WO2008059965A1

WO2008059965A1 - Agent for alleviating or preventing stress symptoms and agent for improving mental conditions

Info

Publication number: WO2008059965A1
Application number: PCT/JP2007/072297
Authority: WO
Inventors: Kenji Fujii; Mikio Kitahara
Original assignee: Kaneka Corporation
Priority date: 2006-11-17
Filing date: 2007-11-16
Publication date: 2008-05-22
Also published as: TW200838496A; JP2010030901A

Abstract

It is intended to provide an agent for alleviating or preventing stress symptoms caused by mental stress such as strain or an agent for improving mental conditions, characterized by containing oxidized coenzyme Q and/or reduced coenzyme Q as an active ingredient; and a food, a health food, a nutritional supplemental food, a supplement, a drug, a quasi drug, a pet food or a feed containing the agent for alleviating or preventing stress symptoms or agent for improving mental conditions.

Description

Specification

Relieving or preventing stress symptoms, mental condition improving agent

Technical field

[0001] The present invention relates to a stress symptom reducing agent, a preventive agent thereof, and a mental condition improving agent. Specifically, as a result of mental stress that occurs in everyday or extraordinary situations, a symptom-relieving or preventing agent for stress symptoms such as tension, and a mental state that improves the mental state for which improvement is desired It provides an improving agent.

Background art

[0002] People are subject to various mental stresses in their daily lives, and are forced to be unaware. The accumulation of mental stress can lead to serious illness. Today, it is important to avoid stress, or to relieve and reduce stress. Is widely recognized. Symptoms that require treatment by a doctor include obsessive-compulsive disorder and autonomic dystonia, and the power with which each treatment is taken into account is still not sufficient. Beyond that, a light level that does not require medical treatment, for example, a condition that is generally accepted, such as being very nervous and not being able to fully demonstrate its ability at the time of a light upset or a test, and being uncomfortable at all times. On the other hand, even the appropriate countermeasures are not clear.

[0003] For example, the symptoms caused by mental stress include tension, irritability, hot flashes, insomnia, ilaila sensation, seizure, stuttering, mental fatigue, gastrointestinal disorders, gastric pain, alopecia, fear, helplessness In addition to weakness, loss of appetite, headache, and sore throat, each individual has various symptoms. On the other hand, it is not clearly associated with mental stress, but in the mental state of daily life, it is angry, unmotivated, depressed, lack of happiness, lack of confidence, self-existence significance There are various mental states that are generally desired to be improved, such as lack of well-being, poorness, lack of concentration, melancholy, loss of life, unpleasantness, and depression.

[0004] Coenzyme Q is a force known from coenzyme Q1 to coenzyme Q13 due to the repeating structure of its side chain S. In mammals, coenzyme Q10 is the main coenzyme Q, and human Uses coenzyme Q10. Coenzyme Q10 is mitochondria, lysosome, Golgi, micro Localized in the some, peroxisome, cell membrane, etc., it is an indispensable substance for maintaining the function of the living body involved in ATP production activation, in vivo antioxidant action, and membrane stabilization as a component of the electron transport system .

[0005] Coenzyme Q10 is known to be oxidized and reduced. The oxidized form is named ubiquinone, and the reduced form is named ubiquinol. In the electron transfer system, coenzyme Q is known to transfer electrons by repeating redox. In addition, since the antioxidative activity is shown only in the reduced form and coenzyme Q in vivo exists in many parts, it is thought that the reduced form is the main form. However, since reduced coenzyme Q has a problem in oxidative stability, only oxidized coenzyme Q has been used in the industry so far. From such a background, when there is a description of coenzyme Q, it is common to indicate oxidized coenzyme Q unless otherwise noted, and when referring to reduced form, ubiquinol or reduced coenzyme is indicated. Q is listed.

[0006] Oxidized coenzyme Q10 has heretofore been used as an adjuvant for congestive heart failure. In recent years, it has been widely used worldwide as a supplement. Its physiological activity has been extensively studied, and many physiological activities such as anti-diabetic, anti-fatigue and anti-arteriosclerosis are known (patent documents;! To 3). As an anti-stress effect of coenzyme Q10, it has been reported that when oxidized coenzyme Q10 is used in combination with octacosanol or ezukogi (Patent Documents 4 and 5), Is a response to the stress of physical cold, and the effect of coenzyme Q on mental stress that occurs in normal life was not known at all.

Patent Document 1: JP-A-7-330584

Patent Document 2: JP-A-7-330593

Patent Document 3: JP-A-10-287560

Patent Document 4: JP 2004-292355

Patent Document 5: JP-A-2004-210728

Disclosure of the invention

Problems to be solved by the invention

[0007] The present invention relates to foods, health foods, dietary supplements, supplements, pharmaceuticals, quasi-drugs, It is an object of the present invention to provide an agent for alleviating or preventing stress symptoms, or an agent for improving mental condition, and a composition containing the agent, which are useful as a food or feed.

Means for solving the problem

[0008] As a result of intensive studies in view of the above circumstances, the present inventors have found that coenzyme Q has an excellent action of alleviating and preventing symptoms caused by mental stress such as tension and improving mental state. As a result, the present invention has been completed. That is, the present invention provides a stress symptom relieving agent or preventive agent or mental condition improving agent characterized by comprising oxidized coenzyme Q and / or reduced coenzyme Q as an active ingredient, and It relates to foods, health foods, dietary supplements, supplements, pharmaceuticals, quasi-drugs, pet foods, or feed containing palliatives or preventives or mental condition improvers.

That is, the present invention provides the following:

[1] Reducing stress symptom characterized by comprising oxidized coenzyme Q represented by the following formula (1) and / or reduced coenzyme Q represented by the following formula (2) as an active ingredient Preventive agent.

[Chemical 1]

[Chemical 2]

OH (2)

(Where n represents an integer of 1 to 12)

[2] Oxidized coenzyme Q represented by the above formula (1) and / or reduction represented by the above formula (2) A mental condition improving agent characterized by comprising type coenzyme Q as an active ingredient.

[3] The agent according to [1] or [2], wherein coenzyme Q is coenzyme Q10 (wherein n is 10).

[4] The agent according to item 1, further comprising a nutritional supplement and / or a health food material [1] to [3].

[5] Nutritional supplements are amino acids, metal ions, sugars, proteins, fatty acids, vitamins, vitamin B derivatives, theanine, γ-aminobutyric acid (GABA), anserine, soy peptide, thioredoxin, wheat dartene hydrolysis , Glutamine, milk peptide, ω-3 fatty acids, phosphatidylserine, wastaxanthin, polyphenols, green tea catechin, saponin, yew leaf extract, saint john's wort, rabu hemp extract, sorghum, coral rust, and rydanans The agent according to [4], which is one or more selected from the group consisting of:

[6] The agent according to [4], wherein the health food material is at least one selected from the group consisting of herbs, herbal medicines, mushrooms and extracts thereof.

[7] The agent according to item 1, further comprising an antioxidant or / and an antioxidant enzyme [1] to [6].

[8] Antioxidant power group consisting of vitamin Ε, vitamin Ε derivatives, vitamin C, vitamin C derivatives, lycopene, vitamin A, carotenoids, vitamin B, vitamin B derivatives, flavonoids, astaxanthin, dartathione and selenium The agent according to [7], which is at least one selected from the group consisting of:

[9] Antioxidant power One or more selected from the group consisting of superoxide dismutase (SOD), dartathione peroxidase, dartathione S transferase, dartathione reductase, force tarase and ascorbate peroxidase [7] The agent according to [7].

[10] [1] to [9] A food, health food, dietary supplement, supplement, pet food, or feed containing the agent according to item 1.

[11] [1] to [9] Any one of the drugs or quasi drugs containing the agent according to 1.

[12] Stress symptoms including administering to a subject an effective amount of oxidized coenzyme Q represented by the above formula (1) and / or reduced coenzyme Q represented by the above formula (2) Mitigation or prevention methods. [13] A mental state comprising administering an effective amount of oxidized coenzyme Q represented by the above formula (1) and / or reduced coenzyme Q represented by the above formula (2) to the administration subject How to improve.

[14] The method according to [12] or [13], wherein the coenzyme Q is coenzyme Q10 (wherein n is 10).

[15] Any force of [1] to [9], agent according to item 1, food according to [10], health food, dietary supplement, supplement, pet food or feed, or according to [11] Use of oxidized coenzyme Q represented by the above formula (1) and / or reduced coenzyme Q represented by the above formula (2) for producing a pharmaceutical product or quasi drug.

[16] The use according to [15], wherein the coenzyme Q is coenzyme Q10 (wherein n is 10).

[17] A composition containing oxidized coenzyme Q represented by the above formula (1) and / or reduced coenzyme Q represented by the above formula (2) as active ingredients, and the composition as a stress A commercial package containing a statement stating that it should or should be used to alleviate or prevent symptoms or improve mental status.

The invention's effect

[0010] The agent for alleviating or preventing stress symptoms or the mental condition improving agent of the present invention is excellent in improving the mental state in normal life as well as alleviating or preventing various symptoms caused by mental stress such as tension. It can be taken on a daily basis without any side effects such as sleepiness. The composition containing the agent for alleviating or preventing stress symptoms or the mental condition improving agent of the present invention is useful as a food, health food, dietary supplement, supplement, pharmaceutical, quasi-drug, pet food, or feed. .

BEST MODE FOR CARRYING OUT THE INVENTION

[0011] The present invention is described in detail below.

The stress symptom-reducing or preventing agent or mental condition-improving agent of the present invention (hereinafter sometimes referred to as the agent of the present invention) is an oxidized coenzyme Q represented by the following formula (1) and / or the following formula (2) A reduced coenzyme Q represented by the formula is used as an active ingredient.

[0012] [Chemical 3]

[0013] [Chemical 4]

[0014] The "stress symptom" in the present invention refers to various symptoms caused by mental stress, and is not limited and varies depending on individuals or individuals. Specifically, tension, irritability, hot flashes, insomnia, Easy to get angry, depressed, irritated, attracted, stuttering, mental fatigue, gastrointestinal disorders, stomach pain, hair loss, fear, helplessness, weakness, decreased motivation, loss of appetite, headache, throat, tics, dry skin Etc. The agent for alleviating or preventing stress symptoms of the present invention has an action of alleviating the stress symptoms or preventing such symptoms from occurring.

[0015] Relieving stress symptoms in the present invention means that the above symptoms are subjectively or objectively normal (a state in which the above symptoms are not conscious or unintentional) or close to a normal state. Means. That is, the stress symptoms of an individual who is aware of the above symptoms in life, or who is judged to be in such a state as viewed from others, take (or ingest) the alleviating agent of the present invention. As a result, stress symptoms can be consciously or objectively improved.

[0016] Further, the prevention of stress symptoms in the present invention refers to a situation in which a so-called stress is expected to occur under certain special circumstances, for example, when something is performed before a test or in front of another person. Or by taking (or ingesting) the preventive agent of the present invention on a daily basis. To prevent or reduce the incidence of symptoms (ie, reduce the risk of developing stress symptoms)!

[0017] In addition, the improvement of the mental state in the present invention is not clearly associated with stress, but the mental state generally desired to be improved in the mental state in daily life. I like it, I will improve it in the direction. The mental states for which the above improvement is desired include anger, lack of motivation, depression, lack of happiness, lack of confidence, lack of self-existence significance, well-being, lack of concentration, anxiety, decline in purpose of life, Mental conditions such as unpleasant and depressed are listed.

[0018] The oxidized coenzyme Q used in the agent of the present invention can be obtained by a conventionally known method such as a fermentation method, a synthesis method, or an extraction method from animals or plants. One that has an all-trans structure obtained by a method other than a synthesis method such as a certain force fermentation method is preferable from the viewpoint of safety, for example, Kaneiki's Coenzyme Q10 (trademark of Kane force).

[0019] The method for obtaining reduced coenzyme Q used in the agent of the present invention is not particularly limited. For example, after obtaining coenzyme Q by a conventional method, reduced form in the effluent is obtained by chromatography. A method of concentrating the coenzyme Q category can be employed. In this case, if necessary, a general reducing agent such as sodium borohydride or sodium dithionite (hydrosulfite sodium) is added to the above-mentioned coenzyme Q, and the above-mentioned supplementation is performed by a conventional method. Concentration by chromatography may be performed after reducing the oxidized coenzyme Q contained in enzyme Q to reduce coenzyme Q. It can also be obtained by a method in which the above reducing agent is allowed to act on existing high-purity oxidized coenzyme Q. Alternatively, cells containing reduced coenzyme Q can also be used. Alternatively, oxidized coenzyme Q can be reduced to reduced coenzyme Q in the preparation by formulating oxidized coenzyme Q together with a substance having a reducing ability such as vitamins. In addition, KANEKA QH (Kaneri Co., Ltd.), which is a high-purity reduced coenzyme Q 10, which has recently been launched, can be preferably used. Also, coenzyme Q, which is a mixture of oxidized and reduced forms obtained by a known method, may be used as it is.

In the agent of the present invention, both oxidized coenzyme Q and reduced coenzyme Q are effective components. It can also be used as a fraction, and can also be coenzyme Q, which is a mixture of oxidized coenzyme Q and reduced coenzyme Q. In that case, the ratio of oxidized and reduced forms in coenzyme Q can be appropriately determined depending on the product receptacle. Increasing the ratio of reduced coenzyme Q in coenzyme Q can be expected to have a higher effect than the potential for cost increase due to stabilization measures. For example, when using coenzyme Q, which is a mixture of oxidized coenzyme Q and reduced coenzyme Q, the ratio of reduced coenzyme Q in coenzyme Q is preferably 20% or more. More preferably, it is more preferably 70% or more. Hereinafter, when simply described as “coenzyme Q” in the present application, it means any of oxidized coenzyme Q alone, reduced coenzyme Q alone, and a mixture of oxidized and reduced forms.

[0020] The ratio of oxidized and reduced forms in coenzyme Q is usually determined by quantifying oxidized coenzyme Q and reduced coenzyme Q in a sample using an HPLC system using a UV detector. There are two methods, one is to calculate the ratio, and the other is to calculate the ratio of oxidized coenzyme Q and reduced coenzyme Q from the peak area using a system that incorporates an electrochemical detector in HPLC. A system incorporating an electrochemical detector can measure redox substances specifically and has a high sensitivity V. Therefore, it is useful when measuring the proportion of reduced forms in living organisms or samples in trace amounts. high. The ratios of oxidized coenzyme Q and reduced coenzyme Q shown in the present invention are not limited to this method, of course, the force quantified by an HPLC system incorporating an electrochemical detector! / ,.

[0021] In the agent of the present invention, it is preferable to use coenzyme Q10 in which n is 10 as coenzyme Q.

In the agent of the present invention, coenzyme Q may be ingested as it is, but since coenzyme Q is fat-soluble, it is preferably dispersed and dissolved in general edible fats and oils. Examples of such edible oils and fats include vegetable oils, processed oils and fats, animal fats and oils, and specifically, rice oil, rapeseed oil, palm oil, coconut oil, corn oil, safflower oil, and cottonseed oil. , Sesame oil, peanut oil, sunflower oil, olive oil, grape seed oil, perilla oil, edible hamani oil, various nut oils, soybean oil, coconut oil, wild tea flower oil, tea oil, evening primrose oil, rosehip oil, pumpkin oil , Red palm oil, lard, medium chain triglycerides, beef tallow, fish oil and mixtures thereof, among others rapeseed oil, corn oil, safra lees Vegetable oils such as mono-oil and mixtures thereof are preferred, but are not limited thereto.

It is possible to ingest the form dissolved in the above edible fats and oils as a form processed by a known technique, for example, an inclusion body by cyclodextrin, an oil-in-water emulsion.

[0022] In addition to coenzyme Q, the agent of the present invention can contain both nutritional supplements, health food ingredients, and more general food ingredients.

[0023] Nutritional supplements are not particularly limited! /, But amino acids, metal ions, sugars, proteins, fatty acids, vitamins such as vitamin B derivatives, theanine, γ-aminobutyric acid (GAB A ), Anserine, soy peptide, thioredoxin, wheat dartene hydrolyzate, dartamine, milk peptide, docosahexaenoic acid, eicosapentaenoic acid and other ω-3 fatty acids, phosphatidylserine, wastaxanthin, polyphenols, green tea catechins, And lignans such as saponin, Ichiyo leaf extract, St. John's wort, Rafu hemp extract, Yezogigi, shark rust and sesamin.

[0024] The health food material is not particularly limited, and examples thereof include herbs, herbal medicines, mushrooms, and extracts thereof. Herbs include, for example, Italian parsley, Erikampain, Olive, Olegano, Carldon, Power Fir Nore, Curry Plant, Cat Yuff. , Caraway, christmas rose, crimson clover, cornflower, common mallow, salada barnet, santorina, cinnamon, jasmine, stevia, sage, sebobo daiju, scented geranium, soapwort, solomons sinole, thyme, tansy, chiichi Bill, Chiave, Nastathium, Jujube, Basil, Honeysuckle, Hyssop, Flux, Fennel, Fox Gloves, Blackley Holly Hock, French Marigold, Betney, Heliotrope, Benolegamotte, Hemp Agrimony, Henno Radar, Pot Mari I Gold, Borigi, White Hoaound , Myrtle, Marlein, Marjoram, Mint, Yarrow, Lavender, Ladies Bed Straw, Lemongrass, Lemonba Downy Na, Remon'no over-time, rose, rosemary, rocket, Wainoredosuto opening Berry, Wai Roh TOLEDO pansies, forget that the present invention is not limited to this force that is like grass. Herbal medicines include, for example, akaneko, Akiyo, Akebei, Azenak, Ikarisou, Isi, Ichiyo, Ilraysen, Chinkou, Wikiwe, Tucon, Usokkko, Uz, Unoku, Ujak, Duyoyo, Engosaku, Ougi, Ogon, Ousei, Obata, Oulen, Ootsafuji, Obaco, Onji, Kai Power, Kaikinsha, Kaigoshii, Kaituhi, Geiha Kagoso, oak, oak yu, gadju, katsukou, katsukon, katsuki, kayak, carocon, caronine, kankyoyou, force nazo, kanrenso, kikiyou, chrysanthemum, kikukoku, pheasant, yellowfin, kiban, giyukaku, kiyoukatsu, kiyoukoku Kinshi Ushi, Gingoyo, Gingin Power, Kinsenso, Kinmizuhiki, Kokushi, Kujin, Kuseki, Keyai, Kiketou, Keishi, Keihi, Kudgek, Kemameshi, Kengoshi, Genjin, Koi, Kou Power, Gukkanhi, Kouko, Koushi, Koju, Kobushi, Kopok, Gou, Gokahi, Gosh, Goshyu, Pepper, Kosaiho, Kotonik, Gonoishi, Konoki, Goboushi, Sesame, Garbage, Korono, Saiko, Saishin, Saffron, Sayou, Hawthorn, Sanjico, Sanshishi, Sansha, Sanshu, Sansho, Sandscon, Sanson, Sanjak, Sanryo, Zhou, Zion, Deer, Sikaru, Zikotsubi, Shikon, Giseki, Shiseikiei, Shiso, Shiso, Shisoyo, Shirishi, Gifushi, Shaksex, Peonies, Jashoushi, Shajin, Shazenshi, Shazensou, Shachu, Jiuwei, Stasha, Shokyo, Shobukon, Shouma, Shomoku, Joteishi, Ziryu, Shiny, Shingi, Genkiyo, Jinko, Seiteuxong, Seisushikon, Seisushi, Seitai, Sehi, Sekii, Sekishaku, Sekishokon, Sekiryuhi, Sekkemei, Sekko, Senkaxou, Senyu Yu, Zenko, Sentai, Sempuku Power, Senrenshi, Sour Power, Sokushi, Sojisou , Sohakuhi, sohiyousho, sopok, soyo, daioh, taisekisha, daiseiyou, taisou, daifukuhi, takusha, taklang, tanjin, chitajo, chitamo, chimo, butterfly kou, chiyorei, chimpi, tyreki, tenkafun, maize , Togashi, Toki, Toshin, Tochu Power Saw, Dokatsu, Tonin, Toshishi, Tochu, Nikujuyou, Nikuzuku, Niyukou, Carrot, Nindo , Mouse mochi, nokugaishi, nokuga, nokunisin, nokuzuk, nokusenpi, nokutowo, nokuhenzu, nokumonto, nogekiten, nokan force, nomaboufu, nonge, noko force, hikai, hishi, Beakku, Beakushi, Beakku Ju, Beakkudan, Beakkubi, Beer Tabcon, Bejakkaja Zessou, Beetsukiyu, Beetsukiyousan, Binguchi Uji, Fukubonshi, Bukkyou, Bushiki, Bekko, Beninona, Henchiku, Bowie, Ho , Buttonpi, Borei, Maikai Power, Maou, Maukon, Machinin, Mankeishi, Mitsumo Power, Myronoh, Mokku, Mokzok, Mokki, Mokko, Yakan, Yakuchi, Yakumo Sou, Yakou Tou, Yutan, Chotaiin, Mogi, Life Powers including, but not limited to, Lacan power, Ryugannik, Ryukid, Ryukko, Ryutan, Ryoukiyo, Ryokuzu, Rengiyo, Rensenso, Rennik, Rokujiyo, Mouth Bow. Examples of mushrooms include matsutake, maitake, shitake, enoki, shimeji, eringi, and beech.

[0025] In addition to coenzyme Q, the agent of the present invention may contain both an antioxidant and an antioxidant enzyme. Antioxidants are not particularly limited. For example, vitamin E, vitamin E derivatives, vitamin C, vitamin C derivatives, lycopene, vitamin A, carotenoids, vitamin B, vitamin B derivatives, flavonoids, dartathione, Examples include staxanthin and selenium.

[0026] The antioxidant enzyme is not particularly limited, and examples thereof include superoxide dismutase (SOD), glutathione peroxidase, glutathione S-transferase, glutathione reductase, catalase, and ascorbate peroxidase. It is done.

[0027] In the agent of the present invention, one or two or more kinds of antioxidant substances, antioxidant enzymes, nutritional supplements, and health food materials as exemplified above can be used as appropriate.

[0028] In addition to the above-mentioned components, other ingredients that are pharmaceutically acceptable or acceptable as foods may be appropriately added to and mixed with the agent of the present invention by conventional methods. Such materials are not particularly limited, and examples thereof include excipients, disintegrants, lubricants, binders, antioxidants, colorants, anti-aggregation agents, absorption promoters, solubilizers, and stabilization. And nourishing tonic ingredients.

[0029] The excipient is not particularly limited, and examples thereof include sucrose, lactose, glucose, corn starch, mannitol, crystalline cellulose, calcium phosphate, and calcium sulfate.

[0030] The disintegrant is not particularly limited, and examples thereof include starch, agar, calcium citrate, calcium carbonate, sodium hydrogen carbonate, dextrin, crystalline cellulose, carboxymethyl cellulose, tragacanth and the like. [0031] The lubricant is not particularly limited, and examples thereof include talc, magnesium stearate, polyethylene glycol, silica, hydrogenated vegetable oil, and the like.

[0032] The binder is not particularly limited, and for example, ethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, tragacanth, shellac, gelatin, gum arabic, polybulur pyrrolidone, polybullic alcohol, polyacrylic acid, polymethacrylic acid. Examples include acids and sorbitol.

[0033] The antioxidant is not particularly limited, and for example, ascorbic acid, tocopherolole

, Vitamin Α, β-carotene, sodium bisulfite, sodium thiosulfate, sodium pyrosulfite, citrate and the like.

[0034] The colorant is not particularly limited. For example, it is permitted to be added to a pharmaceutical product.

V, the ability to use things S

[0035] The aggregation inhibitor is not particularly limited, and examples thereof include stearic acid, talc, light anhydrous caustic acid, and hydrous caustic dioxide.

[0036] The absorption promoter is not particularly limited, and examples thereof include higher alcohols, higher fatty acids, and surfactants such as lecithin, lysolecithin, and glycerin fatty acid ester.

[0037] The dissolution aid is not particularly limited, and examples thereof include organic acids such as fumaric acid, succinic acid, and malic acid.

[0038] The stabilizer is not particularly limited, and examples thereof include benzoic acid, sodium benzoate, paraethyl benzoate, and the like.

[0039] The nourishing tonic component is not particularly limited, and examples thereof include creatine, taurine, vitamin Bl, vitamin koji derivatives, amino acids, and mixtures of these substances.

[0040] The agent of the present invention can be used as it is or as a composition containing the same for foods, health foods, dietary supplements, supplements, pharmaceuticals, quasi drugs, pet foods, or feeds. The term “health food” as used herein refers to all forms of food that can be ingested for health maintenance other than pharmaceuticals, such as health foods, health supplements, foods for specified health use, and functional nutrition foods. In addition, if the food is a so-called health food, the form of ingested unit amount per meal of oxidized coenzyme Q and / or reduced coenzyme Q If the food is a healthy drink, the coenzyme Q is suspended or dissolved in the bottle, etc. A form is mentioned.

The ingestion unit amount per meal is the amount of active ingredient ingested in the case of food. In particular, in the case of foodstuffs, the intake of the whole food varies from person to person, and it is difficult to define it as the content of the active ingredient in the composition. Therefore, taking into account the effective intake per day described below. Therefore, it is recommended to specify as a single intake of active ingredient. The single intake is an amount that varies depending on age, weight, sex, degree of stress, and the like. In the case of pharmaceuticals, examples include a packaged form containing a single intake, that is, the amount of an active ingredient administered at a time, and a form that is contained in a bottle or the like in the form of a single drink.

[0041] The form of the agent of the present invention or a composition containing the agent is not particularly limited, but it is oral, such as capsules, microcapsules, soft capsules, tablets, powders, wearables, syrups, liquids, etc. Edible oil and fat composition, cooking oil, spray oil, butters, margarines, shortenings, whipped cream, concentrated milk, whiteners, dressings, pickle liquids, breads, Cakes, pies, cookies, Japanese confectionery, snacks, oil confectionery, chocolate and chocolate confectionery, rice confectionery, roux, sauces, sauces, toppings, ice confectionery, rice cakes, bakery mixes, Frozen foods, processed meat products, marine products, frozen entrées, livestock frozen foods, frozen foods such as agricultural frozen foods, cooked rice , Jams, cheese, cheese foods, cheese-like foods, gums, candies, fermented milk, canned foods, beverages, etc .; forms useful foods through skins such as patches, lotions, sprays The form to send to

[0042] Furthermore, in combination with ingredients used for aromatherapy, such as herbs and herbal medicines, taking the stress symptom relief or preventive agent of the present application, aromatherapy, bath, massage, listening to music, incense, animal therapy, walking A stronger effect can be expected by using relaxation methods such as these together.

[0043] The effective daily intake of the composition containing the agent of the present invention for humans (adults) is 10 to 500 mg, preferably 50 to 300 mg, more preferably as the amount of reduced coenzyme Q10. Is 50 ~ 200mg. When the intake is 50 mg or more, sufficient relief of symptoms caused by stress, prevention, and improvement of mental status can be obtained.

[0044] The effective ingestion amount is 50 to 1000 mg, preferably 100 to 600 mg, more preferably <(or 200 to 350 mg as the amount of oxidized coenzyme Q 10. In this case, it is possible to sufficiently relieve symptoms and prevent symptoms and improve mental status due to stress, although these intakes are known to vary depending on the dosage form of the drug. If it is a preparation, it can be expected to achieve its intended purpose with a lower intake.The above intake can be taken once or divided into several times a day. However, it is usually 2 weeks or longer, preferably 1 month or longer, especially when taking it as a prophylactic agent for stress symptoms, before the situation where stress symptoms are expected to occur. It is preferable to take it for at least one week.

Since coenzyme Q is not accumulative, the effect of the agent of the present invention is attenuated by terminating the intake. Therefore, it is preferable to take it on a daily basis during periods when stress symptoms are alleviated and mental conditions are expected to be improved or when stress symptoms are expected to occur.

[0045] The agent of the present invention is used in humans and animals other than humans (eg, mammals other than humans (domestic animals such as pigs, horses, horses, dogs, cats, pets), birds such as chickens, etc.) It can be used to alleviate or prevent the above stress symptoms or to improve mental status.

[0046] The present invention provides a method for alleviating or preventing the stress symptoms or a method for improving mental state. The method comprises a subject to be administered the above-mentioned alleviation, prevention or improvement (for example, human or non-human animal), preferably a subject to be aware of or aware of the stress symptoms on a daily basis! Alternatively, a step of administering an effective amount of oxidized coenzyme Q represented by the above formula (1) and / or reduced coenzyme Q represented by the above formula (2) to an administration subject whose mental condition is desired to be improved including.

[0047] The present invention further provides a commercial package for performing the above method. The commercial package includes an oxidized coenzyme Q represented by the above formula (1) and / or a reduced coenzyme Q represented by the above formula (2). Relaxation Or a statement (eg, instructions for carrying out the above method) that states that it can (or should be) used for prevention or improvement of mental status.

[0048] As another aspect, the present invention provides an oxidized coenzyme Q and / or the above-described formula (1) for producing an agent for alleviating or preventing stress symptoms, or an agent for improving mental state. The use of reduced coenzyme Q represented by formula (2) is provided.

Example

Next, the present invention will be described in more detail based on examples, but the present invention is not limited only to such examples.

[0050] (Example 1) Be aware of stress! // There is tension of oxidized coenzyme Q10 for healthy people! /, Is a mental stress alleviating effect

The effect of oxidized coenzyme Q10 on healthy volunteers aware of stress was evaluated by the double-blind crossover method. The volunteers who were conscious of a certain amount of stress were selected by measuring the fatigue (degree of mental stress) of healthy volunteers using the visual alanog scale (VAS). VAS shows the subject a piece of paper with a standard expression (asymptomatic or lowest possible leftmost, highest possible rightmost) on both ends of a 10 cm long line segment. It shows the current state on a line segment and measures subjective fatigue and symptoms. For example, in evaluating subjective stress, the left end of the straight line is “no stress at all” and the right end is “maximum stress that can be experienced”, and the current state of the subject is checked on the line segment. The degree of awareness stress is evaluated by measuring the length from the left edge of the minute. Twenty-six volunteers were divided into two groups. Oxidized coenzyme Q10 capsules (test food) or placebo capsules (control food) with the formulation shown in Table 1 were administered daily for 2 weeks a week. Type coenzyme Q 10 intake 200mg / day) Ingestion, various symptoms before and after intake (7 items: subjective stress, tension, drowsiness, boredom, motivation, wheezing, irritability) Quantified by VAS. Furthermore, an Advanced Trail making test (ATMT), which is an evaluation of work efficiency (puff performance efficiency), was conducted. Blood coenzyme Q 10 was also collected before and after ingestion and quantified using HPLC.

[0051] [Table 1] Test meal composition table (4-oval soft force per capsule)

[0052] Oxidized coenzyme Q 10: KANEKI Co., Ltd.

Safflower oil: Nisshin Oiliognolep Co., Ltd.

Beeswax: Miki Chemical Industry Co., Ltd.

Poem S-100: Glycerin fatty acid ester surfactant, manufactured by Riken Vitamin Co., Ltd. Soy lecithin: manufactured by Sakai Oil Co., Ltd.

[0053] Table 2 shows the VAS results. In the oxygenated coenzyme Q10 intake group, there was a statistically significant (p <0. 05) relaxation in tension and irritability, and a relaxation tendency (p <0.5) in subjective stress and throating. Admitted. On the other hand, there was no difference in sleepiness, motivation and boredom between the group receiving oxidized coenzyme Q10 and the placebo group. In addition, ATMT performance showed a significant reduction in reaction time, indicating that the intake of oxidized coenzyme Q10 increases the work efficiency. Conventional anti-stress substances often have a sedative effect that reduces performance, which is a problem in actual use. These results indicate that the stress-relieving effect of oxidized coenzyme Q 10 is S, a sedative effect. It is shown that it is highly useful without accompanying.

[Table 2]

Subjective evaluation value by VAS

ifii charge before ingestion after ingestion

Tension Placebo 3.64 ± 1.49 3.46 ± 1.50

Oxidized coenzyme Q10 3.64 ± 1. 39 3.05 ± 1.59 ** Ilila feeling Placebo 3.63 ± 1.60 3.53 ± 1.51

Oxidized coenzyme Q10 3.88 Sat 1. 55 3.07 ± 1.75 ** Subjective stress Placebo 4.09 ± 1.67 3.66 ± 1.77

Oxidized coenzyme Q10 4.29 ± 1. 83 3.26 ± 1.74 * Throat Placebo 5.14 ± 1.59 4.79 ± 1.68

Oxidized coenzyme Q10 4.97 ± 1.39 4.51 ± 1.61 * Sleeping placebo 4.80 ± 1.46 4.32 ± 1.88

Oxidized coenzyme Q10 4.86 ± 1.59 4.23 ± 1.85 Motivation Placebo 4.96 ± 1.24 4.79 ± 1.36

Oxidized coenzyme Q10 4.86 ± 1.17 4.61 Sat 1 ・ 59 Boring degree Placebo 3.74 ± 1.26 3.57 ± 1.76

Oxidized coenzyme Q10 3.96 ± 1.52 3.55 ± 1.70

* p 0.5, ** p <0.05 Significant difference from Student t-test placebo group

[0054] The plasma coenzyme Q10 concentration in this study was 986.6 ± 914. Increased calories.

[0055] (Example 2) Be aware of stress! /, There is tension of reduced coenzyme Q10 for healthy people! /, Is a mental stress alleviating effect

In the same manner as in Example 1, conscious of stress! /, The effect of reduced coenzyme Q10 on healthy volunteers was evaluated by a double blind crossover method. Twenty-six healthy volunteers who are aware of stress were divided into two groups, and reduced coenzyme Q10 strength of the formulation composition shown in Table 3 (however, reduced form containing about 1% by weight of oxidized coenzyme Q10) Coenzyme Q 10 was used) (test food) or placebo capsule (control food), one capsule daily for one week. Fatigue before and after intake was measured by VAS, and performance efficiency was quantified by ATMT. Reduced coenzyme Q10 is known to have better oral absorption than oxidized coenzyme Q10, so a preliminary study was conducted, and blood concentration was the same as when 200 mg of oxidized coenzyme Q10 was ingested. The daily intake was set at 50 mg. As a result, similar results were obtained as when 200 mg of oxidized coenzyme Q10 was ingested. Specifically, a statistically significant relaxation was observed in the degree of tension, irritability and subjective stress. An improvement in performance was observed. On the other hand, there was no difference in sleepiness, motivation and boredom between the reduced coenzyme Q 10 intake group and the placebo group. This result is the result of reduced complement Stress relief effect of enzyme Q 10 S, indicating that it is highly useful without sedation, and comparable effect at lower doses compared to oxidized coenzyme Q 10 I have proved that.

[Table 3] Test meal composition table (4- oval soft force per capsule)

[0057] Reduced coenzyme Q 10: KANEKI Co., Ltd.

Safflower oil: Nisshin Oiliognolep Co., Ltd.

Beeswax: Miki Chemical Industry Co., Ltd.

Poem S-100: glycerin fatty acid ester surfactant, manufactured by Riken Vitamin Co., Ltd. soybean lecithin: manufactured by Sakai Oil Co., Ltd.

[0058] (Example 3) Mental condition improving effect of reduced coenzyme Q10 on healthy individuals

The effect of reducing coenzyme Q 10 on mental state was evaluated by the double blind test. Three healthy individuals (18 males and 18 females) were divided into 3 groups. Placebo capsules listed in Table 4 or reduced coenzyme Q 10 capsules daily 3 capsules (including placebo group: 3 placebo capsules, lOOmg intake group: placebo capsule 1 + 2 reduced coenzyme Q 10 capsules, 300 mg intake group: 3 reduced coenzyme Q 10 capsules) for 4 weeks. Carried out. In the questionnaire, participants were asked about each item: 0: none at all, 1: almost none, 2: little, 3: moderate, 4: high, scoring with a score of 2 or more before ingestion The improvement rate after ingestion was evaluated for the items with the score of. As a result, dose-dependent improvements were observed in the four items of anger, lack of motivation, depression, and tension, and these mental states were improved by taking reduced coenzyme Q10. Became clear. [0059] [Table 4] Test food composition table (per 4-oval soft force pellule)

The components used are the same as in Example 2.

[0060] [Table 5] Mental status improvement effect by reduced coenzyme Q 1 0

[0061] It should be noted that the improvement rate (%) is the percentage of subjects who scored 2 or more before taking the capsule (subjects who are expected to improve their mental state) in each item. This is the percentage of subjects whose score was lower than before ingestion.

[0062] (Formulation Example 1) (Powder)

Oxidized coenzyme Q10 was dissolved in propanol, then adsorbed on microcrystalline cellulose, and dried under reduced pressure. This was mixed with corn starch under a nitrogen stream to obtain a powder.

Oxidized coenzyme Q 10 10 parts by weight

40 parts by weight of microcrystalline cellulose

Corn Starch 55 parts by weight

[0063] (Formulation Example ² ) (Capsule)

After preparing a powder with the following formulation in the same manner as in Formulation Example 1, it is filled into gelatin capsules by a conventional method. Filled. The filled capsules were sealed and then packed in a nitrogen atmosphere and stored refrigerated.

Oxidized coenzyme Q 10 20 parts by weight

40 parts by weight of microcrystalline cellulose

Corn starch 20 parts by weight

Lactose 65 parts by weight

I: Department

Polybini Department

[0064] (Formulation Example 3)

Corn oil was heated to 50 ° C, and oxidized coenzyme Q10 melted at the same temperature was added and dissolved. Oxidized coenzyme Q 10 50 parts by weight

350 parts by weight of corn oil

[0065] (Formulation example 4) (Tablet)

Oxidized coenzyme Q10 was dissolved in propanol, adsorbed on microcrystalline cellulose, and dried under reduced pressure. To this, corn starch, lactose, carboxymethylcellulose calcium and magnesium stearate were mixed under a nitrogen atmosphere, and then an aqueous solution of polyburpi-lididone was added as a binder and granulated by a conventional method. After adding and mixing with this as a lubricant, it was compressed into tablets. Tablets were packed in a nitrogen atmosphere and stored refrigerated.

Oxidized coenzyme Q 10 20 parts by weight

Corn starch 25 parts by weight

Lactose 15 parts by weight

10 layers ;!

40 parts by weight of microcrystalline cellulose

Polyvinyl chloride, part talc 10 parts by weight [0066] (Formulation Example 5) (Powder)

Reduced coenzyme Q10 (containing 2% oxidized coenzyme Q10) was dissolved in propanol, then adsorbed onto microcrystalline cellulose, and dried under reduced pressure. This was mixed with corn starch under a nitrogen stream to obtain a powder.

Reduced coenzyme Q10 9.8 parts by weight

Oxidized coenzyme Q10 0.2 parts by weight

40 parts by weight of microcrystalline cellulose

Corn Starch 55 parts by weight

[0067] (Formulation Example 6) (Capsule)

In the same manner as in Preparation Example 1, a powder was prepared according to the following formulation, and then filled into gelatin capsules by a conventional method. The filled capsules were sealed and then packed in a nitrogen atmosphere and stored refrigerated.

Reduced coenzyme Q 10 19.6 parts by weight

Oxidized coenzyme Q 10 0.4 parts by weight

40 parts by weight of microcrystalline cellulose

Corn starch 20 parts by weight

Lactose 65 parts by weight

I: Department

Polyvini: Department

[0068] (Formulation Example 7)

Corn oil was heated to 50 ° C, and reduced coenzyme Q10 (including 2% oxidized coenzyme Q10) melted at the same temperature was added and dissolved. This was soft-encapsulated by a conventional method.

Reduced coenzyme Q 10 49 parts by weight

Oxidized coenzyme Q 10 1 part by weight

350 parts by weight of corn oil

[0069] (Formulation Example 8) (Tablet)

Reduced coenzyme Q10 (containing 2% oxidized coenzyme Q10) was dissolved in propanol, adsorbed onto microcrystalline cellulose, and dried under reduced pressure. Nitrogen atmosphere Below, corn starch, lactose, carboxymethylcellulose calcium and magnesium stearate were mixed and granulated by a conventional method by adding an aqueous solution of polybulurpyrrolidone as a binder. This was mixed with talc as a lubricant, and then compressed into tablets. The tablets were stored refrigerated under a nitrogen atmosphere.

Reduced coenzyme Q 10 19.6 parts by weight

Oxidized coenzyme Q 10 0.4 parts by weight

Corn starch 25 parts by weight

Lactose 15 parts by weight

Tenfolds!

Microcrystalline cellulose

Polyvini, talc

[0070] (Formulation Example 9) (Capsule)

Oxidized coenzyme Q 10 20 parts by weight

Vitamin B 20 parts by weight

Vitamin C 40 parts by weight

Vitamin E 20 parts by weight

40 parts by weight of microcrystalline cellulose

Corn starch 20 parts by weight

Lactose 65 parts by weight

I: Department

Polyview Department

[0071] (Formulation Example 10)

After preparing a powder with the following formulation in the same manner as in Formulation Example 1, it is filled into gelatin capsules by a conventional method. Filled. The filled capsules were sealed and stored refrigerated under a nitrogen atmosphere.

Reduced coenzyme Q 10 20 parts by weight

Oxidized coenzyme Q 10 1 part by weight

Vitamin B 20 parts by weight

Vitamin C 40 parts by weight

Vitamin E 20 parts by weight

40 parts by weight of microcrystalline cellulose

Corn starch 20 parts by weight

Lactose 65 parts by weight

3 parts by weight

Polyview 2 parts by weight

[0072] (Formulation Example 11)

A powder was prepared according to the following formulation in the same manner as in Formulation Example 1, and then filled with a conventional method. The filled capsules were sealed and stored refrigerated under a nitrogen atmosphere.

Oxidized coenzyme Q 10 20 parts by weight

20 parts by weight

40 parts by weight of microcrystalline cellulose

Corn starch 20 parts by weight

Lactose 65 parts by weight

I: Department

Polyview Department

[0073] (Formulation example 12)

Reduced coenzyme Q 10 20 parts by weight Oxidized coenzyme Q 10 1 part by weight

20 parts by weight

40 parts by weight of microcrystalline cellulose

Corn starch 20 parts by weight

Lactose 65 parts by weight

3 parts by weight

2 parts by weight of polybulurpyrrolidone

[0074] (Formulation Example 13) (Powder)

Oxidized coenzyme Q10 and sesamin were dissolved in propanol, then adsorbed to a microcrystalline cell mouth, and then dried under reduced pressure. This was mixed with corn starch under a nitrogen stream to obtain a powder.

Oxidized coenzyme Q 10 10 parts by weight

Sesamin 10 parts by weight

40 parts by weight of microcrystalline cellulose

Corn Starch 55 parts by weight

[0075] (Formulation Example 14) (Powder)

Reduced coenzyme Q10 (including 2% oxidized coenzyme Q10) and sesamin were dissolved in propanol, then adsorbed to microcrystalline cellulose, and then dried under reduced pressure. This was mixed with corn starch under a nitrogen stream to obtain a powder.

Reduced coenzyme Q10 9.8 parts by weight

Oxidized coenzyme Q10 0.2 parts by weight

Sesamin 10 parts by weight

40 parts by weight of microcrystalline cellulose

Corn Starch 55 parts by weight

[0076] (Formulation Example 15) (Soft capsule)

Corn oil was heated to 50 ° C, and dissolved by adding oxidized coenzyme Q10 and licorice extract melted at the same temperature. This is ordinary

Oxidized coenzyme Q 10 50 parts by weight 25 parts by weight of licorice extract

Corn oil 325 parts by weight

[0077] (Formulation Example 16) (Soft capsule)

Corn oil was heated to 50 ° C., and reduced coenzyme Q10 (containing 2% oxidized coenzyme Q10) melted at the same temperature and licorice extract were added and dissolved. This was soft-encapsulated by a conventional method.

Reduced coenzyme Q 10 49 parts by weight

Oxidized coenzyme Q 10 1 part by weight

25 parts by weight of licorice extract

Corn oil 325 parts by weight

[0078] The power S of the specific embodiments of the present invention described in detail above, and the specific embodiments shown by those skilled in the art do not substantially depart from the teachings and advantages of the present invention. Various modifications and changes can be made within the scope. Accordingly, all such modifications and changes are intended to be included within the spirit and scope of the present invention as claimed in the following claims.

[0079] This application is based on Japanese Patent Application No. 2006-311670 filed in Japan, the contents of which are incorporated in full herein.

Claims

The scope of the claims

[Chemical 1]

) CH) H

O (1)

[Chemical 2]

OH (2)

(Where n represents an integer of 1 to 12)

[2] A mental condition improving agent comprising an oxidized coenzyme Q represented by the following formula (1) and / or a reduced coenzyme Q represented by the following formula (2) as an active ingredient.

[Chemical 3]

[Chemical 4] (CH ₂ CH = C (CH ₃ ) CH ₂ ) _n H

OH ( ₂ )

(Where n represents an integer of 1 to 12)

[3] The agent according to claim 1 or 2, wherein the coenzyme Q is coenzyme Q10 (wherein n is 10).

[4] The agent according to any one of claims 1 to 3, further comprising a nutritional supplement and / or a health food ingredient.

[5] Nutritional supplements are amino acids, metal ions, sugars, proteins, fatty acids, vitamins, vitamin B derivatives, theanine, γ-aminobutyric acid (GABA), anserine, soy peptide, thioredoxin, wheat dartene hydrolysis , Glutamine, milk peptide, ω-3 fatty acid, phosphatidylserine, wastaxanthin, polyphenols, green tea catechin, saponin, yew leaf extract, St. Jeon's wort, Rafu hemp extract, Yezo kogi, potato rust, and rydanans The agent according to claim 4, wherein the agent is one or more selected from the group consisting of:

[6] The agent according to claim 4, wherein the health food material is at least one selected from the group consisting of herbs, herbal medicines, mushrooms and extracts thereof.

[7] The agent according to any one of [6] to [6], further comprising an antioxidant or / and an antioxidant enzyme.

[8] Antioxidants from the group consisting of vitamin Ε, vitamin Ε derivatives, vitamin C, vitamin C derivatives, lycopene, vitamin A, carotenoids, vitamin B, vitamin B derivatives, flavonoids, astaxanthin, dartathione and selenium The agent according to claim 7, which is one or more selected.

[9] The antioxidant enzyme is at least one selected from the group consisting of superoxide dismutase (SOD), dartathione peroxidase, dartathione S transferase, dartathione reductase, catalase, and ascorbate peroxidase, The agent according to claim 7.

[10] A food, health food, or dietary supplement containing the power of any one of claims 1 to 9 and the agent of claim 1 Goods, supplements, pet food, or feed.

[11] A medicinal product or quasi-drug containing the agent according to any one of claims 1 to 9.

[12] A stress symptom comprising administering an effective amount of oxidized coenzyme Q represented by the following formula (1) and / or reduced coenzyme Q represented by the following formula (2) to a subject of administration: Mitigation or prevention methods.

[Chemical 5]

[Chemical 6]

OH (2)

(Where n represents an integer of 1 to 12)

[13] A mental state condition comprising administering to a subject an effective amount of oxidized coenzyme Q represented by the following formula (1) and / or reduced coenzyme Q represented by the following formula (2): How to improve.

[Chemical 7]

0 (1)

[Chemical 8] (CH ₂ CH = C (CH ₃ ) CH ₂ ) _n H

OH ( ₂ )

(Where n represents an integer of 1 to 12)

The method according to claim 12 or 13, wherein the coenzyme Q is coenzyme Q10 (wherein n is 10).

[15] Claim; !! The agent according to any one of claims 9 to 9, the food, health food, nutritional supplement, supplement, pet food, or feed according to claim 10, or the pharmaceutical or medicine according to claim 11 Use of oxidized coenzyme Q represented by the following formula (1) and / or reduced coenzyme Q represented by the following formula (2) for producing quasi-drugs.

[Chemical 9]

[Chemical 10]

OH (2)

(Where n represents an integer of 1 to 12)

16. The use according to claim 15, wherein the coenzyme Q is coenzyme Q10 (wherein n is 10).

[17] Oxidized coenzyme Q represented by the following formula (1) and / or reduction represented by the following formula (2) A composition containing type coenzyme Q as an active ingredient, and a statement describing that the composition can or should be used for alleviating or preventing stress symptoms or improving mental status Including commercial package.

[Chemical 11]

[Chemical 12]

(Wherein n represents 1 to; represents an integer of 12)