JP2014508610A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014508610A5 JP2014508610A5 JP2013557128A JP2013557128A JP2014508610A5 JP 2014508610 A5 JP2014508610 A5 JP 2014508610A5 JP 2013557128 A JP2013557128 A JP 2013557128A JP 2013557128 A JP2013557128 A JP 2013557128A JP 2014508610 A5 JP2014508610 A5 JP 2014508610A5
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- hyperbranched polymer
- cationic
- core portion
- polymer molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000587 hyperbranched polymer Polymers 0.000 claims 30
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 13
- 125000002091 cationic group Chemical group 0.000 claims 13
- 229920000669 heparin Polymers 0.000 claims 13
- 229960002897 heparin Drugs 0.000 claims 13
- 239000011248 coating agent Substances 0.000 claims 6
- 238000000576 coating method Methods 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 5
- 239000002344 surface layer Substances 0.000 claims 4
- 239000003146 anticoagulant agent Substances 0.000 claims 3
- 229940127219 anticoagulant drug Drugs 0.000 claims 3
- 239000010410 layer Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229920000962 poly(amidoamine) Polymers 0.000 claims 3
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 229920006318 anionic polymer Polymers 0.000 claims 2
- 229920006317 cationic polymer Polymers 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 239000000412 dendrimer Substances 0.000 claims 2
- 229920000736 dendritic polymer Polymers 0.000 claims 2
- 230000001453 nonthrombogenic effect Effects 0.000 claims 2
- 229920000333 poly(propyleneimine) Polymers 0.000 claims 2
- 229920000768 polyamine Polymers 0.000 claims 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 claims 1
- 229920001586 anionic polysaccharide Polymers 0.000 claims 1
- 150000004836 anionic polysaccharides Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- SENLDUJVTGGYIH-UHFFFAOYSA-N n-(2-aminoethyl)-3-[[3-(2-aminoethylamino)-3-oxopropyl]-[2-[bis[3-(2-aminoethylamino)-3-oxopropyl]amino]ethyl]amino]propanamide Chemical group NCCNC(=O)CCN(CCC(=O)NCCN)CCN(CCC(=O)NCCN)CCC(=O)NCCN SENLDUJVTGGYIH-UHFFFAOYSA-N 0.000 claims 1
- 150000003141 primary amines Chemical group 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451732P | 2011-03-11 | 2011-03-11 | |
| US61/451,732 | 2011-03-11 | ||
| PCT/EP2012/054179 WO2012123384A1 (en) | 2011-03-11 | 2012-03-09 | Improvements to immobilised biological entities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017225620A Division JP6643298B2 (ja) | 2011-03-11 | 2017-11-24 | 固定化された生物学的成分の改良 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508610A JP2014508610A (ja) | 2014-04-10 |
| JP2014508610A5 true JP2014508610A5 (https=) | 2015-04-30 |
| JP6251039B2 JP6251039B2 (ja) | 2017-12-20 |
Family
ID=45814511
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557128A Active JP6251039B2 (ja) | 2011-03-11 | 2012-03-09 | 固定化された生物学的成分の改良 |
| JP2017225620A Active JP6643298B2 (ja) | 2011-03-11 | 2017-11-24 | 固定化された生物学的成分の改良 |
| JP2019161946A Pending JP2019202226A (ja) | 2011-03-11 | 2019-09-05 | 固定化された生物学的成分の改良 |
| JP2020195102A Active JP7222963B2 (ja) | 2011-03-11 | 2020-11-25 | 固定化された生物学的成分の改良 |
| JP2022196345A Pending JP2023017012A (ja) | 2011-03-11 | 2022-12-08 | 固定化された生物学的成分の改良 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017225620A Active JP6643298B2 (ja) | 2011-03-11 | 2017-11-24 | 固定化された生物学的成分の改良 |
| JP2019161946A Pending JP2019202226A (ja) | 2011-03-11 | 2019-09-05 | 固定化された生物学的成分の改良 |
| JP2020195102A Active JP7222963B2 (ja) | 2011-03-11 | 2020-11-25 | 固定化された生物学的成分の改良 |
| JP2022196345A Pending JP2023017012A (ja) | 2011-03-11 | 2022-12-08 | 固定化された生物学的成分の改良 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US9101696B2 (https=) |
| EP (2) | EP2683420B1 (https=) |
| JP (5) | JP6251039B2 (https=) |
| KR (1) | KR101933237B1 (https=) |
| CN (2) | CN103596603B (https=) |
| BR (1) | BR112013023241B1 (https=) |
| CA (1) | CA2828797C (https=) |
| ES (2) | ES2955183T3 (https=) |
| RU (1) | RU2625756C2 (https=) |
| WO (1) | WO2012123384A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2683420B1 (en) | 2011-03-11 | 2018-05-23 | W. L. Gore & Associates, Inc. | Improvements to immobilised biological entities |
| US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
| US10376360B2 (en) | 2012-07-27 | 2019-08-13 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic valve apparatus and methods |
| US9737398B2 (en) | 2012-12-19 | 2017-08-22 | W. L. Gore & Associates, Inc. | Prosthetic valves, frames and leaflets and methods thereof |
| US10321986B2 (en) | 2012-12-19 | 2019-06-18 | W. L. Gore & Associates, Inc. | Multi-frame prosthetic heart valve |
| US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
| US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
| US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
| AU2014211351B2 (en) | 2013-02-04 | 2017-04-13 | W. L. Gore & Associates, Inc. | Coating for substrate |
| DE102013016750A1 (de) * | 2013-10-02 | 2015-04-02 | Friedrich-Schiller-Universität Jena | Neue Poly(ethylenimin) basierte Copolymere zur Anbindung und Freisetzung von genetischem Material, insbesondere von DNA/RNA, sowie Verfahren zu deren Herstellung und Verwendung |
| US9795721B2 (en) * | 2013-11-28 | 2017-10-24 | Toray Industries, Inc. | Antithrombotic material |
| CN103832021B (zh) * | 2014-01-09 | 2016-03-02 | 西南交通大学 | 一种钛基底上制备有机分子杂化TiO2纳米复合薄膜的方法 |
| US11839698B2 (en) * | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
| GR20140100263A (el) * | 2014-05-02 | 2016-02-01 | Εκεφε Δημοκριτος | Καινοτομα υλικα με βαση τον ανθρακα τροποποιημενα με δενδριτικα πολυμερη, που εμφανιζουν αντιβακτηριακη δραση και η επιδραση τους στη φωτοσυνδετικη λειτουργια |
| EP3141191A4 (en) * | 2014-05-09 | 2018-04-04 | Toray Industries, Inc. | Endovascular treatment assistance tool |
| WO2015188716A1 (zh) * | 2014-06-09 | 2015-12-17 | 上海微创医疗器械（集团）有限公司 | 一种抗凝血涂层及其涂覆方法 |
| CN107405431B (zh) * | 2015-03-31 | 2021-02-02 | 东丽株式会社 | 抗血栓性金属材料 |
| EP3095509A1 (en) | 2015-05-18 | 2016-11-23 | Defymed | Membranes functionalized with heparin for bioartificial organs |
| US20180140752A1 (en) * | 2015-05-27 | 2018-05-24 | Toray Industries, Inc. | Antithrombotic material |
| CN106730051B (zh) * | 2016-12-27 | 2020-05-01 | 生纳科技(上海)有限公司 | 抗凝血高分子生物材料及其制备方法和应用 |
| WO2018144481A1 (en) * | 2017-01-31 | 2018-08-09 | The Regents Of The University Of California | Multi-arm block-copolymers for multifunctional self-assembled systems |
| CN111182856B (zh) | 2017-09-12 | 2022-04-29 | W.L.戈尔及同仁股份有限公司 | 用于假体瓣膜的瓣叶框架附连件 |
| CN111132636B (zh) | 2017-09-27 | 2022-04-08 | W.L.戈尔及同仁股份有限公司 | 带有可扩张框架的假体瓣膜以及相关系统和方法 |
| CN111163728B (zh) | 2017-09-27 | 2022-04-29 | W.L.戈尔及同仁股份有限公司 | 具有机械联接的瓣叶的假体瓣膜 |
| US11090153B2 (en) | 2017-10-13 | 2021-08-17 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve and delivery system |
| US11439502B2 (en) | 2017-10-31 | 2022-09-13 | W. L. Gore & Associates, Inc. | Medical valve and leaflet promoting tissue ingrowth |
| EP3703615B1 (en) | 2017-10-31 | 2024-05-15 | W. L. Gore & Associates, Inc. | Transcatheter deployment systems and associated methods |
| JP7429191B2 (ja) * | 2018-03-07 | 2024-02-07 | フォルシュングスフェアバント ベルリン エー．ベー． | アルケンホスホノチオレートまたはアルキンホスホノチオレートおよびアルケンホスホネートまたはアルキンホスホネートとの化学選択的チオールコンジュゲーション |
| AU2019232163B2 (en) | 2018-03-09 | 2025-11-20 | Carmeda Ab | Improvements to processes for immobilising biological entities |
| WO2019170859A2 (en) * | 2018-03-09 | 2019-09-12 | Carmeda Ab | Improvements to immobilising biological entities |
| EP3781222A4 (en) * | 2018-04-20 | 2022-01-26 | Ension, Inc. | MANIPULATED BIOACTIVE HEPARIN MATRIX FOR CLINICAL APPLICATION OF A BLOOD CONTACT SURFACE AND METHODS FOR ITS MANUFACTURE |
| AU2019354085B2 (en) | 2018-10-03 | 2025-06-05 | Carmeda Ab | Immobilised biological entities |
| US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
| CN110028692B (zh) * | 2019-03-14 | 2020-11-03 | 江苏赛腾医疗科技有限公司 | 一种基于离子键-共价键协同表面肝素化抗凝血医用装置的制备方法 |
| JP7381601B2 (ja) | 2019-04-12 | 2023-11-15 | エドワーズ ライフサイエンシーズ コーポレイション | マルチパートフレーム及び関連するレジリエントブリッジ特徴部を備えた弁 |
| CN110464882A (zh) * | 2019-07-29 | 2019-11-19 | 东华大学 | 一种亲水抗菌可降解的输尿管支架管及其制备方法 |
| WO2021022211A1 (en) | 2019-08-01 | 2021-02-04 | W. L. Gore & Associates, Inc. | Transcatheter prosthetic valve with multi-part frame subcomponent transverse deformation resistance |
| WO2021026477A1 (en) | 2019-08-07 | 2021-02-11 | W. L. Gore & Associates, Inc. | Balloon delivery device for a light activable treatment media |
| CN111544646A (zh) * | 2020-03-30 | 2020-08-18 | 东华大学 | 表面接枝肝素涂层的小口径人工血管及其制备方法 |
| AU2022261713B2 (en) | 2021-04-19 | 2025-11-27 | W. L. Gore & Associates, Inc. | Electrochemical analyte biosensors, associated compositions of matter, and methods for making and using same |
| WO2022233944A1 (en) * | 2021-05-04 | 2022-11-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New devices for use for treating cerebral aneurysms |
| WO2022261094A1 (en) | 2021-06-08 | 2022-12-15 | W. L. Gore & Associates, Inc. | Treatment media delivery device and methods for targeted delivery thereof |
| CN114392738B (zh) * | 2022-01-25 | 2023-01-10 | 同济大学 | 共价杂配体、炔基化超支化聚乙撑亚胺矿化法调制金纳米簇和方法、应用 |
| CN115381569A (zh) * | 2022-07-21 | 2022-11-25 | 南方科技大学 | Peek种植体表面改进方法和设备 |
| US20250387532A1 (en) * | 2024-06-19 | 2025-12-25 | W. L. Gore & Associates, Inc. | Implantable absorbable tissue adhesives on biomaterials for long-term adhesion to biological tissues |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE392582B (sv) | 1970-05-21 | 1977-04-04 | Gore & Ass | Forfarande vid framstellning av ett porost material, genom expandering och streckning av en tetrafluoretenpolymer framstelld i ett pastabildande strengsprutningsforfarande |
| JPS6041948B2 (ja) | 1977-12-15 | 1985-09-19 | ユニチカ株式会社 | 固体表面に抗血栓性を付与する方法 |
| US4415490A (en) | 1979-07-24 | 1983-11-15 | Nippon Zeon Co., Ltd. | Non-thrombogenic material |
| US4329383A (en) | 1979-07-24 | 1982-05-11 | Nippon Zeon Co., Ltd. | Non-thrombogenic material comprising substrate which has been reacted with heparin |
| US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
| US4526714A (en) | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| US4678671A (en) | 1981-12-15 | 1987-07-07 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
| SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
| US4600652A (en) | 1985-04-01 | 1986-07-15 | Warner-Lambert Company | Permanently bonded antithrombogenic polyurethane surface |
| IT1213023B (it) | 1986-01-16 | 1989-12-07 | Rolando Barbucci | Materiale capace di adsorbire stabilmente elevate quantita' di eparina, e suo procedimento di preparazione. |
| SE452551B (sv) | 1986-05-27 | 1987-12-07 | Camurus Ab | Artikel belagd med heparinbaserat material samt forfarande for dess framstellning |
| US4745180A (en) | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US5308617A (en) | 1988-08-10 | 1994-05-03 | Halzyme Ltd. | Protein heparin conjugates |
| US5130143A (en) | 1988-11-04 | 1992-07-14 | The Research Foundation Of State University Of New York | Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy |
| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5032666A (en) | 1989-06-19 | 1991-07-16 | Becton, Dickinson And Company | Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface |
| US5049403A (en) | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| US5213898A (en) | 1989-10-12 | 1993-05-25 | Norsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| WO1993005825A1 (en) | 1991-09-20 | 1993-04-01 | Baxter International Inc. | Processes for reducing the thrombogenicity of biomaterials |
| SE470006B (sv) | 1991-09-26 | 1993-10-25 | Corline Systems Ab | Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet |
| IT1254898B (it) | 1992-04-21 | 1995-10-11 | Gianfranco Palumbo | Idrogeli di tipo polietereammidoamminico come materiali eparinizzabili |
| US5532311A (en) | 1995-02-01 | 1996-07-02 | Minnesota Mining And Manufacturing Company | Process for modifying surfaces |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| US5583213A (en) | 1995-05-12 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Process to activate sulfated polysaccharides |
| US5679659A (en) | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
| US5767108A (en) | 1995-08-22 | 1998-06-16 | Medtronic, Inc. | Method for making improved heparinized biomaterials |
| US7045585B2 (en) | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
| NZ325248A (en) | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
| US5922690A (en) | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
| US7034061B1 (en) * | 1996-04-30 | 2006-04-25 | Ajay Kumar Luthra | Non-thrombogenic and anti-thrombogenic polymers |
| GB9608882D0 (en) | 1996-04-30 | 1996-07-03 | Luthra Ajay K | Non-thrombogenic and anti-thrombogenic polymers |
| US5876433A (en) | 1996-05-29 | 1999-03-02 | Ethicon, Inc. | Stent and method of varying amounts of heparin coated thereon to control treatment |
| US5916585A (en) | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
| US5914182A (en) | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
| US5728751A (en) | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
| JPH114883A (ja) | 1997-06-18 | 1999-01-12 | Toray Ind Inc | 抗血栓性医療材料 |
| JP2003506310A (ja) | 1997-10-07 | 2003-02-18 | リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | ヘパリン及びアデノシドａ２アゴニストの組合せで、又はアデノシンでの閉塞性末梢血管疾患及び冠状動脈疾患の治療 |
| FI974321A0 (fi) | 1997-11-25 | 1997-11-25 | Jenny Ja Antti Wihurin Rahasto | Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa |
| AU761192B2 (en) | 1998-06-10 | 2003-05-29 | Converge Medical, Inc. | Sutureless anastomosis systems |
| GB9814420D0 (en) | 1998-07-03 | 1998-09-02 | Cancer Res Campaign Tech | Sequence analysis of saccharide material |
| US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
| NO984143L (no) | 1998-09-09 | 2000-03-10 | Norsk Hydro As | Ny prosess for å fremstille overflatemodifiserende stoffer |
| JP2003525916A (ja) | 1999-04-22 | 2003-09-02 | エイドゲントシッシュ テクニーシェ ホッシュール チューリッヒ | モディファイドタンパク質マトリクス |
| WO2001029118A1 (en) | 1999-10-19 | 2001-04-26 | Commonwealth Scientific And Industrial Research Organisation | Preparation of functional polymeric surface |
| US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
| US7736687B2 (en) | 2006-01-31 | 2010-06-15 | Advance Bio Prosthetic Surfaces, Ltd. | Methods of making medical devices |
| SE515295C2 (sv) | 1999-11-23 | 2001-07-09 | Medicarb Ab | Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat |
| GB9928956D0 (en) * | 1999-12-07 | 2000-02-02 | Malik Navid | Internally supported biomimetic coating systems |
| US6518244B2 (en) | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
| US7875283B2 (en) | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
| AU5574101A (en) | 2000-04-28 | 2001-11-12 | Univ Emory | Decellularized vascular prostheses |
| WO2001087375A1 (en) | 2000-05-12 | 2001-11-22 | Cordis Corporation | Delivery devices for treatment of vascular disease |
| US6509104B2 (en) | 2000-12-05 | 2003-01-21 | Michigan Biotechnology Institute | Antithrombogenic polymer coating |
| US20050059068A1 (en) | 2001-05-23 | 2005-03-17 | Stratagene California | Compositions and methods using dendrimer-treated microassays |
| US6787179B2 (en) | 2001-06-29 | 2004-09-07 | Ethicon, Inc. | Sterilization of bioactive coatings |
| AR038269A1 (es) | 2002-01-09 | 2005-01-12 | Novartis Ag | Articulos polimericos que tienen un recubrimiento lubrico, y metodo para fabricarlos |
| US20030135195A1 (en) | 2002-01-16 | 2003-07-17 | Oscar Jimenez | Highly lubricious hydrophilic coating utilizing dendrimers |
| JP2005044408A (ja) | 2003-07-24 | 2005-02-17 | Pioneer Electronic Corp | 光集積装置および光ピックアップ装置 |
| AU2004266642A1 (en) | 2003-08-12 | 2005-03-03 | University Of Utah Research Foundation | Heparin binding proteins: sensors for heparin detection |
| US20050220841A1 (en) | 2004-04-06 | 2005-10-06 | Dewitt David M | Coating compositions for bioactive agents |
| GB0422877D0 (en) * | 2004-10-14 | 2004-11-17 | Univ Glasgow | Bioactive polymers |
| JP5178506B2 (ja) | 2005-03-14 | 2013-04-10 | バイオベンション ホールディングス リミテッド | ドラッグデリバリー組成物と関連する方法 |
| US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| EP1834636A1 (en) | 2006-03-08 | 2007-09-19 | Sahajanand Medical Technologies PVT. ltd | Compositions comprising porous articles and uses in implantable medical devices |
| US20080279909A1 (en) | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
| US8986713B2 (en) | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
| JP2009545333A (ja) | 2006-05-12 | 2009-12-24 | ゴア エンタープライズ ホールディングス，インコーポレイティド | 物理的操作または殺菌の後に大きな生物活性を有する固定化された生物活性物質 |
| US9114194B2 (en) | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
| WO2008063157A2 (en) * | 2006-10-25 | 2008-05-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | A nanoparticle-based anticoagulant |
| DE102008021894A1 (de) | 2008-05-02 | 2009-11-05 | Biotronik Vi Patent Ag | Implantat umfassend eine Oberfläche mit verringerter Thrombogenität |
| GB0816783D0 (en) | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
| GB201004101D0 (en) | 2010-03-12 | 2010-04-28 | Carmeda Ab | Immobilised biological entities |
| EP2683420B1 (en) * | 2011-03-11 | 2018-05-23 | W. L. Gore & Associates, Inc. | Improvements to immobilised biological entities |
| GB2508574B (en) | 2012-06-24 | 2014-12-17 | Fasmatech Science And Technology Sa | Improvements in and relating to the control of ions |
-
2012
- 2012-03-09 EP EP12708138.8A patent/EP2683420B1/en active Active
- 2012-03-09 US US13/416,880 patent/US9101696B2/en active Active
- 2012-03-09 CA CA2828797A patent/CA2828797C/en active Active
- 2012-03-09 BR BR112013023241-2A patent/BR112013023241B1/pt not_active IP Right Cessation
- 2012-03-09 ES ES18170238T patent/ES2955183T3/es active Active
- 2012-03-09 EP EP18170238.2A patent/EP3375462B1/en active Active
- 2012-03-09 RU RU2013145487A patent/RU2625756C2/ru active
- 2012-03-09 WO PCT/EP2012/054179 patent/WO2012123384A1/en not_active Ceased
- 2012-03-09 CN CN201280012639.0A patent/CN103596603B/zh active Active
- 2012-03-09 CN CN201511008867.2A patent/CN105664252B/zh active Active
- 2012-03-09 ES ES12708138.8T patent/ES2682482T3/es active Active
- 2012-03-09 KR KR1020137026084A patent/KR101933237B1/ko active Active
- 2012-03-09 JP JP2013557128A patent/JP6251039B2/ja active Active
-
2015
- 2015-07-02 US US14/790,205 patent/US9408950B2/en active Active
-
2016
- 2016-07-07 US US15/204,128 patent/US9764068B2/en active Active
-
2017
- 2017-08-23 US US15/684,007 patent/US10736999B2/en active Active
- 2017-11-24 JP JP2017225620A patent/JP6643298B2/ja active Active
-
2019
- 2019-09-05 JP JP2019161946A patent/JP2019202226A/ja active Pending
-
2020
- 2020-06-26 US US16/914,085 patent/US11497838B2/en active Active
- 2020-11-25 JP JP2020195102A patent/JP7222963B2/ja active Active
-
2022
- 2022-12-08 JP JP2022196345A patent/JP2023017012A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014508610A5 (https=) | ||
| Zeng et al. | Desirable strong and tough adhesive inspired by dragonfly wings and plant cell walls | |
| Liang et al. | Ca2+ enhanced nacre-inspired montmorillonite–alginate film with superior mechanical, transparent, fire retardancy, and shape memory properties | |
| Yang et al. | Well-dispersed chitosan/graphene oxide nanocomposites | |
| Wu et al. | Mussel-inspired self-adhesive, antidrying, and antifreezing poly (acrylic acid)/bentonite/polydopamine hybrid glycerol-hydrogel and the sensing application | |
| Thakur et al. | Recent advances in graft copolymerization and applications of chitosan: a review | |
| RU2013145487A (ru) | Усовершенствованные иммобилизованные биологические объекты | |
| Nagandran et al. | The recent progress in modification of polymeric membranes using organic macromolecules for water treatment | |
| Wang et al. | Transparent, healable elastomers with high mechanical strength and elasticity derived from hydrogen-bonded polymer complexes | |
| Lin et al. | Surface self-assembled PEGylation of fluoro-based PVDF membranes via hydrophobic-driven copolymer anchoring for ultra-stable biofouling resistance | |
| JP2012502678A5 (https=) | ||
| Wang et al. | O-(Carboxymethyl)-chitosan nanofiltration membrane surface functionalized with graphene oxide nanosheets for enhanced desalting properties | |
| Yin et al. | Hemocompatible polyethersulfone/polyurethane composite membrane for high‐performance antifouling and antithrombotic dialyzer | |
| JP2014534467A5 (https=) | ||
| Eskandarloo et al. | Highly efficient recovery of heparin using a green and low-cost quaternary ammonium functionalized halloysite nanotube | |
| CN101462388B (zh) | 以环状分子与聚合物的包结物增强的复合膜及其制备方法 | |
| JP2013521838A5 (https=) | ||
| Ren et al. | Stereocomplex crystallite-based eco-friendly nanofiber membranes for removal of Cr (VI) and antibacterial effects | |
| Liu et al. | Syntheses of novel chitosan derivative with excellent solubility, anticoagulation, and antibacterial property by chemical modification | |
| ATE414744T1 (de) | Mit anorganisch/organischen mischschichten beschichtete perlglanzpigmente und verfahren zu deren herstellung | |
| Lee et al. | High strength poly (vinyl alcohol)/poly (acrylic acid) cross-linked nanofibrous hybrid composites incorporating nanohybrid POSS | |
| Xiang et al. | Elastomeric polymer multilayer thin film with sustainable gas barrier at high strain | |
| JP2011511874A5 (https=) | ||
| JP2013023516A5 (https=) | ||
| Wang et al. | Mussel-inspired codepositing interconnected polypyrrole nanohybrids onto cellulose nanofiber networks for fabricating flexible conductive biobased composites |