JP2014513046A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014513046A5 JP2014513046A5 JP2013553647A JP2013553647A JP2014513046A5 JP 2014513046 A5 JP2014513046 A5 JP 2014513046A5 JP 2013553647 A JP2013553647 A JP 2013553647A JP 2013553647 A JP2013553647 A JP 2013553647A JP 2014513046 A5 JP2014513046 A5 JP 2014513046A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- alkyl
- cycloalkyl
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161442451P | 2011-02-14 | 2011-02-14 | |
| US61/442,451 | 2011-02-14 | ||
| US201161484296P | 2011-05-10 | 2011-05-10 | |
| US61/484,296 | 2011-05-10 | ||
| PCT/US2012/024974 WO2012112492A1 (en) | 2011-02-14 | 2012-02-14 | 4-hydroxybutyric acid deuterated analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083295A Division JP6692319B2 (ja) | 2011-02-14 | 2017-04-20 | ４−ヒドロキシ酪酸の重水素化類似体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513046A JP2014513046A (ja) | 2014-05-29 |
| JP2014513046A5 true JP2014513046A5 (https=) | 2015-04-02 |
Family
ID=46672903
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553647A Pending JP2014513046A (ja) | 2011-02-14 | 2012-02-14 | ４−ヒドロキシ酪酸の重水素化類似体 |
| JP2017083295A Active JP6692319B2 (ja) | 2011-02-14 | 2017-04-20 | ４−ヒドロキシ酪酸の重水素化類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083295A Active JP6692319B2 (ja) | 2011-02-14 | 2017-04-20 | ４−ヒドロキシ酪酸の重水素化類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8759394B2 (https=) |
| EP (1) | EP2675771B1 (https=) |
| JP (2) | JP2014513046A (https=) |
| KR (1) | KR101976218B1 (https=) |
| CN (1) | CN103370289B (https=) |
| BR (1) | BR112013020620A2 (https=) |
| ES (1) | ES2804540T3 (https=) |
| IL (1) | IL227754B (https=) |
| MX (1) | MX355742B (https=) |
| WO (1) | WO2012112492A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2421808B1 (en) | 2009-04-23 | 2013-07-31 | Concert Pharmaceuticals Inc. | 4-hydroxybutyric acid analogs |
| CA2794171C (en) | 2010-03-24 | 2018-07-03 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| KR101976218B1 (ko) | 2011-02-14 | 2019-05-07 | 콘서트 파마슈티컬즈, 인크. | 4-히드록시부티르산 중수소화 유사체 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| CA2999367C (en) | 2015-09-23 | 2023-09-26 | Xw Laboratories Inc. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| CN108473411B (zh) * | 2015-11-19 | 2022-08-12 | 协和发酵生化株式会社 | 3-羟基异戊酸的一价阳离子盐的晶体及该晶体的制造方法 |
| CA3028608A1 (en) | 2016-06-24 | 2017-12-28 | Otsuka Pharmaceutical Factory, Inc. | Crystal of amino acid salt of 3-hydroxyisovaleric acid and production method thereof |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11000498B2 (en) | 2016-07-22 | 2021-05-11 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| EP3601235B1 (en) | 2017-03-30 | 2026-03-04 | XWPharma Ltd. | Bicyclic heteroaryl derivatives, preparation and therapeutic uses thereof |
| AU2019239096A1 (en) * | 2018-03-23 | 2020-08-27 | Concert Pharmaceuticals, Inc. | Deuterated analogs of D-beta-hydroxybutyric acid and uses thereof |
| CN114042070A (zh) | 2018-09-30 | 2022-02-15 | 凯瑞康宁生物工程（武汉）有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| CA3115122A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| EP3930702A1 (en) | 2019-03-01 | 2022-01-05 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| TWI899126B (zh) | 2019-12-20 | 2025-10-01 | 香港商凱瑞康寧有限公司 | ４－纈胺醯氧基丁酸的合成方法 |
| TW202139986A (zh) * | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| AU2021293941B2 (en) | 2020-06-18 | 2024-03-28 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| CN115038432B (zh) | 2020-06-18 | 2023-12-26 | 凯瑞康宁生物工程（武汉）有限公司 | 水溶性活性药物成分的控制释放制粒 |
| WO2022020621A1 (en) | 2020-07-24 | 2022-01-27 | XWPharma Ltd. | Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative |
| EP4225274A1 (en) | 2020-10-05 | 2023-08-16 | XWPharma Ltd. | Modified release compositions of a gamma-hydroxybutyric acid derivative |
| WO2022076824A1 (en) | 2020-10-08 | 2022-04-14 | Jazz Pharmaceuticals Ireland Limited | Sodium oxybate to treat idiopathic hypersomnia |
| JP2024511991A (ja) | 2021-03-19 | 2024-03-18 | エックスダブリューファーマ リミテッド | ガンマ－ヒドロキシ酪酸誘導体の組み合わされた放出製剤の薬物動態 |
| CN113200853A (zh) * | 2021-05-19 | 2021-08-03 | 宁波窦氏化学科技有限公司 | 一种制备丁二酸二醇酯的工艺方法 |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| JP2026513019A (ja) | 2023-02-03 | 2026-04-22 | トリス・フアルマ・インコーポレーテツド | １晩１回の低ナトリウムオキシベート組成物 |
| WO2025137671A1 (en) * | 2023-12-22 | 2025-06-26 | Temple University-Of The Commonwealth System Of Higher Education | Short chain fatty acid compounds and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA814854B (en) * | 1980-07-17 | 1982-07-28 | J Klosa | Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts |
| EP0044801B1 (de) | 1980-07-17 | 1984-02-15 | Josef Dr. Klosa | Nichthygroskopische Salze der 4-Hydroxybuttersäure, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Mittel |
| US4548716A (en) * | 1984-07-25 | 1985-10-22 | Lucas Boeve | Method of producing ultrapure, pyrogen-free water |
| US4738985A (en) | 1986-03-19 | 1988-04-19 | The University Of Toronto Innovations Foundations | Pharmaceutical composition and treatment |
| JP2727008B2 (ja) * | 1989-02-01 | 1998-03-11 | 日本酸素株式会社 | 静菌化水の製造方法 |
| DE4113984C2 (de) | 1991-04-29 | 2002-05-08 | Koehler Chemie Dr Franz | Salze der 4-Hydroxy-Buttersäure |
| IT1248588B (it) * | 1991-06-28 | 1995-01-19 | Gaetano Crepaldi | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5840331A (en) | 1995-06-07 | 1998-11-24 | Arch Development Corporation | Use of γ-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin |
| CA2283642C (en) * | 1997-03-17 | 2012-05-15 | Btg International Limited | Therapeutic compositions |
| US5990162A (en) | 1997-08-29 | 1999-11-23 | Orphan Medical, Inc. | Method for treatment of fibromyalgia and chronic fatigue syndrome |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| WO2001019361A2 (en) | 1999-09-14 | 2001-03-22 | Tepha, Inc. | Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate |
| US6204245B1 (en) | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| ES2383673T3 (es) * | 2000-09-22 | 2012-06-25 | Jpi Commercial, Llc | Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos |
| AU2003280960A1 (en) | 2002-07-15 | 2004-02-02 | Alcon, Inc. | Pharmaceutical compositions for otic use |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| EP1934201A1 (en) | 2005-10-06 | 2008-06-25 | Auspex Pharmaceuticals Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| US20080103122A1 (en) | 2006-09-05 | 2008-05-01 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US20090082380A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched rosuvastatin |
| ES2589915T3 (es) * | 2008-10-08 | 2016-11-17 | Xgene Pharmaceutical Inc | Conjugados de GABA y métodos de utilización de los mismos |
| EP2421808B1 (en) | 2009-04-23 | 2013-07-31 | Concert Pharmaceuticals Inc. | 4-hydroxybutyric acid analogs |
| KR101976218B1 (ko) * | 2011-02-14 | 2019-05-07 | 콘서트 파마슈티컬즈, 인크. | 4-히드록시부티르산 중수소화 유사체 |
-
2012
- 2012-02-14 KR KR1020137024419A patent/KR101976218B1/ko active Active
- 2012-02-14 EP EP12704646.4A patent/EP2675771B1/en active Active
- 2012-02-14 CN CN201280008737.7A patent/CN103370289B/zh active Active
- 2012-02-14 ES ES12704646T patent/ES2804540T3/es active Active
- 2012-02-14 MX MX2013009368A patent/MX355742B/es active IP Right Grant
- 2012-02-14 WO PCT/US2012/024974 patent/WO2012112492A1/en not_active Ceased
- 2012-02-14 JP JP2013553647A patent/JP2014513046A/ja active Pending
- 2012-02-14 BR BR112013020620A patent/BR112013020620A2/pt not_active Application Discontinuation
- 2012-02-14 US US13/372,989 patent/US8759394B2/en active Active
-
2013
- 2013-08-01 IL IL227754A patent/IL227754B/en active IP Right Grant
-
2014
- 2014-04-17 US US14/255,331 patent/US9309182B2/en active Active
-
2016
- 2016-04-11 US US15/095,545 patent/US10040748B2/en active Active
-
2017
- 2017-04-20 JP JP2017083295A patent/JP6692319B2/ja active Active
-
2018
- 2018-08-06 US US16/055,407 patent/US20190100484A1/en not_active Abandoned
-
2021
- 2021-02-01 US US17/164,391 patent/US20210403407A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014513046A5 (https=) | ||
| JP7398836B2 (ja) | Ｒ－ケタミンおよびその塩の医薬品としての応用 | |
| IL310501A (en) | Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same | |
| JP2019520417A5 (https=) | ||
| JP2018518537A5 (https=) | ||
| JP2016534063A5 (https=) | ||
| MX2014011946A (es) | Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos. | |
| JP2016510317A5 (https=) | ||
| HRP20171848T1 (hr) | Upotreba malononitrilamida za neuropatsku bol | |
| EA201071298A1 (ru) | Соединение 3-аминокарбазола, фармацевтическая композиция, его содержащая, и способ их получения | |
| JP2014502641A5 (https=) | ||
| AR082150A1 (es) | N-etil-n-fenil-1,2-dihidro-4-hidroxi-5-cloro-1-metil-2-oxoquinolin-3-carboxamida deuterada, sales y usos de la misma, metodo de tratamiento, mezcla compuestos, composicion farmaceutica, proceso de preparacion, compuesto enriquecido con deuterio | |
| JP2016513130A5 (https=) | ||
| BR112014008412A2 (pt) | derivados de pirimidin-4-ona e sua utilização no tratamento, na melhora ou na prevenção de uma doença viral | |
| RU2019141734A (ru) | Терапевтические соединения и композиции и способы их применения | |
| JP2015535247A5 (https=) | ||
| RU2017115726A (ru) | Ингибиторы лизин-специфичного гингипаина | |
| JP2011529069A5 (https=) | ||
| JP2014515407A5 (https=) | ||
| JP2018534300A5 (https=) | ||
| WO2015047982A3 (en) | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | |
| JP2016537432A5 (https=) | ||
| RU2018146504A (ru) | Лечение внутрипеченочных холестатических заболеваний | |
| JP2022510587A5 (https=) | ||
| JP2022536160A5 (https=) |