JP2014512364A - 水溶液中で二量体化できる単量体、およびその使用法 - Google Patents

水溶液中で二量体化できる単量体、およびその使用法 Download PDF

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JP2014512364A
JP2014512364A JP2014504078A JP2014504078A JP2014512364A JP 2014512364 A JP2014512364 A JP 2014512364A JP 2014504078 A JP2014504078 A JP 2014504078A JP 2014504078 A JP2014504078 A JP 2014504078A JP 2014512364 A JP2014512364 A JP 2014512364A
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フランシス バラニー
マニッシュ ピングル
ドナルド イー． ベルイストローム
サラ フィリッパ ジャルディーナ
リー ダニエル アーノルド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2014504078A 2011-04-07 2012-04-09 水溶液中で二量体化できる単量体、およびその使用法 Pending JP2014512364A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161473093P 2011-04-07 2011-04-07
US61/473,093 2011-04-07
PCT/US2012/032809 WO2013058824A1 (en) 2011-04-07 2012-04-09 Monomers capable of dimerizing in an aqueous solution, and methods of using same

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JP2014512364A true JP2014512364A (ja) 2014-05-22
JP2014512364A5 JP2014512364A5 (https=) 2015-05-28

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US (2) US20140194383A1 (https=)
EP (1) EP2694707B1 (https=)
JP (1) JP2014512364A (https=)
WO (1) WO2013058824A1 (https=)

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JP2021017438A (ja) * 2019-07-17 2021-02-15 信越化学工業株式会社 ジメチルシクロブタン環を有するジエステル化合物及びその製造方法、並びにそれから誘導されるジメチルシクロブタン化合物の製造方法

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US20140163229A1 (en) 2011-04-07 2014-06-12 Cornell University Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US9138001B2 (en) 2013-01-30 2015-09-22 Agrofresh Inc. Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
CN103880679B (zh) * 2014-03-13 2015-02-11 河北科技大学 3-乙氧基-4-乙氧羰基苯乙酸的合成方法
CN105017140B (zh) * 2014-04-28 2017-12-29 复旦大学 邻氨基苯甲酰胺化合物及其制备方法和用途
WO2016115360A1 (en) * 2015-01-14 2016-07-21 Coferon, Inc. C-myc ligands capable of dimerizing in an aqueous solution, and methods of using same
JP6987641B2 (ja) 2015-05-12 2022-01-05 ブリンクバイオ インコーポレイテッド シリコン系薬物複合体及びその使用方法
GB201603359D0 (en) * 2016-02-26 2016-04-13 Binding Site Group The Ltd Improved assay
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
CA3026651A1 (en) 2016-06-09 2017-12-14 Blinkbio, Inc. Silanol based therapeutic payloads
CN107573297A (zh) * 2017-08-31 2018-01-12 桂林南药股份有限公司 一种利奈唑胺的酸性水解杂质的制备方法
CN109678701B (zh) * 2019-01-22 2021-08-20 安徽德信佳生物医药有限公司 一种维兰特罗中间体的制备方法
ES2951876T3 (es) * 2019-07-17 2023-10-25 Shinetsu Chemical Co Compuesto diéster que tiene un anillo de dimetilciclobutano, un procedimiento para preparar el mismo, y un procedimiento para preparar compuesto de dimetilciclobutano derivado del compuesto diéster
AU2020408039A1 (en) * 2019-12-20 2022-08-18 Arbutus Biopharma Corporation Synthetic processes and intermediates
AU2021321415A1 (en) * 2020-08-07 2023-02-09 Cornell University Therapeutic composition of cure-pro compounds for targeted degradation of bet domain proteins, and methods of making and usage
JP2023536657A (ja) * 2020-08-07 2023-08-28 コーネル ユニバーシティー タンパク質をｅ３リガーゼの媒介によって分解するための、治療上有用なｃｕｒｅ－ｐｒｏ分子、ならびにその作製方法及び使用方法
CN114315787A (zh) * 2021-12-30 2022-04-12 广州佳途科技股份有限公司 一种维兰特罗ep杂质2的制备方法及应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021017438A (ja) * 2019-07-17 2021-02-15 信越化学工業株式会社 ジメチルシクロブタン環を有するジエステル化合物及びその製造方法、並びにそれから誘導されるジメチルシクロブタン化合物の製造方法
JP7335849B2 (ja) 2019-07-17 2023-08-30 信越化学工業株式会社 ジメチルシクロブタン環を有するジエステル化合物及びその製造方法、並びにそれから誘導されるジメチルシクロブタン化合物の製造方法

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WO2013058824A1 (en) 2013-04-25
US20140194383A1 (en) 2014-07-10
EP2694707B1 (en) 2018-08-15
EP2694707A1 (en) 2014-02-12
US11970448B2 (en) 2024-04-30
US20200354319A1 (en) 2020-11-12
EP2694707A4 (en) 2014-09-10

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