JP2014513046A5 - - Google Patents
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- Publication number
- JP2014513046A5 JP2014513046A5 JP2013553647A JP2013553647A JP2014513046A5 JP 2014513046 A5 JP2014513046 A5 JP 2014513046A5 JP 2013553647 A JP2013553647 A JP 2013553647A JP 2013553647 A JP2013553647 A JP 2013553647A JP 2014513046 A5 JP2014513046 A5 JP 2014513046A5
- Authority
- JP
- Japan
- Prior art keywords
- deuterium
- alkyl
- cycloalkyl
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161442451P | 2011-02-14 | 2011-02-14 | |
| US61/442,451 | 2011-02-14 | ||
| US201161484296P | 2011-05-10 | 2011-05-10 | |
| US61/484,296 | 2011-05-10 | ||
| PCT/US2012/024974 WO2012112492A1 (en) | 2011-02-14 | 2012-02-14 | 4-hydroxybutyric acid deuterated analogs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083295A Division JP6692319B2 (ja) | 2011-02-14 | 2017-04-20 | ４−ヒドロキシ酪酸の重水素化類似体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014513046A JP2014513046A (ja) | 2014-05-29 |
| JP2014513046A5 true JP2014513046A5 (enExample) | 2015-04-02 |
Family
ID=46672903
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553647A Pending JP2014513046A (ja) | 2011-02-14 | 2012-02-14 | ４−ヒドロキシ酪酸の重水素化類似体 |
| JP2017083295A Active JP6692319B2 (ja) | 2011-02-14 | 2017-04-20 | ４−ヒドロキシ酪酸の重水素化類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017083295A Active JP6692319B2 (ja) | 2011-02-14 | 2017-04-20 | ４−ヒドロキシ酪酸の重水素化類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8759394B2 (enExample) |
| EP (1) | EP2675771B1 (enExample) |
| JP (2) | JP2014513046A (enExample) |
| KR (1) | KR101976218B1 (enExample) |
| CN (1) | CN103370289B (enExample) |
| BR (1) | BR112013020620A2 (enExample) |
| ES (1) | ES2804540T3 (enExample) |
| IL (1) | IL227754B (enExample) |
| MX (1) | MX355742B (enExample) |
| WO (1) | WO2012112492A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2433242T3 (es) | 2009-04-23 | 2013-12-10 | Concert Pharmaceuticals Inc. | Análogos del ácido 4-hidroxibutírico |
| AU2011232408B2 (en) | 2010-03-24 | 2015-07-30 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| MX355742B (es) * | 2011-02-14 | 2018-04-26 | Concert Pharmaceuticals Inc | Análogos deuterados del ácido 4-hidroxibutírico. |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| EP4119539A1 (en) | 2015-09-23 | 2023-01-18 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| CN108473411B (zh) | 2015-11-19 | 2022-08-12 | 协和发酵生化株式会社 | 3-羟基异戊酸的一价阳离子盐的晶体及该晶体的制造方法 |
| KR20190028441A (ko) | 2016-06-24 | 2019-03-18 | 가부시키가이샤 오츠카 세이야쿠 고죠 | 3-히드록시이소발레르산의 아미노산염의 결정 및 그 제조 방법 |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11000498B2 (en) | 2016-07-22 | 2021-05-11 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| EP3601235B1 (en) | 2017-03-30 | 2026-03-04 | XWPharma Ltd. | Bicyclic heteroaryl derivatives, preparation and therapeutic uses thereof |
| CN111902139A (zh) * | 2018-03-23 | 2020-11-06 | 康塞特医药品有限公司 | 氘代的D-β-羟基丁酸的类似物及其用途 |
| CN114042070A (zh) | 2018-09-30 | 2022-02-15 | 凯瑞康宁生物工程（武汉）有限公司 | 作为神经元组胺受体-3拮抗剂的化合物及其用途 |
| BR112021006027A2 (pt) | 2018-11-19 | 2021-06-29 | Jazz Pharmaceuticals Ireland Limited | formulações de fármaco resistente a álcool |
| WO2020178695A1 (en) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| CN115244028A (zh) | 2019-12-20 | 2022-10-25 | 凯瑞康宁生物工程有限公司 | 4-缬氨酰氧基丁酸的合成方法 |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| US11357734B2 (en) | 2020-06-18 | 2022-06-14 | XWPharma Ltd. | Pharmaceutical granulations of water-soluble active pharmaceutical ingredients |
| AU2021292406B2 (en) | 2020-06-18 | 2024-03-14 | XWPharma Ltd. | Controlled release granulations of water-soluble active pharmaceutical ingredients |
| CN116261451A (zh) | 2020-07-24 | 2023-06-13 | 凯瑞康宁生物工程有限公司 | γ-羟基丁酸衍生物的药物组合物和药物动力学 |
| CA3194665A1 (en) | 2020-10-05 | 2022-04-14 | Jia-Ning Xiang | Modified release compositions of a gamma-hydroxybutyric acid derivative |
| CN117098533A (zh) | 2021-03-19 | 2023-11-21 | 凯瑞康宁公司 | γ-羟基丁酸衍生物的组合释放型制剂的药物动力学 |
| CN113200853A (zh) * | 2021-05-19 | 2021-08-03 | 宁波窦氏化学科技有限公司 | 一种制备丁二酸二醇酯的工艺方法 |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| EP4658242A1 (en) | 2023-02-03 | 2025-12-10 | Tris Pharma, Inc. | Low sodium oxybate once nightly composition |
| WO2025137671A1 (en) * | 2023-12-22 | 2025-06-26 | Temple University-Of The Commonwealth System Of Higher Education | Short chain fatty acid compounds and uses thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA814854B (en) * | 1980-07-17 | 1982-07-28 | J Klosa | Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts |
| EP0044801B1 (de) | 1980-07-17 | 1984-02-15 | Josef Dr. Klosa | Nichthygroskopische Salze der 4-Hydroxybuttersäure, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Mittel |
| US4548716A (en) * | 1984-07-25 | 1985-10-22 | Lucas Boeve | Method of producing ultrapure, pyrogen-free water |
| US4738985A (en) | 1986-03-19 | 1988-04-19 | The University Of Toronto Innovations Foundations | Pharmaceutical composition and treatment |
| JP2727008B2 (ja) * | 1989-02-01 | 1998-03-11 | 日本酸素株式会社 | 静菌化水の製造方法 |
| DE4113984C2 (de) * | 1991-04-29 | 2002-05-08 | Koehler Chemie Dr Franz | Salze der 4-Hydroxy-Buttersäure |
| IT1248588B (it) * | 1991-06-28 | 1995-01-19 | Gaetano Crepaldi | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| ES2293638T3 (es) | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| US5840331A (en) | 1995-06-07 | 1998-11-24 | Arch Development Corporation | Use of γ-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin |
| AU6513298A (en) | 1997-03-17 | 1998-10-12 | British Technology Group Limited | Therapeutic compositions |
| US5990162A (en) * | 1997-08-29 | 1999-11-23 | Orphan Medical, Inc. | Method for treatment of fibromyalgia and chronic fatigue syndrome |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| US6623730B1 (en) | 1999-09-14 | 2003-09-23 | Tepha, Inc. | Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate |
| US6204245B1 (en) | 1999-09-17 | 2001-03-20 | The Regents Of The University Of California | Treatment of narcolepsy with immunosuppressants |
| EP1104760B1 (en) | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
| ES2383673T3 (es) | 2000-09-22 | 2012-06-25 | Jpi Commercial, Llc | Composiciones de gamma-hidroxibutirato que contienen portadores de hidrato de carbonos |
| US7727549B2 (en) | 2002-07-15 | 2010-06-01 | Alcon, Inc. | Pharmaceutical compositions for otic use |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| CA2624179A1 (en) | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| WO2008030382A1 (en) | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US20090082380A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched rosuvastatin |
| BRPI0919811B1 (pt) * | 2008-10-08 | 2022-04-19 | Xgene Pharmaceutical Inc | Conjugados de gaba e métodos de uso dos mesmos |
| ES2433242T3 (es) * | 2009-04-23 | 2013-12-10 | Concert Pharmaceuticals Inc. | Análogos del ácido 4-hidroxibutírico |
| MX355742B (es) | 2011-02-14 | 2018-04-26 | Concert Pharmaceuticals Inc | Análogos deuterados del ácido 4-hidroxibutírico. |
-
2012
- 2012-02-14 MX MX2013009368A patent/MX355742B/es active IP Right Grant
- 2012-02-14 BR BR112013020620A patent/BR112013020620A2/pt not_active Application Discontinuation
- 2012-02-14 JP JP2013553647A patent/JP2014513046A/ja active Pending
- 2012-02-14 CN CN201280008737.7A patent/CN103370289B/zh active Active
- 2012-02-14 EP EP12704646.4A patent/EP2675771B1/en active Active
- 2012-02-14 KR KR1020137024419A patent/KR101976218B1/ko active Active
- 2012-02-14 WO PCT/US2012/024974 patent/WO2012112492A1/en not_active Ceased
- 2012-02-14 US US13/372,989 patent/US8759394B2/en active Active
- 2012-02-14 ES ES12704646T patent/ES2804540T3/es active Active
-
2013
- 2013-08-01 IL IL227754A patent/IL227754B/en active IP Right Grant
-
2014
- 2014-04-17 US US14/255,331 patent/US9309182B2/en active Active
-
2016
- 2016-04-11 US US15/095,545 patent/US10040748B2/en active Active
-
2017
- 2017-04-20 JP JP2017083295A patent/JP6692319B2/ja active Active
-
2018
- 2018-08-06 US US16/055,407 patent/US20190100484A1/en not_active Abandoned
-
2021
- 2021-02-01 US US17/164,391 patent/US20210403407A1/en not_active Abandoned
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