JP2014511825A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014511825A5 JP2014511825A5 JP2013548650A JP2013548650A JP2014511825A5 JP 2014511825 A5 JP2014511825 A5 JP 2014511825A5 JP 2013548650 A JP2013548650 A JP 2013548650A JP 2013548650 A JP2013548650 A JP 2013548650A JP 2014511825 A5 JP2014511825 A5 JP 2014511825A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- pharmaceutical composition
- hydrogen
- composition according
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 150000001338 aliphatic hydrocarbons Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- PQIOSYKVBBWRRI-UHFFFAOYSA-N methylphosphonyl difluoride Chemical group CP(F)(F)=O PQIOSYKVBBWRRI-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052717 sulfur Chemical group 0.000 claims 2
- 239000011593 sulfur Chemical group 0.000 claims 2
- -1 1,1-difluoropentyl Chemical group 0.000 claims 1
- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 claims 1
- CTQWVWWSERVGET-HZPDHXFCSA-N 7-[(1r,2r)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl]heptanoic acid Chemical compound CCCCC(F)(F)C(=O)CC[C@H]1CCC(=O)[C@@H]1CCCCCCC(O)=O CTQWVWWSERVGET-HZPDHXFCSA-N 0.000 claims 1
- SDDSJMXGJNWMJY-BRHAQHMBSA-N 7-[(2r,4ar,5r,7ar)-2-[(3s)-1,1-difluoro-3-methylpentyl]-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-yl]heptanoic acid Chemical compound O1[C@](C(F)(F)C[C@@H](C)CC)(O)CC[C@@H]2[C@@H](CCCCCCC(O)=O)C(=O)C[C@H]21 SDDSJMXGJNWMJY-BRHAQHMBSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010030216 Oesophagitis Diseases 0.000 claims 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000006881 esophagitis Diseases 0.000 claims 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N hexane carboxylic acid Natural products CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 0 **C(*C1N)C(***=C)C1I Chemical compound **C(*C1N)C(***=C)C1I 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161476992P | 2011-04-19 | 2011-04-19 | |
| US61/476,992 | 2011-04-19 | ||
| US201161489516P | 2011-05-24 | 2011-05-24 | |
| US61/489,516 | 2011-05-24 | ||
| US201161537305P | 2011-09-21 | 2011-09-21 | |
| US61/537,305 | 2011-09-21 | ||
| US201161548458P | 2011-10-18 | 2011-10-18 | |
| US61/548,458 | 2011-10-18 | ||
| PCT/JP2012/061004 WO2012144649A1 (en) | 2011-04-19 | 2012-04-18 | Method for modulating cytokine activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014511825A JP2014511825A (ja) | 2014-05-19 |
| JP2014511825A5 true JP2014511825A5 (https=) | 2015-06-11 |
Family
ID=47021806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013548650A Ceased JP2014511825A (ja) | 2011-04-19 | 2012-04-18 | サイトカイン活性の調節方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20120270945A1 (https=) |
| EP (1) | EP2699244A4 (https=) |
| JP (1) | JP2014511825A (https=) |
| KR (1) | KR20140043075A (https=) |
| CN (2) | CN103781482A (https=) |
| AU (2) | AU2012246999A1 (https=) |
| BR (1) | BR112013026644A2 (https=) |
| CA (1) | CA2831869A1 (https=) |
| IL (1) | IL228700A0 (https=) |
| MX (1) | MX2013012251A (https=) |
| RU (1) | RU2013151166A (https=) |
| TW (1) | TW201247615A (https=) |
| WO (1) | WO2012144649A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2642744C (en) * | 2006-02-28 | 2015-02-24 | Sucampo Ag | Method and composition for treating chronic obstructive pulmonary disease |
| WO2014159679A1 (en) | 2013-03-12 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for using lubiprostone to absorb fluid from the subretinal space |
| US20150099802A1 (en) * | 2013-10-03 | 2015-04-09 | Sucampo Ag | Selective tumor treatment |
| US20160228403A1 (en) * | 2013-10-04 | 2016-08-11 | Tohoku University | Agent for preventing or ameliorating renal dysfunction |
| US20160120840A1 (en) * | 2014-10-30 | 2016-05-05 | Sucampo Ag | Method and composition for treating nonerosive reflux disease |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166174A (en) * | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| DE69124415T2 (de) * | 1990-04-27 | 1997-05-15 | Ueno Seiyaku Oyo Kenkyujo Kk | Verwendung von 15-Dehydroxy-16-Oxoprostaglandin bei der Behandlung von allergischen Erkrankungen |
| JPH0770054A (ja) * | 1993-08-30 | 1995-03-14 | R Tec Ueno:Kk | 生化学的拮抗および疾患処置剤 |
| CA2150287C (en) * | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
| JPH1029942A (ja) * | 1996-04-02 | 1998-02-03 | Yoichi Ichikawa | 慢性関節リウマチ治療剤 |
| US8202909B2 (en) * | 2005-01-27 | 2012-06-19 | Sucampo Ag | Method for treating central nervous system disorders |
| KR20160120809A (ko) * | 2005-03-04 | 2016-10-18 | 수캄포 아게 | 말초 혈관 질환 치료를 위한 방법 및 조성물 |
| CN101180096B (zh) * | 2005-03-21 | 2015-04-22 | 苏坎波公司 | 用于治疗粘膜疾病的方法和组合物 |
| US20060281818A1 (en) * | 2005-03-21 | 2006-12-14 | Sucampo Ag, North Carolina State University | Method for treating mucosal disorders |
| RU2468800C2 (ru) * | 2005-04-12 | 2012-12-10 | Сукампо Аг | Комбинированное применение производного простагландина и ингибитора протонового насоса для лечения желудочно-кишечных заболеваний |
| CA2642744C (en) * | 2006-02-28 | 2015-02-24 | Sucampo Ag | Method and composition for treating chronic obstructive pulmonary disease |
| EP2147672A4 (en) * | 2007-05-08 | 2011-11-02 | Nat University Corp Hamamatsu University School Of Medicine | CYTOTOXIC T CELL ACTIVATOR WITH AN EP4 AGONIST |
| JPWO2009133863A1 (ja) * | 2008-04-28 | 2011-09-01 | 国立大学法人浜松医科大学 | Ｅｐ１アゴニストを含有してなる免疫増強剤 |
| JP2011032262A (ja) * | 2009-06-30 | 2011-02-17 | Sucampo Ag | Ｎｓａｉｄの長期使用のための医薬組成物 |
| BR112013009163A2 (pt) * | 2010-10-15 | 2016-07-26 | Scinopharm Kunshan Biochemical Technology Co Ltd | processo para preparação de lubiprostona |
-
2012
- 2012-04-18 US US13/450,071 patent/US20120270945A1/en not_active Abandoned
- 2012-04-18 CN CN201280030108.4A patent/CN103781482A/zh active Pending
- 2012-04-18 MX MX2013012251A patent/MX2013012251A/es unknown
- 2012-04-18 JP JP2013548650A patent/JP2014511825A/ja not_active Ceased
- 2012-04-18 AU AU2012246999A patent/AU2012246999A1/en not_active Abandoned
- 2012-04-18 CN CN201710153095.4A patent/CN107028952A/zh active Pending
- 2012-04-18 WO PCT/JP2012/061004 patent/WO2012144649A1/en not_active Ceased
- 2012-04-18 CA CA2831869A patent/CA2831869A1/en not_active Abandoned
- 2012-04-18 BR BR112013026644A patent/BR112013026644A2/pt active Search and Examination
- 2012-04-18 KR KR1020137030512A patent/KR20140043075A/ko not_active Ceased
- 2012-04-18 RU RU2013151166/15A patent/RU2013151166A/ru not_active Application Discontinuation
- 2012-04-18 EP EP12774360.7A patent/EP2699244A4/en not_active Withdrawn
- 2012-04-19 TW TW101113907A patent/TW201247615A/zh unknown
-
2013
- 2013-10-03 IL IL228700A patent/IL228700A0/en unknown
-
2017
- 2017-05-16 AU AU2017203276A patent/AU2017203276A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014511825A5 (https=) | ||
| WO2013121449A8 (en) | Compositions and methods for the modulation of specific amidases for n-acylethanolamines for use in the therapy of inflammatory diseases | |
| JP2013512277A5 (https=) | ||
| WO2012122340A8 (en) | Soluble guanylate cyclase activators | |
| AU2009292555B2 (en) | Novel prostaglandin I2 derivative | |
| MX380516B (es) | Procedimiento para la preparacion del acido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidin-6-il-[metil]3-oxo-5,6,8,8a-tetrahidro-1h-imidazo[1,5a]pirazin-2-il-carboxilico | |
| RU2018114518A (ru) | Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca) | |
| JP2018504437A5 (https=) | ||
| JP2014530838A5 (https=) | ||
| JP2014507470A5 (https=) | ||
| RU2018113296A (ru) | Фармацевтическая композиция, содержащая 11-дезокси-простагландиновое соединение и способ стабилизации этого соединения | |
| JP2006513232A5 (https=) | ||
| RU2013151166A (ru) | Способ модуляции активности цитокинов | |
| RU2016151973A (ru) | Пиридиноны, замещенные фенилом и трет-бутилуксусной кислотой, обладающие анти-вич эффектами | |
| JP2008528440A5 (https=) | ||
| JP2009502777A5 (https=) | ||
| JP2010533707A5 (https=) | ||
| JP2014510022A5 (https=) | ||
| JP2006506381A5 (https=) | ||
| JP2004519412A5 (https=) | ||
| JP2014527048A5 (https=) | ||
| JP2014237711A5 (https=) | ||
| JP2016528165A5 (https=) | ||
| CN104530127B (zh) | 一种淫羊藿苷衍生物及其使用方法和用途 | |
| JP2011514893A5 (https=) |