024G−N062E−G097S−S101Q−N116L−S128A−S188D−L217Q,S024G−S101N−Q109N−S128A,S024G−G097S−S101Q−S128A−S188D,S024G−S101Q−L217Q,G097S−S101G−S128A,S024G−S078N−S101Q−S128A−L217Q,S024G−S078N−G097S−S101N−S188D,S024G−G097A−S101N−S128A−M222S,G097A−S101Q−Q109N−S188D−M222S,S024G−S078N−G097S−S101Q,G020K−S101D−S128L−S212P−L217E−S240R,G020K−S101D−S128L−L217E−N218S−S240R,S101D−S128Q,G020K−N062E−S078N−E271L,S101D−E271L,S101D−S240R−E271L,G020K−S101D−E271L,G020K−N116L−S128L−T213A−M222S,G020K−N116L−S128Q−M222S,G020K−N062E−V084A−S128Q−M222S,G020K−N062E−S078N−N116L,S078N−S101N−Q109G−S128A−M222S,S024G−G097S−S101Q−Q109G,G020K−N062E−T213A−L217N,G097S−S101G−S128A−S188D,G020K−S240R,N062E−S078N,G020K−S128Q−M222S,S078N−G097S−S101G−Q109G,G020R−S024G−N043R−S078N−S101Q,G097S−S101N−Q109G−S128A−M222S,S024G−G097S−S101G−Q109N,S024G−S078N−G097A−S101G−Q109N,G020K−N062E−S078N−S101N−N116L−S128A−S188D−L217Q,G020K−N062E−S101Q−Q109G−N116L−S128A−M222S,G020K−S024G−N062E−S101Q−Q109N−N116L,S024G−S078N−S101Q−M222S,S024G−G097A−S101Q−Q109G−S128A,S101Q−Q109N−L217Q,S101Q−Q109G−S188D−L217Q,S024G−G097A−S101N−S188D−M222S,S024G−S078N−G097A−S101Q−Q109N,G097A−S101Q−S128A,G097A−S101Q−Q109G−S128A,S024G−G097S−S101Q−M222S,S078N−S101D−L217E−S240R,G020K−G100S−S128L,G020K−N043R−S078N−S128L−S240R,G020K−N043R−S101D−S240R,G020K−N043R−S078N−S128L,N062E−S128L,G020K−S078N−S101D−S128L,S078N−S101D,G020K−S101D−N116L−T213A−M222S,G020K−T213A−M222S,G020K−N116L−T213A,G020K−N116L,G020K−N062E−S128Q−L217N,S078N−G097S−S101G−Q109N−S128A,S078N−S101Q−Q109G,N062E−S078N−S128L,G020K−N062E−N116L−S128Q−T213A−L217N,G020K−N116L−T213A−M222S,G020K−S024G−N062E−S101Q−Q109H−N116L−M222S,G020K−N116L−S128Q−T213A−M222S,S024G−G097S−S101N,G020K−P0
55T−N062E−N116L−L217N,S024G−S101Q−S128A−S188D−M222S,G020K−M222S,G020K−N062E−S078N−G097A−S101N−N116L−S188D−L217Q,G097S−S101G−Q109N−M222S,G020K−S024G−N062E−S078N−G097A−S101N−N116L−S128A−L217Q−M222S,G020K−S024G−N062E−G097S−S101N−Q109N−N116L−S128A−S188D−L217Q−M222S,G020K−N062E−S078N−S101Q−N116L−S128A,S024G−S078N−S101N−Q109G−S188D−L217Q−M222S,S101N−Q109N−S128A−M222S,S101Q−Q109G−S128A−S188D,G097A−S101G−S188D−M222S,S078N−G097S−S101N−Q109G−S128A−S188D−L217Q−M222S,S024G−G097A−S101Q−M222S,S024G−G097S−S101N−Q109N−S128A−M222S,S024G−S078N−G097S−S101N−M222S,G020K−G102A−S240R,S078N−S128Q−E271L,G020K−N062E−S078N−S128Q,G020K−N062E−S078N−T213A−M222S,G020K−N062E−S078N−S128I−T213A−L217N,S078N−G097A−S101N,G020K−N062E−N116L−S128I−T213A−L217N,S024G−G097A−S101Q−S128A−S188D−M222S,S024G−S078N−G097A−S101N,S024G−S078N−G097S−S101G−M222S,G020K−N062E−S078N−N116L−S128Q−T213A−M222S,G020K−N062E−S128Q−M222S,G020K−N062E−S101Q−N116L,G020K−N062E−S101Q−Q109G−N116L−S188D−L217Q,G020K−S024G−N062E−G097A−S101N−N116L−S128A−S188D,G020K−S024G−N062E−S078N−S101Q−Q109G−N116L−S188D−M222S,S078N−G097S−S101N−Q109G−S128A−L217Q−M222S,S024G−S078N−S101N−Q109G−S128A−L217Q−M222S,G097A−S101Q−S128A−S188D,S024G−S078N−G097A−S101N−Q109N−S128A−S188D−L217Q−M222S,S024G−S078N−G097A−S101G−L217E−M222S,S078N−G097S−S101Q−Q109G−T274I,G097A−S101G−M222S,S101N−Q109N,G020K−L217E−S240R−E271L,S128Q−S240R−E271L,G020K−S101D−N116L−S128Q−M222S,G020K−P055L−N062E−N116L−S128I,G020K−N062E−S101G−N116L−S128A−M222S,G020K−S078N−S101D−S128L−S240R−E271L,G020K−N062E−S078N−G097S−S101Q−Q109N−N116L−L217Q−M222S,S078N−S101D−S240R−E271L,S024G−S078N−S101N−Q109G−L217Q−M222S,G097A−S101G−Q109G−L217Q−M222S,G020K−S024G−N062E−S078N−G097S−S101N−N116L−S128A−L217Q−M222S,G020K−S078N−S128L−E271L,G020K−N062E−S078N−N116L−L217N,G097A−S101G−Q109G−S188D−L217Q−M222S,S024G−S078N−G097S−S101N−Q109G−S128A,G020K−S024G−N062E−S078N−G097S−S101N−N116L−S188D−M222S,G020K−S024G−N062E−G097S−S101Q−N116L−S128A−M222S,G020K−N062E−S078N−G097A−S101G−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−S101G−N116L−S128A−L217Q−M222S,S024G−G097A−S101Q−S188D−M222S,S024G−S101G,I072V−S101Q−S128A,S078N−G097S−S101N−Q109N,S024G−G097A−S101N−Q109N−S188D−L217Q−M222S,S078N−S101Q−Q109N−S188D−L217Q−M222S,G020K−N043R−N062E−S128L−L217E,N043R−G102A−S128L−S240R,G020K−N116L−N123G−T213A−M222S,G020K−S101D−S128Q−T213A−M222S,S024G−G097A−S101Q−Q109G,G020K−S078N,G020K−N062E−S101Q−N116L−S188D,G020K−N062E−S078N−G097S−S101N−Q109G−N116L−S188D−L217Q−M222S,G020K−S024G−N062E−G097S−S101G−N116L−S128A−L217Q−M222S,G020K−N062E−G097A−S101N−N116L−S128A−L217Q−M222S,S078N−G097S−S101G−Q109N−M222S,S024G−G097A−S101Q−Q109N,S024G−G097S−S101N−Q109N−S128A−S188D−L217Q−M222S,S078N−S101N−Q109N−S188D−L217Q−M222S,S078N−S101D−S128L−L217E−S240R,G020K−N062E−S101D−N116L−S128L,G097S−S101N−S188D−M222S,G020K−S078N−S128L−S240R−E271L,G020K−N062E−N116L−S128I−T213A,G020K−S024G−N062E−S078N−G097S−S101Q−N116L−S188D−M222S,G020K−N062E−S101Q−Q109G−N116L−L217Q−M222S,G020K−S024G−N062E−
G097A−S101Q−N116L−L217Q−M222S,G020K−N062E−S078N−G097S−S101Q−N116L−S128A−S188D−M222S−A232T,G020K−S024G−N062E−S078N−G097S−S101Q−Q109N−N116L−S128A−L217Q−M222S,G020K−N062E−G097A−S101Q−N116L−S188D−M222S,S024G−S078N−G097S−S101N−Q109G−S128A−L217Q−M222S,S024G−G097A−S101Q−Q109N−S128A−S188D−L217Q−M222S,G020K−N043R,G020K−N043R−S078N−G102A−S128L,G097R−S101D,G020K−N062E−S078N−I107V−N123G−S128I,G020K−N062E−S078N−N116L−N123G−T213A,G020K−N062E−N116L−S128I−M222S,G020K−N043R−S240R(リスト16)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
03A−V104I−A232M−Q245R,S024R−V026A−N043R−S101A−P210I−G211Q,T022A−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101T−S103G−V104I−A232L−Q245R,G020R−T022W−S024R−N043R−R045T−S101A−G211Q,G020R−S024R−S078G−G118D−Q245R,T022A−S101N−S103A−V104I−S128A−P129S−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−T022W−N043R−S101A−G211Q−T213A,N018K−G020R−S024R−R045T−S101A−P210I−G211Q−T213A,G020R−T022W−S024R−N043R−R045T−S101A,T022R−S101N−S103A−V104L−A232T−Q245R,G020R−S024R−S101A−T213A,T022R−S101N−S103G−V104I−A232V−Q245R,G020R−T022W−S024R−S101A−G211Q−T213A,T022A−S024G−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,S024R−S078G−G118D−P129E−Q245R−H249R,T022R−S101T−S103A−V104L−A232L−Q245R,G020R−S024R−S101A−G211Q−T213A,T022A−S024G−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−T022W−N043R−V051A−S101A−P210I−G211Q,S024R−S078G−G118D−Q245R,N043R−S101A−P210I,T022Y−S101G−S103N−V104I−A232L−Q245R,G020R−T022W−N043R−S101A−T213A,G020R−S024R−S078D−G118S−S188D−Q245R−H249R,T022Y−S101N−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−F050L−S101A−G211Q−T213A,N018S−T022W−S024R−N043R−S101A−G211Q,T022A−S101G−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,T022R−S101N−S103N−V104I−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,S101A−P210I−G211Q−T213A,G020R−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101A−S103N−V104I−A232M−Q245S,G020R−T022W−N043R−R045T−S101A−G211Q,G020R−T022W−N043R−R045T−S101A−N116L−P210I,G020R−S024R−S078D−G118S−Q245R,G020R−T022W−S024R−N043R−S101A−P210I−G211Q−T213A,G020R−S024R−N043R−R045T−V051A−S101A−P210I−G211Q,T022A−S101G−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S078G−G118D−Q245R−N248D−H249R,T022K−S101A−S103N−V104L−A232T−Q245R,T022A−N076D−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,S024R−N043R−R045T−S101A−P210I,T022A−S024G−G061R−S078N−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Q−S101T−S103A−V104L−A232V−Q245R,G020R−T022W−S024R−R045T−S101A−G211Q,P014R,T022R−S101A−S103N−V104L−A232M−Q245R,T022K−S101G−S103N−V104I−A232V−Q245R,G020R−S024R−S078D−G118D−Q245R,T022A−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S101A−P210I−T213A,T022K−S101N−S103N−V104I−A232V−Q245R,T022Y−S101T−S103A−V104I−A232L−Q245R,T022A−N076D−S078N−S101G−S103A−V104I−S1
28A−L217Q−A232V−Q245R,G020R−S024R−N043R−R045T−S101A−P210I−G211Q−T213A,G020R−R045T−S101A−P210I−T213A,G020R−S078D−G118S−Q245R−H249R,G020R−T022W−R045T−V051A−S101A,T022R−S101T−S103A−V104I−A232V−Q245R,N043R−S101A,G020R−S024R−N043R−R045T−S101A−G211Q−T213A,T022R−S101G−S103G−V104I−A232L−Q245R,G020R−S101A−P210I,T022K−S101T−S103N−V104I−A232V−Q245R,G020R−T022W−N043R−V051A−S101A,G020R−T022W−N043R−S101A,G020R−T022W−S024R−N043R−S101A−P210I,G020R−T022W−S024R−N043R−R045T−S101A−P210I−T213A,G020R−N043R−R045T−S101A−T213A,T022A−S024G−S078N−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Y−S101N−S103N−V104L−A232T−Q245R,G020R−S101A−N116L−P210I−G211Q,T022R−S101A−S103N−V104L−A232L−Q245R,G020R−S024R−N043R−S101A,T022R−S101G−S103A−V104L−A232T−Q245R,G020R−S024R−S101A−G211Q,T022A−S101Q−S103A−V104I−P129S−A232V−Q245R,T022A−S024G−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101A−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−R045T−S101A,T022Y−S101G−S103A−V104I−A232V−Q245R,S024R−N043R−R045T−S101A−N116L−P210I−G211Q−T213A,T022A−S024G−S078N−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−N043R−S101A−P210I,T022A−S024G−S078N−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232V−Q245R,P055R,T022A−S101N−S103N−V104I−A232V−Q245R,G020R−T022W−S024R−N043R−N076D−S101A−P210I−T213A,G020R−T022W−S101A−P210I−T213A,T022Q−S101G−S103A−V104L−A232L−Q245R,T022W−S024R−N043R−R045T−S101A,T022A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022K−S101N−S103A−V104I−A232L−Q245R,T022R−S101T−S103N−V104I−A232L−Q245R,G020R−S024R−N043R−R045T−S101A−P210I−T213A,T022A−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−N062E−S078G−G118S−Q245R,T022K−S101A−S103N−V104I−A232L−Q245R,G020R−T022W−S024R−R045T−S101A−P210I−T213A,G020R−S024R−S078G−G118S−S188D−Q245R,T022R−S101T−S103A−V104I−A232V−Q245W,T022R−S101N−S103A−V104I−A232V−Q245R,T022K−S101T−S103N−V104I−A232T−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,T022Q−S101G−S103N−V104I−A232L−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−Q109N−A232V−Q245R,T022Q−S101G−S103A−V104L−A232V−Q245R,T022A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−T022W−N043R−R045T−S101A−P210I,T022R−S101N−S103N−V104I−A232T−Q245R,G020R−N043R−R045T−S101A−N116L−G211Q−T213A,T022Q−S101A−S103N−V104I−A232V−Q245R,T022W−S024R−N043R−R045T−S101A−N116L−P210I,T022A−S078N−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S078D−G118D−Q245R−H249R,G020R−S024R−N043R−S101A−P210I−G211Q−T213A,T022R−S101G−S103N−V104I−A232V−Q245W,T022A−S101T−S103N−V104L−A232L−Q245R,T022A−S024G−S078N−G097S−S101N−
S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232T−Q245R,G020R−N043R−S101A−P210I−T213A,G020R−S024R−N043R−S101A−N116L−G211Q−T213A,S024R−N043R−R045T−S101A−N116L−P210I−G211Q,T022A−S024G−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,E271R,T022K−S101T−S103G−V104I−A232V−Q245R,N043R−S101A−P210I−G211Q,G020R−S024R−S078G−G118S−P129E−G159D−Q245R,T022R−S101T−S103A−V104I−A232T−Q245S,E271W,S024R−N043R−R045T−S101A−N116L−P210I−T213A,T022A−S024G−S078N−S101N−S103A−V104I−A232V−Q245R,T022A−E089G−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022R−S101T−S103A−V104I−A232L−Q245R,T022R−S101G−S103N−V104I−A232T−Q245S,T022A−S101G−S103A−V104I−A232M−Q245R,G020R−T022W−S024R−S101A−T213A,G020R−T022W−S024R−R045T−S101A−P210I,G020R−T022W−S024R−N043R−S101A−T213A,T022A−S024G−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S101A−T213A,E271S,G020R−S078G−G118S−Q245R−N248D−H249R,N043K,T022A−S101G−S103N−V104I−A232V−Q245R,T022Q−S101A−S103A−V104I−A232L−Q245R,G020R−T022W−S024R−R045T−S101A−T213A,G020R−S024R−S078G−G118S−Q245R−N248D−H249R,T022A−S024G−S078N−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S024G−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S101N−S103A−V104I−A232V−Q245R,G020R−T022W−S024R−S101A−N116L−P210I,G020R−T022W−N043R−R045T−S101A−T213A,T022A−S078N−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−S101N−S103A−V104I−L217Q−A232V−Q245R,T022R−S101N−S103G−V104L−A232V−Q245R,G020R−T022W−S024R−S101A−P210I−T213A,G020R−S024R−S078D−G118S−S188D−Q245R,G020R−S024R−S078D−G118S−G159D−Q245R,T022Y−S101T−S103A−V104I−A232M−Q245R,G020R−N043R−R045T−V051A−S101A−P210I−G211Q−T213A,G020R−T022W−S024R−N043R−R045T−S101A−T213A,T022A−S024G−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−S101Q−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S101A−P210I−G211Q,T022Q−S101T−S103G−V104I−A232M−Q245R,G020R−N043R−S101A−G211Q−T213A,T022A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,T022A−S101T−S103N−V104I−A232V−Q245R,G020R−S024R−S078G−G118D−G159D−Q245R−N248D−H249R,G020R−T022W−R045T−S101A−P210I−G211Q,T022A−S078N−S101N−S103A−V104I−A232V−Q245R,T022R−S101T−S103N−V104I−S105G−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−A232V−Q245R,T022A−S101T−S103N−V104I−A232L−Q245R,T022Q−S101N−S103N−V104L−A232V−Q245R,T022R−S101N−S103N−
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R−S078G−G118S−N248D,G020R−S024R−S078G−G118S−G159D−Q245R−N248D,T022A−S024G−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,S024R−S078G−G118D−G159D−Q245R−H249R,T022K−S101T−S103N−V104L−A232V−Q245R,S024R−S078G−G118S−Q245R,T022A−S101A−S103G−V104I−A232L−Q245R,T022A−G097A−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−S078N−G097S−S101G−S103A−V104I−A232V−Q245R,G020R−S078D−G118S−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V−A272V,S101A−P210I−T213A,T022A−S101Q−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,A114L,A016S−T022A−S101G−S103A−V104I−N116A−Y209V−G211Q−T213A−A232V,T022A−S101N−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,T022R−S101A−S103N−V104I−A232L−Q245S,T022Q−S101N−S103A−V104I−A232M−Q245W,T022W−S024R−S101A−N204S−G211Q−T213A,T022A−S101N−S103A−V104L−A232M−Q245R,T022A−S024G−S101Q−S103A−V104I−Q109N−S128A−A232V−Q245R,G020R−S078D−G118S−P129E−Q245R−H249R,T022Q−S101T−S103A−V104I−A232T−Q245S,S024R−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101N−S103G−V104I−A232T−Q245R,S024R−S101A−P210I−G211Q−T213A,T022A−S024G−N076D−G097A−S101G−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−S078G−G118S−S188D−N248D−H249R,T022A−G097S−S101Q−S103A−V104I−Q109G−S128A−A232V−Q245R,G020R−S024R−R045T−S101A−P210I−T213A,T022A−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−S078N−G097A−S101Q−S103A−V104I−A232V−Q245R,T022R−S101G−S103N−V104I−A232T−Q245W,T022K−S101G−S103A−V104I−A232V−Q245R,T022W−S024R−S101A−G211Q−T213A,S024R−N043R−S101A−P210I−G211Q,T022Q−S101T−S103G−V104I−A232T−Q245R,T022A−S101G−S103A−V104I−A232V−Q245R−A272V,T022K−S101G−S103N−V104L−A232M−Q245R,T022A−S024G−G097A−S101Q−S103A−V104I−Q109N−A232V−Q245R,S078D−G118S−G159D−Q245R−H249R,G020R−T022W−S024R−A069T−S101A−P210I−T213A,T022A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−T022W−S024R−N043R−R045T−S101A−P210I−G211Q,G020R−S024R−S078D−G118D−G159D−S188D−Q245R−H249R,T022A−S078N−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118D−G159D−Q245R−N248D−H249R,T022W−R045T−S101A−T213A,G020R−S024R−S078N−G097A−S101A−Q109N−N116L−L217Q,T022R−S024F−S101G−S103A−V104I−A232V−Q245R−E271H,G020R−S024R−S078N−G097S−S101Q−S128A−L217Q,T022R−S101G−S103A−V104I−A232V−Q245R−E271H,G020R−S024R−S101G−N116L−S128A,G020R−S024R−S101A−Q109N−N116L−S128A,T022R−S024F−S101G−S103A−V104I−A232V−Q245R−T260M,G020R−S024R−S078N−S101N−N116L−S128A,G020R−S024R−G097A−S101A−Q109G−N116L,G020R−S024R−S101N−S128A,G020R−S024R−S078N−S101G−S128A−L217Q,T022R−S024F−S101G−S103A−V104I−A232V−Q245R,T022R−S078N−G097S−S101Q−S103A−V104I−Q109N−N116L−A232V−Q245R,G020R−S024R−G097A−S101A−Q109N−N116L−S128A,G020R−S024R−G097S−S101N−Q109N−S128A,T022R−S101G−S103A−V104I−A232V−P239G−Q245R,G020R−S024R−G097S−S101A−S128A,G020R−S024R−S101G−Q109N−N116L−A215V,G020R−S024R−S078N−G097S−S101Q−Q109G−N116L−S128A,G020R−S024R−S078N−G097S−S101N−Q109N,G020R−S024R−S101G−S128A,T022R−S101G−S103A−V104I−A232V−Q245R−T260K−L267N,T022R−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−G097S−S101N−S103A−V104I−A232V−Q245R,T022R−S024F−S101G−S103A−V104I−V121F−A232V−Q245R,G020R−S024R−G097A−S101Q−N116L−S128A−L217Q,T022R−G097A−S101N−S103A−V104I−N116L−A232V−Q245R,G020R−S024R−S078N−G097S−S101A−N116L−S128A,G020R−S024R−G097A−S101G−S128A−L217
Q,T022R−S078N−S101G−S103A−V104I−N116L−A232V−Q245R,G020R−S024G−N043R−S078N−S101Q−Q109G−N116L−S128A−Q206R−L217Q,G020R−S024R−S078N−G097S−S101Q−N116L−S128A,G020R−S024R−S078N−G097S−S101N−Q109N−N116L−S128A,G020R−S024R−S101N−Q109G−N116L,G020R−S024R−S101Q−N116L−S128A−L217Q,G020R−N043R−S078N−S101G−Q109G−N116L,G020R−S024G−N043R−S078N−G097S−S101G−S128A,T022R−S024G−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,T022R−S101G−S103A−V104I−A232V−P239G−Q245R−E271I,G020R−S024R−S101Q−S128A,G020R−S024R−G097A−S101N−Q109G−N116L,G020R−S024G−N043R−S078N−G097A−S101G−Q109G−N116L,G020R−S024R−G097S−S101Q−Q109N−N116L−L217Q,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−G097A−S101G−Q109N−S128A,G020R−S024R−G097S−S101A−Q109N−S128A,T022R−G097S−S101Q−S103A−V104I−Q109G−A232V−Q245R,G020R−S024R−S078N−G097A−S101N−S128A−L217Q,G020R−S024G−N043R−S078N−G097S−S101G−N116L,G020R−S024R−S078N−G097S−S101G−Q109N−N116L−L217Q,T022R−S024G−S078N−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−G097S−S101A−Q109N−S128A−L217Q,G020R−S024R−S078N−G097A−S101G−Q109N−N116L−L217Q,G020R−S024G−N043R−S078N−S101Q,G020R−S024R−S078N−G097A−S101Q−Q109G−N116L,G020R−N043R−G097A−S101N−N116L−S128A,G020R−S024R−S078N−S101G−Q109G−N116L−S128A−L217Q,G020R−S024R−S078N−S101Q−Q109G−N116L−S128A−L217Q,G020R−S024R−S078N−G097S−S101G−Q109N−N116L−S128A,G020R−S024R−S078N−G097S−S101N−Q109N−N116L,T022R−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,T022R−S024G−G097S−S101G−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,T022R−S024G−S078N−S101G−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−S101N−Q109N−N116L,G020R−S024R−S078N−S101A−Q109N−N116L−S128A,T022R−S024G−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,T022R−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S101G−Q109G−N116L−L217Q,G020R−S024R−S078N−S101Q−Q109N−N116L,G020R−S024R−S101G−N116L−S128A−L217Q,G020R−S024R−S101A−Q109G−N116L−S128A,T022R−S024G−S078N−G097A−S101G−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097S−S101Q−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,G020R−N043R−G097A−S101N−S128A−L233I,T022R−S101Q−S103A−V104I−A232V−Q245R,G020R−N043R−G097S−S101Q−Q109G−N116L−S128A,T022R−S078N−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−G097S−S101N−Q109G−N116L,T022R−S078N−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−S101N−S103A−V104I−A232V−Q245R,G020R−S024R−G097A−S101N−Q109G−S128A,G020R−N043R−S101Q−N116L−S128A−L217Q,G020R−S024R−S078N−G097A−S101Q−Q109N−S128A,G020R−S024R−E089D−S101A−Q109N−N116L,G020R−S024R−G097A−S101G−Q109G−S128A,G020R−S024G−N043R−S101G−N116L−S128A−L217Q,G020R−N043R−S078N−S101Q−Q109G−L217Q,G020R−S0
24G−N043R−G097A−S101N−Q109N−N116L−L217Q,G020R−S024R−S078N−G097A−S101G−N116L−S128A,G020R−S024R−G097S−S101A−Q109N−N116L,G020R−S024R−S078N−S101A−Q109G−S128A,G020R−S024R−G097A−S101A−Q109G−N116L−S128A,G020R−N043R−G097A−S101Q−N116L−S128A,G020R−N043R−G097S−S101Q−S128A−L217Q,G020R−S024R−S078N−G097A−S101G−Q109G−N116L−L217Q,G020R−N043R−G097A−S101G−Q109N−N116L−S128A,G020R−N043R−S078N−G097S−S101N−Q109N−L217Q,G020R−S024R−G097S−A098E−S101A−N116L−S128A,G020R−S024R−S078N−G097S−S101A−Q109G−S128A,T022R−S024G−S078N−G097S−S101G−S103A−V104I−Q109N−N116L−L217Q−A232V−Q245R,G020R−S024R−S078N−G097A−S101Q−Q109N−N116L−L217Q,T022R−S024G−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−S101A−Q109N−N116L−S128A−L217Q,G020R−S024R−S101G−Q109G−N116L−S128A−L217Q,T022R−S078N−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,G020R−S024G−N043R−S101N−N116L−S128A−L217Q,G020R−S024R−S078N−G097S−S101A−Q109N−N116L,G020R−S024R−S078N−G097A−S101N−Q109N−N116L−S128A,G020R−S024R−S078N−S101Q−Q109N−N116L−L217Q,T022R−S024G−S078N−S101N−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−N043R−S101G−Q109N−N116L−S128A−L217Q,T022R−S101N−S103A−V104I−L217Q−A232V−Q245R,T022R−G097A−S101N−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−G097A−S101A−S128A−L217Q,T022R−S024G−S078N−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−S078N−G097S−S101N−Q109G−N116L−S128A−L217Q,T022R−S024G−S101G−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−N043R−S101Q−S128A−L217Q,G020R−S024R−S078N−S101N−Q109G−S128A−L217Q,G020R−S024R−S078N−G097A−S101N−Q109N−N116L−S128A−L217Q,T022R−S024G−G097A−S101Q−S103A−V104I−N116L−L217Q−A232V−Q245R,G020R−S024R−S078N−G097S−S101G−S128A−N204S−L217Q,T022R−S024G−S078N−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−G097S−S101Q−Q109N−N116L−L217Q,G020R−S024R−S078N−S099G−S101Q−Q109N−N116L−L217Q,T022R−S024G−G097A−
S101G−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−G097A−S101G−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,G020R−S024R−G097A−S101N−Q109N−S128A−L217Q,T022R−G097S−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−K094R−S101N−N116L−S128A−L217Q,T022R−S024G−S078N−G097A−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,G020R−S024R−G097A−S101A−N116L−S128A−L217Q,G020R−S024R−S078N−G097W−S101Q−Q109N−N116L−L217Q,T022R−G097S−S101N−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S101Q−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−Q109N−N116L−S128A−L217Q−A232V−Q245R,G020R−N043R−G097S−S101Q−Q109G−N116L−S128A−L217Q,T022R−S024G−G097A−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101Q−S103A−V104I−Q109G−N116L−S128A−L217Q−A232V−Q245R,T022R−S078N−G097S−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S024G−T071A−S078N−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101G−S103A−V104I−Q109N−S128A−A232V−Q245R,T022R−S024G−G097S−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S024G−S078N−S101Q−S103A−V104I−Q109N−N116L−S128A−L217Q−A232V−Q245R,T022R−S101G−S103A−A232V−Q245R,T022R−S101G−S103A−V104I−A232V−Q245R−E271A,T022R−S103A−V104I−A232V−Q245R,T022R−S101G−V104I−A232V−Q245R,T022R−S101G−S103A−V104I−Q245R,G020R−N043R−E271A,G020R−S024R−I035T−S101A−N116L,G020R−N043R−P239G,G020R−N043R−S242L,又はG020R−N043R−V234F(リスト17)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
32V−Q245R−A270V,G020R−S024R−S078D−G118S−H249R,S024R−S078G−G118S,T022R−S101G−S103N−V104L−A232V−Q245S,S024R−N043K−R045T−S101A,T022A−N076D−S078N−S101N−S103A−V104I−A232V−Q245R−T274A,T022A−S024G−N076D−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022Q−S101T−S103G−V104I−A232M−Q245W,S024R−S078G−G118S−P129E−Q245R−H249R,T022A−S024R−N076D−S101G−S103A−V104I−A232V−Q245R,V026W,T022R−S101G−S103N−V104I−A232L−Q245W,G020R−S024R−S078D−G118S−N248D,G020R−R045T−S101A−N204S−P210I,G020R−S024R−S078G−G118D−G159D−N248D−H249R,T022Y−S101A−S103N−V104I−A232V−Q245R,T022A−S024G−S078N−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,S024R−S101A−P210I−G211Q,T022R−S101N−S103N−V104I−A232V−Q245S,T022A−S024G−G097A−S101N−S103A−V104I−Q109G−A232V−Q245R,T022A−G097A−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−N076D−S101Q−S103A−V104I−Q109N−A232V−Q245R,G020R−S078G−G118S−H249R,S078G−G118S−Q245R−H249R,T022A−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Y−S101T−S103G−V104I−A232M−Q245R,T022K−S101G−S103N−V104I−A232L−Q245R,T022A−S024G−G097S−S101N−S103A−V104I−A232V−Q245R,S024R−S078G−G118D−G159D−S188D−Q245R−H249R,T022Q−S101N−S103A−V104I−A232V−Q245R,G020R−S024R−S078G−G118D−G159D−Q245R−N248D,T022A−S024G−S101G−S103A−V104I−A232V−Q245R,T022Q−S101G−S103A−V104L−A232T−Q245R,T022Q−S101T−S103A−V104I−A232T−Q245R,T022A−N076D−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−S078N−G097A−S101G−S103A−V104I−A232V−Q245R,T022A−S101G−S103A−V104L−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−G097S−S101G−S103A−V104I−A232V−Q245R,S024R−N043R−S101A−G211Q−T213A,T022A−G097S−S101Q−S103A−V104I−A232V−Q245R,S024R−S078G−G118S−Q245R−N248D,G020R−T022W−S024R−N043R−S101A−N204S−P210I−G211Q,T022A−S024G−S078N−G097S−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,T022A−S101G−S103A−V104I−P129S−A232V−Q245R,T022R−S101T−S103G−V104I−A232T−Q245S,T022A−S024G−I072V−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101A−S103A−V104I−A232V−Q245W,G020R−T022W−S024R−R045T−S101A−N116L−P210I,T022R−S101T−S103G−V104I−A232T−Q245W,T022A−S024G−N076D−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022Y−S101T−S103N−V104L−A232V−Q245R,G020R−S024R−N062E−S078G−G118S−N248D,T022Q−S101G−S103A−V104I−A232V−Q245R,T022A−N076D−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−S078N−S101Q−S103A−V104I−A232V−Q245R,T022A−N076D−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−N076D−S101N−S103A−V104I−A232V−Q245R,T022R−S101N−S103A−V104I−A232L−Q245S,T022A−S078N−S101N−S103A−V104I−Q109N−L217Q−A232V−Q245R,T022R−S101A−S103A−V104I−A232V−Q245W,T022A−S101Q−S103A−V104I−A232V−Q245R,T022A−S078N−G097S−S101N−S103A−V104I−A232V−Q245R,T022A−G097A−S101Q−S103A−V104I−P129S−A232V−Q245R,T022A−S101T−S103A−V104I−A232L−Q245R,T022A−A085T−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S101T−S103N−V104L−S105G−A232M−Q245R,T022A−S101A−S103A−V104I−A232M−Q245S,T022Q−S101A−S103A−V104I−A232M−Q245R,T022Q−S101G−S103A−V104L−A232M−Q245R,T022A−S024G−G097A−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−N076D−S078N−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−H120Q−S128A−A232V−Q245R,T022
A−G097A−S101N−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,G020R−S024R−N062E−S078G−G118D−Q245R,T022K−S101G−S103G−V104I−A232V−Q245R,S078G−G118S−S188D−Q245R−H249R,T022W−N043R−S101A−G211Q−T213A,T022A−S024G−N076D−G097S−S101N−S103A−V104I−Q109N−A232V−Q245R,T022Y−S101A−S103N−V104L−A232M−Q245R,G020R−T022W−S101A−N116L−G211Q−T213A,T022W−S024R−N043R−R045T−S101A−T213A,N043R−S101A−G211Q−T213A,T022Y−S101N−S103N−V104L−A232L−Q245R,T255G,T022A−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022W−S024R−N043R−S101A−P210I−T213A,N269K,T022R−S101T−S103A−V104I−A232L−Q245S,T022A−S024G−I072V−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022K−S101T−S103G−V104I−A232M−Q245R,H017R−N043R−R045T−S101A−P210I−T213A,T022A−S024G−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−A232V−Q245R,T022A−N076D−G097A−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−V026A−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Q−S101T−S103G−V104I−A232L−Q245R,T022W−S024R−S101A−P210I−G211Q−T213A,T022Q−S101N−S103A−V104I−A232M−Q245R,G020R−R045T−S101A,T022Y−S101N−S103N−V104I−A232V−Q245R,T022R−S101G−S103A−V104I−A232L−Q245R,S024R−S078D−G118D−P129E−Q245R−H249R,T022R−S101A−S103A−V104I−A232M−Q245S,G020R−S101A−P210I−G211Q,T022W−N043R−R045T−S101A−P210I−G211Q,T022R−S101G−S103A−V104I−A232M−Q245S,T022A−S024G−N076D−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232V−Q245S,T022Q−S101G−S103N−V104L−A232M−Q245R,T022K−T038I−S101G−S103A−V104I−A232T−Q245S,N043R−R045T−S101A−P210I−G211Q,T022K−S101T−S103A−V104L−A232M−Q245R,T022Y−S101T−S103N−V104I−A232T−Q245R,G020R−S024R−N043R−S101A−P210I−T213A,S099G−S101G,T022A−S101N−S103N−V104L−A232T−Q245R,T022A−S024G−N076D−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,T022R−S101N−S103A−V104I−A232V−Q245W,T022W−N043R−R045T−S101A−P210I,T022K−S101A−S103G−V104I−A232T−Q245R,T022Q−S101N−S103A−V104I−A232T−Q245S,T022A−S101Q−S103A−V104I−Q109G−A232V−Q245R,T022A−G097A−S101Q−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−L217Q−A232V−Q245R,S024R−S078G−G118S−G159D−Q245R,T022K−S101N−S103N−V104I−A232T−Q245R,A098F−S099A−V104I,G020R−R045T−S101A−G211Q−T213A,T022A−N076D−S078N−G097A−S101G−S103A−V104I−A232V−Q245R,S024R−S078D−G118S−G159D−Q245R,T022A−S024G−N076D−S101N−S103A−V104I−Q109N−A232V−Q245R,T022K−S101T−S103N−V104I−A232M−Q245R,T022A−S024G−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022Q−S101T−S103N−V104I−A232L−Q245S,A114T,T022Q−S101N−S103N−V104L−A232T−Q245R,T022A−S078N−S101G−S103A−V104I−Q109N−A232V−Q245R,T022K−S101T−S103A−V104I−A232M−Q245R,T022A−S024G−G097S−S101Q−S103A−V104I−Q109G−S128A−L217Q−A232V−Q245R,T022A−S101G−S103A−V104I−N116L−Y209V−G211Q−A232V,T022A−S101T−S103N−V104I−A232M−Q245W,G020R−T022W−S024R−S101A−N116L−G211Q,T022A−S078N−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−R045T−S101A−G211Q,T022A−N076D−S078N−G097A−S101G−S103A−V104I−S128A−A232V−Q245R,S024R−S101A−T213A,T022A−S078N−S101G−S103A−V104I−A232V−Q245R,G020R−S024R−S078D−G118S−G159D−S188D−Q245R−N248D−H249R,T022Y−S101N−S103N−V104I−A232V−Q245W,T022Y−S101A−S103G−V104I−A232V−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R,G020R−S078G−G118S−G159D−H249R,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R−A272V,T022R−S101N−S103A−V104I−A232V−Q245S,G020R−S101A−P210I−G211
Q−T213A,G020R−S024R−S078D−G118S−G159D−S188D−Q245R,S087R,G020R−S024R−R045T−A048T−S101A−G211Q,T022A−S024G−G097S−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D−H249R,T022A−G097S−S101G−S103A−V104I−Q109N−A232V−Q245R,L021S−T022A−S024G−N076D−S078N−S101G−S103A−V104I−S128A−A232V−Q245R,S242K,T022K−S101A−S103A−V104I−A232V−Q245R,T022K−S101N−S103A−V104L−A232L−Q245R,T022A−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V−A272V,T022R−S101T−S103A−V104I−A232V−Q245S,T022Y−S101N−S103G−V104I−A232L−Q245R,T022Q−S101N−S103G−V104I−A232V−Q245R,T022A−S101G−S103A−V104I−A232V−Q245W,T022R−S101A−S103A−V104I−A232L−Q245S,G020R−T022W−R045T−F050L−S101A−P210I−G211Q−T213A,T022A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S101A−G211Q−T213A,T022A−N076D−S101G−S103A−V104I−A232V−Q245R−A272V,T022A−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V,T022A−S101N−S103G−V104I−A232V−Q245R,G020R−S101A−T208P−P210I−G211Q,D181S,S101G−S103A−V104I−N116L−Y209V−A232V,T022Q−S101A−S103N−V104I−A232T−Q245R,T022A−S101G−S103N−V104L−G211S−A232T−Q245R,T022A−G097A−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S101T−S103N−V104I−A232M−Q245S,T022A−S101G−S103A−V104I−Q109N−A232V−Q245R,T022Q−S101A−S103G−V104I−A232M−Q245R,G020R−S078G−G118S−G159D−N248D−H249R,T022A−N076D−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−G097S−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,T022Q−S101A−S103A−V104I−A232T−Q245R,T022A−S101G−S103A−V104I−A232L−Q245R,T022A−S101G−S103A−V104I−P129E−A232V−N238Y−V244I−Q245R−A270V−A272V,G020R−S024R−S078D−G118D−G159D−Q245R−N248D−H249R,T022R−S101A−S103N−V104I−A232V−Q245W,T022Q−S101A−S103N−V104I−A232M−Q245R,T022Q−S101A−S103N−V104L−A232L−Q245R,T022A−S024G−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Q−S101G−S103G−V104I−A232M−Q245R,G020R−S078G−G118S−G159D−Q245R−H249R,T022R−S101A−S103N−V104L−A232V−Q245S,T022A−S024V−G097S−S101N−S103A−V104I−H120N−S128A−A232V−Q245R,T022A−A073V−N076D−S078N−S101N−S103A−V104I−A232V−Q245R,T022Q−S101G−S103N−V104L−A232V−Q245R−T274I,T022A−S101N−S103N−V104I−A232T−Q245R,T022W−S024R−R045P−S101A−P210I−G211Q−T213A,G020R−S024R−N062E−S078G−G118D−Q245R−N248D,T022Q−S101A−S103N−V104L−A232M−Q245R,T022Q−S101T−S103G−V104L−A232T−Q245R,T022R−S101G−S103N−A232L−Q245R,T022A−G097S−S101Q−S103A−V104I−Q109N−L217Q−A232V−Q245R,T022A−S024G−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,S024
R−S101A−G211Q−T213A,T022R−S101N−S103N−V104L−A232T−Q245S,G020R−R045T−S101A−P210I,T022R−S101A−S103A−V104I−A232M−Q245W,T022A−S101N−S103N−V104I−A232L−Q245R,T022A−S101G−S103G−V104I−A232M−Q245R,G020R−S024R−S078D−G118S−S188D−Q245R−N248D,S099T−S103G,T022W−N043R−S101A−P210I,T022W−A029V−N043R−S101A−P210I,F050R,T022A−S024G−N076D−S078N−G097S−S101Q−S103A−V104I−Q109N−A232V−Q245R,T022A−S024G−N076D−S101G−S103A−V104I−A232V−Q245R,T022R−S101G−S103N−V104L−A232L−Q245R,T022A−S101N−S103A−V104I−Q109N−S128A−A232V−Q245R,S024R−R045T−S101A,T022A−N076D−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Q−S101G−S103A−V104I−A232M−Q245S,T022W−S024R−N043R−R045T−S101A−G211Q−T213A,G020R−S078G−G118S,T022W−N043R−G046C−S101A−P210I−G211Q,S101A−G211Q−T213A,T022A−N076D−S078N−S101G−S103A−V104I−A232V−Q245R,T022A−S024G−N076D−G097S−S101Q−S103A−V104I−A232V−Q245R,T022A−S101N−S103A−V104I−L126I−P129S−A232V−Q245R,T022R−S101T−S103N−V104I−A232L−Q245W,T022A−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V−A272V,S078G−G118D−Q245R,T022A−S024R−S101G−S103A−V104I−P129E−A232V−N238Y−Q245R−A270V,T022A−N076D−G097S−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,T022W−S024R−R045T−S101A−N116L−P210I−T213A,T022R−S101T−S103N−V104I−A232L−Q245S,T022W−S024R−N043R−R045T−S101A−S106L−P210I−G211Q,T022A−E089G−G097A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,T022A−S101A−S103G−V104I−A232L−Q245S,N043R−S101A−P210I−T213A,N043R−R045T−S101A−T213A,S078G−G118D−H120N−H249R,T022Q−S101T−S103N−V104I−A232L−Q245R−R275H,T022Y−S101A−S103A−V104I−A232T−Q245S,T022K−S101N−S103N−V104I−A232M−Q245R,T022R−S101T−S103N−V104L−A232V−Q245S,T022A−N076D−G097S−S101N−S103A−V104I−A232V−Q245R,M119L,A098F−S099A−S101G−V104I,S078D−G118S−Q245R,T022Y−S101N−S103A−V104I−A232L−Q245S,T022A−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118D−N248D−H249R,T022R−S101A−S103N−V104I−A232T−Q245S,T022R−S101G−S103N−V104I−A232L−Q245S,S024R−S078D−G118D−S188D−Q245R−H249R,S132H,A098Q−S099G−S101G−V104L,N043R−S101A−P210I−G211Q−T213A,T022Q−S101G−S103A−V104I−A232M−Q245W,T022A−S101Q−S103A−V104I−L126I−P129S−A232V−Q245R,T022K−S101T−S103G−V104I−A232M−Q245S,T022W−N043R−R045T−S101A−G211Q−T213A,T022Q−S101N−S103G−V104I−A232V−Q245W,D181T,G020R−S024R−S078D−G118S−P129E−G159D−Q245R−H249R,G020R−S024R−S078G−G118D−G159D−S188D−Q245R,T022A−S101T−S103N−V104L−A232L−Q245S,T022A−S101G−S103N−V104L−A232V−Q245S,T022A−S024G−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S024G−N076D−S101N−S103A−V104I−S128A−A232V−Q245R,T022Y−S101T−S103A−V104L−A232M−Q245R,T022Q−S101T−S103N−V104L−A232T−Q245R,F050S,T022Y−S101G−S103N−V104I−A232V−Q245R,G020R−R045T−S101A−T213A,T022K−S101N−S103G−V104I−A232V−Q245W,S024R−S078G−G118D−P129E−G159D−Q245R−H249R,T022Q−S101T−S103N−V104I−A232M−Q245W,S049W,T022A−S101A−S103N−V104L−A232L−Q245R,T022A−N076D−S101G−S103A−V104I−I107V−P129G−A232V−Q245R−A270V,S099A−V104I,T022Q−S101A−S103G−V104I−A232V−Q245W,T022A−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R,T022A−S101G−S103A−V104I−L124
V−L217Q−A232V−Q245R,T022R−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−Q109N−S128A−A232V−Q245R,R010A−T022R−S024F−S101G−S103A−V104I−A232V−Q245R−L267N−E271H,G020R−S024G−N043R−S078N−S101G−Q109N−N116L−L217Q−M222S,G020R−N043R−E271H,G020R−N043R−E271I,G020R−S024R−S101A−N116L−N269I,T022R−S101G−S103A−V104I−A232V−Q245R−E271F,G020R−N043R−E271F,G020R−N043R−N269I,G020R−S024R−S101A−N116L−E271H,T022R−S101G−S103A−V104I−A232V−Q245R−E271H,G020R−I035T−N043R,G020R−S024R−S101A−A114T−N116L,G020R−S024R−S101A−N116L−E271I,G020R−N043R−A114T,G020R−N043R−L267N,G020R−S024R−S101A−N116L−L267N,G020R−S024R−V028A−S101A−N116L,G020R−S024R−S101A−N116L−G258R,G020R−N043R−G258R,G020R−S024R−S101A−N116L−S242L,G020R−S024R−S101A−N116L−P239G,I008N−G020R−S024R−S101A−N116L,G020R−S024R−S101A−N116L−V234F,T022R−S101G−S103A−V104I−A232V,G020R−S024R−S101A−N116L−E271A,R010A−G020R−N043R,G020R−S024R−S101A−N116L−E271F,G020R−V028A−N043R,I008N−G020R−N043R,又はG020R−S024F−S101A−N116L(リスト18)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
A−S103N−V104I−A232L−Q245W,T022Q−S101N−S103A−V104L−A232T−Q245R,T022W−S024R−N043R−R045T−S101A−N116L−P210I−G211Q,T022A−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118S−G159D−S188D−H249R,A013S,A232N,T022A−N076D−S101G−S103A−V104I−A232V−Q245R,T022A−S024G−N076D−S078N−G097S−S101N−S103A−V104I−A232V−Q245R,I035T,V051M,N123A,G020R−S078G−G118S−G159D−Q245R−N248D,T022Y−S101A−S103N−V104I−A232L−Q245W,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R−A270V,G020R−S078D−G118S,T022R−S101N−S103N−V104L−A232M−Q245W,T022A−S024G−N076D−G097S−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S101G−S103N−V104L−A232V−Q245R,T022A−N076D−G097A−S101Q−S103A−V104I−A232V−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−I107V−P129E−A232V−Q245R,S024R−R045T−S101A−P210I−G211Q,T022A−S078N−S101N−S103A−V104I−Q109N−S128A−A232V−Q245R,T022A−S024G−S078N−G097A−S101N−S103A−V104I−Q109N−A232V−Q245R,G020R−S024R−S078G−G118D−P129E−G159D−H249R,G020R−S078G−G118D−P129E−S188D−Q245R−H249R,P014W,G020R−S024R−S078G−G118S−G159D−S188D−Q245R−N248D,T022R−S101G−S103N−V104I−A232M−Q245W,T022R−A098V−S101G−S103N−V104L−A232T−Q245R,T022A−S101T−S103A−V104I−A232V−Q245W,G020R−T022W−R045T−S101A−T213A,N043R−R045T−S101A,T022K−S101N−S103A−V104I−A232V−Q245R,T022K−S101T−S103N−V104I−A232L−Q245S,S056V,G020R−T022W−R045T−S101A−G211Q,G020R−S024R−S078D−G118D−Q245R−N248D,G020R−S024R−S078D−G118S−G159D−V244L−Q245R−N248D,T022A−G097A−S101Q−S103A−V104I−Q109G−S128A−A232V−Q245R,T022A−N076D−G097S−S101G−S103A−V104I−A232V−Q245R,G020R−T022W−R045T−S101A−N116L−P210I,T022Q−S101N−S103N−V104I−A232M−Q245S,T022Y−S101G−S103N−V104I−A232V−Q245W,A114V,S141C,T022A−N076D−S078N−S101N−S103A−V104I−A232V−Q245R,S056H,S078D−G118D−Q245R,S024R−N043R−R045T−S101A−T213A,T022Y−S101T−S103G−V104I−A232V−Q245S,T022A−S024G−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,N269W,S078G−G118S−G159D−Q245R−N248D−H249R,T022W−S024R−R045T−S101A,T022A−S024R−S101G−S103A−V104I−P129E−A232V−N238Y−Q245R−A270V−A272V,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−I107V−P129E−A232V−N238Y−Q245R−A270V−A272V,A122F,S024R−S078D−G118S−P129E−G159D−Q245R−H249R,S099G,T022K−S101T−S103G−V104I−A232V−Q245S,S009G−T022A−S078N−S101Q−S103A−V104I−Q109G−S128A−L217Q−A232V−Q245R,A098Q,T022A−S101N−S103A−V104L−A232L−Q245R,T022A−S101A−S103N−V104I−A232T−Q245W,T022A−S024G−N076D−G097A−S101N−S103A−V104I−A232V−Q245R,S024R−S078G−G118D−G159D−H249R,T022A−S024G−N076D−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−S078N−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S101Q−S103A−V104I−L124V−S128A−P129S−A232V−Q245R,T022R−S101N−S103A−V104I−A232M−W241R−Q245W,R045T−S101A−P210I−G211Q,G020R−S024R−S078G−G118S−P129E−Q245V−N248E,T022Q−S101T−S103N−V104I−A232L−Q245W,T022A−S024G−S078N−S101N−S103A−V104I−Q109G−L217Q−A232V−Q245R,T022A−S024G−G097A−S101N−S103A−V104I−L217Q−A223S−A232V−Q245R,T022K−S101T−S103A−V104I−A232T−Q245W,N043R−S101A−G211Q,T022A−S101G−S103A−V104I−Q109N−S128A−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118S−P129E−H249R,S024R−S078G−G118S−G159D−S188D−Q245R,N043R−R045T−S101A−N204S−P210I−T213A,T022R−S101N−S103A−V104L−A232V−Q245S,T022R−S101N−S103G−V104I−A232V−Q245S,T022K−S101T−S103N−V104I−A232M−Q245S,T022A−N076D−S101N−S103A−V104I−L217Q−A232V−
Q245R,T022A−S024G−N076D−S078N−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,G020R−T022W−R045T−S101A−P210I−T213A,T022A−N076D−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022W−S101A−P210I,T022A−G097A−S101N−S103A−V104I−L126I−P129S−A232V−Q245R,T022A−S078D−S101N−S103A−V104I−S128A−A232V−Q245R,Q236L,T022Y−S101T−S103N−V104I−A232V−Q245S,A200D,G020R−S078G−G118S−S188D−H249R,T022A−S101G−S103N−V104I−A232T−Q245W,T022A−S024G−N076D−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,G157I,G020R−S024R−S078G−G118S−P129E−G159D−S188D−Q245R,T022R−S078N−G097S−S101G−S103A−V104I−Q109G−S128A−A232V−Q245R,R010A−G020R−S024R−S101A−N116L,G020R−N043R−M222S(リスト19)、サブチリシン変異体のアミノ酸位置は、配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる。
本明細書に記載されているのは、単離された核酸、非天然の核酸、又は組み換え核酸(本明細書で「ポリヌクレオチド」とも呼ばれる)で、これは集合的に「本発明に使用されるポリペプチドをコードするための核酸」又は「本発明に使用されるポリペプチドをコードするためのポリヌクレオチド」と呼ばれることもあり、本発明に使用されるポリペプチドをコードする。本発明に使用されるポリペプチドをコードするための核酸は、以下に記載の全てのものを含めて、本発明に使用されるポリペプチドの組み換え体の産生(例えば発現)、典型的には、対象とするポリペプチドをコードしている配列又はそれらの断片を含むプラスミド発現ベクターの発現を介した産生に有用である。上述のように、ポリペプチドには、例えば、酵素活性(例えば、タンパク質分解活性)を有する、変異型サブチリシンのポリペプチドなどの変異型プロテアーゼのポリペプチドが包含され、プロテアーゼ変異体ポリペプチドは、クリーニング用途、及びクリーニングする必要のある物品又は表面(例えば、物品の表面)をクリーニングするためのクリーニング組成物に有用である。
a)試験方法2による性能指数が少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.1〜約10、1.1〜約8、又は更には1.1〜約5;b)試験方法3による性能指数が少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.1〜約10、1.1〜約8、又は更には1.1〜約5;c)試験方法4による性能指数が少なくとも1.0、少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.0〜約10、1.0〜約8、又は更には1.0〜約5;及び/又はd)試験方法6による性能指数が少なくとも1.0、少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.0〜約10、1.0〜約8、又は更には1.0〜約5;及び/又はe)試験方法7による性能指数が少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.1〜約15、1.1〜約10、又は更には1.1〜約7である。試験方法2、試験方法3、試験方法4、試験方法6、及び試験方法7は、以下の実施例1の表題「試験方法」の節で明記される。本明細書で引用される全ての変異は、図1に示されるようなBPN’番号付けスキームを利用する。一部の実施形態では、本明細書で参照される変異体は、BPN’番号付与スキームを用い配列番号2のアミノ酸配列と比較されるアミノ酸配列を有する変異体を指す。
本発明の変異型プロテアーゼをコードする本発明に使用される改変ポリヌクレオチドを生成するのに好適な様々な方法が当該技術分野において既知であり、限定するものではないが、例えば、部分飽和変異導入、系統的変異導入、挿入変異導入、欠失変異導入、ランダム変異導入、部位特異的変異導入、及び定向進化、並びに様々な他の組み換え手法が挙げられる。改変されたポリヌクレオチド及びタンパク質(例えば、変異型プロテアーゼ)の製造方法としては、遺伝子の非相同組み換えに基づく方法、例えばITCHY(Ostermeier et al.,7:2139〜44[1999]を参照されたい)、SCRACHY(Lutz et al.98:11248〜53[2001]を参照されたい)、SHIPREC(Sieber et al.,19:456〜60[2001]を参照されたい)、及びNRR(Bittker et al.,20:1024〜9[2001];Bittker et al.,101:7011〜6[2004])を参照されたい、並びにランダムな及び標的とされる変異、欠失及び/又は挿入を組み込むためにオリゴヌクレオチドを使用することに基づく方法(Ness et al.,20:1251〜5[2002];Coco et al.,20:1246〜50[2002];Zha et al.,4:34〜9[2003];Glaser et al.,149:3903〜13[1992]を参照されたい)などのDNAシャフリング方法が挙げられる。
本明細書に記載されているのは、本明細書に記載の少なくとも1種の本発明のポリヌクレオチド(例えば、本明細書に記載の本発明の変異型プロテアーゼをコードするポリヌクレオチド)を含む単離された又は組み換えベクター、少なくとも1種の本発明の核酸又はポリヌクレオチドを含む単離された又は組み換えプロテアーゼ発現ベクター又は発現カセット、少なくとも1種の本発明の核酸又はポリヌクレオチドを含む単離された、実質的に純粋の、又は組み換えDNAコンストラクト、少なくとも1種の本発明のポリヌクレオチドを含む単離された又は組み換え細胞、少なくとも1種の本発明のポリヌクレオチドを含む細胞を含む細胞培養物、少なくとも1種の本発明の核酸又はポリヌクレオチドを含む細胞培養物、並びにこのようなベクター、核酸、発現ベクター、発現カセット、DNAコンストラクト、細胞、細胞培養物、又はこれらの任意の組み合わせ又はこれらの混合物を1種以上含む組成物である。
一部の実施形態では、本発明のプロテアーゼ変異体、より具体的にはサブチリシン変異体は、助剤とプロテアーゼ変異体とを含む組成物に使用することができ、ここで、組成物は布地ケア及びホームケア製品である。
一部の実施形態では、クリーニング及び/又は処理組成物を含む消費者製品は、少なくとも1つのプロテアーゼ変異体、特にサブチリシン変異体と少なくとも1つの助剤とを含む。一部の実施形態では、これらの助剤は、例えば、クリーニングされる基材を処理する際のクリーニング性能を補助又は強化させるために、あるいは香料、着色剤、又は染料などの場合にはクリーニング組成物の美観を改善するために組み込まれる。これらの助剤が本発明の変異型プロテアーゼに添加されることは理解されたい。このような追加的成分の正確な性質及びその添加濃度は、組成物の物理的形態、及び組成物が使用される洗浄操作の性質によって決まる。クリーニング及び/又は処理助剤は、これらに限定するものではないが、界面活性剤、ビルダー、漂白剤、漂白活性剤、漂白酵素、その他の酵素、酵素安定系、キレート剤、汚れ剥離ポリマー、染料移行剤、分散剤、抑泡剤、染料、香料、着色剤、充填剤塩、ヒドロトロープ、光活性化剤、蛍光剤、布地コンディショナー、布地柔軟剤、加水分解性界面活性剤、防腐剤、酸化防止剤、縮み防止剤、しわ防止剤、殺菌剤、殺真菌剤、カラースペックル、シルバーケア、黄ばみ防止及び/又は腐食防止剤、アルカリ源、可溶化剤、キャリア、加工助剤、顔料、及びpH調節剤、並びに香料、色相剤、界面活性剤、ビルダー、キレート剤、移染防止剤、分散剤、追加酵素、酵素安定剤、触媒材料、漂白活性化剤、過酸化水素、過酸化水素源、予形成過酸、分散剤ポリマー、泥汚れ除去/再付着防止剤、増白剤、抑泡剤、染料、香料、構造弾性化剤、布地柔軟剤、ヒドロトロープ、溶媒及びこれらの混合物を含むカプセル剤を包含するリストから1つ以上選択されてもよい(例えば、全て参照により本明細書に組み込まれる米国特許第6,610,642号、同第6,605,458号、同第5,705,464号、同第5,710,115号、同第5,698,504号、同第5,695,679号、同第5,686,014号、及び同第5,646,101号参照)。クリーニング組成物材料の具体例は以下に詳細に例示する。クリーニング及び/又は処理助剤が、クリーニング組成物中の本発明の変異型プロテアーゼと適合しない実施形態では、2つの成分を組み合わせることが適切になるまでの間、クリーニング助剤及びプロテアーゼを分離した(すなわち、互いに接触させない)ままにしておくという好ましい方法が使用される。このような分離手法には、当該技術分野において既知の任意の好適な方法が包含される(例えば、ゲルキャップ法、カプセル封入、錠剤、物理的分離など)。
式中、R’はH、CH3、CH2O(CH2CH2O)zH、及びそれらの混合物からなる群から選択され、R”はH、CH2O(CH2CH2O)zH、及びそれらの混合物からなる群から選択され、x+y≦10であり、y≧1であり、z=0〜5である。
式中、R3はH、(CH2CH2O)zH、及びこれらの混合物からなる群から選択され、z=0〜10であり、
R4は(C1〜C16)アルキル、アリール基、及びこれらの混合物からなる群から選択される。
(IV) −[(OCHR1−CHR2)a−O−OC−Ar−CO−]d
(V) −[(OCHR3−CHR4)b−O−OC−sAr−CO−]e
(VI) −[(OCHR5−CHR6)c−OR7]f
式中、
a、b、及びcは、1〜200であり、
d、e、及びfは、1〜50であり、
Arは、1,4−置換フェニレンであり、
sArは、位置5をSO3Meにより置換された、1,3−置換フェニレンであり、
Meは、Li、K、Mg/2、Ca/2、Al/3、アンモニウム、モノ−、ジ−、トリ−、若しくはテトラアルキルアンモニウム(アルキル基は、C1〜C18アルキル又はC2〜C10ヒドロキシアルキルである)、又はこれらの混合物であり、
R1、R2、R3、R4、R5、及びR6は、独立して、H、又はC1〜C18 n−若しくはイソ−アルキルから選択され;
R7は、直鎖若しくは分枝鎖C1〜C18アルキル、又は直鎖若しくは分枝鎖C2〜C30アルケニル、又は炭素原子を5〜9個有するシクロアルキル基、又はC8〜C30アリール基、又はC6〜C30アリールアルキル基である。
(a)サブチリシン(EC 3.4.21.62)(Bacillus lentus、B.alkalophilus、B.subtilis、B.amyloliquefaciens、Bacillus pumilus及びBacillus gibsoniiなどのBacillusから誘導されたものを含む)(米国特許第6,312,936(B1)号、同第5,679,630号、同第4,760,025号、同第7,262,042号及び国際公開第09/021867号に記載)。
26、30、33、82、37、106、118、128、133、149、150、160、178、182、186、193、203、214、231、256、257、258、269、270、272、283、295、296、298、299、303、304、305、311、314、315、318、319、339、345、361、378、383、419、421、437、441、444、445、446、447、450、461、471、482、484のうちの1つ以上が置換された変異体であって、好ましくはD183*及びG184*の欠損を含有する変異体。
(4)R−(C=O)−Lを有する漂白活性化剤(式中、Rはアルキル基であり、所望により分枝状であり、漂白活性化剤が疎水性の場合には、6〜14個の炭素原子、又は8〜12個の炭素原子を有し、漂白活性化剤が親水性の場合、6個未満の炭素原子、又は更に4個未満の炭素原子を有し、Lは脱離基である)。好適な脱離基の例は、安息香酸及びそれらの誘導体−特にベンゼンスルホネートである。好適な漂白活性化剤としては、ドデカノイルオキシベンゼンスルホネート、デカノイルオキシベンゼンスルホネート、デカノイルオキシ安息香酸又はその塩、3,5,5−トリメチルヘキサノイルオキシベンゼンスルホネート、テトラアセチルエチレンジアミン(TAED)及びノナノイルオキシベンゼンスルホネート(NOBS)が挙げられる。好適な漂白活性化剤はまた、国際公開第98/17767号に開示されている。任意の好適な漂白活性化剤を使用してもよいが、発明の一態様では、対象組成物は、NOBS、TAED又はこれらの混合物を含んでよい。
式中、Rは直鎖又は分枝鎖、置換又は非置換の、C6〜18アルキル又はアルケニル部分であり、R1及びR2は、独立して、メチル又はエチル部分から選択され、R3は、ヒドロキシル、ヒドロキシメチル、又はヒドロキシエチル部分であり、Xは、電気的中性を提供するアニオンであり、好適なアニオンとしては、例えば、塩化物といったハロゲン化物、サルフェート、及びスルホネートが挙げられる。好適なカチオン性洗浄界面活性剤は、モノC6〜18アルキルモノヒドロキシエチルジメチル第四級アンモニウムクロリドである。非常に好適なカチオン性洗浄界面活性剤は、モノ−C8〜10アルキルモノヒドロキシエチルジメチル四級アンモニウムクロリド、モノ−C10〜12アルキルモノヒドロキシエチルジメチル四級アンモニウムクロリド、及びモノ−C10アルキルモノヒドロキシエチルジメチル四級アンモニウムクロリドである。
本発明は、上記の変異体の少なくとも1つを得る工程と、それを助剤又はその混合物と混合する工程とを含む、上記の組成物の製造方法も提供する。
本発明は、表面、特に布地を処理する方法も提供し、この方法は上記の変異体の少なくとも1つと助剤とを含む水性リカーと表面とを接触させる工程を含む。典型的には、プロテアーゼ変異体及び助剤は、本発明の組成物を水に添加することによって洗浄液を形成するために水に添加される。本発明の方法で処理される表面は、食器、洗濯物、硬質表面、コンタクトレンズ等のようないかなる布地ケア又はホームケアの洗浄対象表面であってもよい。一部の実施形態では、表面の少なくとも一部を、未希釈形態又は好ましくは洗浄液に希釈された本発明のクリーニング組成物の少なくとも1つの実施形態と接触させ、この表面が洗浄され、任意にすすがれる。本発明の目的上、「洗浄すること」は、浸漬すること、擦ること、及び機械的洗浄を包含するがこれらに限定されない。一部の実施形態では、本発明のクリーニング組成物は、溶液中約500ppm〜約15,000ppmの濃度で使用される。洗浄溶媒が水である一部の実施形態では、水温は、典型的には約5℃〜約90℃の範囲である。
本発明は、以降の実施例により、更に詳細に記載されるが、この記載により本発明の範囲が請求されたものとして、本発明の範囲を制限することを意図するものではない。
、Stepan(Stepan,Northfield,IL)、Clariant(Clariant,Sulzbach,Germany)、Industrial Zeolite(Industrial Zeolite Ltd.,Grays,Essex,UK)、Jungbunzlauer(Jungbunzlauer,Basel,Switzerland)、Solvay(Solvay,Brussels,Belgium)、3V Sigma(3V Sigma,Bergamo,Italy)、Innospec(Innospec,Ellesmere Port,UK)、Thermphos(Thermphos,Vlissiggen−Ost,the Netherlands)、Ciba Specialty(Ciba Specialty Chemicals,Basel,Switzerland)、Dow Corning(Dow Corning,Barry,UK)、Enichem(Enichem Iberica,Barcelona,Spain)、Fluka Chemie AG(Fluka Chemie AG,Buchs,Switzerland)、Gist−Brocades(Gist−Brocades,NV,Delft,the Netherlands)、Dow Corning(Dow Corning Corp.,Midland,MI)、Mettler−Toledo(Mettler−Toledo Inc,Columbus,OH)、RB(Reckitt−Benckiser,Slough,UK)、及びMicrosoft(Microsoft,Inc.,Redmond,WA)。
2 −NHにつき20個のエトキシル基を有するポリエチレンイミン(MW=600)。
3 両親媒性グリース洗浄ポリマーは、−NHにつき24個のエトキシル基、及び−NHにつき16個のプロポキシル基を有するポリエチレンイミン(MW=600)である。
4 次の構造を有する可逆性プロテアーゼ抑制剤。
界面活性剤材料は、次の企業から得ることができる:BASF(Ludwigshafen,Germany)(Lutensol(登録商標));Shell Chemicals(London,UK);Stepan(Northfield,Illinois,USA);Huntsman(Huntsman,Salt Lake City,Utah,USA);Clariant(Sulzbach,Germany(Praepagen(登録商標)))。
アッセイ及び試験方法
本実施例は、本発明の展開に使用される様々な試験方法及びアッセイを記載する。提供されるプロトコール由来の任意の変法が関連する実施例に示される。
試験方法1
染料又は顔料材料が本発明の意図する布地色相剤であるか否かを定義するためのプロトコールを以下に記載する。
試験方法2では、顆粒型洗剤組成物10(上記表Dを参照されたい)を用い、以下に記載のBMIマイクロスウォッチアッセイを実施する。洗濯洗剤を、12gpgの硬度を有する水に溶解させ、16℃の温度に調整し、所望のプロテアーゼ変異体酵素を添加する。次いで、記載されるBMIマイクロスウォッチアッセイに従って酵素変異体の性能を測定する。性能指数は、プロテアーゼ変異体酵素の性能を、配列番号2のアミノ酸配列を有するB.レンタスのGG36サブチリシン酵素と比較することで決定する。全ての条件で、酵素の使用濃度は0.1〜5ppm範囲である。プロテアーゼ変異体酵素のうち、性能指数1.1以上のものが冷水用プロテアーゼとして示される。
試験方法3では、顆粒型洗剤組成物7(上記表Dを参照されたい)を用い、以下に記載のBMIマイクロスウォッチアッセイを実施する。洗濯洗剤を、6gpgの硬度を有する水に溶解させ、16℃の温度に調整し、所望のGG36プロテアーゼ変異体酵素を添加する。次いで、記載されるBMIマイクロスウォッチアッセイに従ってプロテアーゼGG36の酵素変異体の性能を測定する。性能指数は、プロテアーゼGG36の変異型酵素の性能を、配列番号2のアミノ酸配列を有するB.レンタスのGG36サブチリシン酵素と比較することで決定する。全ての条件で、酵素の使用濃度は0.1〜5ppm範囲である。プロテアーゼGG36の変異体のうち、性能指数1.1以上のものが冷水用プロテアーゼとして示される。
試験方法4では、顆粒型洗剤組成物7(上記表Dを参照されたい)を用い、BMIマイクロスウォッチアッセイを実施する。洗濯洗剤を、6gpgの硬度を有する水に溶解させ、16℃の温度に調整し、所望のGG36プロテアーゼ変異体酵素を添加する。次いで、記載されるBMIマイクロスウォッチアッセイに従ってプロテアーゼGG36の酵素変異体の性能を測定する。性能指数は、GG36プロテアーゼ変異体酵素の性能を参照酵素GG36−A158Eの性能と比較することによって決定され、GG36−A158E参照酵素は配列番号2のB.レンタスのサブチリシンGG36プロテアーゼのアミノ酸配列の位置158でアラニンがグルタミン酸へと単独置換(すなわち、A158E変異)されており、全ての場合で酵素投与量は0.1〜5ppmの範囲である。性能指数1.0以上のプロテアーゼGG36変異体が、冷水用プロテアーゼとして示される。
試験方法6では、表1−2の洗剤36a〜36nのうちのいずれか1種を用いてBMIマイクロスウォッチアッセイを実施する。表1〜2に記載の水硬度を有する水に洗剤を溶解させ、水温を16℃に調整する。次いで、記載されるBMIマイクロスウォッチアッセイに従って酵素変異体の性能を測定する。性能指数は、変異体の性能を配列番号2の酵素の性能と比較することで決定され、全ての場合で酵素投与量は0.1〜5ppmの範囲である。酵素のうち、性能指数1.1以上のものが冷水用プロテアーゼとして示される。
試験方法7では、表1の洗剤のいずれか1種を用いてBMIマイクロスウォッチアッセイを実施する。表1に記載の水硬度及び緩衝剤を有する水に洗剤を溶解し、水温を16℃又は25℃に調整する。次いで、記載されるBMIマイクロスウォッチアッセイに従って酵素変異体の性能を測定する。性能指数は、変異体の性能を配列番号2の酵素の性能と比較することで決定され、全ての場合で酵素投与量は0.1〜5ppmの範囲である。酵素のうち、性能指数1.1以上のものが冷水用プロテアーゼとして示される。
タンパク質含量を測定するためのTCAアッセイ
加湿条件下でエアレーションしながら250〜300rpmで振盪し、B.サブチリスを37℃で2〜3日増殖させた。酵素を含有している培養上清から遠心沈降及び/又は濾過により細胞を除去した。TCA沈降アッセイを用い、プロテアーゼ/タンパク質/酵素濃度を測定した。100μL/ウェルの0.25NのHClを含有させた96ウェルの平底マイクロタイタープレート(MTP;Costar 9017中結合型透明ポリスチレンプレート)に培養上清のアリコート(20〜25uL)を移した。読み取り「基底値」は、試料を混合した5秒後に405nmで光散乱/吸光を読み取ることで測定した。HClを含有しているプレートに100μL/ウェルの30%(重量/体積)のトリクロロ酢酸(TCA)を加え、室温で10分間インキュベートし、タンパク質の沈殿を促進させた。試料を混合した5秒後に、405nmでこの「試験」プレートの光散乱/吸光度を測定した。試料における濁度/光散乱の増加は、培養上清中の沈殿可能なタンパク質の合計量に相関する。「基底」読み取り値(HClの添加後に得られる)を「試験」読み取り値(TCAの添加後に得られる)から減算することで算出し、存在する総タンパク質を相対的に測定した。タンパク質沈殿とタンパク質濃度を関連づける換算率を、既知濃度のGG36標準について求めた。沈殿は濃度と線形関係にあることから、この換算率は全ての変異体に使用できる。必要に応じて、TCA読み取り値を比活性が既知であるクローンのAAPFプロテアーゼアッセイ(以下に記載)により較正することで、検量線を作成することができる。しかしながら、TCA結果は、50〜500百万分率のタンパク質濃度(ppm)(ここで、1ppmは1mg/Lに相当する)に対して線形であることから、所望の性能を有する変異体を選択するために、酵素性能に対して直接プロットすることができる。
セリンプロテアーゼ変異体、より具体的にはサブチリシン変異体のプロテアーゼ活性を測定するために、N−スクシニル−L−アラニル−L−アラニル−L−プロリル−L−フェニル−p−ニトロアニリド(suc−AAPF−pNA)の加水分解を計測した。使用した試薬溶液は、以下のものであった:0.005%のTWEEN(登録商標)−80を含有している100mMのトリス/HCl(pH 8.6)(トリス希釈緩衝液)、1mMのCaCl2及び0.005%のTWEEN(登録商標)−80を含有している100mMトリス緩衝液(pH 8.6)(トリス/Ca緩衝液)、並びに160mMのsuc−AAPF−pNA/DMSO(suc−AAPF−pNA保存溶液)(Sigma:S−7388)。suc−AAPF−pNA希釈標準溶液を調製するために、1mLのsuc−AAPF−pNA原液を100mLのトリス/Ca緩衝液に加え、少なくとも10秒にわたってウェルをよく混合した。10μLの希釈プロテアーゼ溶液を96ウェルMTPの各ウェルに加え、直ちに1mg/mLのsuc−AAPF−pNA希釈標準溶液190μLを加えてアッセイを実施した。溶液を5秒にわたって混合し、吸光度の変化を、25℃にて、405nmで、MTPリーダーの動的解析モードにより読み取りした(5分毎に25回読み取り)。プロテアーゼ活性はAUとして表記される(活性=ΔOD・min−1 ml−1)。
96ウェルのマイクロタイタープレート(MTP;Corning 3641)中に入れる、予洗し、パンチで型通りに切り取り、血液、ミルク及びインク(BMI)により染色した直径5.5ミリメートルのマイクロスウォッチ(EMPA116)を、Center for Testmaterials BV(Vlaardingen,The Netherlands)から得た。
x=(対象ppm)(vb)/(y−対象ppm)
式中、x=酵素量,y=酵素濃度,vb=緩衝液量
Versispan 8チャンネルアームを持つPerkin−Elmer Janusロボットを使用し、コンダクティブチップを用い原液プレート(TCA酵素濃度アッセイで使用し回収した変異体をプールした、Axygenの深さ半分のウェルプレート)から緩衝液を入れた試験プレートへと様々な容量の酵素を分注した。試料を上下に3回ピペッティングして混合した。均等化したプレートのAAPF活性を測定し、母液プレートと比較することで、酵素希釈の正確さを評価し、性格な希釈がなされたか検証した。
性能指数は、同じタンパク質濃度下で変異体性能(実測値)と標準酵素性能(理論値)とを比較する。加えて、理論値は、標準プロテアーゼの性能用量反応曲線のパラメーターを用いて算出することができる。
GG36の変異体及びコンビナトリアルライブラリの構築
本例は、B.サブチリス発現プラスミドpHPLT−GG36を用いてB.サブチリスに構築されたGG36変異体及びライブラリの冷水クリーニングについて記載する。このB.サブチリスの発現プラスミドは、以下に示すGG36発現カセット、B.リケニフォルミスのLATプロモーター(Plat)、並びにレプリカーゼ遺伝子(reppUB)、ネオマイシン/カナマイシン耐性遺伝子(neo)及びブレオマイシン耐性マーカー(bleo)等のpUB110由来の更なる要素(McKenzie et al.,Plasmid,15:93〜103,1986)(米国特許第6,566,112号、図4を参照)を含有する。pHPLT−GG36プラスミドマップは国際公開第2011140364号に提供されている。GG36発現カセット配列は以下に提供されるものである。
Claims (17)
- 助剤と、単離されたサブチリシン変異体と、を含むクリーニング及び/又は処理組成物であって、前記サブチリシン変異体が、タンパク質分解活性を有する成熟型であり、かつ次から選択される位置にアミノ酸置換の組み合わせを含むアミノ酸配列を含み:T022R+V104I+Q245R,G020R+S024R+S101A,T022R+S103A+V104I,T022R+V104I+A232V,T022R+S103A+Q245R,T022R+A232V+Q245R,T022R+S103A+A232V,T022R+S103A+V104I+A232V,T022R+V104I+A232V+Q245R,T022R+S103A+V104I+Q245R,T022R+S103A+A232V+Q245R,T022R+S103A+V104I+A232V+Q245R,T022A+N076D+S103A+V104I+A232V+Q245R,T022A+N076D+S103A+V104I+A232V,T022A+N076D+V104I+A232V+Q245R,T022A+N076D+S103A+A232V+Q245R,T022A+N076D+S103A+V104I+Q245R,T022A+N076D+V104I+Q245R,T022A+N076D+A232V+Q245R,T022A+N076D+V104I+A232V,T022A+N076D+S103A+Q245R,T022A+N076D+S103A+A232V,T022A+N076D+S103A+V104I,T022A+N076D+S103A,T022A+N076D+V104I,T022A+N076D+A232V,T022A+N076D+Q245R,G020R+S101A+T213A,G020R+R045T+S101A,G020R+S101A+G211Q,S024R+S101A+T213A,G020R+T022W+S101A,S024R+S101A+G211Q,N043R+S101A+T213A,N043R+R045T+S101A,S024R+N043R+S101A,S024R+R045T+S101A,S101A+G211Q+T213A,G020R+N043R+S101A,R045T+S101A+T213A,T022W+S024R+S101A,T022R+S101G+V104I,T022W+S101A+T213A,T022R+S101G+Q245R,T022W+S101A+G211Q,G020R+S024R+Q245R,T022R+S101G+V104I+Q245R,T022R+S101G+A232V,T022R+S101G+S103A,T022R+S101G+S103A+V104I,T022R+S101G+S103A+Q245R,T022R+S101G+A232V+Q245R,T022R+S101G+V104I+A232V,G020R+S024R+S101A+T213A,G020R+S024R+T213AS101N+V104I+A232V,S101N+S103A+V104I,S101N+S103A+A232V,S101N+S103A+V104I+A232V,G020R+S103A+A232V,G020R+V104I+A232V,G020R+S103A+V104I+A232V,G020R+S103A+V104I,N018R+N076D+N116A,N018R+N076D+T213A,N018R+N076D+S101A,N018R+N076D+A215F,又はN018R+N076D+G211Q、又は以下から選択される位置にアミノ酸置換の組み合わせを含み:S103A+V104I+S188D,S188D+Q245R+N248D,S103A+S188D+Q245R,V104I+S188D+Q245R,S103A+V104I+S188D+Q245R,T022A+S103A+S188D,T022A+V104I+S188D,T022A+S103A+V104I+S188D,G159D+S188D+Q245R,S103A+S188D+A232V,S103A+G159D+S188D,V104I+S188D+A232V,V104I+G159D+S188D,S103A+V104I+S188D+A232V,S103A+V104I+G159D+S188D,S103A+S188D+N248D,V104I+S188D+N248D,S103A+V104I+S188D+N248D,G159D+S188D+N248D,S188D+A232V+Q245R,S103A+S188D+A232V+Q245R,V104I+S188D+A232V+Q245R,S103A+V104I+S188D+A232V+Q245R,T022A+S188D+Q245R,T022A+S103A+S188D+Q245R,T022A+V104I+S188D+Q245R,S103A+S188D+E271F,V104I+S188D+E271F,T022A+S103A+V104I+S188D+Q245R,S103A+V104I+S188D+E271F,T022A+S188D+N248D,T022A+S103A+S188D+N248D,T022A+V104I+S188D+N248D,S103A+S188D+Q245R+N248D,T022A+S103A+V104I+S188D+N248D,V104I+S188D+Q245R+N248D,S103A+V104I+S188D+Q245R+N248D,T022A
+S188D+A232V,T022A+S103A+S188D+A232V,T022A+V104I+S188D+A232V,T022A+S103A+V104I+S188D+A232V,S188D+A232V+N248D,S188D+Q245R+E271F,T022A+S188D+E271F,T022A+S188D+Q245R+N248D,S103A+S188D+A232V+N248D,S103A+S188D+Q245R+E271F,S188D+N248D+E271F,V104I+S188D+A232V+N248D,V104I+S188D+Q245R+E271F,T022A+S103A+S188D+E271F,T022A+S103A+S188D+Q245R+N248D,S103A+S188D+N248D+E271F,T022A+V104I+S188D+E271F,T022A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+Q245R+E271F,S103A+V104I+S188D+A232V+N248D,V104I+S188D+N248D+E271F,S188D+A232V+E271F,T022A+S103A+V104I+S188D+E271F,T022A+S103A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+N248D+E271F,S103A+S188D+A232V+E271F,V104I+S188D+A232V+E271F,T022A+S188D+A232V+Q245R,T022A+S188D+Q245R+E271F,T022A+S188D+N248D+E271F,S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+Q245R,S188D+A232V+Q245R+N248D,S188D+Q245R+N248D+E271F,T022A+S188D+A232V+N248D,T022A+S103A+S188D+Q245R+E271F,T022A+S103A+S188D+N248D+E271F,T022A+V104I+S188D+A232V+Q245R,S103A+S188D+A232V+Q245R+N248D,S103A+S188D+Q245R+N248D+E271F,T022A+S103A+S188D+A232V+N248D,T022A+V104I+S188D+N248D+E271F,T022A+V104I+S188D+Q245R+E271F,S188D+A232V+Q245R+E271F,S188D+A232V+N248D+E271F,T022A+S103A+V104I+S188D+A232V+Q245R,V104I+S188D+A232V+Q245R+N248D,T022A+V104I+S188D+A232V+N248D,V104I+S188D+Q245R+N248D+E271F,T022A+S188D+A232V+E271F,T022A+S103A+V104I+S188D+Q245R+E271F,T022A+S103A+V104I+S188D+N248D+E271F,T022A+S188D+Q245R+N248D+E271F,S103A+S188D+A232V+Q245R+E271F,S103A+S188D+A232V+N248D+E271F,S103A+V104I+S188D+Q245R+N248D+E271F,T022A+S103A+V104I+S188D+A232V+N248D,S103A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+A232V+E271F,V104I+S188D+A232V+N248D+E271F,V104I+S188D+A232V+Q245R+E271F,T022A+S103A+S188D+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+E271F,T022A+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D,S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+Q245R+N248D+E271F,S103A+V104I+S188D+A232V+N248D+E271F,S103A+V104I+S188D+A232V+Q245R+E271F,T022A+S188D+A232V+Q245R+E271F,T022A+S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+N248D+E271F,T022A+S103A+S188D+A232V+Q245R+N248D,S103A+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+A232V+Q245R+E271F,T022A+V104I+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D+E271F,V104I+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+E271F,G159D+S188D+Q245R+N248D,T022A+G159D+S188D,T022A+S103A+G159D+S188D,T022A+V104I+G159D+S188D,T022A+S103A+V104I+G159D+S188D,S103A+G159D+S188D+Q245R,V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+Q245R,S103A+G159D+S188D+N248D,V104I+G159D+S188D+N248D,S103A+V104I+G159D+S188D+N248D,G159D+S188D+A232V,S103A+G159D+S188D+A232V,V104I+G159D+S188D+A232V,S103A+V104I+G159D+S188D+A232V,T022A+G159D+S188D+Q245R,G159D+S188D+E271F,T022A+S103A+G159D+S188D+Q245R,S103A+G159D+S188D+E271F,T022A+V104I+G159D+S188D+Q245R,V104I+G159D+S188D+E271F,T022A+S103A+V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+E271F,T022A+G159D+S188D+N248D,T022A+S103A+G159D+S188D+N248D,T022A+V104I+G159D+S188D+N248D,S103A+G159D+S188D+Q245R+N248D,T022A+S103A+V104I+G159D+S188D+N248D,V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+N248D,T022A+G159D+S188D+A232V,T022A+S103A+G15
9D+S188D+A232V,T022A+V104I+G159D+S188D+A232V,G159D+S188D+A232V+Q245R,T022A+S103A+V104I+G159D+S188D+A232V,S103A+G159D+S188D+A232V+Q245R,G159D+S188D+Q245R+E271F,V104I+G159D+S188D+A232V+Q245R,G159D+S188D+A232V+N248D,T022A+G159D+S188D+E271F,S103A+G159D+S188D+Q245R+E271F,G159D+S188D+N248D+E271F,S103A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+A232V+N248D,T022A+G159D+S188D+Q245R+N248D,T022A+S103A+G159D+S188D+E271F,V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+E271F,V104I+G159D+S188D+A232V+N248D,S103A+G159D+S188D+N248D+E271F,T022A+S103A+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+E271F,V104I+G159D+S188D+N248D+E271F,G159D+S188D+A232V+E271F,T022A+S103A+V104I+G159D+S188D+E271F,S103A+V104I+G159D+S188D+A232V+N248D,T022A+V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+N248D+E271F,S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+E271F,T022A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+Q245R,T022A+G159D+S188D+Q245R+E271F,S103A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+Q245R+N248D+E271F,T022A+S103A+G159D+S188D+A232V+Q245R,T022A+S103A+G159D+S188D+Q245R+E271F,T022A+S103A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+N248D,G159D+S188D+A232V+Q245R+N248D,T022A+V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+N248D+E271F,T022A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+Q245R+N248D+E271F,G159D+S188D+A232V+Q245R+E271F,G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+N248D,V104I+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+N248D,T022A+G159D+S188D+A232V+E271F,T022A+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+E271F,T022A+V104I+G159D+S188D+A232V+N248D
,V104I+G159D+S188D+A232V+Q245R+N248D,S103A+G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+Q245R+E271F,V104I+G159D+S188D+A232V+N248D+E271F,T022A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+A232V+Q245R+N248D+E271F,T022A+G159D+S188D+A232V+N248D+E271F,T022A+G159D+S188D+A232V+Q245R+E271F,T022A+G159D+S188D+A232V+Q245R+N248D,S101G+S103A+S188D,S101G+V104I+S188D,S101G+S103A+V104I+S188D、前記サブチリシン変異体のアミノ酸位置が配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、クリーニング及び/又は処理組成物。 - 前記サブチリシン変異体が、タンパク質分解活性を有する成熟型であり、かつ次から選択される位置にアミノ酸置換の組み合わせを含むアミノ酸配列を含み:T022R+V104I+Q245R,G020R+S024R+S101A,T022R+S103A+V104I,T022R+V104I+A232V,T022R+S103A+Q245R,T022R+A232V+Q245R,T022R+S103A+A232V,T022R+S103A+V104I+A232V,T022R+V104I+A232V+Q245R,T022R+S103A+V104I+Q245R,T022R+S103A+A232V+Q245R,T022R+S103A+V104I+A232V+Q245R,T022A+N076D+S103A+V104I+A232V+Q245R,T022A+N076D+S103A+V104I+A232V,T022A+N076D+V104I+A232V+Q245R,T022A+N076D+S103A+A232V+Q245R,T022A+N076D+S103A+V104I+Q245R,T022A+N076D+V104I+Q245R,T022A+N076D+A232V+Q245R,T022A+N076D+V104I+A232V,T022A+N076D+S103A+Q245R,T022A+N076D+S103A+A232V,T022A+N076D+S103A+V104I,T022A+N076D+S103A,T022A+N076D+V104I,T022A+N076D+A232V,T022A+N076D+Q245R,G020R+S101A+T213A,G020R+R045T+S101A,G020R+S101A+G211Q,S024R+S101A+T213A,G020R+T022W+S101A,S024R+S101A+G211Q,N043R+S101A+T213A,N043R+R045T+S101A,S024R+N043R+S101A,S024R+R045T+S101A,S101A+G211Q+T213A,G020R+N043R+S101A,R045T+S101A+T213A,T022W+S024R+S101A,T022R+S101G+V104I,T022W+S101A+T213A,T022R+S101G+Q245R,T022W+S101A+G211Q,G020R+S024R+Q245R,T022R+S101G+V104I+Q245R,T022R+S101G+A232V,T022R+S101G+S103A,T022R+S101G+S103A+V104I,T022R+S101G+S103A+Q245R,T022R+S101G+A232V+Q245R,T022R+S101G+V104I+A232V,G020R+S024R+S101A+T213A,G020R+S024R+T213AS101N+V104I+A232V,S101N+S103A+V104I,S101N+S103A+A232V,S101N+S103A+V104I+A232V,G020R+S103A+A232V,G020R+V104I+A232V,G020R+S103A+V104I+A232V,G020R+S103A+V104I,N018R+N076D+N116A,N018R+N076D+T213A,N018R+N076D+S101A,N018R+N076D+A215F,又はN018R+N076D+G211Q、前記サブチリシン変異体のアミノ酸位置が配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、請求項1に記載の組成物。
- 前記サブチリシン変異体が、タンパク質分解活性を有する成熟型であり、かつ次から選択される位置にアミノ酸置換の組み合わせを含むアミノ酸配列を含み:S103A+V104I+S188D,S188D+Q245R+N248D,S103A+S188D+Q245R,V104I+S188D+Q245R,S103A+V104I+S188D+Q245R,T022A+S103A+S188D,T022A+V104I+S188D,T022A+S103A+V104I+S188D,G159D+S188D+Q245R,S103A+S188D+A232V,S103A+G159D+S188D,V104I+S188D+A232V,V104I+G159D+S188D,S103A+V104I+S188D+A232V,S103A+V104I+G159D+S188D,S103A+S188D+N248D,V104I+S188D+N248D,S103A+V104I+S188D+N248D,G159D+S188D+N248D,S188D+A232V+Q245R,S103A+S188D+A232V+Q245R,V104I+S188D+A232V+Q245R,S103A+V104I+S188D+A232V+Q245R,T022A+S188D+Q245R,T022A+S103A+S188D+Q245R,T022A+V104I+S188D+Q245R,S103A+S188D+E271F,V104I+S188D+E271F,T022A+S103A+V104I+S188D+Q245R,S103A+V104I+S188D+E271F,T022A+S188D+N248D,T022A+S103A+S188D+N248D,T022A+V104I+S188D+N248D,S103A+S188D+Q245R+N248D,T022A+S103A+V104I+S188D+N248D,V104I+S188D+Q245R+N248D,S103A+V104I+S188D+Q245R+N248D,T022A+S188D+A232V,T022A+S103A+S188D+A232V,T022A+V104I+S188D+A232V,T022A+S103A+V104I+S188D+A232V,S188D+A232V+N248D,S188D+Q245R+E271F,T022A+S188D+E271F,T022A+S188D+Q245R+N248D,S103A+S188D+A232V+N248D,S103A+S188D+Q245R+E271F,S188D+N248D+E271F,V104I+S188D+A232V+N248D,V104I+S188D+Q245R+E271F,T022A+S103A+S188D+E271F,T022A+S103A+S188D+Q245R+N248D,S103A+S188D+N248D+E271F,T022
A+V104I+S188D+E271F,T022A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+Q245R+E271F,S103A+V104I+S188D+A232V+N248D,V104I+S188D+N248D+E271F,S188D+A232V+E271F,T022A+S103A+V104I+S188D+E271F,T022A+S103A+V104I+S188D+Q245R+N248D,S103A+V104I+S188D+N248D+E271F,S103A+S188D+A232V+E271F,V104I+S188D+A232V+E271F,T022A+S188D+A232V+Q245R,T022A+S188D+Q245R+E271F,T022A+S188D+N248D+E271F,S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+Q245R,S188D+A232V+Q245R+N248D,S188D+Q245R+N248D+E271F,T022A+S188D+A232V+N248D,T022A+S103A+S188D+Q245R+E271F,T022A+S103A+S188D+N248D+E271F,T022A+V104I+S188D+A232V+Q245R,S103A+S188D+A232V+Q245R+N248D,S103A+S188D+Q245R+N248D+E271F,T022A+S103A+S188D+A232V+N248D,T022A+V104I+S188D+N248D+E271F,T022A+V104I+S188D+Q245R+E271F,S188D+A232V+Q245R+E271F,S188D+A232V+N248D+E271F,T022A+S103A+V104I+S188D+A232V+Q245R,V104I+S188D+A232V+Q245R+N248D,T022A+V104I+S188D+A232V+N248D,V104I+S188D+Q245R+N248D+E271F,T022A+S188D+A232V+E271F,T022A+S103A+V104I+S188D+Q245R+E271F,T022A+S103A+V104I+S188D+N248D+E271F,T022A+S188D+Q245R+N248D+E271F,S103A+S188D+A232V+Q245R+E271F,S103A+S188D+A232V+N248D+E271F,S103A+V104I+S188D+Q245R+N248D+E271F,T022A+S103A+V104I+S188D+A232V+N248D,S103A+V104I+S188D+A232V+Q245R+N248D,T022A+S103A+S188D+A232V+E271F,V104I+S188D+A232V+N248D+E271F,V104I+S188D+A232V+Q245R+E271F,T022A+S103A+S188D+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+E271F,T022A+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D,S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+Q245R+N248D+E271F,S103A+V104I+S188D+A232V+N248D+E271F,S103A+V104I+S188D+A232V+Q245R+E271F,T022A+S188D+A232V+Q245R+E271F,T022A+S103A+V104I+S188D+A232V+E271F,T022A+S103A+S188D+A232V+N248D+E271F,T022A+S103A+S188D+A232V+Q245R+N248D,S103A+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+
Q245R+N248D,T022A+S103A+S188D+A232V+Q245R+E271F,T022A+V104I+S188D+A232V+N248D+E271F,T022A+S188D+A232V+Q245R+N248D+E271F,V104I+S188D+A232V+Q245R+N248D+E271F,T022A+V104I+S188D+A232V+Q245R+E271F,G159D+S188D+Q245R+N248D,T022A+G159D+S188D,T022A+S103A+G159D+S188D,T022A+V104I+G159D+S188D,T022A+S103A+V104I+G159D+S188D,S103A+G159D+S188D+Q245R,V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+Q245R,S103A+G159D+S188D+N248D,V104I+G159D+S188D+N248D,S103A+V104I+G159D+S188D+N248D,G159D+S188D+A232V,S103A+G159D+S188D+A232V,V104I+G159D+S188D+A232V,S103A+V104I+G159D+S188D+A232V,T022A+G159D+S188D+Q245R,G159D+S188D+E271F,T022A+S103A+G159D+S188D+Q245R,S103A+G159D+S188D+E271F,T022A+V104I+G159D+S188D+Q245R,V104I+G159D+S188D+E271F,T022A+S103A+V104I+G159D+S188D+Q245R,S103A+V104I+G159D+S188D+E271F,T022A+G159D+S188D+N248D,T022A+S103A+G159D+S188D+N248D,T022A+V104I+G159D+S188D+N248D,S103A+G159D+S188D+Q245R+N248D,T022A+S103A+V104I+G159D+S188D+N248D,V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+N248D,T022A+G159D+S188D+A232V,T022A+S103A+G159D+S188D+A232V,T022A+V104I+G159D+S188D+A232V,G159D+S188D+A232V+Q245R,T022A+S103A+V104I+G159D+S188D+A232V,S103A+G159D+S188D+A232V+Q245R,G159D+S188D+Q245R+E271F,V104I+G159D+S188D+A232V+Q245R,G159D+S188D+A232V+N248D,T022A+G159D+S188D+E271F,S103A+G159D+S188D+Q245R+E271F,G159D+S188D+N248D+E271F,S103A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+A232V+N248D,T022A+G159D+S188D+Q245R+N248D,T022A+S103A+G159D+S188D+E271F,V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+E271F,V104I+G159D+S188D+A232V+N248D,S103A+G159D+S188D+N248D+E271F,T022A+S103A+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+Q245R+E271F,V104I+G159D+S188D+N248D+E271F,G159D+S188D+A232V+E271F,T022A+S103A+V104I+G159D+S188D+E271F,S103A+V104I+G159D+S188D+A232V+N248D,T022A+V104I+G159D+S188D+Q245R+N248D,S103A+V104I+G159D+S188D+N248D+E271F,S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+E271F,T022A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+Q245R,T022A+G159D+S188D+Q245R+E271F,S103A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+Q245R+N248D+E271F,T022A+S103A+G159D+S188D+A232V+Q245R,T022A+S103A+G159D+S188D+Q245R+E271F,T022A+S103A+G159D+S188D+N248D+E271F,T022A+G159D+S188D+A232V+N248D,G159D+S188D+A232V+Q245R+N248D,T022A+V104I+G159D+S188D+Q245R+E271F,T022A+V104I+G159D+S188D+N248D+E271F,T022A+V104I+G159D+S188D+A232V+Q245R,S103A+G159D+S188D+Q245R+N248D+E271F,G159D+S188D+A232V+Q245R+E271F,G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+N248D,V104I+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+N248D,T022A+G159D+S188D+A232V+E271F,T022A+G159D+S188D+Q245R+N248D+E271F,S103A+G159D+S188D+A232V+Q245R+E271F,T022A+V104I+G159D+S188D+A232V+N248D,V104I+G159D+S188D+A232V+Q245R+N248D,S103A+G159D+S188D+A232V+N248D+E271F,T022A+S103A+G159D+S188D+A232V+E271F,V104I+G159D+S188D+A232V+Q245R+E271F,V104I+G159D+S188D+A232V+N248D+E271F,T022A+V104I+G159D+S188D+A232V+E271F,G159D+S188D+A232V+Q245R+N248D+E271F,T022A+G159D+S188D+A232V+N248D+E271F,T022A+G159D+S188D+A232V+Q245R+E271F,T022A+G159D+S188D+A232V+Q245R+N248D,S101G+S103A+S188D,S101G+V104I+S188D,S101G+S103A+V104I+S188D、前記サブチリシン変異体のアミノ酸位置が配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、請求項1に記載の組成物。 - 助剤と、単離されたサブチリシン変異体と、を含むクリーニング及び/又は処理組成物であって、前記サブチリシン変異体が、タンパク質分解活性を有する成熟型であり、かつ次から選択されるアミノ酸置換の組み合わせを好ましくは含むものから選択されるアミノ酸置換の組み合わせを含むアミノ酸配列を含み:S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D,S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−
N062E−S078G−G118S−S188D−N248D−H249R,S024R−N062E−G118R−A158E−S188D,T022A−S024R−T033S−G118R−S166D−S188D,S024R−N062E−S078G−G118S−S188D−Q245R−N248D,G020R−S024R−N062E−S078D−G118S−P129E−G159D,G020R−S024R−N062E−S078G−G118D−P129E,G020R−S024R−N062E−S078G−G118S−P129E−G159D−S188D−Q245R−N248D,G020R−N062E−S078G−G118S−G159D−Q245R−N248D,S024R−N116L−A158E−S166D,G020R−N062E−S078G−G118S−G159D−S188D−H249R,G020R−S024R−S078G−G118D−P129E−G159D−S188D,S024R−G118R−S166D,T022A−S024R−T033S−G118R−A158E−S166D−A273V,G020R−N062E−S078G−G118S−P129E−G159D−S188D−Q245R,T022A−G118R−A158E−S166D,G020R−S024R−N062E−S078D−G118S−G159D−S188D−Q245R−N248D,T022A−S024R−G118R−S166D−S188D,N062E−S078G−G118S−G159D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271H,G020R−S024R−N062E−S078G−G118D−Q245R−N248D,S024R−T033S−N116L−A158E−S166D,S024R−N062E−S078G−G118D−P129E−G159D−Q245R,G020R−N062E−S078D−G118S−Q245R,T022A−S024R−N062E−N116L−A158E,G020R−N062E−S078G−G118D−P129E,S024R−T033S−N062E−N116L−G118R−S188D,G020R−N062E−S078G−G118D−P129E−G159D−S188D−H249R,S024R−S078G−G118S−P129E−G159D−Q245R−N248D,G020R−N062E−S078G−G118D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245T−N248D−E271T,S078G−G118S−P129E−G159D−S188D−Q245R−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248H−E271T,G020R−S024R−S078D−G118S−G159D−S188D−H249R,G020R−S078D−G118S−P129E−G159D−Q245R−N248D−H249R,S024R−N062E−N116L−G118R,T022A−S024R−N116L−G118R−A158E−S188D,S024R−N062E−S078G−G118S−P129E−Q245R,S024R−N062E−G118R−A158E,G020R−N062E−S078G−G118S−G159D−S188D,G020R−S024R−S078D−G118S−G159D−S188D−Q245R−N248D−H249R,S024R−S078D−G118S−P129E−G159D−Q245R,A098Q−S099T−G102A−S103G,T022A−G118R−S166D−S188D,S024R−S078D−G118S−G159D−S188D−H249R,T022A−S024R−N116L−G118R−S166D−S188D,T022A−N062E−G118R−A158E,G020R−S078G−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118D−G159D−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271F,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271F,G020R−N062E−S078
G−G118S−P129E−N248D−H249R,S024R−N116L−G118R−S128I−S166D−S188D,G020R−S024R−N062E−S078G−G118D−P129E−G159D−S188D−H249R,G020R−S024R−N062E−S078G−G118D−G159D−S188D−N248D,G020R−S024R−S078G−G118D−P129E−S188D−Q245R−N248D,S024R−N062E−S078D−G118S−S188D−H249R,T033S−N062E−G118R,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271H,T033S−G118R−A158E−S166D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248H,G020R−S024R−S078D−G118D−S188D−Q245R−N248D−H249R,T022A−S024R−N062E,G020R−S024R−N062E−S078D−G118D−G159D−S188D−R247L,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248E−E271T,G020R−N062E−S078G−G118S−P129E−G159D−Q245R−N248D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248H,P014S−G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248E−E271L,G020R−S078D−G118D−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248D−E271T,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248E−E271L,S024R−N062E−S078D−G118S−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248E−E271H,G020R−S078D−G118S−P129E−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248H−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248H−E271H,S024F−T033S−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,S024F−S101G−S103A−V104I−N116L−S128N−Y209V−G211Q−T213A−A232V,S024R−S078G−G118S−G159D−S188D−Q245R−N248D,G020R−S024R−S078G−G118S−S188D−Q245R,G020R−S024R−N062E−S078D−G118D−P129E−G159D−Q245R,S024R−S078D−G118D−G159D−S188D−H249R,G020R−S078G−G118S−G159D−S188D−H249R,G020R−S024R−N062E−S078G−G118S−S188D−N248D,S078D−G118S−G159D−Q245R,G020R−S024R−N062E−S078G−G118D−P129E−G159D−N248D−H249R,S024R−N062E−S078G−G118S−P129E−Q245R−N248D,G020R−S078G−G118S−P129E−S188D−Q245R−N248D,S024R−N062E−S078G−G118S−G159D−Q245R,G020R−N062E−S078D−G118D−P129E−Q245R,T022A−S101G−S103A−V104I−G159D−S188E−P210L−A232T−Q245T−N248D−E271T,G020R−S024R−N062E−S078G−G118S−P129E,G020R−S024R−N062E−S078G−G118D−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248D−E271L,A016S−T022A−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248H−E271H,G020R−N062E−S078G−G118D−P129E−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248E,G020R−S024R−S078G−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118S−G159D−Q245R−N248D,G020R−S078G−G118S−G159D−S188D−Q245R,S024R−N062E−S078G−G118S−G159D−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248H−E271H,G020R−S024R−N062E−S078G−G118D−G159D,T022A−S101G−S103A−V104I−G159D−S188D−A232T−V244A−Q245R−N248H−E271H,S024R−S078G−G118S−P129E−G159D−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248D−E271F,G020R−S024R−N062E−S078G−G118D−G159D−S188D−Q245R,T022A−S024R−N062E−S128I−A158E,G020R−S024R−S078G−G118D−N248D−H249R,S024R−S078G−G118D−P129E−Q245R−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q236K−Q245T−N248E,N062E−S078G−G118S−G159D−Q245R−N248D,T033S−G118R−S166D,G020R−S024R−S078G−G118D−P129E−S188D−N248D,G020R−S078G−G118S−P129E−G159D−S188D−Q245R−N248D,A016S−T022A−S101G−S103A−V104I−L111V,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271H,S024R−N116L−G118R−S128I−A158E−S188D−V199I,G020R−S024R−S078D−G118D−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271T,G020R−S024R−S078D−G118S−S188D−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271T,G020R−S024R−S078G−G118D−P129E−S188D−H249R,S024R−N062E−S078G−G118S−S188D−N248D,T022A−S101G−S103A−V104I−N116L−S128N−Y209A−G211Q−T213A−A232V,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271L,S024R−A048V−S078G−G118D−G159D−S188D−H249R,G020R−S024R−N062E−S078D−G118D,G102A−S103G−V104I,G020R−S024R−S078D−G118D−G159D−Q245R−N248D−H249R,T022A−T033S−G118R−A158E,T022A−S024R−N116L−S128I−S188D,G020R−S024R−S078D−G118D−P129E−G159D−Q245R−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−
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E271T,S024R−S101A−S103A−V104I−S188D−P210I−A232V−Q245R,S024R−N062E−N116L−G118R−A158E,G020R−S078G−G118D−S188D−Q245R,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245V−N248E−E271L,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248E−E271H,S024R−S166D−S188D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245T−N248D−E271F,A016S−T022A−S024F−S101G−S103A−V104I−N116A−Y209V−G211Q−A232V,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245T−N248D−E271F,G020R−N062E−S078G−G118D−G159D−S188D−Q245R−N248D,T022A−N062E−N116L−G118R−A158E,S024R−N062E−N116L−G118R−S128I−S166D,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248H,G020R−S024R−N062E−S078D−G118D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245R−N248E−E271L,S024R−N062E−G118R−S128I−S188D,N062E−S078G−G118S−G159D−N248D−H249R,G020K−T022L−N062E−S078D−G118S−G159D−H249R,N062E−S078G−G118D−Q245R−N248D,G020R−S024R−N062E−S078D−G118D−G159D−S188D−H249R,T022A−S024F−S101G−S103A−V104I−N116L−Y209V−T213A−A232V,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271L,S024R−N116L−G118R−S128I−A158E,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248E−E271F,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245V−N248E−E271T,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248D−E271L,A016S−S101G−S103A−V104L−L148I,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245T−N248H−E271T,G020R−N062E−S078G−G118S−S188D−Q245R,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248E−E271H,S024R−S078D−G118D−S188D−Q245R−N248D−H249R,G020R−S024R−S078D−G118S−P129E−Q245R−N248D,G020R−S078G−G118D−G159D−S188D,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245T−N248E−E271T,G020R−S024R−S078D−G118D−G159D−N248D−H249R,S024R−N062E−S078G−G118S−P129E−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188E−A232L−Q245T−N248D−E271T,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248E,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248H−E271F,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248D−E271L,G020R−S024R−N062E−S078D−G118S−P129E−N248D,S024R−N062E−S078D−G118S−P129E−G159D−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−S212L−A232S−Q245V−N248D−E271T,S024R−S078G−G118D−G159D−H249R,T022A−N116L−G118R−S128I−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248D,N062E−S078G−G118D−S188D−Q245R,G020K−S078N−S166D−L217E,N062E−S078G−G118S−P129E−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E−E271F,N062E−N116L−G118R−S166D−S188D,G020R−S024R−S078D−G118S−G159D−N248D,T022A−S024F−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,S078G−G118S−P129E−G159D−Q245R,T022A−T033S−S101G−S103A−V104I−N116L−Y209V−G211Q−T213A−A232V,S078D−G118S−P129E−G159D−S188D−Q245R−N248D−H249R,S101G−S103A−V104I−N116L−S128N−Y209A−G211Q−T213A−A232V,G097P−S101A−S103G,S024R−N062E−S078D−G118S−S188D,G020R−S024R−S078D−G118D−P129E−S188D−H249R,S024R−N062E−S078G−G118S−G159D,A016S−T022A−T033S−S101G−S103A−V104I−N116A−Y209A−A232V,T022A−N116L−G118R−S128I−A158E−S166D,T022Q−S101G−S103A−V104I−G159D−S188E−A232T−Q245R−N248D−E271T,S024R−G118R−S128I,T022A−S101G−S103A−V104I−G159D−S188E−A232L−Q245T−N248E−E271L,S024R−N062E−A158E,S024R−S078D−G118S−P129E,G020R−S024R−S078D−G118S−P129E−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248H−E271F,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248H−E271F,G020R−S024R−N062E−S078G−G118S−G159D,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248H−E271L,S024R−S078D−G118S−P129E−S188D−Q245R−N248D,N062E−S078G−G118S−S188D−Q245R−N248D,N062E−N116L−G118R−S128I−S188D,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248D−E271F,G020R−S024R−S078D−G118S−G159D−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248D−E271T,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248E−E271T,T022A−T033S−N116L−G118R−S188D,G020R−S024R−N062E−S078G−G118S−P129E−S188D−N248D,G020R−N062E−S078G−G118S−P129E−G159D−N248D,S078G−G118S−P129E−G159D−S188D−Q245R,N062E−S078D−G118S−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245R−N248D,T022A−S024R−T033S−N062E−N116L,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248E−E271T,N062E−S078D−G118S−H249R,T022A−S024R−N062E−N116L−G118R−A158E,T022L−S078N−G118R−S166D−L217E,G020R−S024R−N062E−S078D−G118D−S188D−Q245R−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248H−E271L,G020R−S024R−S078G−G118D−P129E−Q245R−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245V−N248D−E271L,S078D−G118S−P129E−S188D−Q245R,S024R−S078G−G118D−G159D−S188D−Q245R−H249R,S078D−G118D−G159D−S188D−Q245R−H249R,S024F−T213A−L217E,S024F−T033S−S101G−S103A−V104I−N116L−S128N−Y209V−G211Q−A232V,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248D−E271H,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271T,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248H−E271H,G020R−S078D−G118D−P129E−G159D−Q245R−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248D−E271T,N062E−S078G−G118S−P129E−Q245R,S078G−G118S−S188D−Q245R−N248D−H249R,S101A−S103G−V104I−L148I,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248H−E271F,T022Q−S101G−S1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8N−Y209A−G211Q−T213A−A232V,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248H−E271T,G020R−N062E−S078D−G118D−G159D,G020R−N062E−S078D−G118S,S024R−N062E−S078D−
G118D−P129E−G159D−Q245R,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245V−N248E−E271T,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248D−E271H,S078G−G118S−G159D,S024F−G118R−T213A−L217E,S024R−N062E−S078D−G118S−P129E−Q245R−N248D,G020R−S024R−S078D−G118S−P129E−G159D−Q245R,S024R−S078D−G118D−G159D−H249R,S024R−N076D−S101A−S103A−V104I−S188D−P210I−A232V−Q245R,G020R−S024R−N062E−S078D−G118D−P129E−G159D−H249R,G020R−S024R−N062E−S078G−G118D−S188D−N248D−H249R,G020R−S024R−N062E−S078G−G118S−P129E−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245T−N248E−E271H,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245V−N248D−E271T,G020R−S024R−S078D−G118D−P129E−G159D−N248D−H249R,G020R−S024R−N062E−S078D−G118S−P129E−G159D−N248D,N062E−S078G−G118D−P129E−H249R,G020K−T022L−S078N−G118R−T213A−L217E,G020R−S024R−N062E−S078G−G118D−P129E−S188D−H249R,T022A−S024R−T033S−N116L−S166D−S188D,S024R−S078G−G118D−G159D−S188D−H249R,T033S−N116L−G118R−A158E−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248H,S101A−S103A−V104I−S188D−P210I−A232V−Q245R,G020R−S024R−N062E−S078G−G118D−S188D−Q245R,T022A−S024R−T033S−N062E−N116L−G118R−P129E−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248E,S024R−S078G−G118S,N062E−S101A−S103A−V104I−P210I−A232V−Q245R,N062E−S078G−G118D−G159D,T022A−S024R−N062E−N116L−G118R−S128I−S166D−S188D,S024R−S078D−G118D−G159D−Q245R,G020R−N062E−S078G−G118S−G159D−S188D−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271H,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−V244I−Q245R−N248H−E271L,S024R−S078G−G118S−P129E−G159D−N248D,S024R−N062E−S078G−G118S−G159D−H249R,T022A−S024F−T033S−S101G−S103A−V104I−N116L−Y209V−G211Q−A232V,A016S−S101G−S103A−V104I−N116A−S128N−Y209V−G211Q−T213A−A232V,G020R−N062E−S078G−G118D−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E−E271H,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245V−N248E−E271L,G020K−S166D−L217E,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271T,G020R−N062E−S078D−G118D−Q245R,S024R−N062E−S078D−G118S−P129E−S188D−Q245R−N248D,A016S−T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209A−G211Q−A232V,S024F−T033S−S101G−S103A−V104I−N116L−Y209A−A232V,T033S−G118R−S188D,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271H,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248D−E271T,G020R−S024R−S078G−G118S−P129E−G159D−S188D−N248D,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245T−N248H−E271F,G020R−S078G−G118D−P129E−S188D−Q245R,G020R−S078G−G118D−G159D−S188D−Q245R−N248D,S024R−S078G−G118D−P129E−N248D−H249R,G020R−S024R−S078D−G118D−P129E,N062E−S078D−G118S−S188D−Q245R,G020R−S024R−S078G−G118S−G159D−S188D,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248H−E271L,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245R−N248D−E271L,N062E−S078G−G118S−G159D−H249R,G020R−S078D−G118S−P129E−G159D−N248D,G020R−S024R−S078D−G118S−G159D−S188D−Q245R,G020R−N062E−S078G−G118D−P129E−S188D−Q245R−N248D,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248H,G020R−S024R−S078D−G118S−G159D−V244L−Q245R−N248D,G020R−S024R−S078G−G118D−P129E−S188D−Q245R−N248D−H249R,T022A−S024F−T033S−S101G−S103A−V104I−N116A−Y209A−A232V,G020R−S024R−N062E−S078D−G118S−P129E−G159D−A272D,N116L−G118R−S128I−A158E−S166D,S024R−S078D−G118S−P129E−H249R,S024R−N062E−S078G−G118S−P129E−N248D,G020R−S078G−G118S−P129E−G159D−S188D,G020R−S024R−S078D−G118S−G159D−N248D−H249R,S024R−S078D−G118D−G159D−S188D−Q245R−N248D−H249R,T033S−S101G−S103A−V104I−N116L−Y209A−G211Q−T213A−A232V,T033S−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248H,N062E−S078G−G118S−N248D−H249R,G020R−N062E−S078D−G118D−G159D−S188D−Q245R,T022A−S024F−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,N043F−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−S078G−G118D−P129E−G159D,G020R−N062E−S078D−G118D−G159D−Q245R−N248D,S024R−S166D,S024R−S078G−G118S−P129E−N248D,N076D−S101A−S103A−V104I−S188D−P210I−A232V−Q245R,G020K−L217E,G118R−S166D−S188D,S024R−S078D−G118S−G159D−S188D,S024R−S078D−G118S−P129E−S188D−Q245R,A016S−S101G−S103A−V104I−N116A−S128N−Y209A−T213A−A232V,N116L−S166D,S024R−N062E−S078G−G118D−P129E−G159D−S188D−Q245R,G020R−S024R−S078D−G118D−P129E−N248D−H249R,N062E−S078G−G118S−G159D−S188D−Q245R,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245V−N248E−E271H,S024R−N062E−S078D−G118S−P129E−H249R,G118R−S166D−T213A,G020R−S024R−N062E−S078G−G118S−P129E−G159D,G020R−S024R−S078D−G115W−G118D−G159D−N248D,A016S−S024F−S101G−S103A−V104I−N116A−Y209A−A232V,S024R−N062E−N116L−S128I−A158E,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248D−E271L,S024R−N062E−S078G−G118S−P129E−H249R,S024R−N062E−S078D−G118D−P129E−N248D−H249R,G020K−T022L−S024F−S078N−G118R−L217E,S101G−G102A−S103A,G020R−S078G−G118S−P129E−Q245R−N248D,G020K−S078N−S166D,T022A−G118R−A158E,G020K−T022L−S024F−S078N−S166D,T022A−T033S−N062E−N116L−G118R−A158E−S188D,S024R−S078G−
G118S−P129E−G159D−H249R,S101G−S103A−V104I−N116L−Y209V−G211Q−A232V,A015D−A016S−S101G−S103A−V104I−N116L−S128N−Y209V−T213A−A232V,G020R−N062E−S078D−G118D−P129E−S188D−H249R,G020K−S024F−S078N−S128D,T033S−N116L−S166D−S188D,G020R−S078G−G118S−P129E−G159D,T022A−S024R−T033S−L082I−G118R−S128I−A158E−S188D,G020R−S024R−S078D−G118S−S188D−N248D,G020R−S078G−G118D−P129E−S188D−Q245R−H249R,N062E−S078G−G118D−Q245R,G020K−T022L−S078N−L217E,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248E−E271L,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E−E271H,T022Q−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248E−E271T,A016S−T033S−S101G−S103A−V104I−N116L−Y209V−G211Q−T213A−A232V,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245K−N248H,N062E−S078D−G118D−Q245R,T022A−S024R−G118R−A158E−S166D,A016S−S101A−S103A−S128N−L148I,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248E,S024R−N062E−S078G−G118D,S024R−N062E−S078G−G118S−P129E−G159D−S188D,S078G−G118D−P129E−G159D−S188D−Q245R−N248D−H249R,G020R−S078D−G118D−P129E−G159D−Q245R,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248H,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271H,G020R−S024R−N062E−S078G−G118D−H249R,S078D−G118S−P129E−G159D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248D−E271H,S024R−S078D−G118D−P129E−G159D−S188D−Q245R,T022L−T213A−L217E,G020R−N062E−S078G−G118S−P129E−G159D−S188D−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248H−E271T,G020R−N062E−S078G−G118D−Q245R,G020R−S024R−N062E−S078G−G118D−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248H−E271T,S024R−S078D−G118D−P129E−H249R,S024R−N062E−N116L−G118R−S188D,S024R−N062E−G118R,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E,G020R−S024R−S078G−G118S−P129E−G159D−S188D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248H,S024R−S078D−G118S−P129E−G159D−N248D,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245V−N248D−E271T,G020R−S078G−G118D−P129E−Q245R−N248D−H249R,G020R−S024R−N062E−S078D−G118D−P129E−S188D−Q245R−N248D,A016S−S024F−T033S−S101G−S103A−V104I−N116L−Y209V−A232V,G097P−A098Q−S099G−V104L,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248D−E271F,G020R−S024R−N062E−S078G−G118S−N248D,A016S−S103A−S128N,S024R−S078G−G118D−P129E−Q245R,S078D−G118D−P129E−S188D−H249R,T022A−S024R−T033S−N062E−N116L−A158E,A016S−T022A−S101G−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,S024R−S078G−G118S−G159D−S188D−Q245R,T033S−N062E−N116L−G118R−A158E−S188D,G020R−S024R−N062E−S078D−G118S−G159D−Q245R−A272V,G118R−S128I−A158E−S166D,G020K−T022L−S024F−S078N−S166D−D181E−L217E,N062E−G118R−S188D,S024F−S101G−S103A−V104I−N116L−S128N−Y209A−T213A−A232V,G020R−S078D−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118D−P129E−N248D−H249R,G020R−S024R−N062E−S078G−G118D−N248D,T022A−V068A−S101G−S103A−V104I−G159D−S188D−T213A−A232V−Q245R−N248D−E271F,G020R−N062E−S078D−G118S−P129E−G159D−S188D−Q245R,S024R−S078G−G118S−P129E−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248H−E271L,T033S−N116L−G118R−S188D,N062E−S078G−G118S−S188D−N248D−H249R,A016S−T022A−S101G−S103A−V104I−S128N−L148I,G020R−S078G−G118S−S188D−N248D−H249R,G020R−S024R−S078D−G118D−P129E−G159D−Q245R−N248D,S024F−T033S−S101G−S103A−V104I−N116L−Y209A−T213A−A232V,S024R−N062E−G118R−S128I−A158E,G020R−S024R−S078D−G118S−G159D−S188D,S024R−N062E−S078G−G118D−G159D−Q245R−N248D−H249R,N062E−G118R−A158E−S166D,G020R−S024R−S078D−G118S−P129E−S188D,S078G−G118D−G159D,G020R−S024R−S078D−G118D−P129E−G159D−S188D−Q245R−N248D,G020R−S078G−G118D−S188D−N248D,G020K−T022L−S078G−G118D−G159D−N248D−H249R,S103G−L148I−M175T,G020R−S024R−S078G−G118S−P129E−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248D−H249R−E271F,T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209A−G211Q−T213A−A232V,A016S−T033S−S101G−S103A−V104I−N116A−Y209A−G211Q−A232V,T022A−S024R−N062E−S166D,G020R−S078D−G118S−G159D−S188D−Q245R−N248D−H249R,T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209V−A232V,T022A−S024R−N062E−N116L−A158E−S188D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248E−E271L,S024R−T033S−N116L−G118R−A158E−S188D,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245V−N248H−E271H,G020R−N062E−S078D−G118S−G159D−N248D,T022A−S024R−N116L−G118R−A158E,G020K−T022L−S024F−G118R−L217E,S024R−S078D−G118S−G159D−S188D−N248D−H249R,G020R−S024R−N062E−S078G−G118D−P129E−S188D−N248D,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271L,G020R−S024R−N062E−S078D−G118S−P129E−G159D−S188D−N248D−H249R,N062E−G118R−S166D,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248D,G020R−N062E−S078D−G118S−P129E−G159D−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248H−E271T,T022L−S024F−G118R−S166D,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D,G020K−S024F−S166D−T213A−L217E,N062E−S078G−G118S−G159D−S188D,S024R−N062E−S078D−G118D−Q245R−N248D,G020K−T022L−S024F−S078N−T213A−L217E,T022A−V068A−S101G−S103A−V104I−N116L−G159D−S188D−T213A−A232V−Q245R−N248D−E271F,N062E−S078G−G118S−P129E−G159D,G020R−S024R−N062E−S078G−G118S−G159D−H249R,G020K−T022L−S024F−S078N−G118R−S166D−T213A−L217E,T022A−N062E−N116L−A158E,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248E−E271L,T022A−S024R−N062E−S128I−S166D,S024R−S078G−G118D−G159D−Q245R−N248D−H249R,G020R−S024R−N062E−S078G−G118S−P129E−G15
9D−H249R,G020R−S078G−G118D−S188D−Q245R−N248D,G020R−S024R−N062E−S078G−G118D−P129E−S188D−Q245R−N248D−H249R,S024R−S078G−G118S−G159D−Q245R,T022A−S024R−N062E−G118R−S128I−A158E,G020R−S078D−G118S−P129E−G159D−S188D−Q245R,S024R−S078G−G118S−Q245R−N248D−H249R,G118R−A158E−S188D,G020K−S024F−G118R−S166D−L217E,G020K−S024F−S078N−G118R−T213A−L217E,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248D−E271L,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245
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D−S188D−Q245R−N248D,G020R−G118R−P129E−G159D−S188D,G020R−G159D−S188D,G020R−G118R−P129E−S188D−N248D,A016S−S024R−S101G−S103A
−V104I−N116A−S128N−Y209V−T213A−A232V,G020K−N062E−S188D−T213A−M222S,A016S−S024F−S101D−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,S024G−S078N−S101N−Q109G−S128A−L217Q,T022A−G097S−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−M222S−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−M222S−A232V−Q245R−N248D−E271F,G020R−P129E−Q245R,S024R−P129E−G159D−Q245R−N248D,S024R−G118R−S188D−N248D,G020R−P129E−H249R,S024R−P129E−Q245R−N248D,T022A−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−S078R−P129E−G159D−S188D−H249R,T022A−S101G−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,G118R−P129E−H249R,G020R−N062E−G118R,G020R−G118R−P129E−G159D−Q245R−N248D,T022A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,S024R−S078R−G118R−P129E−G159D−S188D,P129E−Q245R−N248D−H249R,S024G−G061S−S078N−S101N−Q109G−S128A−L217Q−N243V,S078R−V084A−P129E−Q245R,S024R−G118R−G159D−S188D−N248D,G020R−G118R−P129E−G159D−H249R,S078R−P129E−G159D,G061P−S078N−G097A−S101N−S128A−V203Y−L217Q,P086S−S087G−A088V−G097A−N117S−S128A−L217Q,S024R−S078R−G159D−S188D−Q245R−N248D−H249R,S078R−G118R−P129E,S024G−S078N−S101N−S128A−L217Q−N243V,S024R−S078R−G159D−S188D,G020R−G118R−P129E,G020R−S024R−P129E−G159D−S188D−H249R,S024R−G118R−G159D−S188D,S024R−G118R−P129E−G159D−S188D−Q245R−N248D,S024G−S078N−S101N−S128A−L217Q,S024R−G159D−S188D−Q245R,S024G−S078N−S101N−Q109G−L217Q−N243V−N248A,G020R−S078R−G159D−S188D−Q245R−N248D,S078R−G118R−P129E−S188D−N248D,S024R−S188D−Q245R−N248D,G020R−S024R−S101A−P210I−G211Q,G020R−G159
D−N248D−H249R,G020R−P129E,G020K−N062E−N116L−T213A−M222S,S024G−S078N−A088T−S101N−Q109G−N116T−S128A−A158S−L217Q−N218S−L257G,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S166D−Y209V−T213A−A232V,S024R−N062E−S078R−P129E−H249R,N018K−G020R−S024R−R045T−S101A−P210I−G211Q−T213A,G020R−S024R−G118R−P129E−G159D−S188D−N248D−H249R,G020R−S024R−P129E−H249R,G020R−G118R−S188D−Q245R−N248D−H249R,G020R−S024R−N062E−S078G−G118S−Q245R,G020R−S024R−G118R−P129E−G159D−N248D,S024G−S078N−S101N−Q109G−S128A−L217Q−S256R,S024G−S078N−S101N−S128A−A158S−L217Q−L257G,G020R−S024R−G118R−S188D−N248D,G020R−G118R−G159D−S188D−Q245R−N248D−H249R,G159D−S188D−Q245R−N248D,S078N−G118R−S166D−L217E−M222S,G020R−G118R−P129E−G159D−Q245R−N248D−H249R,T022A−S101Q−S103A−V104I−L124V−S128A−P129S−A232V−Q245R,S024R−N062E−Q245R,S188D−Q245R−N248D,S024R−G118R−P129E−S188D−H249R,T022A−G097A−S101Q−S103A−V104I−P129S−A232V−Q245R,G020R−G118R−S188D−Q245R−N248D,S024G−S078N−S101N−Q109G−N116T−S128A−L217Q−N243V−S256R,G020R−G118R,G020R−S024R−S188D,N062E−P129E−G159D−S188D−Q245R,G020R−G159D−Q245R−N248D,G020R−N043R−S101A−P210I−G211Q,G097A−S101N−S128A−L217Q,G020R−G118R−S188D−N248D,S024R−S188D−N248D,G020R−S024R−S188D−Q245R−N248D,G020R−S024R−G118R−P129E−G159D−N248D−H249R,G020R−P129E−N248D,G159D−S188D,P129E−G159D,G020R−S188D−H249R,P129E−G159D−Q245R−N248D,G020R−G118R−G159D−N248D−H249R,G118R−S188D−N248D−H249R,G020K−S101D−G102A−L217E−S240R,N043R−G102A−L217E,N062E−S078N−S101D−S240R,G102A−L217E,G020K−S128L−L217E−S240R,G020K−N062E−S078N−L217E−S240R,N043R−S101D−S128L−L217E−S240R,G020K−S078N−S101D−G102A−P210L,N043R−S101D−L217E,G020K−G100S−L217E−S240R,S078N−G100S,G020K−N043R−S101D−G102A−L217E,G100S−S240R,G020K−G102A−L217E,G020K−S024G−N062E−S078N−S101N−Q109N−N116L−S128A−S188D,G020K−L217E−S240R,N043R−S101D,N043R−S078N−S101D−S128L−S240R,N043R−S078N−S101D−L217E−S240R,G020K−S078N−S101D,N043R−S128L−S240R,G020K−N062E−N116L−N123G−T213A,G020K−N062E−G097S−S101G−Q109G−N116L−S128A,G020K−N062E−S078N−G097A−S101N−Q109N−N116L−S188D,N043R−S078N−S101D−G102A−L217E,G020K−S078N−S099G−S128L−L217E,G020K−N062E−S101D,G020K−S128L−L217E,G020K−S024G−N062E−S078N−G097S−S101G−Q109G−N116L−L217Q,N043R−G097A−S101D−S128L,G020K−S024G−N062E−S101Q−Q109N−N116L−S128A,G020K−S024G−N062E−S078N−S101N−N116L−S128A−L217Q,S078N−G102A−S240R,N043R−S078N−G100S−L217E−S240R,G020K−S078N−S128L−L217E−S240R,G020K−N062E−N116L−S128Q,G020K−S101G−L217E−S240R,G020K−S024G−N062E−S101N−Q109G−N116L−S128A−L217Q,G020K−N062E−S078N−G097S−S101N−N116L−L217Q,G020K−N062E−G097S−S101N−Q109G−N116L−L217Q,G020K−S024G−N062E−S078N−G097A−S101Q−Q109N−N116L−M222S,G020K−S024G−N062E−S078N−G097S−S101Q−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S078N−S101N−Q109G−N116L−S188D−L217Q,又はG020K−N062E−S105G−N116L−S128L−T213A、又は前記サブチリシン変異体がタンパク質分解活性を有する成熟型であり、次から選択されるアミノ酸置換の組み合わせを含むアミノ酸配列を含み:T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D,S024R−N116L−A158E−S188D,G020K−S024F−S078N−G118R−T213A,T022A−S024R−T033S−N116L−G118R−S128I,G020R−S078D−G118D−S188D−Q245R,S024F−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,S024R−N062E−S078G−G118D−G159D−S188D,T022A−N062E−N116L−G118R−A158E−S166D,G020K−T022L−S078N−S166D−L217E,G020R−S078D−G118D−G159D,T022A−S024R−T033S−N116L,G020R−S078D−G118D−P129E−G159D,G020R−S078D−G118D−G159D−H249R,S024R−N062E−S078G−G118S,S024R−S078D−G118D−S188D−Q245R−H249R,A016S−S024F−T033S−S101G−S103A−V104I−N116L−Y209V−T213A−A232V,G020R−N062E−S078D−G118D−P129E−G159D−Q245R,S024F−S101G−S103A−V104I−N116L−G118V−Y209V−G211Q−A232V
,S024F−S166D−L217E,T022A−S024R−S166D,S024R−N062E−S078G−G118D−P129E−N248D,A016S−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,A016S−T022A−S101G−S103A−V104I−N116A−Y209V−G211Q−A232V,S078D−G118S−G159D−N248D−H249R,S024R−S078G−G118D−P129E−G159D−S188D,T022A−S024R−N062E−N116L−G118R−S128I−S188D,S103A−S128N,T022L−S078N−G118R−S166D−T213A,S024F−T033S−S101G−S103A−V104I−N116L−S128N−Y209A−T213A−A232V,T022A−S024R−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,S024R−S078D−G118S−S128N−P129E,S024R−S078G−G118S−P129E−G159D−S188D−Q245R−H249R,T022A−S024R−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245T−N248D,S024R−T033S−N116L−A158E,S130E−N269K,S024R−T033S−N116L−S128I−A158E,A016V−G020R−S024R−S078D−G118D−P129E−Q245R−N248D,S099G−S101A−G102A−S103G−V104I,A016S−T022A−S101A−V104L−S128N−L148I,G020R−S024R−S078G−G118S−P129E−S188D,S259W,S259H,T022A−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,N018D−S101G−S103A−V104I−N116A−Y209A−G211Q−T213A−A232V,G020K−S024F−S078N−S166D−T213A,N076D−S101A−S103A−V104I−S188D−A232V−Q245R,S078D−G118D−P129E−G159D−H249R,S024R−S078G−G118D−P129E−G159D−N248D,S024R−N062E−S101A−S103A−V104I−S188D−A232V−Q245R,E271R,G020R−S024R−S078D−G118D−P129E−G159D−S188D,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,G020R−N062E−S078D−G118S−G159D−S188D−Q245R−H249R,Q012R−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,G020R−S078G−G118D−P129E−G159D−S188D−Q245R−N248D,G020R−N062E−S078G−G118S−P129E−G159D−S188D−Q245R−H249R,T022A−S101G−S103A−V104I−G118R−S128L−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S078D−G118D−G159D−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,G020R−S024R−N062E−S078D−G118S−P129E−S188D−Q245R−N248D−H249R,G020R−S078G−G118S−G159D−H249R,G020K−T022L−S024F−G118R−S128D−S166D,T022A−S024R−N062E−N116L−G118R−S128I−A158E−S166D,A016S−S103G−V104L
,A016S−T033S−S101G−S103A−V104I−N116L−Y209A−A232V,G020R−S024R−N062E−S078D−G118S−P129E−S188D−N248D,G020K−T022L−S078N−G118R−S166D,G020K−T213A−L217E,S024R−N062E−S078D−G118S−P129E−G159D−S188D−Q245R−N248D−H249R,S078N−S166D−T213A−L217E,S078D−G118S−P129E−G159D−Q245R−H249R,T022A−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,G020K−T022L−G118R−L217E,T022A−V104L−L111V,T022A−S101G−S103A−V104I−S128A−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−N062E−S078G−G118S−P129E−S188D−N248D,G020R−S024R−S078D−G118D−G159D−S188D−N248D,T022L−S078N−L217E,G020R−S024R−S078G−G118S−S188D,S024F−S101G−S103A−V104I−N116L−Y209V−G211Q−T213A−A232V,T022A−N116L−G118R−A158E−S166D,G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D−H249R,T022A−V104I−S128N,S024R−S078G−G118D−Q245R,N062E−S078G−G118S−P129E−G159D−S188D−H249R,T022A−S101G−S103A−V104I−I107V−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,S024R−N062E−S078D−G118S−P129E−G159D−Q245R−N248D−H249R,T022A−T033S−G118R−A158E−S188D,T022A−S078N−G097A−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−S166D−S188D,A016S−S024F−T033S−S101G−S103A−V104I−N116L−Y209A−A232V,T022A−T033S−S128I−A158E,S024R−T033S−N116L−S188D,N062E−N076D−S101A−S103A−V104I−P210I−A232V−Q245R,T022A−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F−A272V,S130D,G020K−T022L−S024F−S078N−G118R−S166D−L217E,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E,S024R−T033S−N116L−S166D−S188D,S024R−S078D−G118S−S188D−Q245R−H249R,T022A−S024R−T033S−A158E−S166D−S188D,G020K−T022L−S024F−S166D−T213A−L217E,T022A−N062E−N116L−G118R−S188D,G020R−S078G−G118D−Q245R−N248D−H249R,T022A−N116L−G118R−S128I,T022L−S078N−S166D,T022L−G118R−S128D,G097P−S099A,T022L−S024F−G118R−S128D,S242K,N062E−S078D−G118S−G159D,A016S−S103G−S128N−L148I,G097P−A098Q−S101A,T022A−S103A−V104L−S128N−L148I,T022A−S101G−S103A−V104I−G118R−G159D−S188D−T213A−A232V−Q245R−N248D−E271F,S099G−S101G−G102A,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245T−N248D,G100S−S101G−V104I,S078D−G118S−G159D−Q245R−N248D,A016S−S024F−T033S−S101G−S103A−V104I−N116A−Y209V−G211Q−T213A−A232V,T022A−S024R−T033S−N116L−A158E,T022A−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024R−N116L−S128I−S166D,S101G−S103A−V104I−N116L−S128N−Y209V−A232V,S024F−S101G−S103A−V104I−N116L−Y209A−A232V,G020R−S078G−G118D−G159D−S188D−N248D,G020R−S078D−G118D−S188D−Q245R−N248D,S024F−S078N−G118R−S128D,T022L−S024F−S078N−G118R−S166D,G020R−S024R−S078D−G118S−P129E−G159D−S188D−Q245R−H249R,S103A−V104L−S128N,T022A−S024R−N062E−N116L−S128I,T022A−N062E−N116L−G118R−A158E−S188D,T022A−S024G−G097S−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−N062E−S078D−G118D−G159D−S188D−Q245R−H249R,N062E−S078D−G118S−S188D−Q245R−N248D,T022A−S103A−L148I,T022A−S024R−N116L−S128I−A158E−S188D,G097P−S099T−S101G−V104I,S166D−T213A−L217E,A016S−T033S−S101G−S103A−V104I−N116L−Y209V−A232V,N062E−S078D−G118S−P129E−G159D−S188D−Q245R,T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209A−G211Q−A232V,G020K−T022L−S078N−G118R−S128D−S166D
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−T213A,G020K−N043R−S078N−G100S−L217E−N218D,S024G−S101N−Q109G−S128A−S188D−L217Q,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S128A−S188D,S078N−S101N−Q109G−S188D−L217Q,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S188D−L217Q,G020K−N062E−S078N−S101Q−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S101G−Q109G−N116L,G020K−S024G−N062E−G097S−S101N−Q109G−N116L−S128A−S188D−M222S,S024G−G097A−S101G−S188D−L217Q,S024G−S078N−G097A−S101G−S128A−S188D,G097S−S101N−Q109G−S128A−S188D,G020K−S078N−S101D−I246T,N043R−S128L−L217E,G020K−S101D−L217E−S240R,S128L−L217E−T224A−E271L,G020K−S078N−S101D−S128Q−L217E−E271L,N062E−S078N−S101D−L217E−S240R,G020K−S101D−L217E−E271L,G020K−S078N−S128Q−L217E−S240R,G020K−N062E−S101D−N116L−T213A,G100S−S101D,S078N−G097S−S101G−S128A−L217Q,G020K−N062E−G097S−S101N−N116L−S128A−L217Q,G020K−N062E−G097S−S101N−N116L−L217Q,S101N−Q109G−S188D,G020K−S024G−N062E−G097S−S101Q−Q109N−N116L−S128A−L217Q,G020K−S024G−N062E−G097S−S101N−N116L,G020K−S024G−N062E−S101N−N116L−S128A,G020K−S024G−N062E−S078N−S101Q−Q109N−N116L−S128A,G020K−N062E−S078N−S101N−Q109G−N116L−S188D,G020K−N062E−S078N−S101N−Q109G−N116L−S128A,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S128A−M222S,G020K−S024G−N062E−S078N−G097S−S101G−N116L−S128A,S024G−S078N−G097S−S101Q−Q109G−S128A−S188D−L217Q,S024G−S078N−S101G−Q109N−S188D−L217Q,S024G−S078N−G097A−S101G−Q109G−S188D,S078N−S101D−S128Q−L217E−S240R−E271L,G020K−S128Q−L217E,S128Q−L217E−S240R−E271L,G020K−S078N−S101D−L217E,G020K−S078N−S101D−L217E−E271L,G020K−N116L−S128Q−T213A,G020K−N116L−N123G,S101G−S188D−L217Q,G020K−S024G−N062E−S078N−S101G−N116L−L217Q,S078N−G097A−S101G−Q109N−S128A−S188D,G020K−S078N−S128L−L217E−E271L,G020K−N062E−S101Q−Q109G−N116L,G020K−S101D−L217E,S024G−G097A−S101N−Q109N−S128A,G020K−S078N−S101D−S128L−L217E−S240R,G097A−S101G−L217Q,S024G−S101Q−Q109G−S128A−L217Q,G020K−S024G−N062E−T071A−S078N−G097S−S101G−N116L−L217Q,G020K−S024G−N062E−S078N−S101G−N116L−S128A,G020K−S024G−N062E−S078N−G097A−S101N−N116L,G020K−N062E−G097A−S101N−N116L,G020K−S024G−N062E−G097A−S101N−Q109G−N116L−S128A,G020K−S024G−N062E−S078N−G097S−S101G−Q109N−N116L,G020K−N062E−S078N−G097S−S101Q−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−S101N−Q109G−N116L−L217Q,G020K−S024G−N062E−G097A−S101N−Q109G−N116L−S188D−L217Q,G020K−S024G−N062E−S101G−N116L,S078N−G097S−S101N−Q109G−G159D−L217Q,S024G−G097A−S101N−Q109G−S188D,S078N−S101G−S128A−L217Q,S078N−G097A−S101N−S128A−S188D−L217Q,S024G−G097S−S101G−S128A−S188D−L217Q,S024G−S078N−G097S−S101Q−Q109G−S128A−S188D−L217Q−V227A,G020K−N062E−S078N,S078N−S128L−L217E−S240R−E271L,G020K−N062E−I072N−S101D−N116L−S128Q,G020K−T057P−N062E−N116L−S128Q−T213A,G020K−N043R−S078N−S101D−S240R,S078N−G097S−S101N−Q109N−S128A−S188D−L217Q,S024G−S101N−Q109N−S128A−S188D,G020K−S024G−N062E−G097S−S101Q−N116L−S128A,S024G−S078N−G097S−S101N−Q109N−S128A−S188D,N043R−G100S,G020K−N062E−S078N−S101Q−Q109G−N116L−S128A,S078N−S101Q−Q109N−S188D−L217Q,G020K−N116L−S128L−T213A,G020K−S078N−S101D−L217E−S240R,G020K−N062E−S101N−Q109N−N116L−M222S,G020K−S024G−N062E−G097A−S101Q−Q109N−N116L−S128A,S078N−G097S−S101G−S128A−S188D,G097S−S101G−Q109N−S128A−M222S,S024G−S078N−G097A−S101Q−S128A−M222S,G097A−S101G−Q109N−L217Q,S024G−S078N−S101G−S128A−S188D−L217Q,S024G−G097A−S101N−Q109G−S128A−S188D,G097S−S101N−Q109G−S128A,S078N−G097A−S101Q−L217Q,G020K−N043R−S078N−S101D,G020K−N043R−E054D−N062E−S078N−S240R,G020K−S101D−S240R,S128Q−L217E−S240R,G020K−S128Q−L217E−V244A−E271L,G020K−L217E−E271L,G020K−S078N−S128L−L217E,S078N−S101D−S128Q−L217E−E271L,G020K−N062E−L217E−E271L,G020K−N062E−S101D−N116L−S128Q−T213A,G020K−N062E−S078N−N116L−S128I,G020K−N062E−S078N−S128Q−T213A,S024G−G097A−S101G−Q109G−S128A,S024G−G097S−S101N−Q109N−S128A−L217Q,G020K−S024G−N062E−S078N−S101N−N116L−S128A−S188D−L217Q,G020K−S101D,G020K−N062E−S078N−G097S−S101Q−N116L−S128A,G020K−N062E−G097S−S101G−N116L−S188D,N043R−S078N−G100S−S128L−S240R,G097S−S101N−Q109N−S188D,G097S−S101Q−Q109N−S128A−L217Q,G020K−N062E−S101N−Q109G−N116L−S128A−S188D−M222S,G020K−S024G−N062E−S078N−G097S−S101Q−Q109G−N116L,G020K−N062E−M222S,G097S−S101Q−Q109G−S188D,G020K−S078N−L217E−S240R,G020K−N062E−S078N−G097A−S101N−Q109G−N116L−S188D,G020K−S024G−N062E−G097S−S101Q−Q109G
−N116L−S188D,G020K−N062E−S078N−G097A−S101Q−N116L−S128A−M222S,G020K−N062E−S078N−S101N−N116L−S188D,G020K−S024G−N062E−S078N−S101G−N116L,G020K−N062E−S078N−S101N−N116L−S128A−S188D,G020K−S024G−N062E−G097S−S101N−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−G097S−S101N−Q109N−N116L,G020K−N062E−S101G−N116L−S188D−L217Q,G097A−S101N−S128A,S101G−Q109N−S128A−M222S,S024G−G097S−S101Q−Q109G−S188D−L217Q,G097S−S101Q−Q109N−S128A−S188D,S024G−S078N−G097A−S101Q−S188D−L217Q,S024G−S078N−S101G−Q109G−S128A−L217Q,G020K−N062E−S128L−S240R,N062E−S078N−S128L−S240R,N043R−G102A−S128L−L217E−S240R,N062E−S078N−L217E−S240R−E271L,S078N−S128Q−L217E−N269S,G020K−N062E−N123G−T213A,G020K−N062E−S078N−S099G−N116L−S128Q−T213A−L217N,G020K−N062E−S078N−S128I−L217N,G097A−S101Q−S128A−S188D−L217Q,G020K−N062E−S078N−G097S−S101N−Q109G−N116L,G020K−S024G−N062E−S078N−G097S−S101N−Q109G−N116L−S188D,G020K−N043R−S128L−S240R,S024G−S078N−G097A−S101N−Q109N−S128A,G020K−N062E−G097S−S101Q−N116L−L217Q,G020K−N062E−S078N−S128I,G020K−S024G−N062E−L090V−G097A−S101Q−N116L−M222S,G020K−N062E−S078N−S101Q−Q109G−N116L−S188D−L217Q,G020K−S024G−N062E−G097A−S101G−N116L−S128A−S188D−L217Q,G020K−N062E−G097S−S101N−Q109N−N116L−S188D−L217Q,G020K−S024G−A048V−N062E−S078N−G097A−S101N−N116L−S128A−L217Q,G020K−N062E−S078N−S101Q−Q109G−N116L,G020K−S024G−N062E−G097S−S101N−Q109N−N116L−S128A,G020K−N062E−S078N−G097A−S101Q−Q109G−N116L−S188D,G020K−N062E−S078N−G097A−S101N−Q109N−N116L−N218D,S024G−S101N−Q109G−S128A−S188D−M222S,S024G−G097A−S101Q−Q109N−S188D−L217Q,S024G−S078N−G097S−S101Q−Q109N−S128A−S188D,S101N−Q109G−M222S,S024G−I072V−G097S−S101N−S128A−L217Q,S101G−S128A,N043R−S078N−G102A−A215G,G020K−S101D−S128L−L217E−S240R,S078N−S101D−S128Q−L217E−S240R,G020K−N116L−S128L−M222S,G020K−N062E−S078N−N116L−T213A−M222S,G020K−N062E−S078N−N116L−S128Q,G020K−N062E−T213A,又はG020K−N062E−S078N−N116L−N123G−M222S、又は前記サブチリシン変異体がタンパク質分解活性を有する成熟型であり、次から選択されるアミノ酸置換の組み合わせを含むアミノ酸配列を含み:T022A−S024G−N076D−G097S−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−T022L−S078N−G118R−S128D−T213A,S024R−S078G−G118S−P129E−S188D−Q245R−H249R,T022A−N076D−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101Q−S103A−V104I−Q109G−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T033S−G118R−S128I−A158E,T022A−S103A−L111V−L148I,T022A−N076D−A085T−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−A158E−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−T022L−S078N−S128D−T213A−L217E,T022A−T033S−P129E−S166D,T022A−S024G−N076D−G097A−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097A−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−S078N−S166D−T213A,T022A−S101Q−S103A−V104I−L124V−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248D,A158E−S166D−S188D,L021S−T022A−S024G−N076D−S101Q−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097A−S101N−S103A−V104I−L124V−S128A−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−N238Y−Q245R−N248D−A270V−E271F,T022A−T033S−N062E−N116L−S188D,T022A−S024G−S049N−N076D−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097S−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,G097P−A098Q−S099A−S103G−V104I,G020K−S024F−G118R−S128D−S166D,T022A−S024G−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−L124V−P129S−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−T033S−G118R−S166D,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−N238Y−Q245R−N248D−A270V−E271F,N062E−S078D−G118S−P129E−N248D−H249R,T022A−S024G−V026I−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G097P−A098Q−S099A−S101A,S078G−G118D−P129E−S188D−Q245R−H249
R,T022A−G097A−S101N−S103A−V104I−L126I−P129E−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−S024R−N062E−S078G−G118D−P129E−G159D−S188D−Q236R−Q245R−N248D,T022A−N076D−S078N−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F−A272V,T022A−N076D−N077D−S078N−G097S−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N043R−N076D−S101G−S103A−V104I−P129E−A158E−S188D−A232V−Q245R−N248D−A270V−E271F,S099G−S101A−G102A−S103A,A016S−T022A−S024F−S101G−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,T022A−S024G−G097A−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−S024R−S078D−G118S−P129E−Q245R,S056C,S024R−T033S−N062E−N116L,T022A−S024G−N076D−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T033S−S101G−S103A−V104I−N116L−S128N−Y209A−T213A−A232V,A098Q−S099A−G100S−S101G−V104I,T022A−S078N−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−Q245R−N248D−A270V−E271F−A272V,T022A−N076D−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−S101N−S103A−V104I−Q109N−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−L090I−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−N062E−S078G−G118D−P129E−G159D−S188D−N248D−H249R,A016S−T033S−S101G−S103A−V104I−N116L−S128N−Y209V−T213A−A232V,G020R−S078G−G118D−N248D−H249R,T022A−N062Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−N062E−N116L−A158E−S166D−S188D,T022A−S024G−N076D−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−A270V−E271F,T022A−N062Q−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S078N−G097A−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−I107V−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N116L−G118R,T022A−S024R−T033S−N062E−N116L−G118R−S128I−A158E−S188D,T022A−N076D−G097S−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,S024R−T033S−N062E−N116L−S128I−S188D,T022A−S024G−N076D−G097S−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,S240V,N062E−G118R,T022A−S1
01G−S103A−V104I−G159D−S188E−A232V−Q245T−N248E,S024R−N062E−S078G−G118D−P129E−S188D−Q245R−N248D,A016S−S103A−V104I,A088P,T022A−S101N−S103A−V104I−Q109N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L126I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G097P−A098F−V104L,T022A−G097S−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101N−S103A−V104I−Q109N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020K−T022L−S128D,T022A−S024G−S101G−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,G020R−S024R−N062E−S078D−G118D−P129E−G159D−S188D−N248D−H249R,S024F−S078N−G118R−L217E,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−A158E−G159E−S188D−A232V−Q245R−N248D−E271F−A272V,S024R−N062E−N116L−G118R−S128I−S188D,G118R−S128D−S166D−T213A,T022A−G097A−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−T033S−S101G−S103A−V104I−N116L−S128L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S078N−S101Q−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−G097S−S101N−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101N−S103A−V104I−Q109N−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−G097A−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−L126I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S078G−G118S−S188D−H249R,T022A−S024G−N076D−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101A−S103A,T022A−N076D−S101G−S103A−V104I−P129E−G159E−S188D−A232V−Q245R−N248D,S024R−S078D−G118D−S188D−N248D−H249R,S099A−V104I,T022A−G097S−S101Q−S103A−V104I−Q109N−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S024R−S078G−G118D−G159D−N248D,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−P129E−G159E−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−L124V−S128A−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−L124V−G159D−S188D−A232V−Q245R−N248D−E271F,S078G−G118D−P129E,S212W,T022A−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−A270V−E271F−A272V,T022A−S078N−S101Q−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,S101G−V104L,T022A−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−N238Y−Q245R−N248D−E271F,T022A−S024R−S101G−S103A−V104I−P129E−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024G−G097A−S101Q−S103A−V104I−Q109N−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024R−N076D−S101G−S103A−V104I−P129E−A158E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−T033S−S101G−S103A−V104I−N116L−N117S−Y209A−G211Q−T213A−A232V,S101G−S103A−V104I−N116L−G118V−Y209A−G211Q−A232V,T022A−N062E−S101N−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S024G−G097S−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271
F,S024F−T213A,T022A−S024G−N076D−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−S078D−G118S−P129E−G159D−Q245R−H249R,T022A−N076D−S101Q−S103A−V104I−Q109G−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S078N−G097A−S099G−S101G−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−S101G−S103A−V104I−G159D−S188D−L217Q−N218S−A232V−Q245R−N248D−E271F,T022A−S024G−N076D−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S101N−S103A−V104I−Q109N−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−S024R−S078D−G118D−Q245R,T022A−S078N−I079V−S101N−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N116L−G118R−S128I−A158E−S166D,S078G−G118D−S188D,G097P−A098Q−S099G−G102A,S099A−S103G,S078D−G118D−P129E−Q245R−N248D,T022A−S024G−S078N−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S078N−S101N−S103A−V104I−Q109G−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−N076D−S078N−G097S−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024R−N116L−S128I−A158E−S166D−S188D,A016S−T022A−S101A−S103G−V104I,T022A−G097S−S101N−S103A−V104I−S128A−G159D−R186H−S188D−A232V−Q245R−N248D−E271F,T022A−G097A−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S101N−S103A−V104I−L126I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101Q−S103A−V104I−L126I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N076D−G097S−S101N−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−N043R−N076D−S101G−S103A−V104I−P129E−S188D−A232V−Q245R−N248D−E271F−A272V,T022A−S024R−T033S−N062E−N116L−S128I−S188D,T022A−S024G−S078N−G097S−S101G−S103A−V104I−S128A−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022L−S078N−G118R−S128D−T213A,T022A−N076D−G097A−A098T−S101Q−S103A−V104I−G159D−S188D−L217Q−A232V−Q245R−N248D−E271F,T022A−S024G−S078N−G097A−S101Q−S103A−V104I−S128A−G159D−S188D−A232V−Q245R−N248D−E271F,S103A−V104L,G020R−S024R−S078D−G118D−P129E−Q245R−H249R,S024R−S078G−G118D−P129E−G159D−S188D−N248D,T022A−S024R−N0
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G020K−N123G,G020K−S128Q−T213A−M222S,S078N−L217E,G020K−N062E−S128I−L217N,G020K−N062E−S078N−S128Q−L217N,G097S−S101N−Q109G−S128A−S188D−M222S,G020K−S024G−N062E−S101Q−Q109N−N116L−S188D,G020K−N062E−S078N−N116L−S128I−L217N,S024G−S078N−G097A−S101N−Q109G−S188D,S024G−G097A−S101Q−Q109N−L217Q,G020K−S101D−S128L,S101N−Q109G−S128A,S078N−S101D−L217E,S024G−S078N−S101N−S128A−M222S,G020K−S024G−N062E−G097A−S101Q−N116L−S128A−S188D,S024G−S078N−G097A−S101N−Q109N−S128A−M222S,G020K−N062E−S078N−G097A−S101N−N116L−S128A−S188D−L217Q,G020K−S024G−N062E−S078N−G097S−S101Q−N116L−S188D,G020K−N062E−S078N−G097S−S101G−N116L−M222S,G020K−S024G−N062E−S078N−S101N−N116L−M222S,G020K−S024G−N062E−G097S−S101Q−N116L,G020K−S024G−N062E−S101Q−Q109G−N116L−S128A−S188D,G020K−S024G−N062E−G097S−S101N−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S078N−G097S−S101N−N116L,S024G−S078N−S101G−Q109G−M222S,S078N−G097A−S101G−Q109G−S128A,S078N−G097S−S101N−Q109N−S128A,S078N−G097A−S101N−Q109N−S188D,S024G−S101N−S128A−S188D−M222S,S101Q−Q109N−S188D−M222S,S101D−G102A−L217E,G020K−N062E−S078N−S101D−L217E,G020K−S078N−S101D−I107T−S128L−S240R,G020K−S078N−G100S−L217E−N218D,G020K−N043R−S101D,N043R−G100S−S128L−L217E,G020K−S078N−S101D−S128L−L217E−E271L,G020K−S101D−S128L−E271L,G020K−S101D−N116L−S128L−T213A,G020K−N062E−S078N−T213A−L217N,G020K−N062E−N116L−L217N,G020K−N062E−S128I−T213A,N062E−S101D−S128L−S240R,G097S−S101N−S128A,G020K−N062E−S078N−N116L−T213A−L217N,G020K−S101D−M222S,S024G−S101G−Q109G,G097A−S101Q−Q109G,G097S−S101Q−Q109N−S188D,G020K−N062E−G097S−S101N−N116L−S128A−S188D−L217Q,S078N−S101Q−S128A−M222S,S078N−G097A−S101Q−Q109N,S024G−S078N−G097A−S101Q−S128A−S188D,S078N−S101D−G102A,G020K−N062E−S078N−G097S−S101Q−Q109G−N116L−S128A−S188D−M222S,G020K−S024G−N062E−S078N−G097S−S101N−Q109N−N116L−S188D−L217Q−M222S,G020K−N062E−G097S−S101Q−N116L−S128A,G020K−S024G−N062E−G097S−S101Q−N116L−S128A−S188D−L217Q,S024G−S101N−Q109N−S128A,S024G−G097S−S101Q−S128A−S188D,S024G−S101Q−L217Q,G097S−S101G−S128A,S024G−S078N−S101Q−S128A−L217Q,S024G−S078N−G097S−S101N−S188D,S024G−G097A−S101N−S128A−M222S,G097A−S101Q−Q109N−S188D−M222S,S024G−S078N−G097S−S101Q,G020K−S101D−S128L−S212P−L217E−S240R,G020K−S101D−S128L−L217E−N218S−S240R,S101D−S128Q,G020K−N062E−S078N−E271L,S101D−E271L,S101D−S240R−E271L,G020K−S101D−E271L,G020K−N116L−S128L−T213A−M222S,G020K−N116L−S128Q−M222S,G020K−N062E−V084A−S128Q−M222S,G020K−N062E−S078N−N116L,S078N−S101N−Q109G−S128A−M222S,S024G−G097S−S101Q−Q109G,G020K−N062E−T213A−L217N,G097S−S101G−S128A−S188D,G020K−S240R,N062E−S078N,G020K−S128Q−M222S,S078N−G097S−S101G−Q109G,G020R−S024G−N043R−S078N−S101Q,G097S−S101N−Q109G−S128A−M222S,S024G−G097S−S101G−Q109N,S024G−S078N−G097A−S101G−Q109N,G020K−N062E−S078N−S101N−N116L−S128A−S188D−L217Q,G020K−N062E−S101Q−Q109G−N116L−S128A−M222S,G020K−S024G−N062E−S101Q−Q109N−N116L,S024G−S078N−S101Q−M222S,S024G−G097A−S101Q−Q109G−S128A,S101Q−Q109N−L217Q,S101Q−Q109G−S188D−L217Q,S024G−G097A−S101N−S188D−M222S,S024G−S078N−G097A−S101Q−Q109N,G097A−S101Q−S128A,G097A−S101Q−Q109G−S128A,S024G−G097S−S1
01Q−M222S,S078N−S101D−L217E−S240R,G020K−G100S−S128L,G020K−N043R−S078N−S128L−S240R,G020K−N043R−S101D−S240R,G020K−N043R−S078N−S128L,N062E−S128L,G020K−S078N−S101D−S128L,S078N−S101D,G020K−S101D−N116L−T213A−M222S,G020K−T213A−M222S,G020K−N116L−T213A,G020K−N116L,G020K−N062E−S128Q−L217N,S078N−G097S−S101G−Q109N−S128A,S078N−S101Q−Q109G,N062E−S078N−S128L,G020K−N062E−N116L−S128Q−T213A−L217N,G020K−N116L−T213A−M222S,G020K−S024G−N062E−S101Q−Q109H−N116L−M222S,G020K−N116L−S128Q−T213A−M222S,S024G−G097S−S101N,G020K−P055T−N062E−N116L−L217N,S024G−S101Q−S128A−S188D−M222S,G020K−M222S,G020K−N062E−S078N−G097A−S101N−N116L−S188D−L217Q,G097S−S101G−Q109N−M222S,G020K−S024G−N062E−S078N−G097A−S101N−N116L−S128A−L217Q−M222S,G020K−S024G−N062E−G097S−S101N−Q109N−N116L−S128A−S188D−L217Q−M222S,G020K−N062E−S078N−S101Q−N116L−S128A,S024G−S078N−S101N−Q109G−S188D−L217Q−M222S,S101N−Q109N−S128A−M222S,S101Q−Q109G−S128A−S188D,G097A−S101G−S188D−M222S,S078N−G097S−S101N−Q109G−S128A−S188D−L217Q−M222S,S024G−G097A−S101Q−M222S,S024G−G097S−S101N−Q109N−S128A−M222S,S024G−S078N−G097S−S101N−M222S,G020K−G102A−S240R,S078N−S128Q−E271L,G020K−N062E−S078N−S128Q,G020K−N062E−S078N−T213A−M222S,G020K−N062E−S078N−S128I−T213A−L217N,S078N−G097A−S101N,G020K−N062E−N116L−S128I−T213A−L217N,S024G−G097A−S101Q−S128A−S188D−M222S,S024G−S078N−G097A−S101N,S024G−S078N−G097S−S101G−M222S,G020K−N062E−S078N−N116L−S128Q−T213A−M222S,G020K−N062E−S128Q−M222S,G020K−N062E−S101Q−N116L,G020K−N062E−S101Q−Q109G−N116L−S188D−L217Q,G020K−S024G−N062E−G097A−S101N−N116L−S128A−S188D,G020K−S024G−N062E−S078N−S101Q−Q109G−N116L−S188D−M222S,S078N−G097S−S101N−Q109G−S128A−L217Q−M222S,S024G−S078N−S101N−Q109G−S128A−L217Q−M222S,G097A−S101Q−S128A−S188D,S024G−S078N−G097A−S101N−Q109N−S128A−S188D−L217Q−M222S,S024G−S078N−G097A−S101G−L217E−M222S,S078N−G097S−S101Q−Q109G−T274I,G097A−S101G−M222S,S101N−Q109N,G020K−L217E−S240R−E271L,S128Q−S240R−E271L,G020K−S101D−N116L−S128Q−M222S,G020K−P055L−N062E−N116L−S128I,G020K−N062E−S101G−N116L−S128A−M222S,G020K−S078N−S101D−S128L−S240R−E271L,G020K−N062E−S078N−G097S−S101Q−Q109N−N116L−L217Q−M222S,S078N−S101D−S240R−E271L,S024G−S078N−S101N−Q109G−L217Q−M222S,G097A−S101G−Q109G−L217Q−M222S,G020K−S024G−N062E−S078N−G0
97S−S101N−N116L−S128A−L217Q−M222S,G020K−S078N−S128L−E271L,G020K−N062E−S078N−N116L−L217N,G097A−S101G−Q109G−S188D−L217Q−M222S,S024G−S078N−G097S−S101N−Q109G−S128A,G020K−S024G−N062E−S078N−G097S−S101N−N116L−S188D−M222S,G020K−S024G−N062E−G097S−S101Q−N116L−S128A−M222S,G020K−N062E−S078N−G097A−S101G−Q109G−N116L−S128A−S188D−L217Q,G020K−N062E−S101G−N116L−S128A−L217Q−M222S,S024G−G097A−S101Q−S188D−M222S,S024G−S101G,I072V−S101Q−S128A,S078N−G097S−S101N−Q109N,S024G−G097A−S101N−Q109N−S188D−L217Q−M222S,S078N−S101Q−Q109N−S188D−L217Q−M222S,G020K−N043R−N062E−S128L−L217E,N043R−G102A−S128L−S240R,G020K−N116L−N123G−T213A−M222S,G020K−S101D−S128Q−T213A−M222S,S024G−G097A−S101Q−Q109G,G020K−S078N,G020K−N062E−S101Q−N116L−S188D,G020K−N062E−S078N−G097S−S101N−Q109G−N116L−S188D−L217Q−M222S,G020K−S024G−N062E−G097S−S101G−N116L−S128A−L217Q−M222S,G020K−N062E−G097A−S101N−N116L−S128A−L217Q−M222S,S078N−G097S−S101G−Q109N−M222S,S024G−G097A−S101Q−Q109N,S024G−G097S−S101N−Q109N−S128A−S188D−L217Q−M222S,S078N−S101N−Q109N−S188D−L217Q−M222S,S078N−S101D−S128L−L217E−S240R,G020K−N062E−S101D−N116L−S128L,G097S−S101N−S188D−M222S,G020K−S078N−S128L−S240R−E271L,G020K−N062E−N116L−S128I−T213A,G020K−S024G−N062E−S078N−G097S−S101Q−N116L−S188D−M222S,G020K−N062E−S101Q−Q109G−N116L−L217Q−M222S,G020K−S024G−N062E−G097A−S101Q−N116L−L217Q−M222S,G020K−N062E−S078N−G097S−S101Q−N116L−S128A−S188D−M222S−A232T,G020K−S024G−N062E−S078N−G097S−S101Q−Q109N−N116L−S128A−L217Q−M222S,G020K−N062E−G097A−S101Q−N116L−S188D−M222S,S024G−S078N−G097S−S101N−Q109G−S128A−L217Q−M222S,S024G−G097A−S101Q−Q109N−S128A−S188D−L217Q−M222S,G020K−N043R,G020K−N043R−S078N−G102A−S128L,G097R−S101D,G020K−N062E−S078N−I107V−N123G−S128I,G020K−N062E−S078N−N116L−N123G−T213A,G020K−N062E−N116L−S128I−M222S,G020K−N043R−S240R、前記サブチリシン変異体のアミノ酸位置は、配列番号1で示されるバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされ、好ましくは前記変異体が次から選択されるアミノ酸置換の組み合わせを含み:S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−V104I−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D,S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−S188D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−N248D−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−E271F,T022A−S101G−S103A−V104I−N116L−G159D−S188D−A232V−Q245R−N248D−E271F,G020R−N062E−S078G−G118S−S188D−N248D−H249R,S024R−N062E−G118R−A158E−S188D,T022A−S024R−T033S−G118R−S166D−S188D,S024R−N062E−S078G−G118S−S188D−Q245R−N248D,G020R−S024R−N062E−S078D−G118S−P129E−G159D,G020R−S024R−N062E−S078G−G118D−P129E,G020R−S024R−N062E−S078G−G118S−P129E−G159D−S188D−Q245R−N248D,G020R−N062E−S078G−G118S−G159D−Q245R−N248D,S024R−N116L−A158E−S166D,G020R−N062E
−S078G−G118S−G159D−S188D−H249R,G020R−S024R−S078G−G118D−P129E−G159D−S188D,S024R−G118R−S166D,T022A−S024R−T033S−G118R−A158E−S166D−A273V,G020R−N062E−S078G−G118S−P129E−G159D−S188D−Q245R,T022A−G118R−A158E−S166D,G020R−S024R−N062E−S078D−G118S−G159D−S188D−Q245R−N248D,T022A−S024R−G118R−S166D−S188D,N062E−S078G−G118S−G159D,T022A−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271H,G020R−S024R−N062E−S078G−G118D−Q245R−N248D,S024R−T033S−N116L−A158E−S166D,S024R−N062E−S078G−G118D−P129E−G159D−Q245R,G020R−N062E−S078D−G118S−Q245R,T022A−S024R−N062E−N116L−A158E,G020R−N062E−S078G−G118D−P129E,S024R−T033S−N062E−N116L−G118R−S188D,G020R−N062E−S078G−G118D−P129E−G159D−S188D−H249R,S024R−S078G−G118S−P129E−G159D−Q245R−N248D,G020R−N062E−S078G−G118D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232L−Q245T−N248D−E271T,S078G−G118S−P129E−G159D−S188D−Q245R−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245T−N248H−E271T,G020R−S024R−S078D−G118S−G159D−S188D−H249R,G020R−S078D−G118S−P129E−G159D−Q245R−N248D−H249R,S024R−N062E−N116L−G118R,T022A−S024R−N116L−G118R−A158E−S188D,S024R−N062E−S078G−G118S−P129E−Q245R,S024R−N062E−G118R−A158E,G020R−N062E−S078G−G118S−G159D−S188D,G020R−S024R−S078D−G118S−G159D−S188D−Q245R−N248D−H249R,S024R−S078D−G118S−P129E−G159D−Q245R,A098Q−S099T−G102A−S103G,T022A−G118R−S166D−S188D,S024R−S078D−G118S−G159D−S188D−H249R,T022A−S024R−N116L−G118R−S166D−S188D,T022A−N062E−G118R−A158E,G020R−S078G−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118D−G159D−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271F,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271F,G020R−N062E−S078G−G118S−P129E−N248D−H249R,S024R−N116L−G118R−S128I−S166D−S188D,G020R−S024R−N062E−S078G−G118D−P129E−G159D−S188D−H249R,G020R−S024R−N062E−S078G−G118D−G159D−S188D−N248D,G020R−S024R−S078G−G118D−P129E−S188D−Q245R−N248D,S024R−N062E−S078D−G118S−S188D−H249R,T033S−N062E−G118R,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245T−N248E−E271H,T033S−G118R−A158E−S166D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248H,G020R−S024R−S078D−G118D−S188D−Q245R−N248D−H249R,T022A−S024R−N062E,G020R−S024R−N062E−S078D−G118D−G159D−S188D−R247L,T022Q−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248E−E271T,G020R−N062E−S078G−G118S−P129E−G159D−Q245R−N248D,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248H,P014S−G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248E−E271L,G020R−S078D−G118D−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248D−E271T,T022A−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248E−E271L,S024R−N062E−S078D−G118S−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232L−Q245R−N248E
−E271H,G020R−S078D−G118S−P129E−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232S−Q245R−N248H−E271F,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248H−E271H,S024F−T033S−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,S024F−S101G−S103A−V104I−N116L−S128N−Y209V−G211Q−T213A−A232V,S024R−S078G−G118S−G159D−S188D−Q245R−N248D,G020R−S024R−S078G−G118S−S188D−Q245R,G020R−S024R−N062E−S078D−G118D−P129E−G159D−Q245R,S024R−S078D−G118D−G159D−S188D−H249R,G020R−S078G−G118S−G159D−S188D−H249R,G020R−S024R−N062E−S078G−G118S−S188D−N248D,S078D−G118S−G159D−Q245R,G020R−S024R−N062E−S078G−G118D−P129E−G159D−N248D−H249R,S024R−N062E−S078G−G118S−P129E−Q245R−N248D,G020R−S078G−G118S−P129E−S188D−Q245R−N248D,S024R−N062E−S078G−G118S−G159D−Q245R,G020R−N062E−S078D−G118D−P129E−Q245R,T022A−S101G−S103A−V104I−G159D−S188E−P210L−A232T−Q245T−N248D−E271T,G020R−S024R−N062E−S078G−G118S−P129E,G020R−S024R−N062E−S078G−G118D−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245V−N248D−E271L,A016S−T022A−S101G−S103A−V104I−N116L−S128N−Y209V−A232V,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245T−N248H−E271H,G020R−N062E−S078G−G118D−P129E−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232L−Q245R−N248E,G020R−S024R−S078G−G118D−G159D−S188D−Q245R,S024R−N062E−S078G−G118S−G159D−Q245R−N248D,G020R−S078G−G118S−G159D−S188D−Q245R,S024R−N062E−S078G−G118S−G159D−S188D,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245R−N248H−E271H,G020R−S024R−N062E−S078G−G118D−G159D,T022A−S101G−S103A−V104I−G159D−S188D−A232T−V244A−Q245R−N248H−E271H,S024R−S078G−G118S−P129E−G159D−S188D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248D−E271F,G020R−S024R−N062E−S078G−G118D−G159D−S188D−Q245R,T022A−S024R−N062E−S128I−A158E,G020R−S024R−S078G−G118D−N248D−H249R,S024R−S078G−G118D−P129E−Q245R−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q236K−Q245T−N248E,N062E−S078G−G118S−G159D−Q245R−N248D,T033S−G118R−S166D,G020R−S024R−S078G−G118D−P129E−S188D−N248D,G020R−S078G−G118S−P129E−G159D−S188D−Q245R−N248D,A016S−T022A−S101G−S103A−V104I−L111V,T022Q−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248E−E271H,S024R−N116L−G118R−S128I−A158E−S188D−V199I,G020R−S024R−S078D−G118D−G159D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232S−Q245R−N248E−E271T,G020R−S024R−S078D−G118S−S188D−N248D−H249R,T022A−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271T,G020R−S024R−S078G−G118D−P129E−S188D−H249R,S024R−N062E−S078G−G118S−S188D−N248D,T022A−S101G−S103A−V104I−N116L−S128N−Y209A−G211Q−T213A−A232V,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271L,S024R−A048V−S078G−G118D−G159D−S188D−H249R,G020R−S024R−N062E−S078D−G118D,G102A−S103G−V104I,G020R−S024R−S078D−G118D−G159D−Q245R−N248D−H249R,T022A−T033S−G118R−A158E,T022A−S024R−N116L−S128I−S188D,G020R−S024R−S078D−G118D−P129E−G159D−Q245R−N248D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232T−Q245T−N248E−E271F,S024R−N062E−S078G−G118S−S188D−Q245R,S024R−N062E−S078G−G118D−G159D,G020R−S024R−N062E−S078D−G118S−P129E−G159D−Q245R,T022Q−S101G−S103A−V104I−G159D−S188E−A232S−Q245V−N248E−E271T,G020R−S078G−G118D−S188D−N248D−H249R,T022A−S024R−N062E−N116L−G118R−A158E−S166D−S188D,S078G−G118S−G159D−S188D−H249R,T022Q−S101G−S103A−V104I−G159D−S188E−A232T−Q245V−N248H−E271F,G020R−S078G−G118S−P129E−G159D−S240F−N248D−H249R,S024F−T033S−S101G−S103A−V104I−N116A−Y209A−G211Q−T213A−A232V,N062E−S078D−G118S−S188D−H249R,T022A−S101G−S103A−V104I−G159D−S188E−A232V−Q245V−N248D−E271T,G020R−S078G−G118S−G159D−S188D−Q245R−N248D,T022Q−S101G−S103A−V104I−G159D−S188D−A232T−Q245R−N248D−E271F,S024R−S078G−G118D−G159D−S188D−Q245R−N248D−H249R,G020R−S024R−N062E−S078D−G118D−Q245R,S024R−S078G−G118D−P129E−S188D−Q245R,N062E−S078G−G118S−S188D−Q245R−N248D−H249R,S024R
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232V,A088L,E271W,N062E−S078D−G118D−P129E−H249R,T022A−V104I−S128N−L148I,T022Q−S101G−S103A−V104I−G159D−S188E−A230V−A232V−Q2
45R−N248H,S101G−S103A−V104I−N116L−G118V−Y209A−T213A−A232V,S024R−S078G−G118D−G159D−Q245R−H249R,G097P−A098F−S099A−V104I,T022L−S024F−S078N−G118R−S166D−T213A,N062E−S078G−G118D−S188D−Q245R−N248D,T022A−S024R−T033S−S166D−S188D,T022A−T033S−R045C−G
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1G−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,A016S−T022A−S024F−S101G−S103A−V104I−N116A−Y209A−T213A−A232V,T022A−S101G−S103
A−V104I−G159D−S188D−T213A−A232V−Q245R−N248D−E271F,A016S−S101G−S103A−V104I−N116L−Y209A−T213A−A232V,G020R−S078D−G118S−S188D,G020R−S078D−G118S−P129E−Q245R−N248D,T022L−S166D−T213A,G020R−S024R−S078D−G118S−P129E−G159D−S188D−N248D,S240G,S078G−G118S−P129E−Q245R−N248D,S024R−S078D−G118D−P129E−G159D−Q245R−N248D,S024R−S078G−G118S
−G159D,T022A−S024R−N076D−S101G−S103A−V104I−G159D−S188D−A232V−Q245R−N248D−E271F−A272V,N062E−S078G−G118S−P129E−S188D−Q245R−N248D−H249R,S024F−S078N−G118R−S166D,S078G−G118S−P129E−N248D,N155W,A016S−S024F−S101G−S103A−V104I−N116A−S128N−Y209V−G211Q−T213A−A232V,G020R−N062E−S078D−G118D−P129E−Q245R−N248D,G020R−S078D−G118D−P129E−S188D−Q236R−N248D−H249R,T022A−S024R−N116L−A158E−S188D,S101G−S103A−V104I−N116A−S128N−Y209V−G211Q−T213A−A232V,S078D−G118S−S188D−Q245R−N248D,T022L−S024F−S078N−L217E,S099A−S101A−G102A,G020R−S078D−G118D−G159D−N248D−H249R,T022A−N076D−S101G−S103A−V104I−I107V−P129E−G159D−S188D−A232V−Q245R−N248D−E271F,T033S−N116L−G118R−S166D−S188D,S024R−G118R−S128I−A158E−S166D−S188D,G020R−S024R−N062E−S078G−G118S−P129E−G159D−Q245R−N248D−H249R,N062E−S078G−G118D−N248D−H249R,N062E−S078R−P129E−S188D−Q245R−N248D,S024R−N062E−G159D−S188D−Q245R,G020R−N062E−G118R−S188D−N248D−H249R,N062E−S078R−P129E−G159D,G020R−S024R−N062E−P129E−S188D−N248D,N062E−S078R−G118R−G159D−S188D−P210L−N248D,N062E−S078R−Q245R−N248D,G020R−G159D−S188D−H249R,G020R−G118R−G159D−S188D−N248D,G118R−P129E−G159D−S188D−H249R,N062E−S078R−G118R−P129E−N248D,N062E−S078R−G159D,N062E−G118R−P129E−S188D−Q245R,G020R−S024R−P129E−G159D−S188D−N248D,S024R−N062E−S078R−G159D−N248D,G020R−P129E−S188D−H249R,G020R−P129E−G159D−S188D−Q245R,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S188D−Y209V−T213A−A232V,G020R−G159D−S188D−Q245R−N248D,G118R−P129E−G159D−Q245R−N248D,G020R−N062E−S078R−P129E−S188D−N248D,G020R−P129E−S188D−Q245R,S024R−N062E−S188D−N248D,S078R−L111I−N185I−I198L−L217E,G020R−P129E−S188D−N248D−H249R,G020R−N062E−G118R−G159D−N248D,G020K−T022L−G118R−P129E−S188D,G020R−G118R−P129E−S188D,G020R−P129E−G159D−Q245R−N248D,G020R−S024R−P129E−G159D,G020R−P129E−G159D−Q245R−N248D−H249R,S024R−P129E−G159D−S188D−Q245R−N248D−H249R,G020R−P129E−Q245R−N248D,N062E−S078R−G159D−N248D,S024R−G118R−P129E−G159D−S188D−Q245R−N248D−H249R,G020R−G061W−P129E−G159D−S188D−Q245R,T022A−S101G−S103A−V104I−G159D−S188D−M222S−A232V−Q245R−N248D−A270V−E271F,N062E−G159D−S188D−H249R,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S130D−Y209V−T213A−A232V,G020R−S024R−P129E−G159D−N248D−H249R,P129E−G159D−S188D−H249R,G118R−P129E−G159D−S188D−K237R−N248D−H249R,G020R−G159D−S188D−Q245R,G020R−S188D−Q245R−N248D−H249R,T022A−S101G−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S078R−G118R−P129E−S188D−N248D,G020R−S024R−G118R−G159D−S188D−Q245R−N248D,G020R−G118R−P129E−G159D−S188D,G020R−G159D−S188D,G020R−G118R−P129E−S188D−N248D,A016S−S024R−S101G−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,G020K−N062E−S188D−T213A−M222S,A016S−S024F−S101D−S103A−V104I−N116A−S128N−Y209V−T213A−A232V,S024G−S078N−S101N−Q109G−S128A−L217Q,T022A−G097S−S101N−S103A−V104I−S128A−G159D−S188D−L217Q−M222S−A232V−Q245R−N248D−E271F,T022A−S101G−S103A−V104I−G159D−S188D−M222S−A232V−Q245R−N248D−E271F,G020R−P129E−Q245R,S024R−P129E−G159D−Q245R−N248D,S024R−G118R−S188D−N248D,G020R−P129E−H249R,S024R−P129E−Q245R−N248D,T022A−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−S078R−P129E−G159D−S188D−H249R,T022A−S101G−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,G118R−P129E−H249R,G020R−N062E−G118R,G020R−G118R−P129E−G159D−Q245R−N248D,T022A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,S024R−S078R−G118R−P129E−G159D−S188D,P129E−Q245R−N248D−H249R,S024G−G061S−S078N−S101N−Q109G−S128A−L217Q−N243V,S078R−V084A−P129E−Q245R,S024R−G118R−G159D−S188D−N248D,G020R−G118R−P129E−G159D−H249R,S078R−P129E−G159D,G061P−S078N−G097A−S101N−S128A−V203Y−L217Q,P086S−S087G−A088V−G097A−N117S−S128A−L217Q,S024R−S078R−G159D−S188D−Q245R−N248D−H249R,S078R−G118R−P129E,S024G−S078N−S101N−S128A−L217Q−N243V,S024R−S078R−G159D−S188D,G020R−G118R−P129E,G020R−S024R−P129E−G159D−S188D−H249R,S024R−G118R−G159D−S188D,S024R−G118R−P129E−G159D−S188D−Q245R−N248D,S024G−S078N−S101N−S128A−L217Q,S024R−G159D−S188D−Q245R,S024G−S078N−S101N−Q109G−L217Q−N243V−N248A,G020R−S078R−G159D−S188D−Q245R−N248D,S078R−G118R−P129E−S188D−N248D,S024R−S188D−Q245R−N248D,G020R−S024R−S101A−P210I−G211Q,G020R−G159D−N248D−H249R,G020R−P129E,G020K−N062E−N116L−T213A−M222S,S024G−S078N−A088T−S101N−Q109G−N116T−S128A−A158S−L217Q−N218S−L257G,A016S−S024F−S101G−S103A−V104I−N116A−S128N−S166D−Y209V−T213A−A232V,S024R−N062E−S078R−P129E−H249R,N018K−G020R−S024R−R045T−S101A−P210I−G211Q−T213A,G020R−S024R−G118R−P129E−G159D−S188D−N248D−H249R,G020R−S024R−P129E−H249R,G020R−G118R−S188D−Q245R−N248D−H249R,G020R−S024R−N062E−S078G−G118S−Q245R,G020R−S024R−G118R−P129E−G159D−N248D,S024G−S078N−S101N−Q109G−S128A−L217Q−S256R,S024G−S078N−S101N−S128A−A158S−L217Q−L257G,G020R−S024R−G118R−S188D−N248D,G020R−G118R−G159D−S188D−Q245R−N248D−H249R,G159D−S188D−Q245R−N248D,S078N−G118R−S166D−L217E−M222S,G020R−G118R−P129E−G159D−Q245R−N248D−H249R,T022A−S101Q−S103A−V104I−L124V−S128A−P129S−A232V−Q245R,S024R−N062E−Q245R,S188D−Q245R−N248D,S024R−G118R−P129E−S188D−H249R,T022A−G097A−S101Q−S103A−V104I−P129S−A232V−Q245R,G020R−G118R−S188D−Q245R−N248D,S024G−S078N−S101N−Q109G−N116T−S128A−L217Q−N243V−S256R,G020R−G118R,G020R−S024R−S188D,N062E−P129E−G159D−S188D−Q245R,G020R−G159D−Q245R−N248D,G020R−N043R−S101A−P210I−G211Q,G097A−S101N−S128A−L217Q,G020R−G118R−S188D−N248D,S024R−S188D−N248D,G020R−S024R−S188D−Q245R−N248D,G020R−S024R−G118R−P129E−G159D−N248D−H249R,G020R−P129E−N248D,G159D−S188D,P129E−G1
59D,G020R−S188D−H249R,P129E−G159D−Q245R−N248D,G020R−G118R−G159D−N248D−H249R,G118R−S188D−N248D−H249R,G020K−S101D−G102A−L217E−S240R,N043R−G102A−L217E,N062E−S078N−S101D−S240R,G102A−L217E,G020K−S128L−L217E−S240R,G020K−N062E−S078N−L217E−S240R,N043R−S101D−S128L−L217E−S240R,G020K−S078N−S101D−G102A−P210L,N043R−S101D−L217E,G020K−G100S−L217E−S240R,S078N−G100S,G020K−N043R−S101D−G102A−L217E,G100S−S240R,G020K−G102A−L217E,G020K−S024G−N062E−S078N−S101N−Q109N−N116L−S128A−S188D,G020K−L217E−S240R,N043R−S101D,N043R−S078N−S101D−S128L−S240R,N043R−S078N−S101D−L217E−S240R,G020K−S078N−S101D,N043R−S128L−S240R,G020K−N062E−N116L−N123G−T213A,G020K−N062E−G097S−S101G−Q109G−N116L−S128A,G020K−N062E−S078N−G097A−S101N−Q109N−N116L−S188D,N043R−S078N−S101D−G102A−L217E,G020K−S078N−S099G−S128L−L217E,G020K−N062E−S101D,G020K−S128L−L217E,G020K−S024G−N062E−S078N−G097S−S101G−Q109G−N116L−L217Q,N043R−G097A−S101D−S128L,G020K−S024G−N062E−S101Q−Q109N−N116L−S128A,G020K−S024G−N062E−S078N−S101N−N116L−S128A−L217Q,S078N−G102A−S240R,N043R−S078N−G100S−L217E−S240R,G020K−S078N−S128L−L217E−S240R,G020K−N062E−N116L−S128Q,G020K−S101G−L217E−S240R,G020K−S024G−N062E−S101N−Q109G−N116L−S128A−L217Q,G020K−N062E−S078N−G097S−S101N−N116L−L217Q,G020K−N062E−G097S−S101N−Q109G−N116L−L217Q,G020K−S024G−N062E−S078N−G097A−S101Q−Q109N−N116L−M222S,G020K−S024G−N062E−S078N−G097S−S101Q−Q109N−N116L−S128A−S188D−L217Q,G020K−N062E−S078N−S101N−Q109G−N116L−S188D−L217Q,又はG020K−N062E−S105G−N116L−S128L−T213A、サブチリシン変異体のアミノ酸位置が配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、クリーニング及び/又は処理組成物。 - 助剤と、単離されたサブチリシン変異体と、を含むクリーニング及び/又は処理組成物であって、前記サブチリシン変異体が、タンパク質分解活性を有する成熟型であり、かつ次から選択される位置にアミノ酸置換の組み合わせを含むアミノ酸配列を含み:G020R−T022W−S024R−R045T−S101A−N204S−G211Q,T022W−S024R−S101A−P210I−T213A,G020R−S101A−G211Q,G020R−S024R−S101A−P210I−G211Q−T213A,G020R−S101A−P210I−T213A,T022W−S024R−N043R−S101A−P210I,G020R−S024R−N043R−R045T−S101A−G211Q,T022R−S101T−S103N−V104L−A232M−Q245R,G020R−T022A−S024R−R045T−S101A−T213A,T022R−S101G−S103N−V104I−A232M−Q245R,G020R−T022W−S024R−S101A−N116L−G211Q−T213A,G020R−T022W−N043R−S101A−N116L−G211Q,G020R−T022W−N043R−R045T−S101A,T022W−N043R−R045T−S101A−P210I−T213A,G020R−S024R−R045T−S101A−Q109R−P210I−G211Q−T213A,S024R−N043K−S101A−N204D−P210I,G020R−S024R−R045T−S101A−P210I,S024R−N043R−R045T−S101A−P210I−T213A,G020R−S024R−R045T−S101A−T213A,T022R−S101A−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−R045T−S101A−N204S−P210I−G211Q,T022W−N043R−S101A−P210I−G211Q,G020R−S024R−N043K−R045T−S101A−N116L−P210I,T022A−S101G−S103A−V104I−I107V−L217Q−A232V−Q245R,S024R−N043R−R045T−S101A−G211Q−T213A,T022R−S101A−S103G−V104I−A232M−Q245R,T022R−S101G−S103N−V104L−A232V−Q245R,S024R−S078G−G118S−Q245R−N248D−H249R,S024R−N043R−S101A−P210I−T213A,T022K−S101N−S103A−V104I−A232T−Q245R,G020R−N043R−S101A−P210I−G211Q,T022R−S101T−S103A−V104I−A232M−Q245R,S024R−V026A−N043R−S101A−P210I−G211Q,T022A−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101T−S103G−V104I−A232L−Q2
45R,G020R−T022W−S024R−N043R−R045T−S101A−G211Q,G020R−S024R−S078G−G118D−Q245R,T022A−S101N−S103A−V104I−S128A−P129S−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−T022W−N043R−S101A−G211Q−T213A,N018K−G020R−S024R−R045T−S101A−P210I−G211Q−T213A,G020R−T022W−S024R−N043R−R045T−S101A,T022R−S101N−S103A−V104L−A232T−Q245R,G020R−S024R−S101A−T213A,T022R−S101N−S103G−V104I−A232V−Q245R,G020R−T022W−S024R−S101A−G211Q−T213A,T022A−S024G−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,S024R−S078G−G118D−P129E−Q245R−H249R,T022R−S101T−S103A−V104L−A232L−Q245R,G020R−S024R−S101A−G211Q−T213A,T022A−S024G−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−T022W−N043R−V051A−S101A−P210I−G211Q,S024R−S078G−G118D−Q245R,N043R−S101A−P210I,T022Y−S101G−S103N−V104I−A232L−Q245R,G020R−T022W−N043R−S101A−T213A,G020R−S024R−S078D−G118S−S188D−Q245R−H249R,T022Y−S101N−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−F050L−S101A−G211Q−T213A,N018S−T022W−S024R−N043R−S101A−G211Q,T022A−S101G−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,T022R−S101N−S103N−V104I−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,S101A−P210I−G211Q−T213A,G020R−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101A−S103N−V104I−A232M−Q245S,G020R−T022W−N043R−R045T−S101A−G211Q,G020R−T022W−N043R−R045T−S101A−N116L−P210I,G020R−S024R−S078D−G118S−Q245R,G020R−T022W−S024R−N043R−S101A−P210I−G211Q−T213A,G020R−S024R−N043R−R045T−V051A−S101A−P210I−G211Q,T022A−S101G−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S078G−G118D−Q245R−N248D−H249R,T022K−S101A−S103N−V104L−A232T−Q245R,T022A−N076D−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,S024R−N043R−R045T−S101A−P210I,T022A−S024G−G061R−S078N−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Q−S101T−S103A−V104L−A232V−Q245R,G020R−T022W−S024R−R045T−S101A−G211Q,P014R,T022R−S101A−S103N−V104L−A232M−Q245R,T022K−S101G−S103N−V104I−A232V−Q245R,G020R−S024R−S078D−G118D−Q245R,T022A−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S101A−P210I−T213A,T022K−S101N−S103N−V104I−A232V−Q245R,T022Y−S101T−S103A−V104I−A232L−Q245R,T022A−N076D−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−N043R−R045T−S101A−P210I−G211Q−T213A,G020R−R045T−S101A−P210I−T213A,G020R−S078D−G118S−Q245R−H249R,G020R−T022W−R045T−V051A−S101A,T022R−S101T−S103A−V104I−A232V−Q245R,N043R−S101A,G020R−S024R−N043R−R045T−S101A−G211Q−T213A,T022R−S101G−S103G−V104I−A232L−Q245R,G020R−S101A−P210I,T022K−S101T−S103N−V104I−A232V−Q245R,G020R−T022W−N043R−V051A−S101A,G020R−T022W−N043R−S101A,G020R−T022W−S024R−N043R−S101A−P210I,G020R−T022W−S024R−N043R−R045T−S101A−P210I−T213A,G020R−N043R−R045T−S101A−T213A,T022A−S024G−S078N−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Y−S101N−S103N−V104L−A232T−Q245R,G020R−S101A−N116L−P210I−G211Q,T022R−S101A−S103N−V104L−A232L−Q245R,G020R−S024R−N043R−S101A,T022R−S101G−S103A−V104L−A232T−Q245R,G020R−S024R−S101A−G211Q,T022A−S101Q−S103A−V104I−P129S−A232V−Q245R,T022A−S024G−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101A−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−R045T−S101A,T022Y−S101G−S103A−V104I−A232V−Q245R,S024R−N043R−R045T−S101A−N116L−P210I−G211Q−T213A,T022A−S024G−S078N−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−N043R−S101A−P210I,T022A−S024G−S078N−G097A−S101G−S103A−V104I−L217
Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232V−Q245R,P055R,T022A−S101N−S103N−V104I−A232V−Q245R,G020R−T022W−S024R−N043R−N076D−S101A−P210I−T213A,G020R−T022W−S101A−P210I−T213A,T022Q−S101G−S103A−V104L−A232L−Q245R,T022W−S024R−N043R−R045T−S101A,T022A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022K−S101N−S103A−V104I−A232L−Q245R,T022R−S101T−S103N−V104I−A232L−Q245R,G020R−S024R−N043R−R045T−S101A−P210I−T213A,T022A−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−N062E−S078G−G118S−Q245R,T022K−S101A−S103N−V104I−A232L−Q245R,G020R−T022W−S024R−R045T−S101A−P210I−T213A,G020R−S024R−S078G−G118S−S188D−Q245R,T022R−S101T−S103A−V104I−A232V−Q245W,T022R−S101N−S103A−V104I−A232V−Q245R,T022K−S101T−S103N−V104I−A232T−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,T022Q−S101G−S103N−V104I−A232L−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−Q109N−A232V−Q245R,T022Q−S101G−S103A−V104L−A232V−Q245R,T022A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−T022W−N043R−R045T−S101A−P210I,T022R−S101N−S103N−V104I−A232T−Q245R,G020R−N043R−R045T−S101A−N116L−G211Q−T213A,T022Q−S101A−S103N−V104I−A232V−Q245R,T022W−S024R−N043R−R045T−S101A−N116L−P210I,T022A−S078N−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S078D−G118D−Q245R−H249R,G020R−S024R−N043R−S101A−P210I−G211Q−T213A,T022R−S101G−S103N−V104I−A232V−Q245W,T022A−S101T−S103N−V104L−A232L−Q245R,T022A−S024G−S078N−G097S−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232T−Q245R,G020R−N043R−S101A−P210I−T213A,G020R−S024R−N043R−S101A−N116L−G211Q−T213A,S024R−N043R−R045T−S101A−N116L−P210I−G211Q,T022A−S024G−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,E271R,T022K−S101T−S103G−V104I−A232V−Q245R,N043R−S101A−P210I−G211Q,G020R−S024R−S078G−G118S−P129E−G159D−Q245R,T022R−S101T−S103A−V104I−A232T−Q245S,E271W,S024R−N043R−R045T−S101A−N116L−P210I−T213A,T022A−S024G−S078N−S101N−S103A−V104I−A232V−Q245R,T022A−E089G−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022R−S101T−S103A−V104I−A232L−Q245R,T022R−S101G−S103N−V104I−A232T−Q245S,T022A−S101G−S103A−V104I−A232M−Q245R,G020R−T022W−S024R−S101A−T213A,G020R−T022W−S024R−R045T−S101A−P210I,G020R−T022W−S024R−N043R−S101A−T213A,T022A−S024G−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S101A−T213A,E271S,G020R−S078G−G118S−Q245R−N248D−H249R,N043K,T022A−S101G−S103N−V104I−A232V−Q245R,T022Q−S101A−S103A−V104I−A232L−Q245R,G020R−T022W−S024R−R045T−S101A−T213A,G020R−S024R−S078G−G118S−Q245R−N248D−H249R,T022A−S024G−S078N−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S024G−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S101N−S103A−V104I−A232V−Q245R,G020R−T022W−S024R−S101A−N116L−P210I,G020R−T022W−N043R−R045T−S101A−T213A,T022A−S078N−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−S101N−S103A−V104I−L217Q−A232V−Q245R,T022R−S101N−S103G−V104L−A232V−Q245R,G020R−T022W−S024R−S101A−P210I−T213A,G020R−S024R−S078D−G118S−S188D−Q245R,G020R−S024R−S078D−G118S−G159D−Q245R,T022Y−S101T−S103A−V104I−A232M−Q245R,G020R−N043R−R045T−V051A−S101A−P210I−G211Q−T213A,G020R−T022W−S024R−N043R−R045T−S101A−T213A,T022A−S024G−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−S101Q−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S101A−P210I−G211Q,T022Q−S101T−S103G−V104I−A232M−Q245R,G020R−N043R−S101A−G211Q−T213A,T022A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,T022A−S101T−S103N−V104I−A232V−Q245R,G020R−S024R−S078G−G118D−G159D−Q245R−N248D−H249R,G020R−T022W−R045T−S101A−P210I−G211Q,T022A−S078N−S101N−S103A−V104I−A232V−Q245R,T022R−S101T−S103N−V104I−S105G−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−A232V−Q245R,T022A−S101T−S103N−V104I−A232L−Q245R,T022Q−S101N−S103N−V104L−A232V−Q245R,T022R−S101N−S103N−V104L−A232M−Q245R,T022Q−S101G−S103N−V104I−A232T−Q245R,T022A−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022Q−S101A−S103A−V104L−A232L−Q245R,G020R−N043R−R045T−S101A−G211Q−T213A,T022A−G097A−S101N−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S024R−R045T−S101A−G211Q−T213A,T022A−S078N−G097A−S101G−S103A−V104I−S128A−A232V−Q245R,G020R−T022W−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101N−S103N−V104I−A232L−Q245R,T022Y−S101G−S103A−V104I−A232M−Q245R,T022R−S101G−S103G−V104I−A232T−Q245R,T022A−S024G−S078N−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S078G−G118D−N248D−H249R,T022A−S101A−S103N−V104L−A232V−Q245R,T022W−S024R−S101A−N116L−G211Q,G020R−S024R−S101A−T208A−P210I−G211Q,T022W−S024R−N043R−R045T−S101A−P210I−G211Q−T213A,T022Y−S101G−S103N−V104I−A232M−Q245R,T022R−S101T−S103A−V104L−A232T−Q245S,G020R−S024R−S078G−G118S−P129E−Q245R−N248D,T022A−S024G−S101Q−S103A−V104I−Q109N−A232V−Q245R,G020R−T022W−S101A,T022W−S024
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N116L,G020R−S024R−S101G−N116L−S128A−L217Q,G020R−S024R−S101A−Q109G−N116L−S128A,T022R−S024G−S078N−G097A−S101G−S103A−V104I−N
116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097S−S101Q−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,G020R−N043R−G097A−S101N−
S128A−L233I,T022R−S101Q−S103A−V104I−A232V−Q245R,G020R−N043R−G097S−S101Q−Q109G−N116L−S128A,T022R−S078N−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−G097S−S101N−Q109G−N116L,T022R−S078N−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−S101N−S103A−V104I−A232V−Q245R,G020R−S024R−G097A−S101N−Q109G−S128A,G020R−N043R−S101Q−N116L−S128A−L217Q,G020R−S024R−S078N−G097A−S101Q−Q109N−S128A,G020R−S024R−E089D−S101A−Q109N−N116L,G020R−S024R−G097A−S101G−Q109G−S128A,G020R−S024G−N043R−S101G−N116L−S128A−L217Q,G020R−N043R−S078N−S101Q−Q109G−L217Q,G020R−S024G−N043R−G097A−S101N−Q109N−N116L−L217Q,G020R−S024R−S078N−G097A−S101G−N116L−S128A,G020R−S024R−G097S−S101A−Q109N−N116L,G020R−S024R−S078N−S101A−Q109G−S128A,G020R−S024R−G097A−S101A−Q109G−N116L−S128A,G020R−N043R−G097A−S101Q−N116L−S128A,G020R−N043R−G097S−S101Q−S128A−L217Q,G020R−S024R−S078N−G097A−S101G−Q109G−N116L−L217Q,G020R−N043R−G097A−S101G−Q109N−N116L−S128A,G020R−N043R−S078N−G097S−S101N−Q109N−L217Q,G020R−S024R−G097S−A098E−S101A−N116L−S128A,G020R−S024R−S078N−G097S−S101A−Q109G−S128A,T022R−S024G−S078N−G097S−S101G−S103A−V104I−Q109N−N116L−L217Q−A232V−Q245R,G020R−S024R−S078N−G097A−S101Q−Q109N−N116L−L217Q,T022R−S024G−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−S101A−Q109N−N116L−S128A−L217Q,G020R−S024R−S101G−Q109G−N116L−S128A−L217Q,T022R−S078N−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,G020R−S024G−N043R−S101N−N116L−S128A−L217Q,G020R−S024R−S078N−G097S−S101A−Q109N−N116L,G020R−S024R−S078N−G097A−S101N−Q109N−N116L−S128A,G020R−S024R−S078N−S101Q−Q109N−N116L−L217Q,T022R−S024G−S078N−S101N−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−N043R−S101G−Q109N−N116L−S128A−L217Q,T022R−S101N−S103A−V104I−L217Q−A232V−Q245R,T022R−G097A−S101N−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−G097A−S101A−S128A−L217Q,T022R−S024G−S078N−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−S078N−G097S−S101N−Q109G−N116L−S128A−L217Q,T022R−S024G−S101G−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−N043R−S101Q−S128A−L217Q,G020R−S024R−S078N−S101N−Q109G−S128A−L217Q,G020R−S024R−S078N−G097A−S101N−Q109N−N116L−S128A−L217Q,T022R−S024G−G097A−S101Q−S103A−V104I−N116L−L217Q−A232V−Q245R,G020R−S024R−S078N−G097S−S101G−S128A−N204S−L217Q,T022R−S024G−S078N−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−G097S−S101Q−Q109N−N116L−L217Q,G020R−S024R−S078N−S099G−S101Q−Q109N−N116L−L217Q,T022R−S024G−G097A−S101G−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−G097A−S101G−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,G020R−S024R−G097A−S101N−Q109N−S128A−L217Q,T022R−G097S−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−K094R−S101N−N116L−S128A−L217Q,T022R−S024G−S078N−G097A−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,G020R−S024R−G097A−S101A−N116L−S128A−L217Q,G020R−S024R−S078N−G097W−S101Q−Q109N−N116L−L217Q,T022R−G097S−S101N−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S101Q−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−Q109N−N116L−S128A−L217Q−A232V−Q245R,G020R−N043R−G097S−S101Q−Q109G−N116L−S128A−L217Q,T022R−S024G−G097A−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101Q−S103A−V104I−Q109G−N116L−S128A−L217Q−A232V−Q245R,T022R−S078N−G097S−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S024G−T071A−S078N−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101G−S103A−V104I−Q109N−S128A−A232V−Q245R,T022R−S024G−G097S−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S024G−S078N−S101Q−S103A−V104I−Q109N−N116L−S128A−L217Q−A232V−Q245R,T022R−S101G−S103A−A232V−Q245R,T022R−S101G−S103A−V104I−A232V−Q245R−E271A,T022R−S103A−V104I−A232V−Q245R,T022R−S101G−V104I−A232V−Q245R,T022R−S101G−S103A−V104I−Q245R,G020R−N043
R−E271A,G020R−S024R−I035T−S101A−N116L,G020R−N043R−P239G,G020R−N043R−S242L,又はG020R−N043R−V234F、前記サブチリシン変異体のアミノ酸位置は、配列番号1で示されるバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされるか、又は次から選択されるアミノ酸置換の組み合わせを含むアミノ酸配列を含み:T022Y−S101N−S103A−V104I−A232T−Q245R,G020R−R045T−S101A−P210I−G211Q−L267F,T022Y−S101N−S103N−V104L−A232M−Q245R,T022A−P052T−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S101G−S103N−V104L−A232T−Q245R,T022Y−S101A−S103N−V104L−A232V−Q245R,T022A−S101A−S103N−V104I−A232T−Q245R,T022Y−S101A−S103N−V104I−A232L−Q245R,T022Y−S101G−S103A−V104I−A232T−Q245R,T022A−S024G−N076D−S078N−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,T022A−S101N−S103N−V104L−A232M−Q245R,T022A−S101Q−S103A−V104I−S128A−P129S−A232V−Q245R,T022A−S101N−S103A−V104I−S128A−A232V−Q245R,S024R−S078D−G118S−G159D−Q245R−H249R,T022K−S101N−S103A−V104L−A232T−Q245R,T022R−S101T−S103N−V104I−A232T−Q245S,T022Q−S101N−S103N−V104I−A232M−Q245R,S024R−S078G−G118D−Q245R−H249R,T022R−S101N−S103N−V104L−A232V−Q245R,T022A−N076D−S101Q−S103A−V104I−Q109G−A232V−Q245R,G020R−S024R−S078G−G118D−S188D−Q245R−N248D,T022Y−S101N−S103A−V104I−A232V−Q245R,T022Q−S101N−S103A−V104L−A232L−Q245R,T022Q−S101N−S103N−V104I−A232L−Q245R,T022A−G097S−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101N−S103N−V104I−A232T−Q245S,G020R−S078D−G118D−G159D−Q245R−H249R,T022R−S101N−S103A−V104L−A232M−Q245R,T022A−N076D−G097S−S101Q−S103A−V104I−Q109N−S128A−A232V−Q245R,T022R−S101G−S103N−V104L−A232T−Q245S,G020R−T022W−N043R−R045T−S101A−G211Q−T213A,T022Q−S101T−S103N−V104I−A232T−Q245R,G020R−S024R−N043R−S101A−N204D−T213A,T022A−S024G−S101Q−S103A−V
104I−Q109G−A232V−Q245R,G020R−S024R−S078D−G118D−S188D−Q245R−N248D−H249R,S024R−N043R−S101A−P210I,T022A−N076D−S101G−S103A−V104I−A232V−Q245R−A270V,G020R−S024R−S078D−G118S−H249R,S024R−S078G−G118S,T022R−S101G−S103N−V104L−A232V−Q245S,S024R−N043K−R045T−S101A,T022A−N076D−S078N−S101N−S103A−V104I−A232V−Q245R−T274A,T022A−S024G−N076D−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022Q−S101T−S103G−V104I−A232M−Q245W,S024R−S078G−G118S−P129E−Q245R−H249R,T022A−S024R−N076D−S101G−S103A−V104I−A232V−Q245R,V026W,T022R−S101G−S103N−V104I−A232L−Q245W,G020R−S024R−S078D−G118S−N248D,G020R−R045T−S101A−N204S−P210I,G020R−S024R−S078G−G118D−G159D−N248D−H249R,T022Y−S101A−S103N−V104I−A232V−Q245R,T022A−S024G−S078N−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,S024R−S101A−P210I−G211Q,T022R−S101N−S103N−V104I−A232V−Q245S,T022A−S024G−G097A−S101N−S103A−V104I−Q109G−A232V−Q245R,T022A−G097A−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−N076D−S101Q−S103A−V104I−Q109N−A232V−Q245R,G020R−S078G−G118S−H249R,S078G−G118S−Q245R−H249R,T022A−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Y−S101T−S103G−V104I−A232M−Q245R,T022K−S101G−S103N−V104I−A232L−Q245R,T022A−S024G−G097S−S101N−S103A−V104I−A232V−Q245R,S024R−S078G−G118D−G159D−S188D−Q245R−H249R,T022Q−S101N−S103A−V104I−A232V−Q245R,G020R−S024R−S078G−G118D−G159D−Q245R−N248D,T022A−S024G−S101G−S103A−V104I−A232V−Q245R,T022Q−S101G−S103A−V104L−A232T−Q245R,T022Q−S101T−S103A−V104I−A232T−Q245R,T022A−N076D−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−S078N−G097A−S101G−S103A−V104I−A232V−Q245R,T022A−S101G−S103A−V104L−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−G097S−S101G−S103A−V104I−A232V−Q245R,S024R−N043R−S101A−G211Q−T213A,T022A−G097S−S101Q−S103A−V104I−A232V−Q245R,S024R−S078G−G118S−Q245R−N248D,G020R−T022W−S024R−N043R−S101A−N204S−P210I−G211Q,T022A−S024G−S078N−G097S−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,T022A−S101G−S103A−V104I−P129S−A232V−Q245R,T022R−S101T−S103G−V104I−A232T−Q245S,T022A−S024G−I072V−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101A−S103A−V104I−A232V−Q245W,G020R−T022W−S024R−R045T−S101A−N116L−P210I,T022R−S101T−S103G−V104I−A232T−Q245W,T022A−S024G−N076D−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022Y−S101T−S103N−V104L−A232V−Q245R,G020R−S024R−N062E−S078G−G118S−N248D,T022Q−S101G−S103A−V104I−A232V−Q245R,T022A−N076D−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−S078N−S101Q−S103A−V104I−A232V−Q245R,T022A−N076D−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−N076D−S101N−S103A−V104I−A232V−Q245R,T022R−S101N−S103A−V104I−A232L−Q245S,T022A−S078N−S101N−S103A−V104I−Q109N−L217Q−A232V−Q245R,T022R−S101A−S103A−V104I−A232V−Q245W,T022A−S101Q−S103A−V104I−A232V−Q245R,T022A−S078N−G097S−S101N−S103A−V104I−A232V−Q245R,T022A−G097A−S101Q−S103A−V104I−P129S−A232V−Q245R,T022A−S101T−S103A−V104I−A232L−Q245R,T022A−A085T−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S101T−S103N−V104L−S105G−A232M−Q245R,T022A−S101A−S103A−V104I−A232M−Q245S,T022Q−S101A−S103A−V104I−A232M−Q245R,T022Q−S101G−S103A−V104L−A232M−Q245R,T022A−S024G−G097A−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−N076D−S078N−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−H120Q−S128A−A232V−Q245R,T022A−G097A−S101N−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,G020R−S024R−N062E
−S078G−G118D−Q245R,T022K−S101G−S103G−V104I−A232V−Q245R,S078G−G118S−S188D−Q245R−H249R,T022W−N043R−S101A−G211Q−T213A,T022A−S024G−N076D−G097S−S101N−S103A−V104I−Q109N−A232V−Q245R,T022Y−S101A−S103N−V104L−A232M−Q245R,G020R−T022W−S101A−N116L−G211Q−T213A,T022W−S024R−N043R−R045T−S101A−T213A,N043R−S101A−G211Q−T213A,T022Y−S101N−S103N−V104L−A232L−Q245R,T255G,T022A−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022W−S024R−N043R−S101A−P210I−T213A,N269K,T022R−S101T−S103A−V104I−A232L−Q245S,T022A−S024G−I072V−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022K−S101T−S103G−V104I−A232M−Q245R,H017R−N043R−R045T−S101A−P210I−T213A,T022A−S024G−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−A232V−Q245R,T022A−N076D−G097A−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−V026A−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Q−S101T−S103G−V104I−A232L−Q245R,T022W−S024R−S101A−P210I−G211Q−T213A,T022Q−S101N−S103A−V104I−A232M−Q245R,G020R−R045T−S101A,T022Y−S101N−S103N−V104I−A232V−Q245R,T022R−S101G−S103A−V104I−A232L−Q245R,S024R−S078D−G118D−P129E−Q245R−H249R,T022R−S101A−S103A−V104I−A232M−Q245S,G020R−S101A−P210I−G211Q,T022W−N043R−R045T−S101A−P210I−G211Q,T022R−S101G−S103A−V104I−A232M−Q245S,T022A−S024G−N076D−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232V−Q245S,T022Q−S101G−S103N−V104L−A232M−Q245R,T022K−T038I−S101G−S103A−V104I−A232T−Q245S,N043R−R045T−S101A−P210I−G211Q,T022K−S101T−S103A−V104L−A232M−Q245R,T022Y−S101T−S103N−V104I−A232T−Q245R,G020R−S024R−N043R−S101A−P210I−T213A,S099G−S101G,T022A−S101N−S103N−V104L−A232T−Q245R,T022A−S024G−N076D−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,T022R−S101N−S103A−V104I−A232V−Q245W,T022W−N043R−R045T−S101A−P210I,T022K−S101A−S103G−V104I−A232T−Q245R,T022Q−S101N−S103A−V104I−A232T−Q245S,T022A−S101Q−S103A−V104I−Q109G−A232V−Q245R,T022A−G097A−S101Q−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−L217Q−A232V−Q245R,S024R−S078G−G118S−G159D−Q245R,T022K−S101N−S103N−V104I−A232T−Q245R,A098F−S099A−V104I,G020R−R045T−S101A−G211Q−T213A,T022A−N076D−S078N−G097A−S101G−S103A−V104I−A232V−Q245R,S024R−S078D−G118S−G159D−Q245R,T022A−S024G−N076D−S101N−S103A−V104I−Q109N−A232V−Q245R,T022K−S101T−S103N−V104I−A232M−Q245R,T022A−S024G−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022Q−S101T−S103N−V104I−A232L−Q245S,A114T,T022Q−S101N−S103N−V104L−A232T−Q245R,T022A−S078N−S101G−S103A−V104I−Q109N−A232V−Q245R,T022K−S101T−S103A−V104I−A232M−Q245R,T022A−S024G−G097S−S101Q−S103A−V104I−Q109G−S128A−L217Q−A232V−Q245R,T022A−S101G−S103A−V104I−N116L−Y209V−G211Q−A232V,T022A−S101T−S103N−V104I−A232M−Q245W,G020R−T022W−S024R−S101A−N116L−G211Q,T022A−S078N−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−R045T−S101A−G211Q,T022A−N076D−S078N−G097A−S101G−S103A−V104I−S128A−A232V−Q245R,S024R−S101A−T213A,T022A−S078N−S101G−S103A−V104I−A232V−Q245R,G020R−S024R−S078D−G118S−G159D−S188D−Q245R−N248D−H249R,T022Y−S101N−S103N−V104I−A232V−Q245W,T022Y−S101A−S103G−V104I−A232V−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R,G020R−S078G−G118S−G159D−H249R,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R−A272V,T022R−S101N−S103A−V104I−A232V−Q245S,G020R−S101A−P210I−G211Q−T213A,G020R−S024R−S078D−G118S−G
159D−S188D−Q245R,S087R,G020R−S024R−R045T−A048T−S101A−G211Q,T022A−S024G−G097S−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−S078G−G118S−P129E−S188D−Q245R−N248D−H249R,T022A−G097S−S101G−S103A−V104I−Q109N−A232V−Q245R,L021S−T022A−S024G−N076D−S078N−S101G−S103A−V104I−S128A−A232V−Q245R,S242K,T022K−S101A−S103A−V104I−A232V−Q245R,T022K−S101N−S103A−V104L−A232L−Q245R,T022A−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V−A272V,T022R−S101T−S103A−V104I−A232V−Q245S,T022Y−S101N−S103G−V104I−A232L−Q245R,T022Q−S101N−S103G−V104I−A232V−Q245R,T022A−S101G−S103A−V104I−A232V−Q245W,T022R−S101A−S103A−V104I−A232L−Q245S,G020R−T022W−R045T−F050L−S101A−P210I−G211Q−T213A,T022A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S101A−G211Q−T213A,T022A−N076D−S101G−S103A−V104I−A232V−Q245R−A272V,T022A−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V,T022A−S101N−S103G−V104I−A232V−Q245R,G020R−S101A−T208P−P210I−G211Q,D181S,S101G−S103A−V104I−N116L−Y209V−A232V,T022Q−S101A−S103N−V104I−A232T−Q245R,T022A−S101G−S103N−V104L−G211S−A232T−Q245R,T022A−G097A−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S101T−S103N−V104I−A232M−Q245S,T022A−S101G−S103A−V104I−Q109N−A232V−Q245R,T022Q−S101A−S103G−V104I−A232M−Q245R,G020R−S078G−G118S−G159D−N248D−H249R,T022A−N076D−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−G097S−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,T022Q−S101A−S103A−V104I−A232T−Q245R,T022A−S101G−S103A−V104I−A232L−Q245R,T022A−S101G−S103A−V104I−P129E−A232V−N238Y−V244I−Q245R−A270V−A272V,G020R−S024R−S078D−G118D−G159D−Q245R−N248D−H249R,T022R−S101A−S103N−V104I−A232V−Q245W,T022Q−S101A−S103N−V104I−A232M−Q245R,T022Q−S101A−S103N−V104L−A232L−Q245R,T022A−S024G−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Q−S101G−S103G−V104I−A232M−Q245R,G020R−S078G−G118S−G159D−Q245R−H249R,T022R−S101A−S103N−V104L−A232V−Q245S,T022A−S024V−G097S−S101N−S103A−V104I−H120N−S128A−A232V−Q245R,T022A−A073V−N076D−S078N−S101N−S103A−V104I−A232V−Q245R,T022Q−S101G−S103N−V104L−A232V−Q245R−T274I,T022A−S101N−S103N−V104I−A232T−Q245R,T022W−S024R−R045P−S101A−P210I−G211Q−T213A,G020R−S024R−N062E−S078G−G118D−Q245R−N248D,T022Q−S101A−S103N−V104L−A232M−Q245R,T022Q−S101T−S103G−V104L−A232T−Q245R,T022R−S101G−S103N−A232L−Q245R,T022A−G097S−S101Q−S103A−V104I−Q109N−L217Q−A232V−Q245R,T022A−S024G−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,S024R−S101A−G211Q−T213A,T022R−S101N−S103N−V104L−A232T−Q245S,G020R−R045T−S101A−P210I,T022R−S101A−S103A−V104I−A232M−Q245W,T022A−S101N−S103N−V104I−A232L−Q245R,T022A−S101G−S103G−V104I−A232M−Q245R,G020R−S024R−S078D−G118S−S188D−Q245R−N248D,S099T−S103G,T022W−N043R−S101A−P210I,T022W−A029V−N043R−S101A−P210I,F050R,T022A−S024G−N076D−S078N−G097S−S101Q−S103A−V104I−Q109N−A232V−Q245R,T022A−S024G−N076D−S101G−S103A−V104I−A232V−Q245R,T022R−S101G−S103N−V104L−A232L−Q245R,T022A−S101N−S103A−V104I−Q109N−S128A−A232V−Q245R,S024R−R045T−S101A,T022A−N076D−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Q−S101G−S103A−V104I−A232M−Q245S,T022W−S024R−N043R−R045T−S101A−G211Q−T213A,G020R−S078G−G118S,T022W−N043R−G046C−S101A−P210I−G211Q,S101A−G211Q−T213A,T022A−N076D−S078N−S101G−S103A−V104I−A232V−Q245R,T022A−S024G−N076D−G097S−S101Q−S103A−V104I−A232V−Q245R,T022A−S101N−S103A−V104I−L126I−P129S−A232V−Q245R,T022R−S101T−S103N−V104I−A232L−Q245W,T022A−S101G−S103A−V104I−A232V−N238Y−Q245R−A270V−A272V,S078G−G118D−Q245R,T022A−S024R−S101G−S103A−V104I−P129E−A232V−N238Y−Q245R−A270V,T022A−N076D−G097S−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,T022W−S024R−R045T−S101A−N116L−P210I−T213A,T022R−S101T
−S103N−V104I−A232L−Q245S,T022W−S024R−N043R−R045T−S101A−S106L−P210I−G211Q,T022A−E089G−G097A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,T022A−S101A−S103G−V104I−A232L−Q245S,N043R−S101A−P210I−T213A,N043R−R045T−S101A−T213A,S078G−G118D−H120N−H249R,T022Q−S101T−S103N−V104I−A232L−Q245R−R275H,T022Y−S101A−S103A−V104I−A232T−Q245S,T022K−S101N−S103N−V104I−A232M−Q245R,T022R−S101T−S103N−V104L−A232V−Q245S,T022A−N076D−G097S−S101N−S103A−V104I−A232V−Q245R,M119L,A098F−S099A−S101G−V104I,S078D−G118S−Q245R,T022Y−S101N−S103A−V104I−A232L−Q245S,T022A−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118D−N248D−H249R,T022R−S101A−S103N−V104I−A232T−Q245S,T022R−S101G−S103N−V104I−A232L−Q245S,S024R−S078D−G118D−S188D−Q245R−H249R,S132H,A098Q−S099G−S101G−V104L,N043R−S101A−P210I−G211Q−T213A,T022Q−S101G−S103A−V104I−A232M−Q245W,T022A−S101Q−S103A−V104I−L126I−P129S−A232V−Q245R,T022K−S101T−S103G−V104I−A232M−Q245S,T022W−N043R−R045T−S101A−G211Q−T213A,T022Q−S101N−S103G−V104I−A232V−Q245W,D181T,G020R−S024R−S078D−G118S−P129E−G159D−Q245R−H249R,G020R−S024R−S078G−G118D−G159D−S188D−Q245R,T022A−S101T−S103N−V104L−A232L−Q245S,T022A−S101G−S103N−V104L−A232V−Q245S,T022A−S024G−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S024G−N076D−S101N−S103A−V104I−S128A−A232V−Q245R,T022Y−S101T−S103A−V104L−A232M−Q245R,T022Q−S101T−S103N−V104L−A232T−Q245R,F050S,T022Y−S101G−S103N−V104I−A232V−Q245R,G020R−R045T−S101A−T213A,T022K−S101N−S103G−V104I−A232V−Q245W,S024R−S078G−G118D−P129E−G159D−Q245R−H249R,T022Q−S101T−S103N−V104I−A232M−Q245W,S049W,T022A−S101A−S103N−V104L−A232L−Q245R,T022A−N076D−S101G−S103A−V104I−I107V−P129G−A232V−Q245R−A270V,S099A−V104I,T022Q−S101A−S103G−V104I−A232V−Q245W,T022A−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R,T022A−S101G−S103A−V104I−L124V−L217Q−A232V−Q245R,T022R−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−Q109N−S128A−A232V−Q245R,R010A−T022R−S024F−S101G−S103A−V104I−A232V−Q245R−L267N−E271H,G020R−S024G−N043R−S078N−S101G−Q109N−N116L−L217Q−M222S,G020R−N043R−E271H,G020R−N043R−E271I,G020R−S024R−S101A−N116L−N269I,T022R−S101G−S103A−V104I−A232V−Q245R−E271F,G020R−N043R−E271F,G020R−N043R−N269I,G020R−S024R−S101A−N116L−E271H,T022R−S101G−S103A−V104I−A232V−Q245R−E271H,G020R−I035T−N043R,G020R−S024R−S101A−A114T−N116L,G020R−S024R−S101A−N116L−E271I,G020R−N043R−A114T,G020R−N043R−L267N,G020R−S024R−S101A−N116L−L267N,G020R−S024R−V028A−S101A−N116L,G020R−S024R−S101A−N116L−G258R,G020R−N043R−G258R,G020R−S024R−S101A−N116L−S242L,G020R−S024R−S101A−N116L−P239G,I008N−G020R−S024R−S101A−N116L,G020R−S024R−S101A−N116L−V234F,T022R−S101G−S103A−V104I−A232V,G020R−S024R−S101A−N116L−E271A,R010A−G020R−N043R,G020R−S024R−S101A−N116L−E271F,G020R−V028A−N043R,I008N−G020R−N043R,又はG020R−S024F−S101A−N116L、次から選択されるアミノ酸置換の組み合わせを含み:G020R−S024R−S078D−G118D−G159D−H249R,G020R−S024R−S078G−G118S−G159D−S188D−Q245R−N248D−H249R,T022A−S101T−S103G−V104I−A232T−Q245S,T022A−S101T−S103G−V104I−A232T−Q245R,T022Q−S101G−S103N−V104I−A232V−Q245W,T022W−N043R−S101A−T213A,T022A−N076D−S078N−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−A232V−Q245R,T022K−S101N−S103N−V104L−A232T−Q245R,T022A−S024G−S101Q−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−N062E−S078G−G118D,G020R−S078G−G118D,T022Y−S101T−S103G−V104L−A232T−Q245R,R010H−T022A−S101G−S103A−V104I−A232V−Q245R−A272V,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R−A270V−A272V,T022A−N076D−S078N−G097S−S101Q−S103A−V104I−Q109G−A232V−Q245R,G020R−S024R−S078D−G118S−P129E−Q245R,T022A−N076D−S101G−S103A−V104I−A232V−N238Y−Q245R−A272V,T022K−S101N−S103N−V104I−A232V−Q245W,T022Q−S101T−S103N−V104I−A232M−Q245S,T022A−S078N−S101N−S103A−V104I−Q109G−L217Q−A23
2V−Q245R,W113Y,T022A−S101A−S103N−V104I−A232M−Q245S,T022A−S101Q−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−S078G−G118D−G159D−S188D−H249R,T022A−S101N−S103G−V104I−A232T−Q245R,T022K−S101G−S103G−V104I−A232L−Q245R,T022A−N076D−G097A−S101Q−S103A−V104I−S128A−A232V−Q245R,T022Q−S101T−S103N−V104I−A232V−Q245S,T022A−S024F−S101G−S103A−V104I−N116L−Y209V−T213A−A232V,T022A−S101N−S103G−V104L−A232T−Q245R,T022A−S024R−S101G−S103A−V104I−P129E−A232V−N238Y−Q245R,T022A−N076D−G097S−S101Q−S103A−V104I−A232V−Q245R,T022A−N076D−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,T022A−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,S259W,A016S−T022A−S024F−S101G−S103A−V104I−N116A−Y209V−G211Q−A232V,T022W−S101A−P210I−G211Q−T213A,T022A−S024G−N076D−G097S−S101N−S103A−V104I−A232V−Q245R,V028T−A215V,S024R−S078D−G118S−S188D−Q245R,T022Q−S101T−S103A−V104I−A232V−Q245W,T022A−S101N−S103A−V104I−Q109G−L217Q−A232V−Q245R,T022A−S024G−T071A−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,H120P,G020R−S024R−N062E−S078D−G118D−Q245R,T022A−N076D−S101Q−S103A−V104I−A232V−Q245R,T022Q−S101A−S103N−V104I−A232L−Q245W,T022Q−S101N−S103A−V104L−A232T−Q245R,T022W−S024R−N043R−R045T−S101A−N116L−P210I−G211Q,T022A−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118S−G159D−S188D−H249R,A013S,A232N,T022A−N076D−S101G−S103A−V104I−A232V−Q245R,T022A−S024G−N076D−S078N−G097S−S101N−S103A−V104I−A232V−Q245R,I035T,V051M,N123A,G020R−S078G−G118S−G159D−Q245R−N248D,T022Y−S101A−S103N−V104I−A232L−Q245W,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R−A270V,G020R−S078D−G118S,T022R−S101N−S103N−V104L−A232M−Q245W,T022A−S024G−N076D−G097S−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S101G−S103N−V104L−A232V−Q245R,T022A−N076D−G097A−S101Q−S103A−V104I−A232V−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−I107V−P129E−A232V−Q245R,S024R−R045T−S101A−P210I−G211Q,T022A−S078N−S101N−S103A−V104I−Q109N−S128A−A232V−Q245R,T022A−S024G−S078N−G097A−S101N−S103A−V104I−Q109N−A232V−Q245R,G020R−S024R−S078G−G118D−P129E−G159D−H249R,G020R−S078G−G118D−P129E−S188D−Q245R−H249R,P014W,G020R−S024R−S078G−G118S−G159D−S188D−Q245R−N248D,T022R−S101G−S103N−V104I−A232M−Q245W,T022R−A098V−S101G−S103N−V104L−A232T−Q245R,T022A−S101T−S103A−V104I−A232V−Q245W,G020R−T022W−R045T−S101A−T213A,N043R−R045T−S101A,T022K−S101N−S103A−V104I−A232V−Q245R,T022K−S101T−S103N−V104I−A232L−Q245S,S056V,G020R−T022W−R045T−S101A−G211Q,G020R−S024R−S078D−G118D−Q245R−N248D,G020R−S024R−S078D−G118S−G159D−V244L−Q245R−N248D,T022A−G097A−S101Q−S103A−V104I−Q109G−S128A−A232V−Q245R,T022A−N076D−G097S−S101G−S103A−V104I−A232V−Q245R,G020R−T022W−R045T−S101A−N116L−P210I,T022Q−S101N−S103N−V104I−A232M−Q245S,T022Y−S101G−S103N−V104I−A232V−Q245W,A114V,S141C,T022A−N076D−S078N−S101N−S103A−V104I−A232V−Q245R,S056H,S078D−G118D−Q245R,S024R−N043R−R045T−S101A−T213A,T022Y−S101T−S103G−V104I−A232V−Q245S,T022A−S024G−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,N269W,S078G−G118S−G159D−Q245R−N248D−H249R,T022W−S024R−R045T−S101A,T022A−S024R−S101G−S103A−V104I−P129E−A232V−N238Y−Q245R−A270V−A272V,T022A−S024R−S101G−S103A−V104I−P129E−A232V−Q245R,T022A−S024R−N076D−S101G−S103A−V104I−I107V−P129E−A232V−N238Y−Q245R−A270V−A272V,A122F,S024R−S078D−G118S−P129E−G159D−Q245R−H249R,S099G,T022K−S101T−S103G−V104I−A232V−Q245S,S009G−T022A−S078N−S101Q−S103A−V104I−Q109G−S128A−L217Q−A232V−Q245R,A098Q,T022A−S101N−S103A−V104L−A232L−Q245R,T022A−S101A−S103N−V104I−A232T−Q245W,T022A−S024G−N076D−G097A−S101N−S103A−V104I−A232V−Q245R,S024R−S078G−G118D−G159D−H249R,T022A−S024G−N076D−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−N076D−S078N−S101Q−S103A−V104I−S128A−A232V−Q245R,T022A−S101Q−S103A−V104I−L124V−S128A−P129S−A232V−Q245R,T022R−S101N−S103A−V104I−A232M−W241R−Q245W,R045T−S101A−P210I−G211Q,G020R−S024R−S078G−G118S−P129E−Q245V−N248E,T022Q−S101T−S103N−V104I−A232L−Q245W,T022A−S024G−S078N−S101N−S103A−V104I−Q109G−L217Q−A232V−Q245R,T022A−S024G−G097A−S101N−S103A−V104I−L217Q−A223S−A232V−Q245R,T022K−S101T−S103A−V104I−A232T−Q245W,N043R−S101A−G211Q,T022A−S101G−S103A−V104I−Q109N−S128A−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118S−P129E−H249R,S024R−S078G−G118S−G159D−S188D−Q245R,N043R−R045T−S101A−N204S−P210I−T213A,T022R−S101N−S103A−V104L−A232V−Q245S,T022R−S101N−S103G−V104I−A232V−Q245S,T022K−S101T−S103N−V104I−A232M−Q245S,T022A−N076D−S101N−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−N076D−S078N−S101N−S103A−V104I−Q109G−S128A−A232V−Q245R,G020R−T022W−R045T−S101A−P210I−T213A,T022A−N076D−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022W−S101A−P210I,T022A−G097A−S101N−S103A−V104I−L126I−P12
9S−A232V−Q245R,T022A−S078D−S101N−S103A−V104I−S128A−A232V−Q245R,Q236L,T022Y−S101T−S103N−V104I−A232V−Q245S,A200D,G020R−S078G−G118S−S188D−H249R,T022A−S101G−S103N−V104I−A232T−Q245W,T022A−S024G−N076D−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,G157I,G020R−S024R−S078G−G118S−P129E−G159D−S188D−Q245R,T022R−S078N−G097S−S101G−S103A−V104I−Q109G−S128A−A232V−Q245R,R010A−G020R−S024R−S101A−N116L,G020R−N043R−M222S、好ましくは、次から選択されるアミノ酸置換の組み合わせを含むアミノ酸配列を含み:G020R−T022W−S024R−R045T−S101A−N204S−G211Q,T022W−S024R−S101A−P210I−T213A,G020R−S101A−G211Q,G020R−S024R−S101A−P210I−G211Q−T213A,G020R−S101A−P210I−T213A,T022W−S024R−N043R−S101A−P210I,G020R−S024R−N043R−R045T−S101A−G211Q,T022R−S101T−S103N−V104L−A232M−Q245R,G020R−T022A−S024R−R045T−S101A−T213A,T022R−S101G−S103N−V104I−A232M−Q245R,G020R−T022W−S024R−S101A−N116L−G211Q−T213A,G020R−T022W−N043R−S101A−N116L−G211Q,G020R−T022W−N043R−R045T−S101A,T022W−N043R−R045T−S101A−P210I−T213A,G020R−S024R−R045T−S101A−Q109R−P210I−G211Q−T213A,S024R−N043K−S101A−N204D−P210I,G020R−S024R−R045T−S101A−P210I,S024R−N043R−R045T−S101A−P210I−T213A,G020R−S024R−R045T−S101A−T213A,T022R−S101A−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−R045T−S101A−N204S−P210I−G211Q,T022W−N043R−S101A−P210I−G211Q,G020R−S024R−N043K−R045T−S101A−N116L−P210I,T022A−S101G−S103A−V104I−I107V−L217Q−A232V−Q245R,S024R−N043R−R045T−S101A−G211Q−T213A,T022R−S101A−S103G−V104I−A232M−Q245R,T022R−S101G−S103N−V104L−A232V−Q245R,S024R−S078G−G118S−Q245R−N248D−H249R,S024R−N043R−S101A−P210I−T213A,T022K−S101N−S103A−V104I−A232T−Q245R,G020R−N043R−S101A−P210I−G211Q,T022R−S101T−S103A−V104I−A232M−Q245R,S024R−V026A−N043R−S101A−P210I−G211Q,T022A−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101T−S103G−V104I−A232L−Q245R,G020R−T022W−S024R−N043R−R045T−S101A−G211Q,G020R−S024R−S078G−G118D−Q245R,T022A−S101N−S103A−V104I−S128A−P129S−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−T022W−N043R−S101A−G211Q−T213A,N018K−G020R−S024R−R045T−S101A−P210I−G211Q−T213A,G020R−T022W−S024R−N043R−R045T−S101A,T022R−S101N−S103A−V104L−A232T−Q245R,G020R−S024R−S101A−T213A,T022R−S101N−S103G−V104I−A232V−Q245R,G020R−T022W−S024R−S101A−G211Q−T213A,T022A−S024G−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,S024R−S078G−G118D−P129E−Q245R−H249R,T022R−S101T−S103A−V104L−A232L−Q245R,G020R−S024R−S101A−G211Q−T213A,T022A−S024G−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−T022W−N043R−V051A−S101A−P210I−G211Q,S024R−S078G−G118D−Q245R,N043R−S101A−P210I,T022Y−S101G−S103N−V104I−A232L−Q245R,G020R−T022W−N043R−S101A−T213A,G020R−S024R−S078D−G118S−S188D−Q245R−H249R,T022Y−S101N−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−F050L−S101A−G211Q−T213A,N018S−T022W−S024R−N043R−S101A−G211Q,T022A−S101G−S103A−V104I−S128A−P129S−L217Q−A232V−Q245R,T022R−S101N−S103N−V104I−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,S101A−P210I−G211Q−T213A,G020R−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101A−S103N−V104I−A232M−Q245S,G020R−T022W−N043R−R045T−S101A−G211Q,G020R−T022W−N043R−R045T−S101A−N116L−P210I,G020R−S024R−S078D−G118S−Q245R,G020R−T022W−S024R−N043R−S101A−P210I−G211Q−T213A,G020R−S024R−N043R−R045T−V051A−S101A−P210I−G211Q,T022A−S101G−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S078G−G118D−Q245R−N248D−H249R,T022K−S101A−S103N−V104L−A232T−Q245R,T022A−N076D−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,S024R−N043R−R045T−S101A−P210I,T022A−S024G−G061R−S078N−S101G−S103A−V104I−S128A−A232V−Q245R,T022A−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−S128A−L217Q−A2
32V−Q245R,T022Q−S101T−S103A−V104L−A232V−Q245R,G020R−T022W−S024R−R045T−S101A−G211Q,P014R,T022R−S101A−S103N−V104L−A232M−Q245R,T022K−S101G−S103N−V104I−A232V−Q245R,G020R−S024R−S078D−G118D−Q245R,T022A−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S101A−P210I−T213A,T022K−S101N−S103N−V104I−A232V−Q245R,T022Y−S101T−S103A−V104I−A232L−Q245R,T022A−N076D−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−N043R−R045T−S101A−P210I−G211Q−T213A,G020R−R045T−S101A−P210I−T213A,G020R−S078D−G118S−Q245R−H249R,G020R−T022W−R045T−V051A−S101A,T022R−S101T−S103A−V104I−A232V−Q245R,N043R−S101A,G020R−S024R−N043R−R045T−S101A−G211Q−T213A,T022R−S101G−S103G−V104I−A232L−Q245R,G020R−S101A−P210I,T022K−S101T−S103N−V104I−A232V−Q245R,G020R−T022W−N043R−V051A−S101A,G020R−T022W−N043R−S101A,G020R−T022W−S024R−N043R−S101A−P210I,G020R−T022W−S024R−N043R−R045T−S101A−P210I−T213A,G020R−N043R−R045T−S101A−T213A,T022A−S024G−S078N−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Y−S101N−S103N−V104L−A232T−Q245R,G020R−S101A−N116L−P210I−G211Q,T022R−S101A−S103N−V104L−A232L−Q245R,G020R−S024R−N043R−S101A,T022R−S101G−S103A−V104L−A232T−Q245R,G020R−S024R−S101A−G211Q,T022A−S101Q−S103A−V104I−P129S−A232V−Q245R,T022A−S024G−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022K−S101A−S103N−V104I−A232T−Q245R,G020R−T022W−S024R−R045T−S101A,T022Y−S101G−S103A−V104I−A232V−Q245R,S024R−N043R−R045T−S101A−N116L−P210I−G211Q−T213A,T022A−S024G−S078N−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−N043R−S101A−P210I,T022A−S024G−S078N−G097A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232V−Q245R,P055R,T022A−S101N−S103N−V104I−A232V−Q245R,G020R−T022W−S024R−N043R−N076D−S101A−P210I−T213A,G020R−T022W−S101A−P210I−T213A,T022Q−S101G−S103A−V104L−A232L−Q245R,T022W−S024R−N043R−R045T−S101A,T022A−S101G−S103A−V104I−L217Q−A232V−Q245R,T022K−S101N−S103A−V104I−A232L−Q245R,T022R−S101T−S103N−V104I−A232L−Q245R,G020R−S024R−N043R−R045T−S101A−P210I−T213A,T022A−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−N062E−S078G−G118S−Q245R,T022K−S101A−S103N−V104I−A232L−Q245R,G020R−T022W−S024R−R045T−S101A−P210I−T213A,G020R−S024R−S078G−G118S−S188D−Q245R,T022R−S101T−S103A−V104I−A232V−Q245W,T022R−S101N−S103A−V104I−A232V−Q245R,T022K−S101T−S103N−V104I−A232T−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,T022Q−S101G−S103N−V104I−A232L−Q245R,T022A−S078N−G097A−S101Q−S103A−V104I−Q109N−A232V−Q245R,T022Q−S101G−S103A−V104L−A232V−Q245R,T022A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−T022W−N043R−R045T−S101A−P210I,T022R−S101N−S103N−V104I−A232T−Q245R,G020R−N043R−R045T−S101A−N116L−G211Q−T213A,T022Q−S101A−S103N−V104I−A232V−Q245R,T022W−S024R−N043R−R045T−S101A−N116L−P210I,T022A−S078N−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S078D−G118D−Q245R−H249R,G020R−S024R−N043R−S101A−P210I−G211Q−T213A,T022R−S101G−S103N−V104I−A232V−Q245W,T022A−S101T−S103N−V104L−A232L−Q245R,T022A−S024G−
S078N−G097S−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101T−S103N−V104I−A232T−Q245R,G020R−N043R−S101A−P210I−T213A,G020R−S024R−N043R−S101A−N116L−G211Q−T213A,S024R−N043R−R045T−S101A−N116L−P210I−G211Q,T022A−S024G−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,E271R,T022K−S101T−S103G−V104I−A232V−Q245R,N043R−S101A−P210I−G211Q,G020R−S024R−S078G−G118S−P129E−G159D−Q245R,T022R−S101T−S103A−V104I−A232T−Q245S,E271W,S024R−N043R−R045T−S101A−N116L−P210I−T213A,T022A−S024G−S078N−S101N−S103A−V104I−A232V−Q245R,T022A−E089G−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,T022R−S101T−S103A−V104I−A232L−Q245R,T022R−S101G−S103N−V104I−A232T−Q245S,T022A−S101G−S103A−V104I−A232M−Q245R,G020R−T022W−S024R−S101A−T213A,G020R−T022W−S024R−R045T−S101A−P210I,G020R−T022W−S024R−N043R−S101A−T213A,T022A−S024G−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S101A−T213A,E271S,G020R−S078G−G118S−Q245R−N248D−H249R,N043K,T022A−S101G−S103N−V104I−A232V−Q245R,T022Q−S101A−S103A−V104I−A232L−Q245R,G020R−T022W−S024R−R045T−S101A−T213A,G020R−S024R−S078G−G118S−Q245R−N248D−H249R,T022A−S024G−S078N−G097A−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022A−S024G−S078N−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S024G−S101N−S103A−V104I−A232V−Q245R,G020R−T022W−S024R−S101A−N116L−P210I,G020R−T022W−N043R−R045T−S101A−T213A,T022A−S078N−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−S101N−S103A−V104I−L217Q−A232V−Q245R,T022R−S101N−S103G−V104L−A232V−Q245R,G020R−T022W−S024R−S101A−P210I−T213A,G020R−S024R−S078D−G118S−S188D−Q245R,G020R−S024R−S078D−G118S−G159D−Q245R,T022Y−S101T−S103A−V104I−A232M−Q245R,G020R−N043R−R045T−V051A−S101A−P210I−G211Q−T213A,G020R−T022W−S024R−N043R−R045T−S101A−T213A,T022A−S024G−S078N−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022A−S078N−S101Q−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S101A−P210I−G211Q,T022Q−S101T−S103G−V104I−A232M−Q245R,G020R−N043R−S101A−G211Q−T213A,T022A−S101Q−S103A−V104I−P129S−L217Q−A232V−Q245R,T022A−S101T−S103N−V104I−A232V−Q245R,G020R−S024R−S078G−G118D−G159D−Q245R−N248D−H249R,G020R−T022W−R045T−S101A−P210I−G211Q,T022A−S078N−S101N−S103A−V104I−A232V−Q245R,T022R−S101T−S103N−V104I−S105G−A232V−Q245R,T022A−S024G−S078N−S101Q−S103A−V104I−A232V−Q245R,T022A−S101T−S103N−V104I−A232L−Q245R,T022Q−S101N−S103N−V104L−A232V−Q245R,T022R−S101N−S103N−V104L−A232M−Q245R,T022Q−S101G−S103N−V104I−A232T−Q245R,T022A−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022Q−S101A−S103A−V104L−A232L−Q245R,G020R−N043R−R045T−S101A−G211Q−T213A,T022A−G097A−S101N−S103A−V104I−P129S−L217Q−A232V−Q245R,G020R−S024R−R045T−S101A−G211Q−T213A,T022A−S078N−G097A−S101G−S103A−V104I−S128A−A232V−Q245R,G020R−T022W−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101N−S103N−V104I−A232L−Q245R,T022Y−S101G−S103A−V104I−A232M−Q245R,T022R−S101G−S103G−V104I−A232T−Q245R,T022A−S024G−S078N−G097S−S101N−S103A−V104I−L217Q−A232V−Q245R,G020R−S024R−S078G−G118D−N248D−H249R,T022A−S101A−S103N−V104L−A232V−Q245R,T022W−S024R−S101A−N116L−G211Q,G020R−S024R−S101A−T208A−P210I−G211Q,T022W−S024R−N043R−R045T−S101A−P210I−G211Q−T213A,T022Y−S101G−S103N−V104I−A232M−Q245R,T022R−S101T−S103A−V104L−A232T−Q245S,G020R−S024R−S078G−G118S−P129E−Q245R−N248D,T022A−S024G−S101Q−S103A−V104I−Q109N−A232V−Q245R,G020R−T022W−S101A,T022W−S024R−N043R−S101A−P210I−G211Q,G020R−S024R−N043R−S101A−P210I−G211Q,G020R−S024R−N062E−S078G−G118D−H249R,G020R−S024R−G047C−S101A−G211Q,G020R−S024R−S078D−G118D−P129E−Q245R−H249R,T022A−S101A−S103A−V104L−A232V−Q245R,T022A−S101T−S103N−V104L−A232M−Q245R,N018S−G020R−T022W−N043R−S101A−G211Q,T022Y−S101T−S103G−V104I−A232T−Q245R,T022K−S101A−S103A−V104I−A232M−Q245R,T022A−S024G−G097A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022Y−S101N−S103N−V104L−A232V−Q245R,T022A−S101G−S103A−V104I−A232V−Q245R,T022A−G097A−S101G−S103A−V104I−P129S−A232V−Q245R,G020R−S078G−G118S−P129E−Q245R−H249R,T022A−G097S−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022Y−S101A−S103G−V104I−A232M−Q245R,S024R−S101A−G211Q,T022A−S024G−G097A−S101Q−S103A−V104I−Q109G−A232V−Q245R,T022A−S024G−S101G−S103A−V104I−S128A−A232V−Q245R,R045T−S101A−I107V−Q109R−P210I−G211Q−T213A,T022A−G097S−S101Q−S103A−V104I−L217Q−A232V−Q245R,T022K−S101T−S103A−V104I−A232T−Q245R,Q012R−T022A−S101G−S103A−V104I−N116L−Y209A−T213A−A232V,T022W−S024R−N043R−R045T−S101A−P210I,T022A−S101N−S103A−V104I−A232V−Q245R,T022A−S024G−S078N−G097A−S101N−S103A−V104I−A232V−Q245R,G020R−S024R−S078G−G118S−G159D,T022Y−S101T−S103A−V104I−A232T−Q245R,T022Q−S101G−S103N−V104I−A232V−Q245R,S024R−S101A−P210I−T213A,T022A−S101N−S103A−V104I−L217Q−A232V−Q245R,T022A−S101G−S103N−V104L−A232L−Q245R,T022A−S024G−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S101G−S103A−V104I−S128A−P129S−A232V−Q245R,T022A−S101N−S103A−V104L−A232T−Q245R,S024R−S101A−P210I,T022Y−S101T−S103N−V104I−A232V−Q245R,G020R−T022W−N043R−S101A−N116L,T022Q−S101N−S103
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Q245S,T022Q−S101N−S103A−V104I−A232M−Q245W,T022W−S024R−S101A−N204S−G211Q−T213A,T022A−S101N−S103A−V104L−A232M−Q245R,T022A−S024G−S101Q−S103A−V104I−Q109N−S128A−A232V−Q245R,G020R−S078D−G118S−P129E−Q245R−H249R,T022Q−S101T−S103A−V104I−A232T−Q245S,S024R−N043R−R045T−S101A−P210I−G211Q−T213A,T022R−S101N−S103G−V104I−A232T−Q245R,S024R−S101A−P210I−G211Q−T213A,T022A−S024G−N076D−G097A−S101G−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−S078G−G118S−S188D−N248D−H249R,T022A−G097S−S101Q−S103A−V104I−Q109G−S128A−A232V−Q245R,G020R−S024R−R045T−S101A−P210I−T213A,T022A−S078N−G097S−S101N−S103A−V104I−S128A−A232V−Q245R,T022A−S024G−S078N−G097A−S101Q−S103A−V104I−A232V−Q245R,T022R−S101G−S103N−V104I−A232T−Q245W,T022K−S101G−S103A−V104I−A232V−Q245R,T022W−S024R−S101A−G211Q−T213A,S024R−N043R−S101A−P210I−G211Q,T022Q−S101T−S103G−V104I−A232T−Q245R,T022A−S101G−S103A−V104I−A232V−Q245R−A272V,T022K−S101G−S103N−V104L−A232M−Q245R,T022A−S024G−G097A−S101Q−S103A−V104I−Q109N−A232V−Q245R,S078D−G118S−G159D−Q245R−H249R,G020R−T022W−S024R−A069T−S101A−P210I−T213A,T022A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−T022W−S024R−N043R−R045T−S101A−P210I−G211Q,G020R−S024R−S078D−G118D−G159D−S188D−Q245R−H249R,T022A−S078N−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S078G−G118D−G159D−Q245R−N248D−H249R,T022W−R045T−S101A−T213A,G020R−S024R−S078N−G097A−S101A−Q109N−N116L−L217Q,T022R−S024F−S101G−S103A−V104I−A232V−Q245R−E271H,G020R−S024R−S078N−G097S−S101Q−S128A−L217Q,T022R−S101G−S103A−V104I−A232V−Q245R−E271H,G020R−S024R−S101G−N116L−S128A,G020R−S024R−S101A−Q109N−N116L−S128A,T022R−S024F−S101G−S103A−V104I−A232V−Q245R−T260M,G020R−S024R−S078N−S101N−N116L−S128A,G020R−S024R−G097A−S101A−Q109G−N116L,G020R−S024R−S101N−S128A,G020R−S024R−S078N−S101G−S128A−L217Q,T022R−S024F−S101G−S103A−V104I−A232V−Q245R,T022R−S078N−G097S−S101Q−S103A−V104I−Q109N−N116L−A232V−Q245R,G020R−S024R−G097A−S101A−Q109N−N116L−S128A,G020R−S024R−G097S−S101N−Q109N−S128A,T022R−S101G−S103A−V104I−A232V−P239G−Q245R,G020R−S024R−G097S−S101A−S128A,G020R−S024R−S101G−Q109N−N116L−A215V,G020R−S024R−S078N−G097S−S101Q−Q109G−N116L−S128A,G020R−S024R−S078N−G097S−S101N−Q109N,G020R−S024R−S101G−S128A,T022R−S101G−S103A−V104I−A232V−Q245R−T260K−L267N,T022R−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−G097S−S101N−S103A−V104I−A232V−Q245R,T022R−S024F−S101G−S103A−V104I−V121F−A232V−Q245R,G020R−S024R−G097A−S101Q−N116L−S128A−L217Q,T022R−G097A−S101N−S103A−V104I−N116L−A232V−Q245R,G020R−S024R−S078N−G097S−S101A−N116L−S128A,G020R−S024R−G097A−S101G−S128A−L217Q,T022R−S078N−S101G−S103A−V104I−N116L−A232V−Q245R,G020R−S024G−N043R−S078N−S101Q−Q109G−N116L−S128A−Q206R−L217Q,G020R−S024R−S078N−G097S−S101Q−N116L−S128A,G020R−S024R−S078N−G097S−S101N−Q109N−N116L−S128A,G020R−S024R−S101N−Q109G−N116L,G020R−S024R−S101Q−N116L−S128A−L217Q,G020R−N043R−S078N−S101G−Q109G−N116L,G020R−S024G−N043R−S078N−G097S−S101G−S128A,T022R−S024G−S078N−S101N−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,T022R−S101G−S103A−V104I−A232V−P239G−Q245R−E271I,G020R−S024R−S101Q−S128A,G020R−S024R−G097A−S101N−Q109G−N116L,G020R−S024G−N043R−S078N−G097A−S101G−Q109G−N116L,G020R−S024R−G097S−S101Q−Q109N−N116L−L217Q,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−G097A−S101G−Q109N−S128A,G020R−S024R−G097S−S101A−Q109N−S128A,T022R−G097S−S101Q−S103A−V104I−Q109G−A232V−Q245R,G020R−S024R−S078N−G097A−S101N−S128A−L217Q,G020R−S024G−N043R−S078N−G097S−S101G−N116L,G020R−S024R−S078N−G097S−S101G−Q109N−N116L−L217Q,T022R−S024G−S078N−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−G097S−S101A−Q109N−S128A−L217Q,G020R−S024R−S078N−G0
97A−S101G−Q109N−N116L−L217Q,G020R−S024G−N043R−S078N−S101Q,G020R−S024R−S078N−G097A−S101Q−Q109G−N116L,G020R−N043R−G097A−S101N−N116L−S128A,G020R−S024R−S078N−S101G−Q109G−N116L−S128A−L217Q,G020R−S024R−S078N−S101Q−Q109G−N116L−S128A−L217Q,G020R−S024R−S078N−G097S−S101G−Q109N−N116L−S128A,G020R−S024R−S078N−G097S−S101N−Q109N−N116L,T022R−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,T022R−S024G−G097S−S101G−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,T022R−S024G−S078N−S101G−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−S101N−Q109N−N116L,G020R−S024R−S078N−S101A−Q109N−N116L−S128A,T022R−S024G−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,T022R−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−S078N−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S101G−Q109G−N116L−L217Q,G020R−S024R−S078N−S101Q−Q109N−N116L,G020R−S024R−S101G−N116L−S128A−L217Q,G020R−S024R−S101A−Q109G−N116L−S128A,T022R−S024G−S078N−G097A−S101G−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097S−S101Q−S103A−V104I−Q109G−N116L−S128A−A232V−Q245R,G020R−N043R−G097A−S101N−S128A−L233I,T022R−S101Q−S103A−V104I−A232V−Q245R,G020R−N043R−G097S−S101Q−Q109G−N116L−S128A,T022R−S078N−S101Q−S103A−V104I−A232V−Q245R,G020R−S024R−G097S−S101N−Q109G−N116L,T022R−S078N−G097S−S101G−S103A−V104I−S128A−A232V−Q245R,T022R−S024G−S101N−S103A−V104I−A232V−Q245R,G020R−S024R−G097A−S101N−Q109G−S128A,G020R−N043R−S101Q−N116L−S128A−L217Q,G020R−S024R−S078N−G097A−S101Q−Q109N−S128A,G020R−S024R−E089D−S101A−Q109N−N116L,G020R−S024R−G097A−S101G−Q109G−S128A,G020R−S024G−N043R−S101G−N116L−S128A−L217Q,G020R−N043R−S078N−S101Q−Q109G−L217Q,G020R−S024G−N043R−G097A−S101N−Q109N−N116L−L217Q,G020R−S024R−S078N−G097A−S101G−N116L−S128A,G020R−S024R−G097S−S101A−Q109N−N116L,G020R−S024R−S078N−S101A−Q109G−S128A,G020R−S024R−G097A−S101A−Q109G−N116L−S128A,G020R−N043R−G097A−S101Q−N116L−S128A,G020R−N043R−G097S−S101Q−S128A−L217Q,G020R−S024R−S078N−G097A−S101G−Q109G−N116L−L217Q,G020R−N043R−G097A−S101G−Q109N−N116L−S128A,G020R−N043R−S078N−G097S−S101N−Q109N−L217Q,G020R−S024R−G097S−A098E−S101A−N116L−S128A,G020R−S024R−S078N−G097S−S101A−Q109G−S128A,T022R−S024G−S078N−G097S−S101G−S103A−V104I−Q109N−N116L−L217Q−A232V−Q245R,G020R−S024R−S078N−G097A−S101Q−Q109N−N116L−L217Q,T022R−S024G−G097S−S101Q−S103A−V104I−S128A−A232V−Q245R,G020R−S024R−S101A−Q109N−N116L−S128A−L217Q,G020R−S024R−S101G−Q109G−N116L−S128A−L217Q,T022R−S078N−G097A−S101N−S103A−V104I−S128A−A232V−Q245R,G020R−S024G−N043R−S101N−N116L−S128A−L217Q,G020R−S024R−S078N−G097S−S101A−Q109N−N116L,G020R−S024R−S078N−G097A−S101N−Q109N−N116L−S128A,G020R−S024R−S078N−S101Q−Q109N−N116L−L217Q,T022R−S024G−S078N−S101N−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−N043R−S101G−Q109N−N116L−S128A−L217Q,T022R−S101N−S103A−V104I−L217Q−A232V−Q245R,T022R−G097A−S101N−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−G097A−S101A−S128A−L217Q,T022R−S024G−S078N−G097A−S101N−S103A−V104I−S128A−L217Q−A232V−Q245R,G020R−S024R−S078N−G097S−S101N−Q109G−N116L−S128A−L217Q,T022R−S024G−S101G−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−G097A−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−N043R−S101Q−S128A−L217Q,G020R−S024R−S078N−S101N−Q109G−S128A−L217Q,G020R−S024R−S078N−G097A−S101N−Q109N−N116L−S128A−L217Q,T022R−S024G−G097A−S101Q−S103A−V104I−N116L−L217Q−A232V−Q245R,G020R−S024R−S078N−G097S−S101G−S128A−N204S−L217Q,T022R−S024G−S078N−S101Q−S103A−V104I−N116L−S128A−A232V−Q245R,G020R−S024R−S078N−G097S−S101Q−Q109N−N116L−L217Q,G020R−S024R−S078N−S099G−S101Q−Q109N−N116L−L217Q,T022R−S024G−G097A−S101G−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−G097A−S101G−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,G020R−S024R−G097A−S101N−Q109N−S128A−L217Q,T022R−G097S−S101N−S103A−V104I−S128A−L217Q−A232V−Q245
R,G020R−S024R−K094R−S101N−N116L−S128A−L217Q,T022R−S024G−S078N−G097A−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,G020R−S024R−G097A−S101A−N116L−S128A−L217Q,G020R−S024R−S078N−G097W−S101Q−Q109N−N116L−L217Q,T022R−G097S−S101N−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S101Q−S103A−V104I−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S078N−G097A−S101Q−S103A−V104I−Q109N−N116L−S128A−L217Q−A232V−Q245R,G020R−N043R−G097S−S101Q−Q109G−N116L−S128A−L217Q,T022R−S024G−G097A−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−G097S−S101G−S103A−V104I−L217Q−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−Q109G−N116L−L217Q−A232V−Q245R,T022R−S024G−S078N−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101Q−S103A−V104I−Q109G−N116L−S128A−L217Q−A232V−Q245R,T022R−S078N−G097S−S101G−S103A−V104I−N116L−S128A−L217Q−A232V−Q245R,T022R−S024G−T071A−S078N−S101N−S103A−V104I−Q109N−N116L−S128A−A232V−Q245R,T022R−S024G−G097A−S101Q−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S101G−S103A−V104I−Q109N−S128A−A232V−Q245R,T022R−S024G−G097S−S101G−S103A−V104I−S128A−L217Q−A232V−Q245R,T022R−S024G−S078N−S101Q−S103A−V104I−Q109N−N116L−S128A−L217Q−A232V−Q245R,T022R−S101G−S103A−A232V−Q245R,T022R−S101G−S103A−V104I−A232V−Q245R−E271A,T022R−S103A−V104I−A232V−Q245R,T022R−S101G−V104I−A232V−Q245R,T022R−S101G−S103A−V104I−Q245R,G020R−N043R−E271A,G020R−S024R−I035T−S101A−N116L,G020R−N043R−P239G,G020R−N043R−S242L、又はG020R−N043R−V234F、前記サブチリシン変異体のアミノ酸位置が配列番号1に示すバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、クリーニング及び/又は処理組成物。 - 前記単離されたサブチリシン変異体が、バチルス・レンタスのサブチリシンGG36プロテアーゼのサブチリシン変異体であり、前記バチルス・レンタスのサブチリシンGG36プロテアーゼが、配列番号2に示すアミノ酸配列を含む、請求項1〜5のいずれか一項に記載の組成物。
- 前記単離されたサブチリシン変異体が、配列番号2に示すアミノ酸配列を含む前記バチルス・レンタスのサブチリシンGG36プロテアーゼに対して少なくとも90%のアミノ酸同一性を有する、請求項1〜6のいずれか一項に記載の組成物。
- 前記単離されたサブチリシン変異体の総正味電荷が、前記バチルス・レンタスのサブチリシンGG36プロテアーゼの総正味電荷を基準にして−1、0、+1、+2、+3、+4、+5、−1、−2、−3、−4、又は−5であり、前記バチルス・レンタスのサブチリシンGG36プロテアーゼの総正味電荷を基準にして好ましくは0、+1、+2、+3、+4、又は+5である、請求項1〜7のいずれか一項に記載の組成物。
- 前記変異体の総正味電荷が、前記バチルス・レンタスのサブチリシンGG36プロテアーゼの総正味電荷を基準にして+1、0、−1、−2、−3、又は−4であり、バチルス・レンタスのサブチリシンGG36プロテアーゼの総正味電荷を基準にして好ましくは0、−1、−2、−3、又は−4である、請求項22に記載の単離されたサブチリシン変異体。
- 前記単離されたサブチリシン変異体の総正味電荷が、次から選択される1つ以上の置換によって得られ:A001E、V004E、R010H/A、Q012E、A015D、N018D、R019H/S、V026D、K027E、N043D、R045C/T/S/P、S049D、V051E、G061E、N062D/E、N076D、N077D、S078D、S087D、A098E、S101D、S106E、G115E、G118D、N123D、S128D、P129E、S130D/E、S132D、A158E、G159D/E、S160D、S166D、R170T、N183D、N184D、N185E、R186H、S188D/E、A194E、A200D、Y209E、A215D、N204D、S212D、L217D/E、N218D、A230E、K235F、N237D、K237E、N238D、S240D、N243D、Q245D、R247L、N248D/E、K251C、N263D、N269D/E、A272D、A273E、又はR275H/S、前記プロテアーゼ変異体のアミノ酸位置が、配列番号1で示されるバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、請求項1〜9のいずれか一項に記載のクリーニング及び/又は処理組成物。
- 前記単離されたサブチリシン変異体の総正味電荷が、次から選択される1つ以上の置換によって得られ:A001R、V004R、Q012R、P014R、H017R、N018R/K、G020K/R、T022R/K、S024R/K、G025R、D032I、D041K/L/N、N043R/K、G046R、A048R、F050R/K、P055R、S056R/K、T057R、Q059K、G061R、N076K、S078R、P086R、S087R、E089G/P/I、G097R、S099R、Q109R、G115R、G118R、S132K、S144R、G159R/K、D181C/S/T、L196K、N204K、Q206R、K235R、Q236R/K、K237R、N238R、S240R、W241R、S242R/K、V244R、Q245R/K、N248R、H249R、N252R/K、S256R、G258R、T260K、N269R/K、又はE271F/H/T/L/W/R/S/I/A/G/V、前記プロテアーゼ変異体のアミノ酸位置が配列番号1で示されるバチルス・アミロリケファシエンスのサブチリシンBPN’のアミノ酸配列の、対応するアミノ酸位置に割り振られた番号に従って番号付けされる、請求項1〜10のいずれか一項に記載のクリーニング及び/又は処理組成物。
- 前記単離されたサブチリシン変異体が、次の特性:a)試験方法2による性能指数が少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.1〜約10、1.1〜約8、又は更には1.1〜約5;b)試験方法3による性能指数が少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.1〜約10、1.1〜約8、又は更には1.1〜約5;c)試験方法4による性能指数が少なくとも1.0、少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.0〜約10、1.0〜約8、又は更には1.0〜約5;及び/又はd)試験方法6による性能指数が少なくとも1.0、少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.0〜約10、1.0〜約8、又は更には1.0〜約5;及び/又はe)試験方法7による性能指数が少なくとも1.1、少なくとも1.2、少なくとも1.3、少なくとも1.4、少なくとも1.5、少なくとも1.6、少なくとも1.7、少なくとも1.8、少なくとも1.9、少なくとも2、1.1〜約15、1.1〜約10、又は更には1.1〜約7である、の1つ以上を有する、請求項1〜11のいずれか一項に記載のクリーニング及び/又は処理組成物。
- ヘミセルラーゼ、セルラーゼ、ペルオキシダーゼ、プロテアーゼ、メタロプロテアーゼ、キシラナーゼ、リパーゼ、ホスホリパーゼ、エステラーゼ、ペルヒドロラーゼ、クチナーゼ、ペクチナーゼ、ペクチン酸リアーゼ、マンナナーゼ、ケラチナーゼ、レダクターゼ、オキシダーゼ、フェノールオキシダーゼ、リポキシゲナーゼ、リグニナーゼ、プルラナーゼ、タンナーゼ、ペントサナーゼ、マラナーゼ、β−グルカナーゼ、アラビノシダーゼ、ヒアルロニダーゼ、コンドロイチナーゼ、ラッカーゼ、及びアミラーゼ、又はこれらの任意の組み合わせから選択される、少なくとも1つの追加を更に含む、請求項1〜12のいずれか一項に記載の組成物。
- 前記助剤を前記プロテアーゼ変異体と混合する工程を含む、請求項1〜13のいずれか一項に記載の組成物の製造方法。
- 請求項1〜13のいずれか一項に記載の組成物を含む水性洗浄液と、表面とを接触させる工程を含む、表面、特に布地の処理方法。
- 前記水性洗浄液が0.1〜3、好ましくは0.3〜2.5mS/cmの伝導度を有し、好ましくは前記組成物が請求項3又は請求項4に記載の組成物である、請求項15に記載の方法。
- 前記水性洗浄液が3〜30mS/cm、好ましくは3.5〜20mS/cmの伝導度を有し、好ましくは前記組成物が請求項2又は請求項5に記載の組成物である、請求項15に記載の方法。
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