JP2014504940A - 多孔質の3次元支持体及びその製造方法 - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
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- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
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Abstract
Description
本発明に係る生分解性高分子製のチューブ状の丸編は、合成及び天然の生分解性高分子素材の中でも、溶融紡糸、ウェット紡糸などによって繊維状を呈して1〜50デニールのモノフィラメントまたは100〜500デニールのマルチフィラメント状に紡糸可能な繊維または合成及び天然の単繊維紡績糸である必要がある。
本発明に係る多孔質の3次元支持体は、丸編の内部に挿入される生分解性マルチフィラメント仮撚り糸のバルキー構造において、細胞培養、細胞伝達または薬物伝達の機能を行う。
1)生分解性高分子製のマルチフィラメント合糸を細幅丸編織機に投入してチューブ状の丸編を得る工程と、
2)生分解性高分子を溶融紡糸法またはウェット紡糸法によりモノフィラメントまたはマルチフィラメント糸に紡糸した後に合糸し、且つ、仮撚して生分解性マルチフィラメント仮撚り糸を得る工程と、
3)前記工程1)において得られたチューブ状の丸編に工程2)において得られた生分解性マルチフィラメント仮撚り糸を挿入する工程と、
4)前記挿入された生分解性マルチフィラメント仮撚り糸を引っ張ってバルキー性を与える工程と、を含む多孔質の3次元支持体の製造方法を提供する。
ラクチド及びグリコーリドが10:90の重量比で共重合されたポリ乳酸−グリコール酸の共重合体(PLGA)高分子チップから製造したマルチフィラメント糸4本を合糸したものを細幅丸編織機に投入して、8mmの直径及び100mmの長さを有する丸編を製造した。
前記実施例1に従い製造されたポリ乳酸−グリコール酸の共重合体(PLGA)200de/64filaのDTY系仮撚り糸を16合、32合、100合、150合及び200合にそれぞれ合糸した以外は、前記実施例1の方法と同様にして多孔質の3次元支持体を製造した。
Claims (13)
- 生分解性高分子製のネット状の網目状構造を有するチューブ状の丸編の内部に、150〜1000%のバルキー性付き生分解性マルチフィラメント仮撚り糸が挿入されている多孔質の3次元支持体。
- 前記生分解性高分子製のチューブ状の丸編が、モノフィラメント、マルチフィラメントまたは紡績繊維であることを特徴とする請求項1に記載の多孔質の3次元支持体。
- 前記生分解性高分子が、ポリ乳酸、ポリグリコール酸、ポリカプロラクトン、ポリ乳酸−グリコール酸の共重合体、ポリヒドロキシ酪酸、ポリヒドロキシ吉草酸及びポリヒドロキシ酪酸−吉草酸の共重合体よりなる群から選ばれるいずれか1種以上であることを特徴とする請求項1に記載の多孔質の3次元支持体。
- 前記チューブ状の丸編が、5〜20mmの断面径を有することを特徴とする請求項1に記載の多孔質の3次元支持体。
- 前記生分解性マルチフィラメント仮撚り糸が、ポリ乳酸、ポリグリコール酸、ポリカプロラクトン、ポリ乳酸−グリコール酸の共重合体、ポリヒドロキシ酪酸、ポリヒドロキシ吉草酸及びポリヒドロキシ酪酸−吉草酸の共重合体、ジオキサノン、トリメチレンカーボネート及びエチレンオキシドよりなる群から選ばれる化合物の単一重合体またはこれらを含む共重合体の生分解性合成高分子またはコラーゲン、酸化セルロース、キトサン、キチン、ゼラチン及びシルクフィブロインよりなる群から選ばれる生分解性天然高分子から選ばれた素材から由来するものであることを特徴とする請求項1に記載の多孔質の3次元支持体。
- 前記生分解性マルチフィラメント仮撚り糸が、ラクチド及びグリコーリドが10:90〜30:70の重量比で共重合されたポリ乳酸−グリコール酸の共重合体であることを特徴とする請求項1に記載の多孔質の3次元支持体。
- 前記生分解性マルチフィラメント仮撚り糸に10〜150μmの気孔が与えられることを特徴とする請求項1に記載の多孔質の3次元支持体。
- 生分解性高分子製のマルチフィラメント合糸を細幅丸編織機に投入してネット状の網目状構造を有するチューブ状の丸編を得る工程と、
生分解性高分子を溶融紡糸またはウェット紡糸によりモノフィラメントまたはマルチフィラメント糸に紡糸した後に合糸し、且つ、仮撚して生分解性マルチフィラメント仮撚り糸を得る工程と、
前記ネット状の網目状構造を有するチューブ状の丸編に前記生分解性マルチフィラメント仮撚り糸を挿入する工程と、
前記挿入された生分解性マルチフィラメント仮撚り糸を引っ張ってバルキー性を与える工程と、を含むことを特徴とする多孔質の3次元支持体の製造方法。 - 前記生分解性マルチフィラメント仮撚り糸を得る工程におけるモノフィラメントまたはマルチフィラメント糸の単糸直径が5〜30μmであることを特徴とする請求項8に記載の多孔質の3次元支持体の製造方法。
- 前記生分解性マルチフィラメント仮撚り糸を得る工程における合糸後のマルチフィラメント糸の直径が80〜8000μmであることを特徴とする請求項8に記載の多孔質の3次元支持体の製造方法。
- 前記引張りが5〜20%にて行われることを特徴とする請求項8に記載の多孔質の3次元支持体の製造方法。
- 前記引張りによって生分解性マルチフィラメント仮撚り糸に10〜150μmの気孔が与えられることを特徴とする請求項8に記載の多孔質の3次元支持体の製造方法。
- 前記引張りによってバルキー性が与えられていない生分解性マルチフィラメント仮撚り糸に比べて150〜1000%嵩張ったバルキー性が与えられていることを特徴とする請求項8に記載の多孔質の3次元支持体の製造方法。
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KR10-2011-0049996 | 2011-05-26 | ||
KR1020110049996A KR101275163B1 (ko) | 2011-05-26 | 2011-05-26 | 다공질의 3차원 지지체 및 그의 제조방법 |
PCT/KR2012/001873 WO2012161413A2 (ko) | 2011-05-26 | 2012-03-15 | 다공질의 3차원 지지체 및 그의 제조방법 |
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JP2014504940A true JP2014504940A (ja) | 2014-02-27 |
JP5844388B2 JP5844388B2 (ja) | 2016-01-13 |
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US (1) | US20140005797A1 (ja) |
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WO2019013533A3 (ko) * | 2017-07-10 | 2019-04-18 | 주식회사 아모라이프사이언스 | 세포배양 지지체용 혼섬사 제조방법, 이를 통해 구현된 세포배양 지지체용 혼섬사 및 이를 포함하는 원단 |
KR20190066546A (ko) * | 2017-12-05 | 2019-06-13 | 한국생산기술연구원 | 3차원 섬유형 스캐폴드 |
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KR101856575B1 (ko) * | 2016-05-25 | 2018-06-19 | 주식회사 아모그린텍 | 세포배양 지지체용 원사 및 이를 포함하는 원단 |
KR101872283B1 (ko) * | 2016-12-07 | 2018-06-29 | 한국생산기술연구원 | 섬유충진 3차원 지지체의 제조방법 |
CN108384717A (zh) | 2017-02-03 | 2018-08-10 | 财团法人工业技术研究院 | 细胞培养载体模块与细胞培养系统 |
US20190077933A1 (en) * | 2017-09-08 | 2019-03-14 | Indian Institute Of Technology Delhi | Process for preparing three dimensional porous scaffold and the three dimensional porous scaffold formed thereof |
KR102172383B1 (ko) | 2019-11-27 | 2020-10-30 | 한국생산기술연구원 | 생분해성 실의 마이크로 공극 형성 장치 및 방법 |
KR102587534B1 (ko) * | 2019-12-11 | 2023-10-11 | 주식회사 엠아이텍 | 방사선 불투과성 물질이 포함된 생분해성 튜브 |
CN112843334B (zh) * | 2021-01-13 | 2022-07-08 | 东华大学 | 一种三维打印复合气凝胶构建仿生气管及其制备方法 |
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WO2019013533A3 (ko) * | 2017-07-10 | 2019-04-18 | 주식회사 아모라이프사이언스 | 세포배양 지지체용 혼섬사 제조방법, 이를 통해 구현된 세포배양 지지체용 혼섬사 및 이를 포함하는 원단 |
KR20190066546A (ko) * | 2017-12-05 | 2019-06-13 | 한국생산기술연구원 | 3차원 섬유형 스캐폴드 |
KR102233499B1 (ko) | 2017-12-05 | 2021-03-29 | 한국생산기술연구원 | 3차원 섬유형 스캐폴드 |
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WO2012161413A3 (ko) | 2013-01-17 |
KR101275163B1 (ko) | 2013-06-17 |
JP5844388B2 (ja) | 2016-01-13 |
WO2012161413A4 (ko) | 2013-03-07 |
KR20120131664A (ko) | 2012-12-05 |
WO2012161413A2 (ko) | 2012-11-29 |
US20140005797A1 (en) | 2014-01-02 |
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