TW200838496A - Agent for alleviating or preventing stress symptoms and agent for improving mental conditions - Google Patents

Abstract

It is intended to provide an agent for alleviating or preventing stress symptoms caused by mental stress such as strain or an agent for improving mental conditions, characterized by containing oxidized coenzyme Q and/or reduced coenzyme Q as an active ingredient; and a food, a health food, a nutritional supplemental food, a supplement, a drug, a quasi drug, a pet food or a feed containing the agent for alleviating or preventing stress symptoms or agent for improving mental conditions.

Description

200838496 IX. Description of the Invention: [Technical Field] The present invention relates to a stress symptom soothing agent and a prophylactic agent thereof, and a mental condition improving agent. In particular, the present invention provides a stressor or a prophylactic agent thereof for stress symptoms such as stress caused by stress caused by abnormal or abnormal conditions, and a psychoticity improving agent for improving a mental condition which is desired to be improved. [Prior Art] ~ People withstand various mental stresses in their daily lives, and they will become unconscious. It is now widely recognized that the accumulation of mental stress can sometimes lead to serious illnesses, avoiding repeated efforts or soothing and alleviating the importance of repeated efforts in everyday life. As a symptom that must be treated by a doctor, there are known obsessive-compulsive disorder, autonomic dysfunction, etc., and the treatment is considered separately for these diseases, but it is not satisfactory. In addition, the status quo is a relatively mild degree of no need for treatment, such as extremely light stress disorder or difficulty in exerting strength when 2 is not strong enough, and always has a bad mood, a common state, and even corresponding The treatment methods are not clear. Fine, for example, as a result of mental stress, there are tension, God: allergies, getting angry, insomnia, irritability, extraction, stuttering, mental fatigue: two gastrointestinal disorders, stomach pain, hair loss, horror, weakness Feelings, feelings of weakness, lack of energy, headache, thirst, and other symptoms that vary from person to person. : Face, obviously has nothing to do with the essence (four) force, but the spirit of life in the constant life is irritating, no enthusiasm, melancholy, lack of happiness, lack of self..., lack of self-presence, worry, lack of concentration, care, survival 126845.doc 200838496 The conditions that are generally expected to be improved, such as reduced meaning, unhappiness, depression, etc.辅 Coenzyme Q, known as coenzyme qi to coenzyme Q13 according to the repeat structure of its side chain, but the main coenzyme of the mammal (4) coenzyme (10), human coenzyme Qi〇. Coenzyme Q1G is present in mitochondria, lysosomes, steroidal microsomes, peroxisomes (P(10)xis〇me), or cell membranes, and is a component of an electron transport system that maintains activation with ATP, organisms. It is an essential substance for the anti-oxidation action and the function of the organism related to membrane stabilization. An oxidized form and a reduced form are known in the coenzyme (10), and the oxidized form is named as a brewer. The reduced form is named panthenol. It is known that in the electron transport system, the coenzyme Q system transfers electrons by repeatedly performing redox. Further, only the reduced form shows an antioxidant activity, and a large part of the coenzyme Q in the body of the living body is present in a reduced form, and thus the reduced form is considered to be the main form. However, the reduced coenzyme Q has problems in oxidative stability. Therefore, only the oxidized coenzyme Q has been used in the industry. According to this background, when the moon hall and 6 are contained as coenzyme Q, generally, as long as there is no special credit, t ± #, and the condition is not emulsified coenzyme Q, which is indicated as a reduced type. At the time, it is recorded as, more than _ 戟 ,, lack of knowledge or visit prototype coenzyme Q. Oxidized coenzyme Q10 has been used in your previous use as an adjunct to your septic heart failure, but it has been widely used in the world as a supplement in recent years. Its physiological activity has been extensively studied, and many physiological activities such as anti-Ministry, anti-fatigue, anti-fatigue, and anti-arteriosclerosis have been known (Patent Literature. 3) as an anti-stress effect of the auxiliary S#Q10. When oxidized coenzyme Ql 〇 一 ν υ υ υ 或者 或者 或者 or acanthopanax senticosus, it is useful for cold stress response (true method 丨 5 (search for literature 4, 5), but these are cold physical The response of stress, but the effect of 补 = a on the 126845.doc 200838496 mental stress produced in normal life is completely unknown. [Patent Document 1] Japanese Patent Laid-Open No. 7 - 3 3 0 5 [Patent Document 2] Japanese Patent Laid-Open No. Hei 7-330593 [Patent Document 3] Japanese Patent Laid-Open Publication No. Hei-28756 [Patent Document 4] Japanese Patent Laid-Open No. 2〇〇4·2ΐ〇728 [Summary of the Invention] [Problems to be Solved by the Invention]

An object of the present invention is to provide a stress symptom soothing agent or a preventive agent or a mental condition improving agent which is useful as a food, a health food, a nutritional supplement food, a supplement, a medicine, a sputum medicine, a pet food, or a feed, and the same combination. [Technical means for solving the problem] In view of the above-mentioned situation, the inventors of the present invention have tried hard to study, and found that Coenzyme Q has the symptoms of soothing and preventing mental stress caused by stress and tension, and The excellent effect of improving the mental condition is finally completed. That is, tr month is a kind of stress symptom soothing agent or pre- or mental state, the stress symptom soothing agent or prophylactic agent or mental food agent food, health food, nutritional supplement food, supplement, medicine mouth , quasi-drugs, pet foods or feeds · > v agents or mental condition improvement #丨之特心 A ml prevention features —— oxidized coenzyme Q and / or prototype coenzyme Q as active ingredients. That is, the present invention provides the following: [1] The symptoms of sputum stress are relieved or prevented _ ^ The person is only sputum-proof, and is characterized by the oxidized form represented by the following formula (1) 126845.doc 200838496 enzyme The coenzyme Q and/or the reduced form Q represented by the following formula (2) are used as an active ingredient. [Chemical 1] 〇

[Chemical 2]

(CH2CH=C(CH3)CH2)nH (1)

(CH2CH=C(CH3)CH2)nH h3co (2) (where η represents an integer from 1 to 12) [2] A mental condition improving agent, Yu Sheng J, and the special desire lies in: (1) The oxidized coenzyme Q and/or the above formula 〇4 are not active ingredients. The (w) enzyme w (four) enzyme Q is used as coenzyme Q as coenzyme Ql (in the formula n [3] as described in [1] or [2], wherein 10) 〇 [4] such as [1] to [ 3] Any of the pharmacy contained in the δ, which further contains nutritional supplements and/or health food materials. 5养[5] The agent described in [4], the nutritional supplement component is selected from the group consisting of amino acids, metal ions, sugars, protein, workers, fatty acids, vitamins, vitamins and derivatives, tea Amino acid 'h-aminobutyric acid (GABA), anserine (aserine), soybean peptide, thioredoxin, wheat bran 126845.doc 200838496 shell hydrolysate proline, lactopeptide, ω· 3 fatty acids, serotonic acid, reduced astaxanthin, polyphenols, green tea catechins, medlar ring, ginkgo biloba extract, St. John's wort (st. j〇Ws wort), apocynum extract, thorn five More than the types of work in the group consisting of Jia, Shancai and lignan. [6] The agent described in [4] wherein the health food material is selected from the group consisting of herbs, crude drugs, terpenoids, and extracts thereof. [7] The agent according to any one of (1) to [6] wherein the step further comprises an antioxidant shellfish or/and an antioxidant enzyme.

m, as described in m, wherein the antioxidant is selected from the group consisting of vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamin B derivatives, The agent described in the group [9], wherein the antioxidant enzyme is selected from the group consisting of superoxide dismutase (SOD), wherein the antioxidant enzyme is selected from the group consisting of the super yellow dismutase (SOD). One or more of the group consisting of 'superoxide dismutase), glutathione peroxidase, glutathione-S-transferase, glutathione reductase, catalase, and ascorbate peroxidase. [1〇] - a food, a health food, a nutritional supplement, a supplement, a pet food or a feed. The medicament according to any one of (1) to [9]. &lt; [11] A drug or quasi-drug containing the agent of [lm [9]. [12] A method for relieving or preventing stress symptoms, which comprises administering an effective amount of the oxidized coenzyme Q represented by the above formula (1) and/or the reduced coenzyme Q of the above formula (2) The steps taken by the object. Plant, 126845.doc 200838496 =] - a method for improving mental condition, comprising administering an effective amount of the above-mentioned formula (auxiliary: oxidized coenzyme (4) or reduced coenzyme Q represented by the above formula (7) to the cast Or the method described in [13], wherein η is 1〇 in the coenzyme (4).乂# The use of the oxidized coenzyme Q represented by the above formula (1) and/or the coenzyme Q of the above formula (2), which is used for the manufacture of the nutritional supplement foods of [1] to [9] Healthy food, drugs or quasi-drugs, or products or feeds, or as described in [11], [15], where coenzyme (10) coenzyme (10) (in the formula, Π7) a commercial package, 苴Sentence coenzyme Q and ^ ρ + &quot; package 3. The composition containing the oxidized component represented by the above formula (1): and the reduced coenzyme Q represented by = as effective for preventing repeated symptoms or modifying the two compositions Use or should be used for the relief or the improvement of the mental condition of the second person. [Effect of the invention] Only the soothing or preventive agent or the mental condition improving agent is not relieved; Symptoms, while sleeping, etc. (4) (4), the excellent effect, not accompanied by sleepy · #田丨J action, can be used to relieve the symptoms of the day or pre- _ _ _ _ _ _ _ _ _ _ _ In the form of food-μ, help food, supplement m, quasi-荜, dragon food, or feed 126845.doc 200838496 [Embodiment] The present invention is described in detail below. The stress symptom of the present invention is % or the prophylactic agent 哎 (hereinafter also referred to as the South I 彳 神 状况 状况 状况 状况 本 蒋 蒋 蒋 蒋 蒋 蒋 蒋 蒋 蒋 蒋The oxidized coenzyme Q and/or the active ingredient represented by the eighth (2) represented by the formula (1). <Reduced Coenzyme Q as [Chemical 1]

0

CH3 (CH2CH-C(〇h )CHJ Η ° 2' η [Chemical 2] (1) h3coh3co

OHΐέχ0&quot;3 ^Y^(CH2CH=C(CH3)CH2)n Η OH η (2) The "stress symptoms" of the present invention refer to various symptoms caused by mental stress, and therefore are not limited according to individuals or individuals. Specifically, stress, nervousness, getting angry, insomnia, irritability, depression, anxiety, convulsions, stuttering, mental fatigue, gastrointestinal disorders, stomach pain, hair loss, horror, powerlessness, weakness The enthusiasm is lowered, the appetite is lost, the headache, the thirst, the phlegm, the dry skin, etc. The stress symptom soothing or preventing agent of the present invention has the effect of relieving the above stress symptoms or preventing the occurrence of such symptoms. 126845.doc -11 · 200838496 The so-called soothing of stress symptoms means that the above symptoms are consciously or unconsciously become a normal state (consciously or without the state of the above symptoms), or close to a normal state. That is, in life, the above symptoms are perceived or judged by others. For the symptoms of individual stress in such a state, the stress disorder can be consciously or unconsciously improved by ingesting (or ingesting) the soothing agent of the present invention. ϋ In addition, the prevention of the so-called dusty symptoms of the present invention refers to the daily intake (or ingestion) in a special situation, such as a situation in which a pre-examination test or a person in front of others is expected to produce a so-called stress. The prophylactic agent of the present invention can prevent the occurrence of the above-mentioned symptoms, or reduce the frequency of occurrence (i.e., reduce the risk of the onset of stress symptoms). Moreover, the improvement of the so-called mental condition of the present invention means that although it is clearly independent of dust, In the mental state of daily life, the mental state of "the hope is improved" is improved in a good direction. As for the above-mentioned mental state of hope to improve, it can be cited as: irritability, no enthusiasm, depression, lack of happiness, lack of self-confidence, lack of Self-existence consciousness, worry, lack of concentration, over-consideration, decreased vitality, unpleasantness, depression, etc. The oxidized coenzyme Q used in the agent of the present invention can be used as previously known by the method (four), synthesis, automatic Obtained by the method of plant t extraction, but in terms of safety, it is better to use the method of synthesis The all-trans structure obtained by the method is, for example, K_ka·Coenzyme (10) (registered trademark of Kaneka Co., Ltd.). The method for obtaining the reduced coenzyme q used in the agent of the present invention is not particularly limited, for example. (4) A method of obtaining a coenzyme Q' 126845.doc -12-200838496 by a previous method, and then concentrating the reduced coenzyme Q portion in the effluent by a chromatography method, etc. In this case, 'the above-mentioned coenzyme Q can also be used as needed. A general reducing agent such as sodium borohydride or sodium disulfinate (sodium hydrogen sulfite) is added thereto, and the oxidized coenzyme Q contained in the above coenzyme Q is reduced to a reduced coenzyme Q' by a usual method and then subjected to chromatography. The method is concentrated, and it can also be obtained by a method in which the above-mentioned reducing agent is applied to the existing high-purity oxidized coenzyme Q. Alternatively, a bacterial cell containing reduced coenzyme Q or the like can also be used. Alternatively, the oxidized coenzyme Q may be reduced to a reduced coenzyme in the preparation by combining the oxidized coenzyme Q with a substance having a (four) original ability such as a vitamin. . Further, it is also possible to use the high-purity reduced coenzyme (10) which has recently been sold, that is, kaNEKA QH (Kaneka Co., Ltd. registered trademark). Further, it is also possible to use a coenzyme Q which is obtained by a known method as a mixture of an oxidized form and a reduced form.

In the agent of the present invention, oxidized coenzyme Q and reduced coenzyme Q can be used as an active ingredient, and coenzyme Q which is a mixture of oxidized auxiliary :: prototype coenzyme (10) can also be used. In this case, the ratio of ^ ^ ^ ^ ^ 虱 1 to the reduced form in Coenzyme Q can be appropriately determined according to the concept of potting and printing. The ratio of the reduced-type auxiliary material to the thin-mouthed portion in the intermediate surface Q is extremely high, although the cost may be increased due to the % deuteration measures, etc., for example, the effect of using the oxidized coenzyme is more. In the case of coenzyme Q, the mixture of coenzyme-reduced coenzyme Q is 20% in proportion to the coenzyme-reducing coenzyme Q, preferably 疋ζυ/〇 or more, more preferably in the present, and more preferably in the above. . In the following, when the Oxygen 1 f曰 early 'self-contained as the coenzyme Q', it also means that the emulsified coenzyme Q alone, the monoterpene π-butyr reduction coenzyme Q, the oxidized and the reduced type 126845.doc 200838496 Any of the mixtures. Is there an oxidized coenzyme in the sample and a reduction using an HPLC (two-effect liquid chromatography) system using an uv (ultraviolet) detector? Coenzyme Q is quantified to obtain a ratio of the ratio of the oxidized form to the reduced form in the coenzyme q; and the oxidized coenzyme Q and the reduced coenzyme are calculated from the peak area by using a system equipped with an electrochemical detector in HPLC. (Method of ratio of ^. In a system equipped with an electrochemical detector, the ratio of the reduced type present in the sample to the living body due to the specific measurement of the redox species and the high sensitivity, 0 is measured. In view of the above, the usefulness of the oxidized coenzyme Q and the reduced coenzyme Q shown in the present invention is all quantified by the HPLd system equipped with the electrochemical detector, and is of course not limited to the method. In the pharmaceutical agent of the invention, it is preferred to use coenzyme Q10 having a η of 1 〇 as a coenzyme Q. In the agent of the present invention, coenzyme Q can be taken in a monomer form, but since coenzyme q is fat-soluble, it is preferred to use a coenzyme. Q is dispersed and dissolved in general edible fats and oils for ingestion. / As such edible fats and oils, there are mentioned vegetable fats, processed fats, animal fats, blending oils, and the like; Out: rice oil, rapeseed II, palm oil, coconut oil, corn oil, safflower oil, cottonseed oil, sesame oil, peanut oil, sunflower seeds &gt; 'Y, 撖 油, grape seed oil, perilla oil, edible Asia: Xuan oil , various nut oils, soybean oil, oyster sauce, camellia oil, tea oil, evening primrose oil, rosehip oil, pumpkin oil, red palm oil, lard, medium long chain diglyceride, tallow, fish oil and mixtures thereof Of which == 126845.doc -14- 200838496 Vegetable oils such as rapeseed oil, corn oil, liquefied oil, and the like, and are not limited thereto.

The form of the oily emulsion in water is taken up.

In addition to vitamins, theanine, and the like, it may also contain nutrient-assisted or further general food materials. The γ-aminobutyric acid (GABA), the carnosine, the soybean peptide, the sulfur redox protein, and the wheat bran such as amino acid, gold, fatty acid, and vitamin B derivative are mentioned. Hydrolyzate, glutamic acid, lactopeptide, docosahexaenoic acid, eicosapentaenoic acid, etc., co-3 fatty acid, phospholipidic acid, reduced astaxanthin, polyphenols, green tea , saponin, ginkgo leaf extract, sacred grass, apocynum extract, acanthopanax senticosus, wasabi, sesamin xylan and so on. The health food material is not particularly limited, and examples thereof include herbal medicines, biopharmaceuticals, anthraquinones, or the like. As for the herbs, for example, flat-leaf parsley, earthy wood, olive, oregano, cardoon, chamomile, curry piant, Catnip, caraway, Christmas rose, trifolium incartanum L., cornflower, malva sylvestris, salad burnet, cotton lavender 〇tt〇n lavender), cassia, jasmine, stevia, red root grass, primrose, geranium, soapwort, polygonatum odoratum, 麝126845.doc -15- 200838496 vanilla, tansy, chicory ( Chervil), chive, nasturtium, jujube, basil, honeysuckle, hyssop, flax, fennel, digitalis, brackley hollyhock, peacock (tagetes patula), betony, heliotrope, incense, eupatorium cannabinum, musk, calendula, borage, white bo arhoimd, myrtle, , verb as cum tbapsus, marjoram, mint, yarrow, lavender, gallium verum, lemongrass, lemon verbena (remonbabena, lemon balm, rose, Rosemary, arugula, wild strawberry, wild pansy, forget-me-not, etc., but not limited to such. For the raw medicine, for example, valerian root, donkey-hide gelatin, Mutong, catechu, Xiaoyan, Yishui, Ginkgo biloba, Clematis, Artemisia scoparia, Fennel, Turmeric, Cuttlefish, Begonia, Ume, Black Medicine, Limonite, Corydalis, Astragalus, Astragalus, Polygonatum, Phellodendron, Huanglian, Qingteng, plantain), Yuanzhi, 槐花, sea golden sand (spores of Japanese climbing fem), Achyranthes bidentata, sea off skin, white stalk, wormwood, Prunella vulgaris, filigree, Polygonum, turmeric, musk, puerarin, Talc, mango, melon root, melon seed, dried ginger, licorice, sputum, platycodon, chrysanthemum, crust, solid, scutellaria, turtle, horn, sway, almond, polygonatum, sakura, ginkgo, Honeysuckle, Lysimachia, Atoll (agr) Imonia), scorpion, bitter, dog ridge, schizonepeta, spatholobus, cassia twig, cinnamon, medlar (兮77), cassia seed, taurus, scrophularia, sugar, safflower, acacia, scent, red purple, toon , Xiangfuzi, Magnolia, Niuhuang, Wujiapi, Achyranthes, Wusong, Pepper, Drynaria, Walnut, Galla, Amber, Burdock, Sesame, Schisandra, Fenugreek, Bupleurum, Asarum, Saffron , 飞龙掌血, 126845.doc -16- 200838496 Hawthorn, Shanzizi, Hawthorn, Silkworm, Hawthorn, Pepper, Soybean Root, Suanzaoren, Shanle, Rhizome of common burreed, Rehmannia, Aster , purple diced, loofah, bone skin (r〇〇t-bark Chinese wolfberry), purple root, otolith, amethyst (flu〇rhe), perilla, perilla, perilla leaf, avocado, kochia, azurite Fat, peony, Cnidium, Coral, Psyllium, Plantain, Aphid, 茺 子, Amomum, Ginger, Calamus, Cimicifuga, Peony, Ligustrum, Dilong, Xinyi, Shenque, Qin , agarwood, leeches, valerian roots, green boxes, barley, green skin Dendrobium, red peony, sarcophagus, pomegranate peel, stone cassia, gypsum, crane grass, Chuanxiong, Qianhu, 蝉 、, inula flower, Chuanxiongzi, grass fruit (tas〇k〇), y force, grass, cocklebur, atractylodes, tortoise, mulberry, mulberry (mantis egg-case), hematoxylin, perilla leaf, rhubarb, 夕彳七丰シ10, Daqingye, jujube , Big belly skin, Alisma, Zeeland, Salvia, Zhuru, Zhu Meng (千夕七々), Zhimu, Uncaria, Pork, Chenpi, 葶苈子 (seed 〇f pepperweed), Tianhua powder, Tianzhu yellow , Tiannanxing, Tianma, Asparagus, Winter melon seeds, Angelica, Dengxin, Cordyceps sinensis, Duhuo, Huanren, Cuscuta, Eucommia, Cistanche, Nutmeg, Frankincense, Mantis, Honeysuckle, Nvwa, White mustard, Malt, Baiziren, white cardamom, white fresh skin (roo bark of deusufruit pittany), pulsatilla, white lentils (white hyacinth bean), maimen winter, basmati, mint northern ginseng, pinellia, saffron, pimple,荸荠, lily, white peony, atractylodes, white sandalwood, white virgin, hundred roots, white flower snake, white and white Stupid, betel nut 7, raspberry, scented tea, aconite, f (turtle shell), safflower, stagnation, anti-self, maogan, wind, pudding, dandelion, psoralen, peony bark, oyster, rose, ephedra , Ephedra root, Maziren, Viburnum, honey, flower, 126845.doc •17- 200838496 pear (termmalia chebura retz), Mutong, wood thief, papaya, wood, medicine pot, Yizhi, motherwort' Night vine, bear bile, coix seed, good burning grass, Lei Wan, Laiwuzi, Luo Han Guo, Longan meat, Artemisia, keel, gentian, galangal, mung bean, wing, even money grass, bent meat, antler, dew The hive, etc. 'but is not limited to this. Examples of the yam are: pine velvet, maitake, fragrant sage, hackberry, clumping mouth, snow velvet, and long tooth white tooth g (myeGiept. - aitchisonii). In addition to _Q, the antioxidant of the present invention may be an antioxidant substance, and the antioxidant substance is not particularly limited, and examples thereof include vitamin E derivatives, vitamin C, vitamin C derivatives, and vitamins. Vitamin A, carotenoids, vitamin B, vitamin B derivatives, yellowoids, glutathione, reduced ruthenium, guanidine and the like. Further, the antioxidant enzyme is not particularly limited, and examples thereof include _), a glutathione peroxidase, a glycotransferase, a glucoside reductase, a catalase, and an ascorbate __transferase. The agent of the invention may be used in combination with an antioxidant substance or an antioxidant enzyme exemplified above, and one or more of them may be used as a food material. S component, health, and the agent of the present invention may be appropriately added and mixed as a drug in addition to the above. Learn or. ', can use the common law in such a dragon without special duties such as = Xu (four) his material. For lubricants, adhesives, antioxidants: out. Shaped 剤, disintegrating agent, injection, dissolution aid, stability For the above-mentioned excipients, there are no special/strong ingredients, etc. 疋, for example, white sugar, milk 126845.doc -18- 200838496 sugar, glucose, corn house powder, Mannitol, rhododendron calcium sulfate, etc., ', 曰曰 cellulose, calcium phosphate, and the above disintegration agent is not particularly limited, s匕# speaks, for example, J: starch, Qiongyue, #棣酸Calcium calcium carbonate, hydrogen carbonate steel, betrayal methyl The cellulose, the ceresin, etc. The dextrins and the crystalline cellulose are not particularly limited, and the magnesium stearate, the diol, and the second binder are not particularly limited, and the m ^ 1 J can be used. For example: ethyl cellulose, methyl cellulose, hydroxypropyl fluorenyl cellulose ^ ^ ^ page gum, shellac, gelatin, gum arabic, polyvinylpyrrolidone, jujube straight two π # t ethyl alcohol, Polyacrylic acid, hydrazine methacrylic acid, sorbitol, etc. The above antioxidant is not particularly limited, and ^ , ^ v ^ may, for example, be ascorbic acid, raw phenol, vitamin A, beta carotene,舻铷^ ^ ^ ^ ', sodium creatine hydride, thiosulfanone, sodium pyrophosphate, lemon: acid, etc. The coloring agent is not particularly limited, and may be used, for example, in pharmaceuticals. The anti-aggregation agent is not particularly limited, and the talc powder, the light anhydrous material, and the aqueous dioxide may be, for example, stearic acid or the above-mentioned absorption enhancer is not particularly limited, and examples thereof include, for example, : Higher alcohols, terpene fatty acids, or lecithin, hemolysis, acid In the case of the above-mentioned dissolution aid, the above-mentioned dissolution aid is not particularly limited, and examples thereof include organic acids such as argonic acid, succinic acid, and malic acid. There is no particular limitation, for example, J. benzoic acid, 126845.doc -19-200838496 sodium benzoate, ethyl p-hydroxybenzoate, etc. Examples include creatinine, amino acids, and the like for nourishment. The strong component is not particularly limited, and the taurine, the vitamin m, and the vitamin B derivative are compounded. The agent of the present invention or the group containing the drug, the health food, and the nutritional supplement 0 σ in the food test object σ ^ auxiliary ", supplements, pharmaceuticals, quasi-drugs, month 1 &amp; ° σ, or the use of feed. Here the sleeve # # a β The health food here means

»In addition to Jiankang products, health foods, foods for specific health care, camps, food, food, etc., all foods that are healthy and ingestible except for medicines: form. In the case where the food is a so-called healthy food, a form in which the oxidized coenzyme Q and/or the reduced coenzyme Q are packaged in an intake unit amount of 2 times per ounce is used, and the food is a healthy drink. In the case of the case, the beverage in which the coenzyme Q is suspended or dissolved is put into a bottle or the like in a form of being drunk every time. It is to be noted that the amount of the unit intake per one time refers to the amount of the active ingredient taken in the case of food. In particular, in the case of foods, there is a personal difference in the overall intake of the food, and it is difficult to specify the content of the active ingredient in the composition. Therefore, it is recommended to use the active ingredient in consideration of the following effective intake per day. The amount of intake is specified once. The amount of this intake is appropriately changed depending on the age, body weight, sex, degree of stress, and the like. In the case of the pharmaceutical product, the form of the package containing the amount of the active ingredient once administered once, or the form of being filled into a bottle or the like in the form of one drink per serving, may be mentioned. The form of the agent of the present invention or the composition containing the same is not specifically limited to 126845.doc -20-200838496, and examples thereof include a capsule, a microcapsule, a soft capsule powder, a chewable preparation, a sugar polymerization, and a liquid. Agents, etc., which can be taken orally. j Oil composition, conditioning oil, fuel oil, butter, human::, edible edible oil, foamed emulsifiable concentrate, concentrated milk, whitening agent, :,, bubble liquid, bread, cake, (four), cookies,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,

Oil-fried flour, sauces, sauces, side dishes, ice-creams, noodles, mixed doughs, fried foods, processed meat products, cold-growing products of aquatic products, cold foods for livestock, Cold food for agriculture; cold foods such as East food, rice, jam, milk road, milk road food, milk-like food, rubber, sugar, fermented milk, canned food, beverage, etc. The form of the food; the form of the useful ingredient is sent to the body by means of a patch, an emulsion, a spray, and the like. Furthermore, it can be combined with ingredients used in aromatherapy towels such as herbal medicines and crude medicine ingredients, or combined with aromatherapy, bathing, massage, music appreciation, and fragrant party, together with the stress symptom soothing or preventive agent in the case of ingestion. Animal therapy, walking and other relaxation methods, etc., and expect a stronger effect. The effective intake of the composition containing the agent of the present invention per day is 10 to 5 mg, preferably 5 to 3 mg, more preferably 50, based on the amount of reduced coenzyme Q10. ~200 mg. When the intake is 5 〇 mg or more, the soothing or preventive effects of the symptoms caused by the stress and the improvement of the mental condition can be sufficiently obtained. The above effective intake is 5 〇 1 to 1 mg, preferably 100 to 600 mg, more preferably 2 to 35 mg, based on the amount of the oxidized coenzyme Q1. When ingesting 126845.doc -21 - 200838496 1 is 200 mg or more, the effect of the relief or prevention of the symptoms caused by (4) force and the improvement of mental state can be sufficiently obtained. However, it is known that these intakes differ depending on the dosage form of (4), and if it is a high-absorbent, it is expected to achieve a specific purpose with a lower intake. And: the intake can be divided into several times in 1 or 1 time. In the case of the ingestion period, it is usually limited to 'usually 2 weeks or more, and preferably more than i months or more, when the temple is ingested as a preventive agent for stress symptoms,

Before the symptom state, it is preferred that the coenzyme Q is not accumulated for at least one week in advance, and therefore the agent of the present invention is weakened by the end of the administration. Therefore, during the period of expecting to relieve stress symptoms or improve mental status, or during the prediction of stress symptoms, it is more common. The agent of the present invention can be used for soothing or preventing animals other than humans and humans [for example, the above-mentioned stress symptoms of mammals other than humans (pig, cow, horse, dog, domestic animals and animals), chickens and the like] Or for improving mental condition. The present invention provides a method for soothing or preventing the above-mentioned stress symptoms or a method for improving a mental condition. The method includes: administering to a subject (for example, a person or a person who must be relieved, prevented or improved) It is better for the animal other than the human being to consciously or for the above-mentioned stress symptoms, or for the target of the mental state, and to cast an effective amount of the above formula (丨) The step of the coenzyme Q and/or the reduced coenzyme Q represented by the above formula (2). The present invention further provides a commercial package for carrying out the above method. 126845.doc -22- 200838496 The commercial package comprises the oxidized coenzyme Q represented by the above formula (1) and/or the reduced form _Q of the above formula (2) (4), and further comprises the description that the coenzyme q can be used (or The use of the article for relieving or preventing the above-mentioned stress symptoms or improving the mental condition (for example, the instructions for carrying out the above method as other aspects, the present invention provides - (iv) to provide a soothing or preventive agent for stress symptoms, or a spirit The use of the oxidized coenzyme Q represented by the above formula (1) and/or the reduced coenzyme q represented by the above formula (7) in the condition improving agent. [Examples] Next, the present invention will be described in more detail based on examples, but the present invention It is not limited to this embodiment. (Example 1) Oxidation-type coenzyme Q10 The stress-relieving effect of stress or mental stress on a healthy person with self-consciousness is evaluated by the double-blind test method to evaluate the health of oxidative coenzyme Q1〇 for conscious stress. The effect of volunteers. Pre-test the fatigue of healthy volunteers (degree of mental stress) with Visual alan〇g 8_ (cafe, visual analog scale), will consciously have some kind of Volunteers of degree pressure are distinguished. The VAS (Visual Analog Scale) will be recorded as a benchmark at both ends of the line with a length of 丨〇cm (the asymptomatic or s will endure the low degree of agriculture as the left end, The highest-range sound is taken as the t-end paper to the testee, and the current state of the testee is indicated on the line segment to determine the subjective fatigue or symptoms. For example, as the evaluation of the conscious pressure, the left end of the straight line can be regarded as "completely "Pressure", the right end is regarded as "experience and maximum pressure obtained" by letting the testee mark the current state on the line segment, and measuring the length of the left end of the distance segment, and evaluating the conscious pressure 126845.doc -23- 200838496 The degree of the selected volunteers was divided into two groups, and they were inoculated with oxidized coenzyme Q10 capsule (tested food) or placebo capsule (control food) having the composition of the preparation described in Table 1 for 2 capsules per day. Capsule (in the case of the food to be tested, the oxidized coenzyme Q10 intake is 200 mg / 曰), the same symptoms are used before and after the intake of VAS (7 items: conscious pressure, tight Zhang-degree, lethargy, fatigue, desire, thirst, and anxiety. Further, the implementation of the operational efficiency (behavior efficiency) is the Advanced Trail making test (ATMT). In addition, the blood CoQlO The amount is also measured by ingestion. Blood is collected before and after, and quantified by HPLC. [Table 1] Test composition table (one round of 4-round soft capsule) Composition of the test food control oxidized coenzyme Q1 〇 (mg) 100 - Safflower oil (mg) 134.67 234.67 Bee sting (mg) 4.33 4.33 POEM S-lOO(mg) 0.6 0.6 Soybean egg yolk (mg) 0.4 0.4 Oxidized coenzyme Q10: Kaneka Co., Ltd. safflower oil: Nisshin-oillio Co., Ltd. manufactures yellow beeswax··Miki Chemical Industry Co., Ltd. manufactures POEM S-1 00: glycerin fatty acid ester surfactant, Riken Vitamin Co., Ltd. manufactures soybean egg liposuction: results of VAS manufactured by Tsuji_seiyu Co., Ltd. Shown in Table 2. In the oxidized coenzyme Q10 ingestion group, statistically intentional (p&lt;(K〇5) soothing was found in the tension and eschar of sensation, which was found in conscious stress and thirst from 126845.doc -24· 200838496 The tendency to soothe (p&lt;0.5). On the other hand, 'the level of drowsiness, desire, and fatigue' was not found to differ between the oxidized coenzyme Q10 ingestion group and the placebo group. Further, in the performance of ATMT, It was found that the intentional shortening of the reaction time showed that the work efficiency was improved by taking up the oxidized coenzyme Q10. Most of the previous anti-stress substances were accompanied by a sedative effect of lowering the behavior, which would become a problem in actual use, but the results were It is shown that ^ The pressure-relieving effect of oxidized coenzyme Q10 is not accompanied by sedation. 'There is higher usefulness. * [Table 2] Subjective evaluation value of VAS Samples before ingestion Tension after placebo 3·64 Soil 1.49 3.46±1 ·50 oxidized coenzyme Q10 3·64±1·39 3.05±1.59** eschar sensitizing placebo 3.63 士 1.60 3.53±1.51 oxidized coenzyme Q10 3.88 soil 1.55 3.07 士 1.75** conscious pressure placebo 4.09 士 1.67 3.66 1.77 Oxidized Coenzyme Q10 4.29±1.83 3.26 Soil 1.74* Thirsty Placebo 5.14 ± 1.59 4.79 ± 1.68 Oxidized Coenzyme Q10 4.97±1.39 4.51±1.61* Sleepy Placebo 4.80±1.46 4.32 ±1.88 Oxidized Coenzyme Q10 4.86 Earth 1.59 4.23 soil 1.85 intended placebo 4·96±1·24 4.79 soil 1.36 oxidized coenzyme Q10 4.86±1.17 4·61 soil 1.59 fatigue placebo 3.74±1.26 3.57 ± 1.76, 氺氺 oxidized coenzyme Q10 3·96 ±1·52 3.55 soil 1.70 *ρ&lt;0.5 ' **ρ&lt;〇·〇5 relative to the student t-test placebo group. The concentration of coenzyme Qi in the plasma in this test is 986·6 before ingestion. ±914·1 nmol/L, after ingestion, 3679.4 soil 1652.7 nmol/L increased to approximately 3.7 times. 126845.doc -25 - 200838496 (K Example 2) Reduced coenzyme Q1〇 is stressful to healthy people with conscious stress or The soothing effect of mental stress In the same manner as in Example 1, the cross-over method of double-blind test was used to evaluate the effect of coenzyme Q10 in reducing stress on healthy volunteers who were consciously stressed. Twenty-six healthy volunteers who were consciously stressed were divided into two groups, one capsule per day, one capsule of the reduced coenzyme Q1 capsule containing the preparation of the table 3 brothers (wherein 3 used 1 to 1% oxidation) The coenzyme Q1〇 reduced coenzyme Qi〇) or placebo capsule (control diet) was quantified by VAS before and after ingestion, and the behavioral efficiency was quantified by ATMT. It is known that the reductive coenzyme Q10 is better than the oxidized coenzyme Q1〇, so a preliminary study will be carried out to obtain a blood/increase 50 mg setting equivalent to the intake of 2 mg of oxidized coenzyme Q1〇. It is the intake of the reduced coenzyme q1 for one day. ~ The fruit was found to be similar to the result of ingesting 2 mg of oxidized coenzyme q1 ,, specifically, &amp;, found statistically intentional soothing in tension, eschar and conscious stress and found improvement in ATMT behavior . On the other hand, in the levels of sleepiness, thought and fatigue, there was no difference between the reduced coenzyme Q丨〇 intake group and the placebo group. The results showed that the pressure-relieving effect of the reduced coenzyme Q10 was not accompanied by sedative effect, and the usefulness was high, and compared with the oxidized coenzyme Ql ,, it was confirmed that the effect was found at a lower dose. 126845.doc 26 - 200838496 [Table 3] Test food composition table (per round 'soft capsules') Composition b-type coenzyme Q10 (mg) Control ^ 50 - (containing 1% by weight of oxidized coenzyme Q10) Safflower oil ( Mg) /1 〇ο Beeswax (mg) 184.67 POEM S-lOO(mg) 4.33 | Soybean egg fat (mg) 0.6 ------- A Λ 0.6 υ·4 ----- 0.4

Safflower oil: manufactured by Nisshin-omio Co., Ltd., manufactured by Bees Butterfly, Ermu Chemical Industry Co., Ltd. ° POEM S-100: glycerol fatty acid ester, Chenkou (2) Yule interface active agent, made by Riken Vitamin Co., Ltd. Phospholipid: manufactured by Tsuji-seiyu Co., Ltd. (Example 3) Effect of reducing coenzyme Q10 on mental state of healthy person The double-blind test method was used to evaluate the effect of reduced coenzyme Q10 on mental state. 36 healthy people (18 males and 18 females) were divided into three groups, and three capsules of placebo capsules or reduced coenzyme Q10 capsules as shown in Table 4 (wherein, placebo group: 3 placebo capsules) were taken. 1 〇〇mg ingestion group: 1 capsule of placebo capsule + 2 capsules of reduced coenzyme q1 〇 capsule, 3 〇〇mg of ingestion group · · Reduced coenzyme Q1 0 capsules, 3 capsules), for 4 weeks, consciously before and after ingestion Questionnaire survey of symptoms. In the questionnaire survey, participants were asked to rate each item, 〇··completely absent, 1··almost no, 2: less, 3: moderate, 4 ··height' for projects with a score of 2 or higher before ingestion Evaluation of the improvement after ingestion 126845.doc •27- 200838496 rate. As a result, a dose-dependent improvement was found in the 4 items of irritability, unintentionality, depression, and nervousness, thus indicating that these mental states were improved by ingesting reduced coenzyme Q10. [Table 4] Test food composition table (each one 4-round soft capsule) Ingredients consisting of reduced coenzyme Q10 capsule placebo capsule oxidized coenzyme Q1 〇 (mg) 100 - (containing 1% by weight of oxidized coenzyme Q10) safflower Oil (mg) 134.67 234.67 Beeswax (mg) 4.33 4.33 POEM S-lOO (mg) 0.6 0.6 Da Li egg fat filling (mg) 0.4 0.4 The ingredients used are the same as in Example 2 [Table 5] The spirit of reduced coenzyme Q10 Condition improvement effect improvement rate (%) Placebo 100 mg 300 mg Irritability 0 33 80 Unintentional 0 33 75 Melancholy 0 85 100 Tension 0 100 100 Again, improvement rate (%), is the capsule intake in each item Among the subjects whose pre-scores are 2 or more (who are expected to improve the mental state), the ratio of the score after capsule intake is lower than that of the target before the ingestion. (Formulation Example 1) (Powder) The oxidized coenzyme Q1 is dissolved in propanol and then adsorbed to the microcrystalline fiber 126845.doc -28- 200838496

In the vitamins, the powder is mixed with the powder under reduced pressure to prepare a powder. Oxidized Coenzyme Q 1 〇 Microcrystalline Cellulose Corn Powder (Formulation Example 2) (Capsule) M Dry ° 10 parts by weight of 40 parts by weight of 55 parts by weight in a nitrogen stream and a cornfield A 4 , filled in gelatin capsules with a method. Put the έ &gt; 芦 k, and the filled capsules, seal them, and store them in cold storage. Moxibustion-oxidized Coenzyme Q10 Microcrystalline Cellulose Corn Starch Lactose Magnesium Stearate Polyvinylpyrrolidone (Formulation Example 3) (Soft Capsule) 20 parts by weight 40 parts by weight 20 parts by weight 65 parts by weight 3 parts by weight 2 weight The corn oil is warmed to 50 by nitrogen. (:, dissolved in oxidized coenzyme Q10 melted at the same temperature to dissolve it. It is made into a soft capsule by a conventional method. Oxidized Coenzyme Q10 50 parts by weight of 350 parts by weight of corn oil (Formulation Example 4) (tablet) The oxidized coenzyme Q10 is dissolved in propanol, adsorbed in microcrystalline cellulose, and then dried under reduced pressure. Corn starch, lactose, carboxymethylcellulose calcium, magnesium stearate in a nitrogen atmosphere Mixing with it, and then adding an aqueous solution of I26845.doc -29- 200838496 polyvinylpyrrolidone as a binder, which is granulated by a conventional method, and talc powder is added as a lubricant and then mixed, and then 20 parts by weight and 25 parts by weight are added. 15 parts by weight of 1 part by weight, 40 parts by weight, 5 parts by weight, 3 parts by weight, and 1 part by weight of the tablet. The tablet is packaged in a nitrogen atmosphere and stored in a refrigerated state. Oxidized Coenzyme Q 1 〇 Corn Starch Lactose Cellulose dance microcrystalline cellulose polyethyl sigma-pyrrolidone magnesium stearate talc powder (Formulation Example 5) (Powder) Reduced Coenzyme Q10 Oxidation Coenzyme Q10 Microcrystalline Cellulose Corn Starch (Formulation Example 6) capsule In the same manner as in Formulation Example 1, the powder was prepared in the following manner, and then filled in a gelatin capsule by a conventional method. The capsule filled with Shengyuan was sealed, packaged in a nitrogen atmosphere, and stored in a refrigerated manner. Reduced coenzyme Q10 19.6 parts by weight Reduced coenzyme QH) (including 2% oxidized coenzyme Qi 〇) was dissolved in propanol, which was then adsorbed to microcrystalline cellulose, and then decompressed Dry it underneath. It was mixed with corn starch in a stream of nitrogen to prepare a powder. 9_8 parts by weight 0.2 parts by weight 4 parts by weight 55 parts by weight 126845.doc -30· 200838496 (K4 parts by weight 40 parts by weight 20 parts by weight 65 parts by weight 3 parts by weight 2 parts by weight of oxidized coenzyme Q1 0 microcrystalline cellulose corn starch Lactose stearic acid meter, polyethylene, °, haha, and the same (formulation example 7) (soft capsule)

Warm the corn oil to 50. (:, the reduced coenzyme Q10 (containing 2% of the oxidized coenzyme q10) which was melted at the same temperature was dissolved and dissolved in a soft capsule by a conventional method. Reduced coenzyme Q10 49 parts by weight gasification type Coenzyme Q10 1 part by weight of corn oil 350 parts by weight (Formulation Example 8) (tablet) The reduced coenzyme Q10 (containing 2% of the oxidized coenzyme q1 oxime) is dissolved in propanol to be adsorbed to the microcrystalline fiber The medium is then dried under reduced pressure. Corn starch, lactose, calcium carboxymethylcellulose, and more magnesium strontium are mixed in a nitrogen atmosphere, followed by an aqueous solution of polyvinylpyrrolidone: = binder, utilized It is made into granules by the usual method. The talc powder is added as the wetting 'month 4 and then mixed, and then the tablet is put into a tablet. The tablet is packaged in a nitrogen atmosphere and stored in a refrigerated state. Reduced coenzyme Q10 19.6 parts by weight of oxidized coenzyme Q10 0.4 parts by weight corn powder 壬〇 壬〇 壬〇 126845.doc 31- 200838496 lactose 15 parts by weight carboxymethyl cellulose about 1 〇 weight injury ^ microcrystalline cellulose 4 〇 parts by weight polyvinylpyrrolidone 5 parts by weight magnesium stearate 3 parts by weight slippery 10 parts by weight of stone powder (Formulation Example 9) (capsule)

In the same manner as in Formulation Example 1, the following formulas were prepared: ... Bu Jian prescription to prepare a powder, which was filled in a gelatin capsule by a usual method. The sealed and filled capsules are sealed and stored in an air environment. Then benefit, nitrogen

Oxidized Coenzyme Q1 〇 Vitamin B Vitamin C Vitamin E Microcrystalline Cellulose Corn Starch Lactose Magnesium Stearate Polyvinylpyrrolidone (Formulation Example 10) (Capsule) 20 parts by weight 20 parts by weight 40 parts by weight 20 parts by weight 40 20 parts by weight, 6 parts by weight, 6 parts by weight, 3 parts by weight, 2 parts by weight, "in the same manner, filled in a gelatin capsule in a conventional manner", packaged in an air environment, stored in a refrigerated state, and filled with a reduced coenzyme Q1 〇 20 parts by weight and then benefit, nitrogen 126845.doc -32- 200838496 1 part by weight 20 parts by weight 40 parts by weight 20 parts by weight 40 parts by weight 20 parts by weight 65 parts by weight 3 parts by weight 2 parts by weight oxidized coenzyme Q10 vitamin B Vitamin C Vitamin E Microcrystalline Cellulose Corn Starch Lactose

Magnesium stearate

(Formulation Example 11) (Capsule) In the same manner as in Formulation Example 1, the powder was prepared by filling the gelatin capsule in a usual manner. .^ Α Elbow, and the filled capsule seal (4) Packed in the environment for cold storage. Then, in the nitrogen oxidation type coenzyme Q1 glutathione microcrystalline cellulose corn starch lactose magnesium stearate polyvinylpyrrolidone (Formulation Example 12) 20 parts by weight 20 parts by weight 40 parts by weight 20 parts by weight 65 parts by weight 3 2 parts by weight (capsule) in parts by weight and preparation examples! In the same way, it is filled in the gelatin capsule soil by the usual method: the package is made in a diffused atmosphere for packaging, and the capsule is 1200845.doc, and then the nitrogen-33-200838496 reduced coenzyme Q10 20 parts by weight oxidation type. Coenzyme Q10 1 part by weight glutathione 20 parts by weight microcrystalline cellulose 40 parts by weight corn starch 20 parts by weight lactose 65 parts by weight magnesium stearate 3 parts by weight polyethylene strontium bismuth with 2 parts by weight

(Formulation Example 13) (volume), which is then adsorbed in a nitrogen stream, and the oxidized coenzyme Q10 and sesamin are dissolved in propanol in microcrystalline cellulose, and then dried under reduced pressure to be mixed with corn starch. , made into powder. Oxidized Coenzyme Q10 10 parts by weight Sesamin 10 parts by weight Microcrystalline cellulose 40 parts by weight Corn cake powder 5 5 parts by weight (Formulation Example 14) (Powder) Reduced Coenzyme Q10 (including 2% oxidized coenzyme q10) Sesamin is dissolved in propanol, which is then adsorbed to microcrystalline cellulose, and then dried under reduced pressure. It was mixed with corn starch in a stream of nitrogen to prepare a powder. 9.8 parts by weight, 0.2 parts by weight, 10 parts by weight, reduced coenzyme Q10, oxidized coenzyme Q10, sesamin 126845.doc 34-200838496 microcrystalline cellulose, 40 parts by weight, Yuzhu yudian powder, 5 parts by weight (formulation 15) (soft capsule) The corn oil was warmed to 50 ° C, and oxidized coenzyme Q10 and licorice extract melted at the same temperature were added to dissolve. It is made into a soft capsule by a conventional method. Oxidized Coenzyme Q10 50 parts by weight Licorice Extract 25 parts by weight

325 parts by weight of corn oil (Formulation Example 16) (soft capsule) The corn oil was warmed to 5 ° C, and reduced coenzyme Q10 (containing 2% of the oxidized coenzyme q1 熔融) which was melted at the same temperature was added. And the licorice extract is dissolved. It is made into a soft capsule by a conventional method. Reduced coenzyme Q10 49 parts by weight oxidized coenzyme Q10 1 part by weight licorice extract 25 parts by weight corn oil 325 parts by weight or more, detailing several specific aspects of the invention, the industry can not reveal the specific sadness Various modifications and changes can be made without departing from the spirit and scope of the invention. Therefore, such modifications and variations are intended to be included within the spirit and scope of the invention as claimed. The present application is based on Japanese Patent Application No. 2006-31 1670, the entire disclosure of which is incorporated herein by reference. 126845.doc -35-

Claims (1)

200838496 X. Patent application scope: The agent 'is characterized by reducing coenzyme represented by the following formula (2) A stress symptom that is soothing or preventing oxidized coenzyme Q and/or Q as an active ingredient, [Chemical 1] Ο Ch3 (CH2CH=C(CH3)CH2)nH [Chemical 2] (1) 2. OH h3co h3co CH3 (CH2CH=C(CH3)CH2)nH I OH (wherein n represents an integer from i to 12). (2) A mental condition improving agent characterized by comprising a coenzyme of the oxidized coenzyme Q of the following formula and/or a reduced coenzyme represented by the following formula (2), ^ ^ [Chemical 1] 0 H3c 〇Jsy^ (ch2ch=c(ch 3)ch2) η Η [Chemical 2] 126845.doc 200838496 OH H3C〇^T^Tr^CH3 H3C〇^Y^(CH2CH=C(CH3)CH2)nH OH (2 (where n represents 丨~; ^ is an integer). 3. The agent according to claim 1 or 2, wherein the coenzyme Q is coenzyme Q10 (wherein η is 10) 〇 4. The medicament of claim 1 or 2, further comprising a nutritional supplement and/or a health food material. 5. The medicament according to claim 4, wherein the nutritional auxiliary component is selected from the group consisting of amino acids, metal ions, sugars, proteins, fatty acids, vitamins, vitamin oxime derivatives, theanine, γ-aminobutyric acid ( GABA), muscle carnosine, big ugly, sulphur redox protein, wheat gluten hydrolysate, glutamic acid, milky, omega-3 fatty acids, phospholipids, reduced astaxanthin, multi-aged, green tea One or more of the group consisting of catechin, saponin, ginkgo biloba extract, St. John's wort, apocynum extract, acanthopanax, wasabi, and xylan. 6. The agent according to claim 4, wherein the health food material is selected from the group consisting of herbs, crude drugs, terpenoids, and extracts thereof. The agent of item 2 or 2 further contains an antioxidant or/and an antioxidant enzyme. 8. The agent according to claim 7, wherein the antioxidant substance is selected from the group consisting of vitamin B:-E-derivatives and vitamins. , vitamins. Derivatives, crocetin, serotonin A, carotenoid S, vitamin B, vitamin B derivatives, 126845.doc 200838496 kuflasin and selenium More than ruthenium. 9. The agent according to claim 7, wherein the emulsification enzyme is selected from the group consisting of superoxide dismutase (SOD), cholestyramine catalyzed enzyme, glutathione transferase, and glutathione reduction One or more of the group consisting of enzyme, peroxidation &gt; wind enzyme and ascorbate peroxidase. 〇 〇 — — a food, health food or feed that contains, for example, a drug or quasi drug, agent 0 12. Lu Yang supplementary food, supplement, pet food The medicament of any one of claims 1 to 9. The method according to any one of claims 1 to 9 wherein the stress symptom is a soothing or preventing method, which comprises an effective amount of an oxidized coenzyme oxime expressed by 弋(1) and/or The reduced coenzyme Q represented by the formula (2) is administered to the subject, [Chemical 1] 0 (1) 126845.doc (2) 200838496 13 - A method for improving mental conditions, comprising oxidized coenzyme Q represented by formula (1) and/or formula (2) Representing the reduced coenzyme Q to the target of the drug, [Chemical 1] 〇 Ch3 (CH2CH=C(CH3)CH2)nH (1) [Chemical 2] OH h3co h3co CH3 (CH2CH=C(CH 3)CH2) n H OH (wherein n represents an integer from i to 12). (2) 14. The method according to claim 12 or 13, wherein the coenzyme Q is a coenzyme qi 〇 (wherein ^^ is 10) 〇 15. - an oxidized coenzyme q represented by the following formula (1) and/or the following formula (p) the use of the co-enzyme Q as indicated in the claim 1, wherein the medicament of any one of the claims (1), such as the food of claim 1G, a health food, a nutritional supplement, a supplement, a pet food or a feed, Or as required for the drug or quasi-drug of item n, [Chem. 1] 126845.doc (1) 3 200838496 Ο CH (CH2CH=C(CH3)CH2)nH [Chemical 2] (CH2CH=C(CH3)CH2)nH 〇H (2) (wherein n represents an integer from 1 to 12). 16. The use of claim 15, wherein coenzyme Q is coenzyme Q10 (wherein η is 10). 17. A commercial package comprising: a composition comprising an oxidized coenzyme Q represented by the following formula (1) and/or a reduced coenzyme Q represented by the following formula (2) as an active ingredient, and The composition may be used or should be used for the purpose of soothing or preventing stress symptoms or improving mental state, [Chemical 1] 〇 (1) ΟΗ (where η represents an integer from 1 to 12) 126845.doc (2) 200838496 VII. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbol of the representative figure is simple. Explanation: 8. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: 126845.doc