JP2014503499A5 - - Google Patents
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- JP2014503499A5 JP2014503499A5 JP2013540060A JP2013540060A JP2014503499A5 JP 2014503499 A5 JP2014503499 A5 JP 2014503499A5 JP 2013540060 A JP2013540060 A JP 2013540060A JP 2013540060 A JP2013540060 A JP 2013540060A JP 2014503499 A5 JP2014503499 A5 JP 2014503499A5
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- Prior art keywords
- cancer
- ldh
- ldh5
- ldh4
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 18
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 15
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 14
- 108010088350 Lactate Dehydrogenase 5 Proteins 0.000 claims 13
- 206010021143 Hypoxia Diseases 0.000 claims 12
- 201000011510 cancer Diseases 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 11
- 108010029485 Protein Isoforms Proteins 0.000 claims 9
- 102000001708 Protein Isoforms Human genes 0.000 claims 9
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 230000007954 hypoxia Effects 0.000 claims 6
- 102100031357 L-lactate dehydrogenase C chain Human genes 0.000 claims 5
- 101150050566 LDHC gene Proteins 0.000 claims 5
- 230000001146 hypoxic effect Effects 0.000 claims 5
- 101150035055 ldh3 gene Proteins 0.000 claims 5
- 101001090713 Homo sapiens L-lactate dehydrogenase A chain Proteins 0.000 claims 4
- 102100034671 L-lactate dehydrogenase A chain Human genes 0.000 claims 4
- 108010087599 lactate dehydrogenase 1 Proteins 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- -1 LDH4 Proteins 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 229960000397 bevacizumab Drugs 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 101001051207 Homo sapiens L-lactate dehydrogenase B chain Proteins 0.000 claims 2
- 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 claims 2
- 102000004207 Neuropilin-1 Human genes 0.000 claims 2
- 108090000772 Neuropilin-1 Proteins 0.000 claims 2
- 102000052812 Ornithine decarboxylases Human genes 0.000 claims 2
- 108700005126 Ornithine decarboxylases Proteins 0.000 claims 2
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 2
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- MWTUOSWPJOUADP-XDJHFCHBSA-N (5z)-5-(4-hydroxy-6-oxo-3-propan-2-ylcyclohexa-2,4-dien-1-ylidene)-4-(1-methylindol-5-yl)-1,2,4-triazolidin-3-one Chemical compound O=C1C=C(O)C(C(C)C)=C\C1=C\1N(C=2C=C3C=CN(C)C3=CC=2)C(=O)NN/1 MWTUOSWPJOUADP-XDJHFCHBSA-N 0.000 claims 1
- WVWOOAYQYLJEFD-UHFFFAOYSA-N 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol Chemical compound C1=CN=C([N+]([O-])=O)N1CC(O)CN1CCCCC1 WVWOOAYQYLJEFD-UHFFFAOYSA-N 0.000 claims 1
- RGHYDLZMTYDBDT-UHFFFAOYSA-N 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone Chemical compound O=C1N(CC)C2=NC(N)=NC(C)=C2C=C1C=1C=CNN=1 RGHYDLZMTYDBDT-UHFFFAOYSA-N 0.000 claims 1
- XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 claims 1
- 102100030907 Aryl hydrocarbon receptor nuclear translocator Human genes 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
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- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
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- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 claims 1
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- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000793115 Homo sapiens Aryl hydrocarbon receptor nuclear translocator Proteins 0.000 claims 1
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 1
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- 208000015021 Meningeal Neoplasms Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
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- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
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- 208000003019 Neurofibromatosis 1 Diseases 0.000 claims 1
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- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
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- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010061332 Paraganglion neoplasm Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
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- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
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- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 1
- 229960003005 axitinib Drugs 0.000 claims 1
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- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical compound O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 claims 1
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- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
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- 229950004161 ganetespib Drugs 0.000 claims 1
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- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41515810P | 2010-11-18 | 2010-11-18 | |
| US41515510P | 2010-11-18 | 2010-11-18 | |
| US41515610P | 2010-11-18 | 2010-11-18 | |
| US41512210P | 2010-11-18 | 2010-11-18 | |
| US41513610P | 2010-11-18 | 2010-11-18 | |
| US41514710P | 2010-11-18 | 2010-11-18 | |
| US41513910P | 2010-11-18 | 2010-11-18 | |
| US61/415,155 | 2010-11-18 | ||
| US61/415,139 | 2010-11-18 | ||
| US61/415,156 | 2010-11-18 | ||
| US61/415,147 | 2010-11-18 | ||
| US61/415,158 | 2010-11-18 | ||
| US61/415,122 | 2010-11-18 | ||
| US61/415,136 | 2010-11-18 | ||
| US201161510648P | 2011-07-22 | 2011-07-22 | |
| US201161510660P | 2011-07-22 | 2011-07-22 | |
| US201161510653P | 2011-07-22 | 2011-07-22 | |
| US61/510,660 | 2011-07-22 | ||
| US61/510,648 | 2011-07-22 | ||
| US61/510,653 | 2011-07-22 | ||
| PCT/US2011/061440 WO2012068483A1 (en) | 2010-11-18 | 2011-11-18 | Preselection of subjects for therapeutic treatment based on hypoxic status |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503499A JP2014503499A (ja) | 2014-02-13 |
| JP2014503499A5 true JP2014503499A5 (enExample) | 2015-01-15 |
Family
ID=45217699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540060A Pending JP2014503499A (ja) | 2010-11-18 | 2011-11-18 | 低酸素状態に基づく治療に適した被験体の事前選択 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20120128665A1 (enExample) |
| EP (1) | EP2640385A1 (enExample) |
| JP (1) | JP2014503499A (enExample) |
| CN (1) | CN103327976A (enExample) |
| AU (1) | AU2011329681A1 (enExample) |
| CA (1) | CA2817564A1 (enExample) |
| WO (1) | WO2012068483A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8053456B2 (en) | 2006-05-25 | 2011-11-08 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate Hsp90 activity |
| EP2323737A2 (en) | 2008-08-08 | 2011-05-25 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| JP2014534228A (ja) | 2011-11-02 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 白金含有剤とｈｓｐ９０阻害剤の組合せ療法 |
| JP2014532712A (ja) | 2011-11-02 | 2014-12-08 | シンタ ファーマシューティカルズ コーポレーション | トポイソメラーゼｉ阻害剤とｈｓｐ９０阻害剤の組合せを使用する癌療法 |
| AU2012339679A1 (en) | 2011-11-14 | 2014-06-12 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with BRAF inhibitors |
| WO2013170182A1 (en) * | 2012-05-11 | 2013-11-14 | Synta Pharmaceuticals Corp. | Treating cancer with an hsp90 inhibitory compound |
| CA2872942A1 (en) * | 2012-05-16 | 2013-11-21 | Synta Pharmaceuticals Corp. | Pre-selection of subjects for therapeutic treatment with an hsp90 inhibitor based on hypoxic status |
| US20160022757A1 (en) * | 2013-03-15 | 2016-01-28 | Icahn School Of Medicine At Mount Sinai | Therapeutic methods for treating solid tumors and related diagnostic methods |
| US9927437B2 (en) * | 2013-12-12 | 2018-03-27 | The Brigham And Women's Hospital, Inc. | Treating neurodegenerative disease |
| LT3179991T (lt) | 2014-08-11 | 2021-11-10 | Acerta Pharma B.V. | Terapiniai btk inhibitoriaus ir bcl-2 inhibitoriaus deriniai |
| WO2016024232A1 (en) | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor and/or a cdk 4/6 inhibitor |
| US20170239351A1 (en) | 2014-08-11 | 2017-08-24 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, a PD-1 Inhibitor, and/or a PD-L1 Inhibitor |
| CN104267191B (zh) * | 2014-09-09 | 2016-03-23 | 北京大学口腔医学院 | 口腔鳞状细胞癌的生物标志物及其应用 |
| WO2016073669A1 (en) * | 2014-11-05 | 2016-05-12 | Vojo Vukovic | Combination therapy of hsp90 inhibitory compounds with mtor inhibitors |
| WO2017136326A1 (en) * | 2016-02-01 | 2017-08-10 | Board Of Regents, The University Of Texas System | Using spectral ct to diagnose thyroid nodules |
| CN105709239A (zh) * | 2016-03-22 | 2016-06-29 | 山东省肿瘤医院 | 一种非小细胞肺癌放疗相关的HIF-1α的抑制剂 |
| JPWO2023276768A1 (enExample) * | 2021-06-29 | 2023-01-05 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250255A (en) | 1977-07-11 | 1981-02-10 | Eastman Kodak Company | Assay method for isoenzyme activity |
| US6242208B1 (en) | 1988-07-15 | 2001-06-05 | International Reagents Corporation | LDH1 assay |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| US7087613B2 (en) | 1999-11-11 | 2006-08-08 | Osi Pharmaceuticals, Inc. | Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride |
| US7417055B2 (en) | 2003-04-25 | 2008-08-26 | Gilead Sciences, Inc. | Kinase inhibitory phosphonate analogs |
| CN101072759B (zh) | 2004-11-18 | 2013-06-19 | Synta医药公司 | 调节hsp90活性的三唑化合物 |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| WO2007123793A2 (en) * | 2006-04-04 | 2007-11-01 | Stc.Unm | Swellable particles for drug delivery |
| GB0610925D0 (en) * | 2006-06-02 | 2006-07-12 | Novartis Ag | Use of vascular endothelial growth factor receptor inhibitors for the treatment of cancer |
| SE530596C2 (sv) | 2006-10-13 | 2008-07-15 | Mathias Karlsson | Metod att fastställa syrebrist i blod från skalpen under förlossning |
| US8592166B2 (en) | 2006-11-21 | 2013-11-26 | Beth Israel Deaconess Medical Center, Inc. | Hypoxia related genes and proteins for the treatment and diagnosis of pregnancy related complications |
| US20080318241A1 (en) * | 2007-06-18 | 2008-12-25 | The Regents Of The University Of Michigan | Methods and Systems for Detecting Antiangiogenesis |
-
2011
- 2011-11-18 CN CN2011800653411A patent/CN103327976A/zh active Pending
- 2011-11-18 WO PCT/US2011/061440 patent/WO2012068483A1/en not_active Ceased
- 2011-11-18 EP EP11793607.0A patent/EP2640385A1/en not_active Withdrawn
- 2011-11-18 JP JP2013540060A patent/JP2014503499A/ja active Pending
- 2011-11-18 US US13/300,221 patent/US20120128665A1/en not_active Abandoned
- 2011-11-18 AU AU2011329681A patent/AU2011329681A1/en not_active Abandoned
- 2011-11-18 CA CA2817564A patent/CA2817564A1/en not_active Abandoned
-
2013
- 2013-12-17 US US14/109,543 patent/US20140178366A1/en not_active Abandoned
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