JP2014506250A5 - - Google Patents
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- Publication number
- JP2014506250A5 JP2014506250A5 JP2013546292A JP2013546292A JP2014506250A5 JP 2014506250 A5 JP2014506250 A5 JP 2014506250A5 JP 2013546292 A JP2013546292 A JP 2013546292A JP 2013546292 A JP2013546292 A JP 2013546292A JP 2014506250 A5 JP2014506250 A5 JP 2014506250A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- linear
- optionally substituted
- hydroxyl
- acetylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 50
- 102000004190 Enzymes Human genes 0.000 claims description 46
- 108090000790 Enzymes Proteins 0.000 claims description 46
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 45
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 40
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 32
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 150000002148 esters Chemical class 0.000 claims description 30
- 239000003054 catalyst Substances 0.000 claims description 25
- 230000000694 effects Effects 0.000 claims description 23
- 125000004432 carbon atom Chemical group C* 0.000 claims description 20
- 125000001072 heteroaryl group Chemical group 0.000 claims description 20
- 150000004965 peroxy acids Chemical class 0.000 claims description 20
- 102000037865 fusion proteins Human genes 0.000 claims description 18
- 108020001507 fusion proteins Proteins 0.000 claims description 18
- 239000000047 product Substances 0.000 claims description 17
- 150000001720 carbohydrates Chemical class 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 239000000758 substrate Substances 0.000 claims description 13
- 229920001184 polypeptide Polymers 0.000 claims description 11
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 10
- 125000003342 alkenyl group Chemical group 0.000 claims description 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 10
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims description 10
- 125000000304 alkynyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000002843 carboxylic acid group Chemical group 0.000 claims description 10
- 150000002016 disaccharides Chemical class 0.000 claims description 10
- 125000004185 ester group Chemical group 0.000 claims description 10
- 150000004676 glycans Chemical class 0.000 claims description 10
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- 150000002772 monosaccharides Chemical class 0.000 claims description 10
- 229920001282 polysaccharide Polymers 0.000 claims description 10
- 239000005017 polysaccharide Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 108090000371 Esterases Proteins 0.000 claims description 9
- XJJPVDONOLMSOS-UHFFFAOYSA-N 3-[(2-chlorophenyl)-(4-hydroxy-2-oxochromen-3-yl)methyl]-4-hydroxychromen-2-one Chemical compound O=C1OC=2C=CC=CC=2C(O)=C1C(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1Cl XJJPVDONOLMSOS-UHFFFAOYSA-N 0.000 claims description 6
- 230000002087 whitening effect Effects 0.000 claims description 6
- 238000004061 bleaching Methods 0.000 claims description 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 238000005202 decontamination Methods 0.000 claims description 4
- 230000003588 decontaminative effect Effects 0.000 claims description 4
- 238000004332 deodorization Methods 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 208000007027 Oral Candidiasis Diseases 0.000 claims description 2
- 239000007844 bleaching agent Substances 0.000 claims description 2
- 208000002925 dental caries Diseases 0.000 claims description 2
- 208000007565 gingivitis Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000013588 oral product Substances 0.000 claims description 2
- 201000001245 periodontitis Diseases 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 description 21
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 8
- 210000003298 dental enamel Anatomy 0.000 description 8
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 108010009043 arylesterase Proteins 0.000 description 3
- 102000028848 arylesterase Human genes 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 102000057234 Acyl transferases Human genes 0.000 description 2
- 108700016155 Acyl transferases Proteins 0.000 description 2
- -1 CE-7 carbohydrate Chemical class 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108700014220 acyltransferase activity proteins Proteins 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 0 CC*O[N+](*)[O-] Chemical compound CC*O[N+](*)[O-] 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 241000187480 Mycobacterium smegmatis Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424903P | 2010-12-20 | 2010-12-20 | |
| US61/424,903 | 2010-12-20 | ||
| PCT/US2011/065912 WO2012087970A2 (en) | 2010-12-20 | 2011-12-19 | Enzymatic peracid generation for use in oral care products |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016248580A Division JP6410786B2 (ja) | 2010-12-20 | 2016-12-22 | 口腔ケア製品において使用するための酵素的な過酸の発生 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506250A JP2014506250A (ja) | 2014-03-13 |
| JP2014506250A5 true JP2014506250A5 (enExample) | 2015-02-05 |
| JP6359831B2 JP6359831B2 (ja) | 2018-07-18 |
Family
ID=46314812
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546292A Active JP6359831B2 (ja) | 2010-12-20 | 2011-12-19 | 口腔ケア製品において使用するための酵素的な過酸の発生 |
| JP2016248580A Active JP6410786B2 (ja) | 2010-12-20 | 2016-12-22 | 口腔ケア製品において使用するための酵素的な過酸の発生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016248580A Active JP6410786B2 (ja) | 2010-12-20 | 2016-12-22 | 口腔ケア製品において使用するための酵素的な過酸の発生 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8663616B2 (enExample) |
| EP (1) | EP2654695B8 (enExample) |
| JP (2) | JP6359831B2 (enExample) |
| KR (1) | KR20130132936A (enExample) |
| CN (1) | CN103269679B (enExample) |
| AU (1) | AU2011349451A1 (enExample) |
| BR (1) | BR112013015459B8 (enExample) |
| CA (1) | CA2822422C (enExample) |
| ES (1) | ES2784495T3 (enExample) |
| MX (1) | MX2013006994A (enExample) |
| PH (1) | PH12013501285A1 (enExample) |
| RU (1) | RU2660373C2 (enExample) |
| WO (1) | WO2012087970A2 (enExample) |
| ZA (1) | ZA201303372B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101801521B (zh) | 2007-05-14 | 2015-06-17 | 纽约州立大学研究基金会 | 生物膜中细菌细胞内的生理学分散响应诱导 |
| SG2014011993A (en) * | 2011-09-14 | 2014-04-28 | Colgate Palmolive Co | Tooth whitening strip |
| JP6141316B2 (ja) * | 2011-12-19 | 2017-06-07 | コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ | 酵素触媒反応を提供するシステム |
| CN104470491A (zh) | 2011-12-19 | 2015-03-25 | 高露洁-棕榄公司 | 提供过水解酶催化反应的系统 |
| AU2015201460B2 (en) * | 2011-12-19 | 2017-03-16 | Colgate-Palmolive Company | System providing enzyme-catalyzed reaction |
| PL2793822T3 (pl) * | 2011-12-19 | 2017-11-30 | Colgate-Palmolive Company | Kompozycje wytwarzające kwas nadtlenowy |
| WO2013148187A1 (en) | 2012-03-30 | 2013-10-03 | E. I. Du Pont De Nemours And Company | Enzymes useful for peracid production |
| US8911977B2 (en) | 2012-03-30 | 2014-12-16 | E. I. Du Pont De Nemours And Company | Enzymes useful for peracid production |
| CN104411822B (zh) | 2012-03-30 | 2018-11-06 | 纳幕尔杜邦公司 | 对于过酸的生产有用的酶 |
| RU2644336C2 (ru) | 2012-03-30 | 2018-02-08 | Е.И.Дюпон Де Немур Энд Компани | Ферменты, пригодные для получения перкислот |
| BR112014024207B1 (pt) | 2012-03-30 | 2022-04-05 | E.I. Du Pont De Nemours And Company | Processo para a produção de um ácido peroxicarboxílico, composição e sistema de geração e fornecimento de perácido |
| TWI561248B (en) * | 2012-12-22 | 2016-12-11 | Colgate Palmolive Co | Peracid-generating compositions |
| WO2018118553A1 (en) * | 2016-12-20 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions and methods for increasing the stability of the same |
| AU2017382664B2 (en) * | 2016-12-20 | 2020-05-14 | Colgate-Palmolive Company | Oral care compositions and methods for whitening teeth |
| RU2755664C2 (ru) * | 2016-12-20 | 2021-09-20 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы отбеливания зубов |
| US10973885B2 (en) | 2018-12-27 | 2021-04-13 | Colgate-Palmolive Company | Oral care compositions |
| AU2021237644A1 (en) * | 2020-03-18 | 2022-10-13 | Sri International | Molecular transport system to the Central Nervous System |
| WO2024128080A1 (ja) * | 2022-12-16 | 2024-06-20 | 東亞合成株式会社 | 合成ペプチド及び構築物 |
| WO2025128645A1 (en) | 2023-12-13 | 2025-06-19 | Colgate-Palmolive Company | Oral care compositions and methods for whitening teeth |
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| US20100298535A1 (en) | 2009-05-20 | 2010-11-25 | E. I. Du Pont De Nemours And Company | Pmma binding peptides |
| US8455614B2 (en) | 2009-05-20 | 2013-06-04 | E.I. Du Pont De Nemours And Company | PMMA binding peptides |
| US8206693B2 (en) | 2009-05-20 | 2012-06-26 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US8404214B2 (en) | 2009-05-20 | 2013-03-26 | E I Du Pont De Nemours And Company | PMMA binding peptides |
| US20100310495A1 (en) | 2009-06-08 | 2010-12-09 | E. I. Du Pont De Nemours And Company | Peptides having affinity for poly (benzyl methacrylate-co-methacrylic acid) potassium salt copolymers and methods of use |
| US8222012B2 (en) | 2009-10-01 | 2012-07-17 | E. I. Du Pont De Nemours And Company | Perhydrolase for enzymatic peracid production |
| US7932072B1 (en) | 2009-12-07 | 2011-04-26 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7927854B1 (en) | 2009-12-07 | 2011-04-19 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7923233B1 (en) | 2009-12-07 | 2011-04-12 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7910347B1 (en) | 2009-12-07 | 2011-03-22 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| US7960528B1 (en) | 2009-12-07 | 2011-06-14 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved peracid stability |
| WO2011119706A1 (en) | 2010-03-26 | 2011-09-29 | E.I. Dupont De Nemours And Company | Perhydrolase providing improved specific activity |
| US8586339B2 (en) | 2010-03-26 | 2013-11-19 | E. I. Du Pont De Nemours And Company | Facilitated process for purification of proteins |
| US8206964B2 (en) * | 2010-03-26 | 2012-06-26 | E. I. Du Pont De Nemours And Company | Perhydrolase providing improved specific activity |
-
2011
- 2011-12-19 ES ES11850480T patent/ES2784495T3/es active Active
- 2011-12-19 PH PH1/2013/501285A patent/PH12013501285A1/en unknown
- 2011-12-19 AU AU2011349451A patent/AU2011349451A1/en not_active Abandoned
- 2011-12-19 CN CN201180061614.5A patent/CN103269679B/zh active Active
- 2011-12-19 EP EP11850480.2A patent/EP2654695B8/en active Active
- 2011-12-19 US US13/330,261 patent/US8663616B2/en active Active
- 2011-12-19 JP JP2013546292A patent/JP6359831B2/ja active Active
- 2011-12-19 MX MX2013006994A patent/MX2013006994A/es unknown
- 2011-12-19 CA CA2822422A patent/CA2822422C/en active Active
- 2011-12-19 KR KR20137019091A patent/KR20130132936A/ko not_active Withdrawn
- 2011-12-19 BR BR112013015459A patent/BR112013015459B8/pt active IP Right Grant
- 2011-12-19 WO PCT/US2011/065912 patent/WO2012087970A2/en not_active Ceased
- 2011-12-19 RU RU2013133831A patent/RU2660373C2/ru active
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2013
- 2013-05-09 ZA ZA2013/03372A patent/ZA201303372B/en unknown
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2016
- 2016-12-22 JP JP2016248580A patent/JP6410786B2/ja active Active
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