JP2014514340A5 - - Google Patents
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- Publication number
- JP2014514340A5 JP2014514340A5 JP2014508740A JP2014508740A JP2014514340A5 JP 2014514340 A5 JP2014514340 A5 JP 2014514340A5 JP 2014508740 A JP2014508740 A JP 2014508740A JP 2014508740 A JP2014508740 A JP 2014508740A JP 2014514340 A5 JP2014514340 A5 JP 2014514340A5
- Authority
- JP
- Japan
- Prior art keywords
- dose
- composition according
- policosanol
- acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 14
- 229960001109 policosanol Drugs 0.000 claims 9
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 9
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 6
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 5
- 241000209094 Oryza Species 0.000 claims 5
- 235000007164 Oryza sativa Nutrition 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 235000009566 rice Nutrition 0.000 claims 5
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims 4
- 230000002378 acidificating effect Effects 0.000 claims 4
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 4
- 229940110767 coenzyme Q10 Drugs 0.000 claims 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 4
- 235000021283 resveratrol Nutrition 0.000 claims 4
- 229940016667 resveratrol Drugs 0.000 claims 4
- REZQBEBOWJAQKS-UHFFFAOYSA-N triacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO REZQBEBOWJAQKS-UHFFFAOYSA-N 0.000 claims 4
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 3
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 3
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 3
- 229930003231 vitamin Natural products 0.000 claims 3
- 239000011782 vitamin Substances 0.000 claims 3
- 235000013343 vitamin Nutrition 0.000 claims 3
- 229940088594 vitamin Drugs 0.000 claims 3
- 101000765308 Aspergillus niger N-(5'-phosphoribosyl)anthranilate isomerase Proteins 0.000 claims 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 2
- 229940009098 aspartate Drugs 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- IRHTZOCLLONTOC-UHFFFAOYSA-N hexacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCO IRHTZOCLLONTOC-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims 2
- 229940095064 tartrate Drugs 0.000 claims 2
- TYWMIZZBOVGFOV-UHFFFAOYSA-N tetracosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCO TYWMIZZBOVGFOV-UHFFFAOYSA-N 0.000 claims 2
- -1 vial Substances 0.000 claims 2
- 235000019158 vitamin B6 Nutrition 0.000 claims 2
- 239000011726 vitamin B6 Substances 0.000 claims 2
- 229940011671 vitamin b6 Drugs 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- RZALONVQKUWRRY-FYZOBXCZSA-N 2,3-dihydroxybutanedioic acid;(3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound OC(=O)C(O)C(O)C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O RZALONVQKUWRRY-FYZOBXCZSA-N 0.000 claims 1
- XOAAWQZATWQOTB-UHFFFAOYSA-M 2-aminoethanesulfonate Chemical compound NCCS([O-])(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-M 0.000 claims 1
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 claims 1
- HJPIFBJPTYTSEX-UHFFFAOYSA-N 2h-tetracen-1-one Chemical compound C1=CC=C2C=C(C=C3C(=O)CC=CC3=C3)C3=CC2=C1 HJPIFBJPTYTSEX-UHFFFAOYSA-N 0.000 claims 1
- 241000228245 Aspergillus niger Species 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 235000008100 Ginkgo biloba Nutrition 0.000 claims 1
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 1
- 244000113306 Monascus purpureus Species 0.000 claims 1
- 235000002322 Monascus purpureus Nutrition 0.000 claims 1
- 240000000111 Saccharum officinarum Species 0.000 claims 1
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 1
- 208000001435 Thromboembolism Diseases 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 229930003451 Vitamin B1 Natural products 0.000 claims 1
- 229930003779 Vitamin B12 Natural products 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 230000003143 atherosclerotic effect Effects 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 1
- 239000005515 coenzyme Substances 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- 229960005336 magnesium citrate Drugs 0.000 claims 1
- 235000002538 magnesium citrate Nutrition 0.000 claims 1
- 239000004337 magnesium citrate Substances 0.000 claims 1
- 229940095060 magnesium tartrate Drugs 0.000 claims 1
- MUZDLCBWNVUYIR-ZVGUSBNCSA-L magnesium;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O MUZDLCBWNVUYIR-ZVGUSBNCSA-L 0.000 claims 1
- QUIOHQITLKCGNW-TYYBGVCCSA-L magnesium;(e)-but-2-enedioate Chemical compound [Mg+2].[O-]C(=O)\C=C\C([O-])=O QUIOHQITLKCGNW-TYYBGVCCSA-L 0.000 claims 1
- YZURQOBSFRVSEB-UHFFFAOYSA-L magnesium;2-aminoethanesulfonate Chemical compound [Mg+2].NCCS([O-])(=O)=O.NCCS([O-])(=O)=O YZURQOBSFRVSEB-UHFFFAOYSA-L 0.000 claims 1
- 229940057059 monascus purpureus Drugs 0.000 claims 1
- 229930014626 natural product Natural products 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229940057070 sugarcane extract Drugs 0.000 claims 1
- 229960003495 thiamine Drugs 0.000 claims 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 1
- 229940066528 trichloroacetate Drugs 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- ABDKAPXRBAPSQN-UHFFFAOYSA-N veratrole Chemical compound COC1=CC=CC=C1OC ABDKAPXRBAPSQN-UHFFFAOYSA-N 0.000 claims 1
- 235000010374 vitamin B1 Nutrition 0.000 claims 1
- 239000011691 vitamin B1 Substances 0.000 claims 1
- 235000019163 vitamin B12 Nutrition 0.000 claims 1
- 239000011715 vitamin B12 Substances 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11164526 | 2011-05-03 | ||
| EP11164526.3 | 2011-05-03 | ||
| PCT/EP2012/057428 WO2012150146A1 (en) | 2011-05-03 | 2012-04-24 | Composition useful for the treatment of lipid metabolism disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014514340A JP2014514340A (ja) | 2014-06-19 |
| JP2014514340A5 true JP2014514340A5 (https=) | 2015-06-11 |
Family
ID=44645300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508740A Pending JP2014514340A (ja) | 2011-05-03 | 2012-04-24 | 脂質代謝障害の治療に有用な組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9125903B2 (https=) |
| EP (1) | EP2704734B1 (https=) |
| JP (1) | JP2014514340A (https=) |
| KR (1) | KR101840082B1 (https=) |
| CN (1) | CN103517711B (https=) |
| AR (1) | AR086231A1 (https=) |
| AU (1) | AU2012251818B2 (https=) |
| CA (1) | CA2834173A1 (https=) |
| CL (1) | CL2013003144A1 (https=) |
| CY (1) | CY1116612T1 (https=) |
| DK (1) | DK2704734T3 (https=) |
| EA (1) | EA025256B1 (https=) |
| ES (1) | ES2542412T3 (https=) |
| HR (1) | HRP20150767T1 (https=) |
| IL (1) | IL229205A (https=) |
| ME (1) | ME02180B (https=) |
| MX (1) | MX361038B (https=) |
| MY (1) | MY176018A (https=) |
| NZ (1) | NZ617641A (https=) |
| PH (1) | PH12013502229A1 (https=) |
| PL (1) | PL2704734T3 (https=) |
| PT (1) | PT2704734E (https=) |
| RS (1) | RS54100B1 (https=) |
| SG (1) | SG194679A1 (https=) |
| SI (1) | SI2704734T1 (https=) |
| SM (1) | SMT201500173B (https=) |
| UA (1) | UA112182C2 (https=) |
| WO (1) | WO2012150146A1 (https=) |
| ZA (1) | ZA201309205B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103202471B (zh) * | 2013-04-25 | 2014-06-11 | 福建永生活力生物工程有限公司 | 一种辅助降血脂的保健食品及其制备方法 |
| WO2016193096A1 (en) | 2015-05-29 | 2016-12-08 | Givaudan Sa | Spray drying |
| CN105395925A (zh) * | 2015-11-27 | 2016-03-16 | 杭州海王生物工程有限公司 | 一种以降血脂为基础的具有降血压和减肥功效的组合物 |
| CN105475580A (zh) * | 2016-01-19 | 2016-04-13 | 苟春虎 | 黑青稞降血脂茶（奶茶） |
| CN105853347A (zh) * | 2016-04-01 | 2016-08-17 | 海南合瑞制药股份有限公司 | 一种左卡尼汀的组合物及其制备方法 |
| IT201600075378A1 (it) * | 2016-07-19 | 2018-01-19 | Farm Legnani Del Dottor De Zanetti Andrea | Integratore alimentare a base di riso rosso fermentato |
| IT201600078969A1 (it) | 2016-07-27 | 2018-01-27 | Buonamici Gugliemo | Integratore alimentare |
| CA3069352A1 (en) | 2017-07-26 | 2019-01-31 | Vincent YACYSHYN | Removing polyphenol contaminants from feedstock-based polyphenols |
| CN111629784A (zh) * | 2018-01-04 | 2020-09-04 | 纯护理专业有限责任公司 | 用于调节总血液胆固醇的天然组合产品和方法 |
| US11173187B2 (en) | 2018-11-13 | 2021-11-16 | Immortazyme Company Ltd. | Concentrated oil-based polyphenol composition and a method of producing the oil-based polyphenol composition |
| IT201900007002A1 (it) * | 2019-05-20 | 2020-11-20 | Angelo Montecuollo | Integratore alimentare a base di caffè |
| CN112056563A (zh) * | 2020-09-15 | 2020-12-11 | 王胜林 | 用于修复脂质代谢障碍的营养素组合物及其应用 |
| KR102418383B1 (ko) * | 2020-11-19 | 2022-07-07 | 한국식품산업클러스터진흥원 | 천연 복합물을 포함하는 비만 예방 또는 치료용 조성물 |
| IT202200003191A1 (it) * | 2022-02-21 | 2023-08-21 | Inpha Res S R L | Composizione per il controllo delle iperlipidemie |
| CN119424573B (zh) * | 2024-02-05 | 2025-09-26 | 天津铭瑞医药科技有限公司 | 用于治疗高脂血症的中西药物组合 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2903558C2 (de) * | 1978-02-03 | 1994-09-01 | Sigma Tau Ind Farmaceuti | Verwendung von L-Carnitin |
| IT1277953B1 (it) | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per |
| JP3926888B2 (ja) * | 1997-05-27 | 2007-06-06 | 株式会社カネカ | コレステロール低下剤 |
| ITRM20030178A1 (it) | 2003-04-17 | 2004-10-18 | Sigma Tau Ind Farmaceuti | Uso della l-carnitina per il trattamento di patologie cardiovascolari. |
| PL1732605T3 (pl) * | 2004-03-29 | 2019-09-30 | Wyeth Llc | Multiwitaminowe i mineralne suplementy odżywcze |
| US20100119600A1 (en) * | 2007-06-01 | 2010-05-13 | Joar Opheim | Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof |
-
2012
- 2012-04-24 SI SI201230258T patent/SI2704734T1/sl unknown
- 2012-04-24 HR HRP20150767TT patent/HRP20150767T1/hr unknown
- 2012-04-24 KR KR1020137028752A patent/KR101840082B1/ko not_active Expired - Fee Related
- 2012-04-24 EA EA201391622A patent/EA025256B1/ru not_active IP Right Cessation
- 2012-04-24 MX MX2013012781A patent/MX361038B/es active IP Right Grant
- 2012-04-24 EP EP12716038.0A patent/EP2704734B1/en active Active
- 2012-04-24 MY MYPI2013003970A patent/MY176018A/en unknown
- 2012-04-24 PT PT127160380T patent/PT2704734E/pt unknown
- 2012-04-24 ES ES12716038.0T patent/ES2542412T3/es active Active
- 2012-04-24 RS RS20150464A patent/RS54100B1/sr unknown
- 2012-04-24 AU AU2012251818A patent/AU2012251818B2/en not_active Ceased
- 2012-04-24 ME MEP-2015-107A patent/ME02180B/me unknown
- 2012-04-24 WO PCT/EP2012/057428 patent/WO2012150146A1/en not_active Ceased
- 2012-04-24 PL PL12716038T patent/PL2704734T3/pl unknown
- 2012-04-24 PH PH1/2013/502229A patent/PH12013502229A1/en unknown
- 2012-04-24 CA CA2834173A patent/CA2834173A1/en not_active Abandoned
- 2012-04-24 US US14/114,830 patent/US9125903B2/en active Active
- 2012-04-24 JP JP2014508740A patent/JP2014514340A/ja active Pending
- 2012-04-24 DK DK12716038.0T patent/DK2704734T3/en active
- 2012-04-24 UA UAA201314009A patent/UA112182C2/uk unknown
- 2012-04-24 SG SG2013080130A patent/SG194679A1/en unknown
- 2012-04-24 NZ NZ617641A patent/NZ617641A/en not_active IP Right Cessation
- 2012-04-24 CN CN201280021733.2A patent/CN103517711B/zh not_active Expired - Fee Related
- 2012-05-02 AR ARP120101533A patent/AR086231A1/es unknown
-
2013
- 2013-10-30 CL CL2013003144A patent/CL2013003144A1/es unknown
- 2013-10-31 IL IL229205A patent/IL229205A/en active IP Right Grant
- 2013-11-29 ZA ZA2013/09205A patent/ZA201309205B/en unknown
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2015
- 2015-07-17 CY CY20151100624T patent/CY1116612T1/el unknown
- 2015-07-20 SM SM201500173T patent/SMT201500173B/xx unknown
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