JP2014510037A5 - - Google Patents
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- Publication number
- JP2014510037A5 JP2014510037A5 JP2013549896A JP2013549896A JP2014510037A5 JP 2014510037 A5 JP2014510037 A5 JP 2014510037A5 JP 2013549896 A JP2013549896 A JP 2013549896A JP 2013549896 A JP2013549896 A JP 2013549896A JP 2014510037 A5 JP2014510037 A5 JP 2014510037A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- aryl
- heteroaryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN184/MUM/2011 | 2011-01-21 | ||
| IN184MU2011 | 2011-01-21 | ||
| PCT/GB2012/050132 WO2012098416A1 (en) | 2011-01-21 | 2012-01-23 | Diarylacetylene hydrazide containing tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510037A JP2014510037A (ja) | 2014-04-24 |
| JP2014510037A5 true JP2014510037A5 (https=) | 2015-03-12 |
| JP5905028B2 JP5905028B2 (ja) | 2016-04-20 |
Family
ID=45540888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013549896A Active JP5905028B2 (ja) | 2011-01-21 | 2012-01-23 | ジアリールアセチレンヒドラジドを含有するチロシンキナーゼ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9024021B2 (https=) |
| EP (1) | EP2665709B1 (https=) |
| JP (1) | JP5905028B2 (https=) |
| KR (1) | KR101892574B1 (https=) |
| CN (1) | CN103502217B (https=) |
| AU (1) | AU2012208388C1 (https=) |
| BR (1) | BR112013018212B1 (https=) |
| CA (1) | CA2825367C (https=) |
| EA (1) | EA024194B8 (https=) |
| ES (1) | ES2608829T3 (https=) |
| MX (1) | MX336051B (https=) |
| WO (1) | WO2012098416A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351123B2 (en) | 2017-03-15 | 2022-06-07 | Sun Pharma Advanced Research Company Limited | Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013166295A1 (en) | 2012-05-02 | 2013-11-07 | Georgetown University | Treating neural disease with tyrosine kinase inhibitors |
| CN103664787B (zh) * | 2012-09-17 | 2015-09-09 | 南京圣和药业股份有限公司 | 炔杂芳环化合物及其应用 |
| EP2818471A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 |
| GB2518873A (en) * | 2013-10-03 | 2015-04-08 | Agency Science Tech & Res | Bicyclic alkyne derivatives and uses thereof |
| CA2930584A1 (en) * | 2013-11-15 | 2015-05-21 | The Wistar Institute Of Anatomy And Biology | Ebna1 inhibitors and their method of use |
| AU2016262572B2 (en) | 2015-05-14 | 2020-04-30 | The Wistar Institute Of Anatomy And Biology | EBNA1 inhibitors and methods using same |
| ES2774501T3 (es) * | 2015-05-18 | 2020-07-21 | Sun Pharma Advanced Res Co Ltd | Etinos de amidoheteroaril aroil hidrazida novedosos |
| CN108884066B (zh) * | 2016-02-16 | 2021-08-24 | 韩国科学技术研究院 | 作为蛋白激酶抑制剂的2，3，5-取代的噻吩化合物 |
| SG11201810294QA (en) * | 2016-06-02 | 2018-12-28 | Sun Pharma Advanced Res Co Ltd | Treatment for parkinson's disease |
| EA037697B1 (ru) * | 2016-06-02 | 2021-05-12 | Сан Фарма Адвансед Ресёрч Компани Лимитед | Лечение болезни паркинсона |
| RU2768887C2 (ru) * | 2017-03-15 | 2022-03-25 | Сан Фарма Эдвансд Рисёч Компани Лимитед | Новая аморфная дисперсия (5-{ 5-[n'-(2-хлор-6-метилбензоил)гидразинокарбонил]-2-метил-фенилэтинил} -пиридин-2-ил)амида циклопропанкарбоновой кислоты |
| EP3793546B1 (en) | 2018-05-17 | 2025-11-19 | The Wistar Institute | Ebna1 inhibitor crystalline forms, and methods of preparing and using same |
| JP7629200B2 (ja) | 2018-11-20 | 2025-02-13 | ジョージタウン ユニバーシティ | 神経変性、筋変性及びリソソーム蓄積障害を治療するための組成物及び方法 |
| CA3142899A1 (en) | 2019-06-11 | 2020-12-17 | Sun Pharma Advanced Research Company Ltd. | Treatment for synucleinopathies |
| MX2022007988A (es) * | 2019-12-26 | 2022-07-11 | Beijing Innocare Pharma Tech Co Ltd | Formas cristalinas de (s)-1-(1-acriloilpirrolidin-3-il)-3-((3,5-di metoxifenil)etinil)-5-(metilamino)-1h-pirazol-4-carboxamida. |
| JP7505719B2 (ja) | 2020-02-28 | 2024-06-25 | テグ－キョンプク メディカル イノベーション ファウンデーション | ３－（（８－（（１Ｈ－ピラゾール－４－イル）アミノ）イミダゾ［１，２－ａ］ピリジン－３－イル）エチニル）－Ｎ－フェニルベンズアミド誘導体、その調製法、それを活性成分として含有する癌の予防用又は治療用医薬組成物 |
| EP4188351A1 (en) * | 2020-07-31 | 2023-06-07 | Sun Pharma Advanced Research Company Ltd | N'-(2-chloro-6-methylbenzoyl)-4-methyl-3-[2-(3-quinolyl) ethynyl]-benzohydrazide for treatment of alzheimer's disease |
| TW202317530A (zh) | 2021-06-29 | 2023-05-01 | 日商住友化學股份有限公司 | 雜環化合物及含有其之組成物之抗藥性有害節肢動物防除方法 |
| WO2024042483A1 (en) | 2022-08-25 | 2024-02-29 | Sun Pharma Advanced Research Company Limited | Methods of treating chronic myeloid leukemia using the tyrosine kinase inhibitor vodobatinib |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| PL215901B1 (pl) | 1999-04-15 | 2014-02-28 | Bristol Myers Squibb Co | Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek |
| MXPA02010231A (es) * | 2001-11-27 | 2004-12-13 | Warner Lambert Co | Inhibidores aminotransferasa dependientes de aminoacidos de cadena ramificada y su uso en el tratamiento de las enfermedades neurodegenerativas. |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7915424B2 (en) * | 2004-03-22 | 2011-03-29 | Eli Lilly And Company | Pyridyl derivatives and their use as mGlu5 antagonists |
| SI2495016T1 (sl) * | 2005-12-23 | 2020-04-30 | Ariad Pharmaceuticals, Inc. | Biciklične heteroarilne spojine |
| CN101389338B (zh) * | 2005-12-23 | 2013-06-26 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| WO2009100536A1 (en) * | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
-
2012
- 2012-01-23 CN CN201280014166.8A patent/CN103502217B/zh active Active
- 2012-01-23 WO PCT/GB2012/050132 patent/WO2012098416A1/en not_active Ceased
- 2012-01-23 JP JP2013549896A patent/JP5905028B2/ja active Active
- 2012-01-23 US US13/980,108 patent/US9024021B2/en active Active
- 2012-01-23 EA EA201370166A patent/EA024194B8/ru unknown
- 2012-01-23 EP EP12701370.4A patent/EP2665709B1/en active Active
- 2012-01-23 MX MX2013008296A patent/MX336051B/es unknown
- 2012-01-23 BR BR112013018212-1A patent/BR112013018212B1/pt active IP Right Grant
- 2012-01-23 AU AU2012208388A patent/AU2012208388C1/en active Active
- 2012-01-23 ES ES12701370.4T patent/ES2608829T3/es active Active
- 2012-01-23 KR KR1020137021626A patent/KR101892574B1/ko active Active
- 2012-01-23 CA CA2825367A patent/CA2825367C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351123B2 (en) | 2017-03-15 | 2022-06-07 | Sun Pharma Advanced Research Company Limited | Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n'-(2-chloro-6-methyl-benzoyl) hydrazide |
| US12194153B2 (en) | 2017-03-15 | 2025-01-14 | Sun Pharma Advanced Research Company Limited | Amorphous dispersion of 4-methyl-3-quinolin-3-ylethynyl-benzoic acid n′-(2-chloro-6-methyl-benzoyl) hydrazide |