JP2014513916A5 - - Google Patents
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- JP2014513916A5 JP2014513916A5 JP2013551435A JP2013551435A JP2014513916A5 JP 2014513916 A5 JP2014513916 A5 JP 2014513916A5 JP 2013551435 A JP2013551435 A JP 2013551435A JP 2013551435 A JP2013551435 A JP 2013551435A JP 2014513916 A5 JP2014513916 A5 JP 2014513916A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437854P | 2011-01-31 | 2011-01-31 | |
| US61/437,854 | 2011-01-31 | ||
| US201161444067P | 2011-02-17 | 2011-02-17 | |
| US61/444,067 | 2011-02-17 | ||
| PCT/US2012/023411 WO2012106385A2 (en) | 2011-01-31 | 2012-01-31 | Methods of identifying multiple epitopes in cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513916A JP2014513916A (ja) | 2014-06-19 |
| JP2014513916A5 true JP2014513916A5 (cg-RX-API-DMAC7.html) | 2015-03-19 |
| JP6069224B2 JP6069224B2 (ja) | 2017-02-01 |
Family
ID=46603278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551435A Active JP6069224B2 (ja) | 2011-01-31 | 2012-01-31 | 細胞において複数のエピトープを同定する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (23) | US10144950B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2670863B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6069224B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103703143B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2687761T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012106385A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| WO2007133710A2 (en) | 2006-05-11 | 2007-11-22 | Raindance Technologies, Inc. | Microfluidic devices and methods of use thereof |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| EP2534267B1 (en) | 2010-02-12 | 2018-04-11 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| US11560585B2 (en) * | 2011-01-31 | 2023-01-24 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US10144950B2 (en) | 2011-01-31 | 2018-12-04 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US10995362B2 (en) | 2011-01-31 | 2021-05-04 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US10982271B2 (en) | 2011-01-31 | 2021-04-20 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| EP3736281A1 (en) | 2011-02-18 | 2020-11-11 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| EP3789498B1 (en) * | 2011-04-25 | 2025-08-13 | Bio-Rad Laboratories, Inc. | Methods for nucleic acid analysis |
| US9556470B2 (en) | 2011-06-02 | 2017-01-31 | Raindance Technologies, Inc. | Enzyme quantification |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| EP2820158B1 (en) | 2012-02-27 | 2018-01-10 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| US10174310B2 (en) | 2012-08-08 | 2019-01-08 | Roche Sequencing Solutions, Inc. | Increasing dynamic range for identifying multiple epitopes in cells |
| EP4001426A1 (en) | 2012-08-13 | 2022-05-25 | The Regents of The University of California | Methods and systems for detecting biological components |
| WO2014028537A1 (en) | 2012-08-14 | 2014-02-20 | 10X Technologies, Inc. | Microcapsule compositions and methods |
| US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10584381B2 (en) | 2012-08-14 | 2020-03-10 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
| US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP2931919B1 (en) | 2012-12-14 | 2019-02-20 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| AU2014214682B2 (en) | 2013-02-08 | 2018-07-26 | 10X Genomics, Inc. | Polynucleotide barcode generation |
| EP3611262B1 (en) | 2013-03-15 | 2020-11-11 | Lineage Biosciences, Inc. | Methods of sequencing the immune repertoire |
| JP6545682B2 (ja) | 2013-08-28 | 2019-07-17 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 大規模並列単一細胞分析 |
| WO2015047186A1 (en) * | 2013-09-30 | 2015-04-02 | Di Wu | Methods to profile molecular complexes by using proximity bar-coding |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| MX2016013156A (es) | 2014-04-10 | 2017-02-14 | 10X Genomics Inc | Dispositivos, sistemas y metodos fluidicos, para encapsular y dividir reactivos, y aplicaciones de los mismos. |
| WO2015200869A1 (en) | 2014-06-26 | 2015-12-30 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| US12312640B2 (en) | 2014-06-26 | 2025-05-27 | 10X Genomics, Inc. | Analysis of nucleic acid sequences |
| MX2016016902A (es) | 2014-06-26 | 2017-03-27 | 10X Genomics Inc | Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas. |
| US10697007B2 (en) | 2014-06-27 | 2020-06-30 | The Regents Of The University Of California | PCR-activated sorting (PAS) |
| ES2968004T3 (es) | 2014-07-30 | 2024-05-06 | Harvard College | Construcción de bibliotecas de sondas |
| US10900065B2 (en) | 2014-11-14 | 2021-01-26 | University Of Washington | Methods and kits for labeling cellular molecules |
| US20180320241A1 (en) | 2014-12-19 | 2018-11-08 | Roche Sequencing Solutions, Inc. | Methods for identifying multiple epitopes in selected sub-populations of cells |
| MX367432B (es) | 2015-01-12 | 2019-08-08 | 10X Genomics Inc | Procesos y sistemas para la preparación de bibliotecas de secuenciación de ácido nucleico y bibliotecas preparadas con estos. |
| EP3253479B1 (en) | 2015-02-04 | 2022-09-21 | The Regents of The University of California | Sequencing of nucleic acids via barcoding in discrete entities |
| US11634707B2 (en) * | 2015-02-10 | 2023-04-25 | Illumina, Inc. | Methods and compositions for analyzing cellular components |
| WO2016137973A1 (en) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Partition processing methods and systems |
| WO2016145416A2 (en) * | 2015-03-11 | 2016-09-15 | The Broad Institute, Inc. | Proteomic analysis with nucleic acid identifiers |
| US20160289769A1 (en) * | 2015-03-30 | 2016-10-06 | Verily Life Sciences Llc | Methods for Combining Single Cell Profiling with Combinatorial Nanoparticle Conjugate Library Screening and In Vivo Diagnostic System |
| US20160298187A1 (en) * | 2015-04-08 | 2016-10-13 | Verily Life Sciences Llc | Methods of tagging particles for multiplexed functional screening |
| HK1252248A1 (zh) * | 2015-04-27 | 2019-05-24 | Abvitro Llc | 对治疗剂和疾病特异性抗原进行测序、确定、配对和验证的方法 |
| SG10202107055SA (en) | 2015-07-17 | 2021-08-30 | Nanostring Technologies Inc | Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue |
| AU2016295158B2 (en) | 2015-07-17 | 2021-02-25 | Bruker Spatial Biology, Inc. | Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue |
| WO2017075265A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute, Inc. | Multiplex analysis of single cell constituents |
| US11371094B2 (en) | 2015-11-19 | 2022-06-28 | 10X Genomics, Inc. | Systems and methods for nucleic acid processing using degenerate nucleotides |
| EP3397764A4 (en) | 2015-12-30 | 2019-05-22 | Bio-Rad Laboratories, Inc. | DIGITAL PROTEIN QUANTIFICATION |
| US10900974B2 (en) * | 2016-03-22 | 2021-01-26 | California Institute Of Technology | Methods for identifying macromolecule interactions |
| WO2017190020A1 (en) * | 2016-04-28 | 2017-11-02 | The Scripps Research Institute | Oligonucleotide conjugates and uses thereof |
| US12297495B2 (en) * | 2016-05-17 | 2025-05-13 | Dname-It Nv | Methods for identification of samples |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| IL265478B2 (en) | 2016-09-26 | 2024-10-01 | Becton Dickinson Co | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| EP4339956A3 (en) * | 2016-11-08 | 2024-06-19 | President and Fellows of Harvard College | Multiplexed imaging using merfish, expansion microscopy, and related technologies |
| US20210072255A1 (en) | 2016-12-16 | 2021-03-11 | The Brigham And Women's Hospital, Inc. | System and method for protein corona sensor array for early detection of diseases |
| DE202017007363U1 (de) * | 2016-12-16 | 2021-02-16 | The Brigham And Women's Hospital, Inc. | Zusammensetzung von Partikeln mit Eisenoxidkernen |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| JP7033602B2 (ja) * | 2017-01-27 | 2022-03-10 | エフ．ホフマン－ラ ロシュ アーゲー | ロングレンジ配列決定のためのバーコードを付けられたｄｎａ |
| US12264411B2 (en) | 2017-01-30 | 2025-04-01 | 10X Genomics, Inc. | Methods and systems for analysis |
| EP4310183B1 (en) | 2017-01-30 | 2025-07-09 | 10X Genomics, Inc. | Methods and systems for droplet-based single cell barcoding |
| DK3583214T5 (da) * | 2017-02-02 | 2024-09-02 | New York Genome Center Inc | Fremgangsmåder og sammensætninger til identificering eller kvantificering af mål i en biologisk prøve |
| US10995333B2 (en) | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
| US11788123B2 (en) | 2017-05-26 | 2023-10-17 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
| CN116064732A (zh) | 2017-05-26 | 2023-05-05 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
| AU2018281745B2 (en) | 2017-06-05 | 2022-05-19 | Becton, Dickinson And Company | Sample indexing for single cells |
| AU2018335876B2 (en) | 2017-09-22 | 2024-03-14 | University Of Washington | In situ combinatorial labeling of cellular molecules |
| SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
| US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
| WO2019113506A1 (en) | 2017-12-07 | 2019-06-13 | The Broad Institute, Inc. | Methods and compositions for multiplexing single cell and single nuclei sequencing |
| CN118547046A (zh) | 2017-12-22 | 2024-08-27 | 10X基因组学有限公司 | 用于处理来自一个或多个细胞的核酸分子的系统和方法 |
| SG11202007686VA (en) | 2018-02-12 | 2020-09-29 | 10X Genomics Inc | Methods characterizing multiple analytes from individual cells or cell populations |
| SG11202007501SA (en) | 2018-02-12 | 2020-09-29 | Nanostring Technologies Inc | Biomolecular probes and methods of detecting gene and protein expression |
| US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
| WO2019195166A1 (en) | 2018-04-06 | 2019-10-10 | 10X Genomics, Inc. | Systems and methods for quality control in single cell processing |
| EP3788171B1 (en) | 2018-05-03 | 2023-04-05 | Becton, Dickinson and Company | High throughput multiomics sample analysis |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| AU2019274469A1 (en) * | 2018-05-21 | 2020-11-26 | The Regents Of The University Of California | Single cell mapping and transcriptome analysis |
| US20200032335A1 (en) | 2018-07-27 | 2020-01-30 | 10X Genomics, Inc. | Systems and methods for metabolome analysis |
| JP2021535739A (ja) | 2018-08-27 | 2021-12-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 下流精製でのラマン分光法の使用 |
| US11078480B2 (en) * | 2018-09-19 | 2021-08-03 | California Institute Of Technology | High-throughput identification of intermolecular interactions |
| CN118853827A (zh) | 2018-10-01 | 2024-10-29 | 贝克顿迪金森公司 | 确定5’转录物序列 |
| SG11202104619WA (en) | 2018-11-07 | 2021-06-29 | Seer Inc | Compositions, methods and systems for protein corona analysis and uses thereof |
| EP3891299A1 (en) * | 2018-12-04 | 2021-10-13 | F. Hoffmann-La Roche AG | Spatially oriented quantum barcoding of cellular targets |
| US11459607B1 (en) | 2018-12-10 | 2022-10-04 | 10X Genomics, Inc. | Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes |
| KR20210104779A (ko) | 2018-12-13 | 2021-08-25 | 디엔에이 스크립트 | 세포 및 생체분자 상의 직접 올리고뉴클레오타이드 합성 |
| EP3894583A4 (en) | 2018-12-13 | 2022-11-09 | President and Fellows of Harvard College | AMPLIFICATION METHODS AND SYSTEMS FOR MERFISH AND OTHER APPLICATIONS |
| EP3903104A4 (en) * | 2018-12-27 | 2022-09-21 | Bio-Rad Laboratories, Inc. | SEQUENCE MULTIPLEX WESTERN BLOT |
| US11845983B1 (en) | 2019-01-09 | 2023-12-19 | 10X Genomics, Inc. | Methods and systems for multiplexing of droplet based assays |
| CN113574178B (zh) | 2019-01-23 | 2024-10-29 | 贝克顿迪金森公司 | 与抗体关联的寡核苷酸 |
| WO2020185312A2 (en) | 2019-01-25 | 2020-09-17 | President And Fellows Of Harvard College | Compositions and method for synthesizing nucleic acids |
| US11634766B2 (en) * | 2019-02-04 | 2023-04-25 | The Broad Institute, Inc. | Methods and compositions for analyzing nucleic acids |
| US11851683B1 (en) | 2019-02-12 | 2023-12-26 | 10X Genomics, Inc. | Methods and systems for selective analysis of cellular samples |
| US12071617B2 (en) | 2019-02-14 | 2024-08-27 | Becton, Dickinson And Company | Hybrid targeted and whole transcriptome amplification |
| GB2599796A (en) | 2019-03-26 | 2022-04-13 | Seer Inc | Compositions, methods and systems for protein corona analysis from biofluids and uses thereof |
| US11965208B2 (en) * | 2019-04-19 | 2024-04-23 | Becton, Dickinson And Company | Methods of associating phenotypical data and single cell sequencing data |
| EP3958727A4 (en) | 2019-04-23 | 2023-05-03 | Encodia, Inc. | METHODS FOR SPATIAL ANALYSIS OF PROTEINS AND RELATED KITS |
| WO2021016239A1 (en) | 2019-07-22 | 2021-01-28 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| CN117233413A (zh) | 2019-08-05 | 2023-12-15 | 禧尔公司 | 用于样品制备、数据生成和蛋白质冠分析的系统和方法 |
| US12235262B1 (en) | 2019-09-09 | 2025-02-25 | 10X Genomics, Inc. | Methods and systems for single cell protein analysis |
| US12252741B2 (en) | 2019-10-28 | 2025-03-18 | Pixelgen Technologies Ab | Method for mapping rolling circle amplification products |
| ES2987640T3 (es) | 2019-11-08 | 2024-11-15 | Becton Dickinson Co | Uso de cebado aleatorio para obtener información de V(D)J de longitud completa para la secuenciación del repertorio inmunitario |
| CN110819656B (zh) * | 2019-11-11 | 2021-06-04 | 中国科学院上海高等研究院 | 一种基于同步光源的x-射线多色遗传标记探针及其制备方法以及应用 |
| US12163189B2 (en) | 2019-11-27 | 2024-12-10 | University Of Washington | Method for preparation and high-throughput microbial single-cell RNA sequencing of bacteria |
| WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
| WO2021144396A1 (en) | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Microfluidic device and method for automated split-pool synthesis |
| US12165747B2 (en) | 2020-01-23 | 2024-12-10 | The Broad Institute, Inc. | Molecular spatial mapping of metastatic tumor microenvironment |
| CN115335520A (zh) | 2020-01-29 | 2022-11-11 | 贝克顿迪金森公司 | 用于通过测序对单细胞进行空间映射的条形码化的孔 |
| US12153043B2 (en) | 2020-02-25 | 2024-11-26 | Becton, Dickinson And Company | Bi-specific probes to enable the use of single-cell samples as single color compensation control |
| WO2021185682A1 (en) | 2020-03-17 | 2021-09-23 | F. Hoffmann-La Roche Ag | Method of improving cell recovery in single-cell analysis |
| JP2023523825A (ja) | 2020-05-01 | 2023-06-07 | エフ． ホフマン－ラ ロシュ アーゲー | マルチウェルプレート用サンプル収集トレイ |
| US20230242971A1 (en) | 2020-05-08 | 2023-08-03 | Roche Sequencing Solutions, Inc. | Removal of excess oligonucleotides from a reation mixture |
| EP4150118A1 (en) | 2020-05-14 | 2023-03-22 | Becton Dickinson and Company | Primers for immune repertoire profiling |
| US12157913B2 (en) | 2020-06-02 | 2024-12-03 | Becton, Dickinson And Company | Oligonucleotides and beads for 5 prime gene expression assay |
| WO2021249816A1 (en) | 2020-06-08 | 2021-12-16 | F. Hoffmann-La Roche Ag | Method of single-cell analysis of multiple samples |
| WO2022008649A1 (en) | 2020-07-08 | 2022-01-13 | F. Hoffmann-La Roche Ag | Spatial analysis of multiple targets in tissue samples |
| US20230249178A1 (en) | 2020-07-08 | 2023-08-10 | Roche Sequencing Solutions, Inc. | Split-pool synthesis apparatus and methods of performing split-pool synthesis |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| US12391940B2 (en) | 2020-07-31 | 2025-08-19 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| JP2023540904A (ja) | 2020-08-25 | 2023-09-27 | シアー， インコーポレイテッド | タンパク質および核酸をアッセイするための組成物および方法 |
| WO2022109343A1 (en) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| US12378596B2 (en) | 2020-12-03 | 2025-08-05 | Roche Sequencing Solutions, Inc. | Whole transcriptome analysis in single cells |
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| WO2022164893A1 (en) * | 2021-01-26 | 2022-08-04 | Chan Zuckerberg Biohub, Inc. | Quantification of cellular proteins using barcoded binding moieties |
| WO2022182682A1 (en) | 2021-02-23 | 2022-09-01 | 10X Genomics, Inc. | Probe-based analysis of nucleic acids and proteins |
| CN113189078B (zh) * | 2021-03-04 | 2024-04-16 | 吉林大学 | 一种靶向药物的高通量筛选方法 |
| CA3213800A1 (en) | 2021-03-30 | 2022-10-06 | Simon Fredriksson | Spatial mapping by serial primer extension |
| EP4334706A4 (en) | 2021-05-05 | 2025-08-06 | Singular Genomics Systems Inc | MULTIOMICS ANALYSIS DEVICE AND METHODS OF USE THEREOF |
| EP4430206A1 (en) | 2021-11-10 | 2024-09-18 | Encodia, Inc. | Methods for barcoding macromolecules in individual cells |
| EP4206674B1 (en) | 2021-12-28 | 2025-10-22 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
| EP4499867A2 (en) | 2022-03-24 | 2025-02-05 | Digital Biology Inc. | Tissue spatial omics |
| AU2023308992A1 (en) * | 2022-07-19 | 2025-01-30 | Digital Biology Inc. | Barcode diffusion-based spatial omics |
| WO2024238690A1 (en) * | 2023-05-16 | 2024-11-21 | California Institute Of Technology | Methods for identifying nucleic acid binding proteins |
Family Cites Families (132)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| JP2955759B2 (ja) | 1988-07-20 | 1999-10-04 | セゲブ・ダイアグノスティックス・インコーポレイテッド | 核酸配列を増幅及び検出する方法 |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| EP0439182B1 (en) | 1990-01-26 | 1996-04-24 | Abbott Laboratories | Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| JPH11505126A (ja) | 1995-05-19 | 1999-05-18 | アボツト・ラボラトリーズ | プライマーシリーズ集団を使用する広い動的範囲の核酸検出 |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6607878B2 (en) * | 1997-10-06 | 2003-08-19 | Stratagene | Collections of uniquely tagged molecules |
| US6180340B1 (en) | 1997-10-31 | 2001-01-30 | Gen-Probe Incorporated | Extended dynamic range assays |
| US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US20040106110A1 (en) | 1998-07-30 | 2004-06-03 | Solexa, Ltd. | Preparation of polynucleotide arrays |
| US6221613B1 (en) | 1998-12-31 | 2001-04-24 | Synaptic Pharmaceutical Corporation | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| ATE320443T1 (de) | 1999-07-15 | 2006-04-15 | Qiagen Gmbh | Verfahren zur trennung von teilchenförmigen substraten aus einer lösung indem man den teilchenverlust minimiert |
| US6262490B1 (en) | 1999-11-05 | 2001-07-17 | Advanced Semiconductor Engineering, Inc. | Substrate strip for use in packaging semiconductor chips |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| EP1254367A4 (en) | 2000-02-03 | 2006-07-05 | Nanoscale Combinatorial Synthe | METHOD FOR IDENTIFYING STRUCTURES BY MASS DETERMINATION |
| WO2001057268A2 (en) | 2000-02-07 | 2001-08-09 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| SE516272C2 (sv) | 2000-02-18 | 2001-12-10 | Ulf Landegren | Metoder och kit för analytdetektion mha proximitets-probning |
| AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| WO2002027029A2 (en) | 2000-09-27 | 2002-04-04 | Lynx Therapeutics, Inc. | Method for determining relative abundance of nucleic acid sequences |
| EP2381116A1 (en) | 2000-11-16 | 2011-10-26 | California Institute of Technology | Apparatus and methods for conducting assays and high throughput screening |
| DE10120797B4 (de) | 2001-04-27 | 2005-12-22 | Genovoxx Gmbh | Verfahren zur Analyse von Nukleinsäureketten |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| WO2003020968A2 (de) | 2001-08-29 | 2003-03-13 | Genovoxx Gmbh | Verfahren zur analyse von nukleinsäurekettensequenzen und der genexpression |
| JP2003101204A (ja) | 2001-09-25 | 2003-04-04 | Nec Kansai Ltd | 配線基板及び配線基板の製造方法並びに電子部品 |
| US20030082551A1 (en) | 2001-09-28 | 2003-05-01 | Zarling David A. | High-throughput gene cloning and phenotypic screening |
| DE10246005A1 (de) | 2001-10-04 | 2003-04-30 | Genovoxx Gmbh | Gerät zur Sequenzierung von Nukleinsäuremolekülen |
| DE10149786B4 (de) | 2001-10-09 | 2013-04-25 | Dmitry Cherkasov | Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen |
| US20050124022A1 (en) | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US20030219801A1 (en) | 2002-03-06 | 2003-11-27 | Affymetrix, Inc. | Aptamer base technique for ligand identification |
| DE10214395A1 (de) | 2002-03-30 | 2003-10-23 | Dmitri Tcherkassov | Verfahren zur Analyse von Einzelnukleotidpolymorphismen |
| US7108976B2 (en) | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
| AU2003255147A1 (en) | 2002-07-24 | 2004-02-09 | Tdk Corporation | Functional film for transfer having functional layer, object furnished with functional layer and process for producing the same |
| GB0222846D0 (en) | 2002-10-03 | 2002-11-06 | Choo Yen | Cell culture |
| CA2452112A1 (en) | 2002-12-09 | 2004-06-09 | Mold-Masters Limited | Nozzle tip and seal |
| US20040110153A1 (en) | 2002-12-10 | 2004-06-10 | Affymetrix, Inc. | Compleixity management of genomic DNA by semi-specific amplification |
| US7122319B2 (en) * | 2002-12-18 | 2006-10-17 | Monogram Biosciences, Inc | Multiplexed immunohistochemical assays using molecular tags |
| CN102212614B (zh) | 2003-01-29 | 2013-12-25 | 454生命科学公司 | 核酸扩增和测序的方法 |
| DE602004018631D1 (de) | 2003-04-24 | 2009-02-05 | Afshin Ahmadian | En |
| WO2005010159A2 (en) | 2003-07-17 | 2005-02-03 | Children's Hospital Medical Center | Rolling circle amplification of micro-rna samples |
| US8637650B2 (en) | 2003-11-05 | 2014-01-28 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
| DE10356837A1 (de) | 2003-12-05 | 2005-06-30 | Dmitry Cherkasov | Modifizierte Nukleotide und Nukleoside |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| WO2005050224A2 (en) | 2003-11-13 | 2005-06-02 | Epitome Biosystems Inc. | Small molecule and peptide arrays and uses thereof |
| WO2005071110A2 (en) | 2004-01-23 | 2005-08-04 | Lingvitae As | Improving polynucleotide ligation reactions |
| DE102004009704A1 (de) | 2004-02-27 | 2005-09-15 | Dmitry Cherkasov | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
| US20060275923A1 (en) | 2004-03-23 | 2006-12-07 | Hammond David J | Methods for reducing the range in concentrations of analyte species in a sample |
| DE102004025694A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten |
| DE102004025696A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten |
| DE102004025695A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten |
| DE102004025744A1 (de) | 2004-05-26 | 2005-12-29 | Dmitry Cherkasov | Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen |
| DE102004025746A1 (de) | 2004-05-26 | 2005-12-15 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten |
| DE102004025745A1 (de) | 2004-05-26 | 2005-12-15 | Cherkasov, Dmitry | Oberfläche für die Analysen an einzelnen Molekülen |
| WO2005123963A2 (en) | 2004-06-14 | 2005-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in analyte detection using proximity probes |
| US20060002471A1 (en) | 2004-06-30 | 2006-01-05 | Lippincott Louis A | Motion estimation unit |
| US20060024711A1 (en) | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
| US20060012793A1 (en) | 2004-07-19 | 2006-01-19 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US7276720B2 (en) | 2004-07-19 | 2007-10-02 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US20060024678A1 (en) | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
| US9035035B2 (en) | 2004-11-05 | 2015-05-19 | Genovoxx Gmbh | Macromolecular nucleotide compounds and methods for using the same |
| JP2008533974A (ja) | 2005-01-21 | 2008-08-28 | サード・ウェーブ・テクノロジーズ・インク | 核酸分子の増大したダイナミックレンジ検出のための組成物および方法 |
| DE102006012317A1 (de) | 2005-03-17 | 2007-01-18 | Cherkasov, Dmitry, Dr. | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
| CN101466847B (zh) | 2005-06-15 | 2014-02-19 | 考利达基因组股份有限公司 | 用于遗传和化学分析的单分子阵列 |
| US20070020640A1 (en) * | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| AU2007249635B2 (en) | 2005-10-07 | 2012-05-31 | Complete Genomics, Inc. | High throughput genome sequencing on DNA arrays |
| WO2007076128A2 (en) | 2005-12-23 | 2007-07-05 | Nanostring Technologies, Inc. | Nanoreporters and methods of manufacturing and use thereof |
| US8986926B2 (en) | 2005-12-23 | 2015-03-24 | Nanostring Technologies, Inc. | Compositions comprising oriented, immobilized macromolecules and methods for their preparation |
| US8394590B2 (en) * | 2006-08-02 | 2013-03-12 | California Institute Of Technology | Capture agents and related methods and systems for detecting and/or sorting targets |
| ES2679996T3 (es) | 2006-11-15 | 2018-09-03 | Biospherex Llc | Secuenciación multi-etiqueta y análisis ecogenómico |
| US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
| US8003312B2 (en) | 2007-02-16 | 2011-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplex cellular assays using detectable cell barcodes |
| US8090603B2 (en) | 2007-05-11 | 2012-01-03 | Fansnap, Inc. | System and method for selecting event tickets |
| WO2008155599A1 (en) | 2007-06-20 | 2008-12-24 | Taag-Genetics Sa | Nested multiplex amplification method for identification of multiple biological entities |
| US20090068170A1 (en) * | 2007-07-13 | 2009-03-12 | President And Fellows Of Harvard College | Droplet-based selection |
| US8999652B2 (en) | 2007-08-10 | 2015-04-07 | Primity Bio, Inc. | Biological encoding of large numbers of cells |
| US8268564B2 (en) * | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| US8114681B2 (en) * | 2007-10-05 | 2012-02-14 | Affymetrix, Inc. | Highly multiplexed particle-based assays |
| EP2247708A4 (en) | 2007-12-17 | 2013-02-27 | Yeda Res & Dev | SYSTEM AND METHOD FOR PROCESSING AND MANIPULATING DNA |
| WO2009126290A2 (en) | 2008-04-09 | 2009-10-15 | Cornell University | Coferons and methods of making and using them |
| DE102008025992B4 (de) | 2008-05-30 | 2011-01-27 | Siemens Healthcare Diagnostics Gmbh | Titerplatte und Verfahren zur Detektion eines Analyten |
| WO2010019826A1 (en) | 2008-08-14 | 2010-02-18 | Nanostring Technologies, Inc | Stable nanoreporters |
| US8697363B2 (en) | 2008-08-26 | 2014-04-15 | Fluidigm Corporation | Methods for detecting multiple target nucleic acids in multiple samples by use nucleotide tags |
| DE102008044946B4 (de) | 2008-08-29 | 2022-06-15 | Evonik Superabsorber Gmbh | Einsatz von Schaumkörpern in Oxidations-Reaktoren zur Herstellung ungesättigter Carbonsäuren |
| GB0816976D0 (en) | 2008-09-16 | 2008-10-22 | Natural Environment Res Council | Protein |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US8481698B2 (en) | 2009-03-19 | 2013-07-09 | The President And Fellows Of Harvard College | Parallel proximity ligation event analysis |
| US20120010091A1 (en) * | 2009-03-30 | 2012-01-12 | Illumina, Inc. | Gene expression analysis in single cells |
| EP3029141A1 (en) * | 2009-08-20 | 2016-06-08 | Population Genetics Technologies Ltd. | Compositions and methods for intramolecular nucleic acid rearrangement |
| CN102203281B (zh) | 2009-08-21 | 2013-04-17 | 赛业（广州）生物科技有限公司 | 复制条码筛选检测 |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US8648016B2 (en) | 2010-02-08 | 2014-02-11 | Robert Bosch Gmbh | Array with extended dynamic range and associated method |
| US10787701B2 (en) * | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| SG185543A1 (en) | 2010-05-14 | 2012-12-28 | Fluidigm Corp | Assays for the detection of genotype, mutations, and/or aneuploidy |
| WO2011146942A1 (en) | 2010-05-21 | 2011-11-24 | The Translational Genomics Research Institute | Methods and kits to analyze microrna by nucleic acid sequencing |
| US9696332B2 (en) | 2010-07-23 | 2017-07-04 | Matrix Technologies Llc | Automated liquid handling device |
| EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| EP3561159B1 (en) * | 2010-10-08 | 2023-09-20 | President and Fellows of Harvard College | High-throughput single cell barcoding |
| EP3000883B8 (en) | 2010-11-12 | 2018-02-28 | Gen9, Inc. | Methods and devices for nucleic acids synthesis |
| WO2012083225A2 (en) | 2010-12-16 | 2012-06-21 | Gigagen, Inc. | System and methods for massively parallel analysis of nycleic acids in single cells |
| US10144950B2 (en) | 2011-01-31 | 2018-12-04 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US20200157603A1 (en) | 2011-01-31 | 2020-05-21 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US10995362B2 (en) | 2011-01-31 | 2021-05-04 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US10982271B2 (en) | 2011-01-31 | 2021-04-20 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| US11560585B2 (en) | 2011-01-31 | 2023-01-24 | Roche Sequencing Solutions, Inc. | Methods of identifying multiple epitopes in cells |
| RU2671980C2 (ru) | 2011-02-09 | 2018-11-08 | Натера, Инк. | Способы неинвазивного пренатального установления плоидности |
| WO2012142242A2 (en) | 2011-04-12 | 2012-10-18 | Siloam Biosciences, Inc. | Assay method for extended dynamic range |
| WO2013137737A1 (en) | 2012-03-16 | 2013-09-19 | Flexgen B.V. | Methods of creating and screening of dna encoded combinatorial libraries of chemical antibodies |
| US10174310B2 (en) | 2012-08-08 | 2019-01-08 | Roche Sequencing Solutions, Inc. | Increasing dynamic range for identifying multiple epitopes in cells |
| CN103730314A (zh) | 2012-10-12 | 2014-04-16 | 无锡慧明电子科技有限公司 | 一种气体离子源进气实时控制系统 |
| SG10201704932UA (en) | 2012-12-17 | 2017-07-28 | Harvard College | Rna-guided human genome engineering |
| CN105683397A (zh) | 2013-09-04 | 2016-06-15 | 富鲁达公司 | 用于检测单细胞中的核酸和蛋白的邻近测定 |
| GB201401885D0 (en) | 2014-02-04 | 2014-03-19 | Olink Ab | Proximity assay with detection based on hybridisation chain reaction (HCR) |
| US10900065B2 (en) | 2014-11-14 | 2021-01-26 | University Of Washington | Methods and kits for labeling cellular molecules |
| US20180320241A1 (en) | 2014-12-19 | 2018-11-08 | Roche Sequencing Solutions, Inc. | Methods for identifying multiple epitopes in selected sub-populations of cells |
| CN206096158U (zh) | 2016-09-19 | 2017-04-12 | 清华大学 | 自动液体处理系统 |
| US20180089373A1 (en) | 2016-09-23 | 2018-03-29 | Driver, Inc. | Integrated systems and methods for automated processing and analysis of biological samples, clinical information processing and clinical trial matching |
| WO2018213591A1 (en) | 2017-05-19 | 2018-11-22 | Counsyl, Inc. | Modular robotic system for laboratory diagnostics |
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