JP2014513136A5 - - Google Patents
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- JP2014513136A5 JP2014513136A5 JP2014509491A JP2014509491A JP2014513136A5 JP 2014513136 A5 JP2014513136 A5 JP 2014513136A5 JP 2014509491 A JP2014509491 A JP 2014509491A JP 2014509491 A JP2014509491 A JP 2014509491A JP 2014513136 A5 JP2014513136 A5 JP 2014513136A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
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- compound
- formula
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 10
- 208000005017 Glioblastoma Diseases 0.000 claims description 6
- 206010018338 Glioma Diseases 0.000 claims description 4
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Nitrumon Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims description 4
- 102100004939 PDGFRB Human genes 0.000 claims description 4
- 101710018346 PDGFRB Proteins 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- LXZZYRPGZAFOLE-UHFFFAOYSA-L transplatin Chemical compound [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H] LXZZYRPGZAFOLE-UHFFFAOYSA-L 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 206010003571 Astrocytoma Diseases 0.000 claims description 2
- 108010005144 Bevacizumab Proteins 0.000 claims description 2
- 210000004556 Brain Anatomy 0.000 claims description 2
- 206010014967 Ependymoma Diseases 0.000 claims description 2
- AAKJLRGGTJKAMG-UHFFFAOYSA-N Erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 2
- 229960001433 Erlotinib Drugs 0.000 claims description 2
- XGALLCVXEZPNRQ-UHFFFAOYSA-N Gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims description 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N Irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims description 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 2
- 206010027476 Metastasis Diseases 0.000 claims description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 2
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temodal Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims description 2
- 125000005431 alkyl carboxamide group Chemical group 0.000 claims description 2
- 239000002168 alkylating agent Substances 0.000 claims description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 2
- 229960000397 bevacizumab Drugs 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 229930003827 cannabinoid Natural products 0.000 claims description 2
- 239000003557 cannabinoid Substances 0.000 claims description 2
- 230000002149 cannabinoid Effects 0.000 claims description 2
- 229940065144 cannabinoids Drugs 0.000 claims description 2
- 229960005243 carmustine Drugs 0.000 claims description 2
- 229960004316 cisplatin Drugs 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 229960002584 gefitinib Drugs 0.000 claims description 2
- 201000010915 glioblastoma multiforme Diseases 0.000 claims description 2
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 229960004768 irinotecan Drugs 0.000 claims description 2
- 201000004058 mixed glioma Diseases 0.000 claims description 2
- 201000010133 oligodendroglioma Diseases 0.000 claims description 2
- 239000000546 pharmaceutic aid Substances 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229960004964 temozolomide Drugs 0.000 claims description 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims description 2
- 229940121358 tyrosine kinase inhibitors Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 229940100198 ALKYLATING AGENTS Drugs 0.000 claims 1
- 229940045719 antineoplastic alkylating agents Nitrosoureas Drugs 0.000 claims 1
- 0 *C1=CCC(OCc2ccc3nc(N*)[s]c3c2)=CC=N1 Chemical compound *C1=CCC(OCc2ccc3nc(N*)[s]c3c2)=CC=N1 0.000 description 8
- OJKXHONIYMURKZ-VEDKUMTNSA-N C/C=C(\C=C(\c1c[n](C)nc1)/N)/Oc1ccc2nc(NC[C@@H](CCCC3)[C@H]3O)[s]c2c1 Chemical compound C/C=C(\C=C(\c1c[n](C)nc1)/N)/Oc1ccc2nc(NC[C@@H](CCCC3)[C@H]3O)[s]c2c1 OJKXHONIYMURKZ-VEDKUMTNSA-N 0.000 description 1
- QHPUOUFNQKXOJA-UHFFFAOYSA-N CNC(C(C1)N=CC=C1Oc(cc1)cc2c1nc(NC(CCCC1)C1O)[s]2)=O Chemical compound CNC(C(C1)N=CC=C1Oc(cc1)cc2c1nc(NC(CCCC1)C1O)[s]2)=O QHPUOUFNQKXOJA-UHFFFAOYSA-N 0.000 description 1
- ADZBMFGQQWPHMJ-YOEHRIQHSA-N CNC(c1cc(Oc2ccc3nc(N[C@@H](CCCC4)[C@H]4O)[s]c3c2)ccn1)=O Chemical compound CNC(c1cc(Oc2ccc3nc(N[C@@H](CCCC4)[C@H]4O)[s]c3c2)ccn1)=O ADZBMFGQQWPHMJ-YOEHRIQHSA-N 0.000 description 1
- ADZBMFGQQWPHMJ-UHFFFAOYSA-N CNC(c1nccc(Oc2ccc3nc(NC(CCCC4)C4O)[s]c3c2)c1)=O Chemical compound CNC(c1nccc(Oc2ccc3nc(NC(CCCC4)C4O)[s]c3c2)c1)=O ADZBMFGQQWPHMJ-UHFFFAOYSA-N 0.000 description 1
- ADZBMFGQQWPHMJ-RHSMWYFYSA-N CNC(c1nccc(Oc2ccc3nc(N[C@H](CCCC4)[C@@H]4O)[s]c3c2)c1)=O Chemical compound CNC(c1nccc(Oc2ccc3nc(N[C@H](CCCC4)[C@@H]4O)[s]c3c2)c1)=O ADZBMFGQQWPHMJ-RHSMWYFYSA-N 0.000 description 1
- NJUWXYYFKUUWGU-UHFFFAOYSA-N CNCc1nccc(Oc2ccc3nc(N)[s]c3c2)c1 Chemical compound CNCc1nccc(Oc2ccc3nc(N)[s]c3c2)c1 NJUWXYYFKUUWGU-UHFFFAOYSA-N 0.000 description 1
- AIXXITODYRLCRH-MSOLQXFVSA-N C[n]1ncc(-c2cc(Oc3ccc4nc(NC[C@H](CCCC5)[C@@H]5C=C)[s]c4c3)ccn2)c1 Chemical compound C[n]1ncc(-c2cc(Oc3ccc4nc(NC[C@H](CCCC5)[C@@H]5C=C)[s]c4c3)ccn2)c1 AIXXITODYRLCRH-MSOLQXFVSA-N 0.000 description 1
- FCCUUXVXNBHGAZ-YLJYHZDGSA-N C[n]1ncc(-c2nccc(Oc3ccc4nc(N[C@H](CCCC5)[C@@H]5O)[s]c4c3)c2)c1 Chemical compound C[n]1ncc(-c2nccc(Oc3ccc4nc(N[C@H](CCCC5)[C@@H]5O)[s]c4c3)c2)c1 FCCUUXVXNBHGAZ-YLJYHZDGSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N Nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004083 survival Effects 0.000 description 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
- -1 ukulein Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482723P | 2011-05-05 | 2011-05-05 | |
| US61/482,723 | 2011-05-05 | ||
| US201261624861P | 2012-04-16 | 2012-04-16 | |
| US61/624,861 | 2012-04-16 | ||
| PCT/US2012/036589 WO2012151523A1 (en) | 2011-05-05 | 2012-05-04 | Csf-1r inhibitors for treatment of brain tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513136A JP2014513136A (ja) | 2014-05-29 |
| JP2014513136A5 true JP2014513136A5 (US07981874-20110719-C00313.png) | 2015-06-25 |
| JP6046702B2 JP6046702B2 (ja) | 2016-12-21 |
Family
ID=46062775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509491A Active JP6046702B2 (ja) | 2011-05-05 | 2012-05-04 | 脳腫瘍の処置用のｃｓｆ−１ｒ阻害剤 |
Country Status (19)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014147631A1 (en) * | 2013-03-22 | 2014-09-25 | Natco Pharma Limited | Formulation comprising gefitinib as oral suspension |
| US10722517B2 (en) | 2015-05-08 | 2020-07-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treatment of glioma |
| MA47395A (fr) * | 2015-05-27 | 2019-12-11 | Ucb Biopharma Sprl | Méthode pour le traitement d'une maladie neurologique |
| JP6587756B2 (ja) * | 2015-11-04 | 2019-10-09 | デューク ユニバーシティー | 免疫毒素およびチェックポイント阻害剤の併用療法 |
| BR112019006914A2 (pt) * | 2016-10-14 | 2019-07-02 | Novartis Ag | formas cristalinas de 4-(2-((1r,2r)-2-hidroxiciclo-hexilamino)benzotiazol-6-ilóxi)-n-metilpicolinamida |
| WO2018069893A1 (en) * | 2016-10-14 | 2018-04-19 | Novartis Ag | Methods for treating ocular disease using inhibitors of csf-1r |
| MA46716A (fr) | 2016-11-03 | 2019-09-11 | Juno Therapeutics Inc | Polythérapie de thérapie cellulaire et d'inhibiteur de la microglie |
| MX2019014288A (es) | 2017-06-02 | 2020-08-03 | Juno Therapeutics Inc | Articulos de manufactura y metodos relacionados a toxicidad asociada con terapia celular. |
| US11413310B2 (en) | 2017-06-02 | 2022-08-16 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| CA3067602A1 (en) | 2017-06-29 | 2019-01-03 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
| MA50057A (fr) | 2017-09-01 | 2020-07-08 | Juno Therapeutics Inc | Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| EP3836951A1 (en) | 2018-08-13 | 2021-06-23 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| JP2022513689A (ja) | 2018-11-30 | 2022-02-09 | ジュノー セラピューティクス インコーポレイテッド | 養子細胞療法におけるｂ細胞悪性腫瘍の投与および処置のための方法 |
| KR20210117260A (ko) | 2018-11-30 | 2021-09-28 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법을 사용한 치료방법 |
| CN110468210A (zh) * | 2019-09-12 | 2019-11-19 | 暨南大学 | Cdc45作为胶质母细胞瘤标志物及其作为治疗靶点的应用 |
| WO2021113770A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating b cell malignancies |
| CA3195511A1 (en) * | 2020-09-21 | 2022-03-24 | Hutchison Medipharma Limited | Heteroaromatic compounds and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100721656B1 (ko) | 2005-11-01 | 2007-05-23 | 주식회사 엘지화학 | 유기 전기 소자 |
| PL2010496T3 (pl) * | 2006-04-14 | 2011-01-31 | Astrazeneca Ab | 4-Anilinochinolino-3-karboksyamidy jako inhibitory kinazy CSF-1R |
| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| US7553854B2 (en) * | 2006-04-19 | 2009-06-30 | Novartis Vaccines And Diagnostics, Inc. | 6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling |
| CA2649739C (en) | 2006-04-20 | 2015-09-01 | Janssen Pharmaceutica N.V. | Inhibitors of c-fms kinase |
| EP2152700B1 (en) * | 2007-05-21 | 2013-12-11 | Novartis AG | Csf-1r inhibitors, compositions, and methods of use |
-
2012
- 2012-05-04 HU HUE12720761A patent/HUE032754T2/en unknown
- 2012-05-04 SI SI201230916A patent/SI2704713T1/sl unknown
- 2012-05-04 PL PL12720761T patent/PL2704713T3/pl unknown
- 2012-05-04 JP JP2014509491A patent/JP6046702B2/ja active Active
- 2012-05-04 EA EA201391629A patent/EA023999B1/ru not_active IP Right Cessation
- 2012-05-04 US US14/114,878 patent/US20140065141A1/en not_active Abandoned
- 2012-05-04 KR KR1020137031960A patent/KR101938431B1/ko active IP Right Grant
- 2012-05-04 WO PCT/US2012/036589 patent/WO2012151523A1/en active Application Filing
- 2012-05-04 LT LTEP12720761.1T patent/LT2704713T/lt unknown
- 2012-05-04 CN CN201280021878.2A patent/CN103501785B/zh active Active
- 2012-05-04 DK DK12720761.1T patent/DK2704713T3/en active
- 2012-05-04 EP EP12720761.1A patent/EP2704713B1/en active Active
- 2012-05-04 MX MX2013012939A patent/MX347616B/es active IP Right Grant
- 2012-05-04 PT PT127207611T patent/PT2704713T/pt unknown
- 2012-05-04 BR BR112013028095-6A patent/BR112013028095B1/pt not_active IP Right Cessation
- 2012-05-04 CA CA2834696A patent/CA2834696C/en active Active
- 2012-05-04 ES ES12720761.1T patent/ES2622527T3/es active Active
-
2015
- 2015-06-29 US US14/754,152 patent/US20150306085A1/en not_active Abandoned
-
2017
- 2017-04-10 CY CY20171100426T patent/CY1119642T1/el unknown
- 2017-04-12 HR HRP20170593TT patent/HRP20170593T1/hr unknown
-
2018
- 2018-06-04 US US15/996,945 patent/US10537561B2/en active Active
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