JP2014512409A5 - - Google Patents
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- JP2014512409A5 JP2014512409A5 JP2014508125A JP2014508125A JP2014512409A5 JP 2014512409 A5 JP2014512409 A5 JP 2014512409A5 JP 2014508125 A JP2014508125 A JP 2014508125A JP 2014508125 A JP2014508125 A JP 2014508125A JP 2014512409 A5 JP2014512409 A5 JP 2014512409A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161479847P | 2011-04-28 | 2011-04-28 | |
| US61/479,847 | 2011-04-28 | ||
| PCT/US2012/035529 WO2012149376A2 (en) | 2011-04-28 | 2012-04-27 | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014512409A JP2014512409A (ja) | 2014-05-22 |
| JP2014512409A5 true JP2014512409A5 (https=) | 2015-06-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508125A Pending JP2014512409A (ja) | 2011-04-28 | 2012-04-27 | 標的送達用の多孔性ナノ粒子に担持された脂質二重層（プロトセル）及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9579283B2 (https=) |
| EP (1) | EP2701686A4 (https=) |
| JP (1) | JP2014512409A (https=) |
| CN (1) | CN103687590A (https=) |
| AU (1) | AU2012249474A1 (https=) |
| CA (1) | CA2834365A1 (https=) |
| WO (1) | WO2012149376A2 (https=) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2599630T3 (es) * | 2006-09-28 | 2017-02-02 | Hadasit Medical Research Services & Development Limited | Uso de glicerofosfolípidos para lubricación de las articulaciones |
| US8992984B1 (en) | 2009-10-21 | 2015-03-31 | Stc.Unm | Protocells and their use for targeted delivery of multicomponent cargos to cancer cells |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| AU2012249474A1 (en) * | 2011-04-28 | 2013-11-07 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
| CN103857387B (zh) * | 2011-06-02 | 2017-03-15 | 加利福尼亚大学董事会 | 膜包封的纳米颗粒及使用方法 |
| BR112014001346A8 (pt) | 2011-07-19 | 2018-05-08 | Stc Unm | composto nanotransportador, método, composto farmacêutico e uso de um composto |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| JP2014532071A (ja) * | 2011-10-14 | 2014-12-04 | エスティーシー． ユーエヌエムＳｔｃ．Ｕｎｍ | カーゴの経皮送達を含む標的送達用の多孔性ナノ粒子に担持された脂質二重層（プロトセル）及びその方法 |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| WO2013103614A1 (en) * | 2011-12-30 | 2013-07-11 | Stc.Unm | Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all) |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9273305B1 (en) | 2012-04-25 | 2016-03-01 | Sandia Corporation | Cell-based composite materials with programmed structures and functions |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US20160008399A1 (en) | 2013-01-14 | 2016-01-14 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| EP4378461A3 (en) * | 2013-03-05 | 2024-09-11 | The Regents of University of California | Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents |
| EP2968191B1 (en) | 2013-03-14 | 2021-06-16 | Abraxis BioScience, LLC | Methods of treating bladder cancer |
| US9603799B2 (en) | 2013-03-15 | 2017-03-28 | Htd Biosystems Inc. | Liposomal vaccine adjuvants and methods of making and using same |
| US20140271815A1 (en) * | 2013-03-15 | 2014-09-18 | Aryo Sorayya | Heat-and freeze-stable vaccines and methods of making and using same |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US20160151482A1 (en) * | 2013-04-02 | 2016-06-02 | Stc. Unm | Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery |
| CN103989631A (zh) * | 2013-04-15 | 2014-08-20 | 中国人民解放军第二军医大学 | 萝卜硫素制剂及其制备方法和应用 |
| CN103990130A (zh) * | 2013-06-24 | 2014-08-20 | 中国人民解放军第二军医大学 | 介孔二氧化硅纳米制剂及其制备方法和应用 |
| US10272137B2 (en) | 2013-06-27 | 2019-04-30 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomaker-induced muscle cell fusion |
| WO2015042268A1 (en) * | 2013-09-18 | 2015-03-26 | Stc.Unm | Core and surface modification of mesoporous silica nanoparticles to achieve cell specific targeting in vivo |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| SG10201912038TA (en) | 2014-04-23 | 2020-02-27 | Modernatx Inc | Nucleic acid vaccines |
| EP3173074A4 (en) | 2014-07-22 | 2018-03-07 | Lemonex Inc. | Composition for delivering bioactive material or protein, and use thereof |
| US20160090603A1 (en) * | 2014-09-30 | 2016-03-31 | Sandia Corporation | Delivery platforms for the domestication of algae and plants |
| CN104667290A (zh) * | 2014-10-25 | 2015-06-03 | 中国科学技术大学 | 一种靶向肽修饰的金纳米颗粒及其制备方法和其作为四价铂前体药物载体的应用 |
| WO2016205515A1 (en) * | 2015-06-17 | 2016-12-22 | The Curators Of The University Of Missouri | GOLD NANOROD BASED DIAGNOSTIC AGENT FOR DETECTION AND QUANTIFICATION OF c-MET (HGF) RECEPTORS |
| CN114533898B (zh) * | 2015-07-09 | 2025-07-01 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| LU92784B1 (en) * | 2015-07-22 | 2017-01-31 | Luxembourg Inst Of Science And Tech (List) | Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector |
| LU92783B1 (en) * | 2015-07-22 | 2017-01-31 | Luxembourg Inst Of Science And Tech (List) | Highly aminated self-assembling fuctionalized Mesoporous Silicia Nanoparticles and methods of synthesis |
| WO2017020026A1 (en) | 2015-07-30 | 2017-02-02 | Modernatx, Inc. | Concatemeric peptide epitopes rnas |
| JP2017038539A (ja) * | 2015-08-18 | 2017-02-23 | 日本電信電話株式会社 | 脂質二分子膜基板 |
| US20190262469A1 (en) * | 2015-09-04 | 2019-08-29 | C. Jeffrey Brinker | Protocells to treat microbial infection and for synergistic delivery |
| WO2017041033A1 (en) * | 2015-09-04 | 2017-03-09 | Brinker C Jeffrey | Mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles for biomedical applications |
| EP4286012A3 (en) | 2015-09-17 | 2024-05-29 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| US10016422B2 (en) * | 2015-09-30 | 2018-07-10 | Oregon State University | Nanocarrier drug delivery platform |
| EP3364949A4 (en) | 2015-10-22 | 2019-07-31 | ModernaTX, Inc. | CANCER VACCINES |
| LT3365020T (lt) * | 2015-10-22 | 2019-10-25 | Delsitech Oy | Hidrogelio kompozicijos depo vaisto forma |
| HUE057877T2 (hu) | 2015-12-22 | 2022-06-28 | Modernatx Inc | Vegyületek és készítmények terápiás szerek intracelluláris bejuttatására |
| CN105456198B (zh) * | 2015-12-25 | 2017-04-26 | 正大天晴药业集团股份有限公司 | 一种荷载恩替卡韦介孔二氧化硅纳米粒及其制备方法 |
| US11696959B2 (en) | 2015-12-31 | 2023-07-11 | City Of Hope | Nanoparticle-cell construct with platinum anti-cancer agent |
| US11672866B2 (en) * | 2016-01-08 | 2023-06-13 | Paul N. DURFEE | Osteotropic nanoparticles for prevention or treatment of bone metastases |
| CN108601746B (zh) | 2016-01-08 | 2024-09-13 | 加利福尼亚大学董事会 | 用于运载物递送的具有脂质双层包衣的中孔二氧化硅纳米颗粒 |
| US20190298681A1 (en) * | 2016-03-16 | 2019-10-03 | Merrimack Pharmaceuticals, Inc. | Nanoliposomal Targeting of Ephrin Receptor A2 (Epha2) and Related Diagnostics |
| EP3442540A4 (en) * | 2016-04-14 | 2019-12-18 | Spinnaker Biosciences Inc. | POROUS SILICON MATERIALS WITH A METAL SILICATE FOR DELIVERING THERAPEUTIC ACTIVE SUBSTANCES |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| US10663450B2 (en) * | 2016-06-15 | 2020-05-26 | The University Of Chicago | Amorphous, porous silicon materials and related methods |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| US20190336532A1 (en) * | 2016-12-21 | 2019-11-07 | Fred Hutchinson Cancer Research Center | Scaffolds to treat solid tumor cells and escape variants |
| US10874768B2 (en) * | 2017-01-20 | 2020-12-29 | Covidien Lp | Drug eluting medical device |
| KR20180091768A (ko) | 2017-02-06 | 2018-08-16 | 주식회사 레모넥스 | 생리활성물질 전달체 |
| WO2018160865A1 (en) | 2017-03-01 | 2018-09-07 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
| US11969506B2 (en) | 2017-03-15 | 2024-04-30 | Modernatx, Inc. | Lipid nanoparticle formulation |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| SMT202300097T1 (it) | 2017-03-15 | 2023-05-12 | Modernatx Inc | Composto e composizioni per il rilascio intracellulare di agenti terapeutici |
| WO2018187287A1 (en) * | 2017-04-03 | 2018-10-11 | Charles Jeffrey Brinker | Porous nanoparticle-supported lipid bilayer delivery of transcriptional gene modulators |
| WO2018187590A1 (en) | 2017-04-05 | 2018-10-11 | Modernatx, Inc. | Reduction or elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
| AU2018266111B2 (en) * | 2017-05-08 | 2024-11-07 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| US12077501B2 (en) | 2017-06-14 | 2024-09-03 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| US11007516B1 (en) | 2017-06-19 | 2021-05-18 | National Technology & Engineering Solutions Of Sandia, Llc | Tunable metal-organic framework compositions and methods thereof |
| WO2019005830A1 (en) * | 2017-06-26 | 2019-01-03 | Fordoz Pharma Corp. | NANOSOME FORMULATIONS OF APREPITANT AND METHODS AND APPLICATIONS THEREOF |
| US20200163885A1 (en) * | 2017-07-25 | 2020-05-28 | Lemonex Inc. | Composition for delivering physiologically active ingredients into blood vessel |
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| KR102152348B1 (ko) | 2017-09-05 | 2020-09-08 | 주식회사 레모넥스 | 세포 운명 조절용 조성물 |
| CN111107842B (zh) * | 2017-09-22 | 2021-10-08 | 杭州景杰生物科技股份有限公司 | 利用微混合和卡培他滨两亲性特性的卡培他滨的聚合物-脂质混杂纳米颗粒 |
| US10933027B1 (en) | 2017-09-25 | 2021-03-02 | National Technology & Engineering Solutions Of Sandia, Llc | Expanded pore particles and delivery methods thereof |
| US12383499B2 (en) | 2018-01-01 | 2025-08-12 | The Regents Of The University Of California | Scale up synthesis of silicasome nanocarriers |
| WO2019169152A1 (en) * | 2018-02-28 | 2019-09-06 | Noureddine Achraf | Starry mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles |
| EP3814765A4 (en) * | 2018-05-08 | 2022-06-01 | Yale University | PROTEIN UPtake MEMBRANE AND METHODS OF USE THEREOF |
| US11045554B1 (en) * | 2018-06-22 | 2021-06-29 | National Technology & Engineering Solutions Of Sandia, Llc | Lipid-coated particles for treating viral infections |
| EP3820509A1 (en) | 2018-07-09 | 2021-05-19 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
| CN108938595B (zh) * | 2018-07-15 | 2021-09-14 | 河南工业大学 | 一种共载siRNA与化疗药物的阳离子脂质-介孔硅复合纳米载体的制备方法 |
| US12263248B2 (en) | 2018-09-19 | 2025-04-01 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| CN113271926A (zh) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| WO2020068798A1 (en) | 2018-09-24 | 2020-04-02 | Guo Jimin | Living mammalian cells modified with functional modular nanoparticles |
| EP3880832A1 (en) * | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for hematopoietic stem cell delivery |
| US12496274B2 (en) | 2018-11-14 | 2025-12-16 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| US12208164B2 (en) | 2019-02-28 | 2025-01-28 | Unm Rainforest Innovations | Modular metal-organic polyhedra superassembly compositions |
| EP3938379A4 (en) | 2019-03-15 | 2023-02-22 | ModernaTX, Inc. | Hiv rna vaccines |
| CN110120249B (zh) * | 2019-05-23 | 2023-01-06 | 复旦大学 | 通过靶向调控动力学路径构造靶向构造目标结构的方法 |
| BR112022004936A2 (pt) | 2019-09-19 | 2022-06-14 | Modernatx Inc | Compostos lipídicos contendo carbonato e composições para distribuição intracelular de agentes terapêuticos |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CN111529504B (zh) * | 2020-03-25 | 2023-01-10 | 西安组织工程与再生医学研究所 | 功能性嵌合凋亡小体及其制备方法和应用 |
| CN111529505B (zh) * | 2020-03-25 | 2023-04-11 | 西安组织工程与再生医学研究所 | 功能性嵌合凋亡小体及其制备方法和应用 |
| US11433121B1 (en) | 2020-04-03 | 2022-09-06 | National Technology & Engineering Solutions Of Sandia, Llc | Lipid composition for the delivery of therapeutic cargos |
| CN111588704B (zh) * | 2020-07-01 | 2023-04-11 | 西安组织工程与再生医学研究所 | 靶向响应性释放系统及其制备方法和应用 |
| CN111991558B (zh) * | 2020-08-28 | 2022-08-09 | 安徽贝克生物制药有限公司 | 一种抗逆转录病毒药物组合物及其制备方法 |
| CN112168977A (zh) * | 2020-10-27 | 2021-01-05 | 西南大学 | 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用 |
| CN112480212A (zh) * | 2020-12-17 | 2021-03-12 | 中国药科大学 | 靶向肝细胞生长因子的高亲和肽及其应用 |
| IL307544A (en) | 2021-04-08 | 2023-12-01 | Sana Biotechnology Inc | Cd8-specific antibody constructs and compositions thereof |
| US20230321032A1 (en) * | 2022-04-06 | 2023-10-12 | University Of Kentucky Research Foundation | Functionalized mesoporous silica nanoparticles for treatment of periodontal disease |
| US12194458B2 (en) * | 2022-08-16 | 2025-01-14 | Nicole Shamayev | Device and method of portable drug testing |
| US12098200B1 (en) | 2022-10-12 | 2024-09-24 | National Technology & Engineering Solutions Of Sandia, Llc | Brain-targeting single domain antibodies and purification methods |
| WO2024182425A1 (en) * | 2023-02-27 | 2024-09-06 | Noureddine Achraf | Compositions and methods for treating metabolic diseases/disorders |
| CN120504733A (zh) * | 2025-03-28 | 2025-08-19 | 江南大学 | 一种用于骨折修复的生物合成类i型胶原蛋白水凝胶及其制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5277913A (en) | 1991-09-09 | 1994-01-11 | Thompson David H | Liposomal delivery system with photoactivatable triggered release |
| US5820879A (en) | 1993-02-12 | 1998-10-13 | Access Pharmaceuticals, Inc. | Method of delivering a lipid-coated condensed-phase microparticle composition |
| ATE209887T1 (de) | 1993-04-02 | 2001-12-15 | Anticancer Inc | Verfahren zur verabreichung von förderlichen zusammensetzungen auf die haarfollikel |
| US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| IL142869A0 (en) * | 1998-11-13 | 2002-03-10 | Cyclacel Ltd | Transport vectors |
| WO2000076556A2 (en) | 1999-06-11 | 2000-12-21 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| GB0104259D0 (en) * | 2001-02-21 | 2001-04-11 | Smithkline Beecham Biolog | Novel compounds |
| WO2003016040A1 (en) | 2001-04-16 | 2003-02-27 | The Regents Of The University Of California | Membrane mimetic architectures on nanoporous materials |
| US20060177495A1 (en) | 2001-12-21 | 2006-08-10 | Christine Allen | Polymer-lipid delivery vehicles |
| US20040005352A1 (en) | 2002-04-16 | 2004-01-08 | Lopez Gabriel P. | Biologically functionalized porous microspheres |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| US7563451B2 (en) | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
| KR20070110084A (ko) | 2005-02-14 | 2007-11-15 | 오스트레일리언뉴클리어사이언스앤드테크놀로지오거나이제이션 | 층상 나노입자 |
| US7514267B1 (en) | 2005-08-19 | 2009-04-07 | Stcunm | Detection systems utilizing supported lipid bilayers |
| EP1954714A2 (en) | 2005-11-10 | 2008-08-13 | Receptor Biologix, Inc. | Hepatocyte growth factor intron fusion proteins |
| US20080160313A1 (en) * | 2006-04-26 | 2008-07-03 | Gabriel Lopez | Lipid bilayers on nanotextured solid surfaces |
| CA2657946A1 (en) | 2006-06-09 | 2007-12-13 | Protox Therapeutics Incorporated | Modified protein toxins targeting cytokine -receptor bearing cells and use thereof for treating disease |
| WO2008024427A2 (en) | 2006-08-23 | 2008-02-28 | Science & Technology Corporation @ Unm | A virus-like platform for rapid vaccine discovery |
| EP2099496A2 (en) | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
| US20080279764A1 (en) | 2007-03-09 | 2008-11-13 | Anthony Manganaro | Method and composition for treating cancer |
| US9993437B2 (en) | 2007-12-06 | 2018-06-12 | The Regents Of The University Of California | Mesoporous silica nanoparticles for biomedical applications |
| US20110105995A1 (en) | 2008-01-16 | 2011-05-05 | Zhu Ting F | Uniform-sized, multi-drug carrying, and photosensitive liposomes for advanced drug delivery |
| CA2722183C (en) | 2008-04-25 | 2018-09-18 | Northwestern University | Nanostructures suitable for sequestering cholesterol and other molecules |
| CN101658533A (zh) | 2008-08-29 | 2010-03-03 | 首都医科大学宣武医院 | 抗肿瘤药物的干细胞递送 |
| US9732324B2 (en) | 2008-10-23 | 2017-08-15 | Cornell University | Anti-viral method |
| US20110230372A1 (en) | 2008-11-14 | 2011-09-22 | Stc Unm | Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and outcome prediction in pediatric b-precursor acute lymphoblastic leukemia |
| WO2010078569A2 (en) * | 2009-01-05 | 2010-07-08 | Stc.Unm | Porous nanoparticle supported lipid bilayer nanostructures |
| US8992984B1 (en) | 2009-10-21 | 2015-03-31 | Stc.Unm | Protocells and their use for targeted delivery of multicomponent cargos to cancer cells |
| US20130017210A1 (en) | 2010-03-17 | 2013-01-17 | Stc.Unm | Display of antibody fragments on virus-like particles of rna bacteriophages |
| US20110300186A1 (en) | 2010-04-14 | 2011-12-08 | Battelle Memorial Institute | Functionalized Nano- and Micro-materials for Medical Therapies |
| AU2012249474A1 (en) | 2011-04-28 | 2013-11-07 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
| BR112014001346A8 (pt) | 2011-07-19 | 2018-05-08 | Stc Unm | composto nanotransportador, método, composto farmacêutico e uso de um composto |
| JP2014532071A (ja) | 2011-10-14 | 2014-12-04 | エスティーシー． ユーエヌエムＳｔｃ．Ｕｎｍ | カーゴの経皮送達を含む標的送達用の多孔性ナノ粒子に担持された脂質二重層（プロトセル）及びその方法 |
| WO2013103614A1 (en) | 2011-12-30 | 2013-07-11 | Stc.Unm | Crlf-2 binding peptides, protocells and viral-like particles useful in the treatment of cancer, including acute lymphoblastic leukemia (all) |
| US20160151482A1 (en) | 2013-04-02 | 2016-06-02 | Stc. Unm | Mesoporous alum nanoparticles as a universal platform for antigen adsorption, presentation, and delivery |
| WO2014165608A1 (en) | 2013-04-02 | 2014-10-09 | Stc. Unm | Antibiotic protocells and related pharmaceutical formulations and methods of treatment |
| EP3046543A1 (en) | 2013-09-18 | 2016-07-27 | Stc.Unm | Torroidal mesoporous silica nanoparticles (tmsnps) and related protocells |
-
2012
- 2012-04-27 AU AU2012249474A patent/AU2012249474A1/en not_active Abandoned
- 2012-04-27 CA CA2834365A patent/CA2834365A1/en not_active Abandoned
- 2012-04-27 JP JP2014508125A patent/JP2014512409A/ja active Pending
- 2012-04-27 CN CN201280031496.8A patent/CN103687590A/zh active Pending
- 2012-04-27 WO PCT/US2012/035529 patent/WO2012149376A2/en not_active Ceased
- 2012-04-27 EP EP12776480.1A patent/EP2701686A4/en not_active Withdrawn
- 2012-04-27 US US14/113,371 patent/US9579283B2/en active Active
-
2015
- 2015-12-16 US US14/970,998 patent/US10022327B2/en not_active Expired - Fee Related
-
2018
- 2018-07-02 US US16/025,557 patent/US20190091150A1/en not_active Abandoned
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