JP2018503697A5 - - Google Patents

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JP2018503697A5
JP2018503697A5 JP2017559279A JP2017559279A JP2018503697A5 JP 2018503697 A5 JP2018503697 A5 JP 2018503697A5 JP 2017559279 A JP2017559279 A JP 2017559279A JP 2017559279 A JP2017559279 A JP 2017559279A JP 2018503697 A5 JP2018503697 A5 JP 2018503697A5
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hydroxy
cancer
alkoxy
medicament according
hydrogen
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JP2017559279A
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JP2018503697A (ja
JP6824906B2 (ja
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Priority claimed from PCT/US2016/016008 external-priority patent/WO2016126618A1/en
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JP2017559279A 2015-02-02 2016-02-01 併用療法 Active JP6824906B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562111030P 2015-02-02 2015-02-02
US62/111,030 2015-02-02
PCT/US2016/016008 WO2016126618A1 (en) 2015-02-02 2016-02-01 Combination therapies

Publications (3)

Publication Number Publication Date
JP2018503697A JP2018503697A (ja) 2018-02-08
JP2018503697A5 true JP2018503697A5 (enExample) 2019-02-28
JP6824906B2 JP6824906B2 (ja) 2021-02-03

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JP2017559279A Active JP6824906B2 (ja) 2015-02-02 2016-02-01 併用療法

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US (2) US10980774B2 (enExample)
EP (1) EP3253208B1 (enExample)
JP (1) JP6824906B2 (enExample)
CN (2) CN107427003B (enExample)
AU (1) AU2016215515B2 (enExample)
CA (1) CA2974123C (enExample)
DK (1) DK3253208T3 (enExample)
ES (1) ES2877712T3 (enExample)
HU (1) HUE054998T2 (enExample)
MX (1) MX381863B (enExample)
PL (1) PL3253208T3 (enExample)
PT (1) PT3253208T (enExample)
WO (1) WO2016126618A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3253208T (pt) * 2015-02-02 2021-06-17 The Spanish National Cancer Res Centre Terapêuticas de combinação para utilização no tratamento do cancro da mama
CN106860867A (zh) * 2017-02-23 2017-06-20 中山大学 己糖激酶2特异性抑制剂在急性中枢神经系统损伤疾病中的应用
EP3600322A1 (en) * 2017-03-28 2020-02-05 Boehringer Ingelheim International GmbH Nintedanib for use in methods for the treatment of muscular dystrophy
CN112074485A (zh) * 2018-03-16 2020-12-11 小利兰·斯坦福大学托管委员会 癌症治疗反应分析
CN110917199A (zh) * 2019-11-22 2020-03-27 上海市肺科医院 一种小分子化合物在制备肺癌化疗增敏药物中的应用
EP4164632A4 (en) * 2020-06-11 2024-06-05 MEI Pharma, Inc. COMBINATION THERAPIES
US20250170096A1 (en) * 2022-02-16 2025-05-29 ImmunoMet Therapeutics, Inc. Oxphos inhibitors for use in treating cancer
WO2024137472A2 (en) * 2022-12-19 2024-06-27 Mei Pharma, Inc. Combination therapies
WO2026130838A1 (en) * 2024-12-17 2026-06-25 Vivesto Ab The combination of trx-e-002-1 with a bcl-2 inhibitor or a hypomethylating agent in the treatment of acute myeloid leukemia

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340276A (en) 1964-04-01 1967-09-05 Ciba Geigy Corp 3, 4-diphenyl-chromans
DE1518002C3 (de) 1965-01-02 1975-01-23 Merck Patent Gmbh, 6100 Darmstadt Isoflavane und Isoflavene und Verfahren zu Ihrer Herstellung sowie diese enthaltende Arzneimittel
DE1543749A1 (de) 1966-02-16 1969-12-11 Merck Ag E Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen
GB1433013A (enExample) 1973-06-08 1976-04-22
US4264509A (en) 1977-06-08 1981-04-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4157984A (en) 1977-06-08 1979-06-12 Z-L Limited Antioxidants, antioxidant compositions and methods of preparing and using same
US4218489A (en) 1977-06-08 1980-08-19 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
US4232122A (en) 1979-01-17 1980-11-04 Z-L Limited Partnership Antioxidants, antioxidant compositions and methods of preparing and using same
US4368264A (en) 1979-03-19 1983-01-11 Z-L Limited Partnership Fermentation methods of preparing ergostadientriols
US4234577A (en) 1979-03-19 1980-11-18 Z-L Limited Partnership Ergostadientriols, compositions containing same, and methods of preparing and using same
US4366248A (en) 1979-04-11 1982-12-28 Z-L Limited Partnership Fermentation method of preparing antioxidants
US4390559A (en) 1979-04-11 1983-06-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4366082A (en) 1979-04-11 1982-12-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US4447622A (en) 1981-09-22 1984-05-08 Council Of Scientific And Industrial Research Rafi Marg Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof
US4644012A (en) 1983-12-21 1987-02-17 Takeda Chemical Industries, Ltd. Treatment for osteoporosis
GB8626344D0 (en) 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
MX13485A (es) 1987-10-19 1993-05-01 Pfizer Procedimiento para obtener tetralinas, cromados y compuestos relacionados, sustituidos
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
DE69023906T2 (de) 1990-08-09 1996-04-11 Council Scient Ind Res Benzopyrane und Verfahren zu deren Herstellung.
CA2146005A1 (en) 1992-10-21 1994-04-28 Charles W. Murtiashaw, Iii Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic acids
US5280040A (en) 1993-03-11 1994-01-18 Zymogenetics, Inc. Methods for reducing bone loss using centchroman derivatives
US5451603A (en) 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5389646A (en) 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
US5792776A (en) 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
HUP9702244A3 (en) 1995-01-13 1999-12-28 Novo Nordisk As Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders
WO1996021442A1 (en) 1995-01-13 1996-07-18 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment of prophylaxis of idiopathic or physiologic gynaecomastia
CN1168098A (zh) 1995-01-13 1997-12-17 诺沃挪第克公司 3,4-二苯基苯并二氢吡喃在生产用于治疗或预防高脂蛋白血症、高甘油三酯血症、高脂血症或高胆固醇血症或动脉硬化或用于抗凝治疗的药物组合物中的用途
CZ212097A3 (en) 1995-01-20 1997-11-12 Novo Nordisk As Use of 3,4-diphenylchromans for preparing a medicament intended for treating or prophylaxis of cerebral degenerative diseases
EP0804188A1 (en) 1995-01-20 1997-11-05 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for vasodilatory treatment or prophylaxis
TW448046B (en) 1995-01-20 2001-08-01 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of obesity
US5849461A (en) 1995-08-01 1998-12-15 Shin-Etsu Chemical Co., Ltd. Chemically amplified positive resist composition
HUP9902683A3 (en) 1996-01-11 2001-08-28 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of menopausal symptoms
US5726202A (en) 1996-01-11 1998-03-10 Novo Nordisk A/S Benign prostatic hypertrophy
US5883118A (en) 1996-01-11 1999-03-16 Nova Nordisk A/S Prostatic carcinoma
US5747059A (en) 1996-01-11 1998-05-05 Novo Nordisk A/S Atrophy of skin/mucous membrane
US5756539A (en) 1996-07-11 1998-05-26 Novo Nordis A/S 3, 4-diphenyl chromans for inhibiting one or more psychiatric disorders
WO1998002156A1 (en) 1996-07-12 1998-01-22 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for lowering intraocular pressure
WO1998002154A1 (en) 1996-07-12 1998-01-22 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more symptoms of premenstrual syndrome
AUPO203996A0 (en) 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
US6043269A (en) 1996-10-28 2000-03-28 Novo Nordisk A/S cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
IL129623A0 (en) 1996-10-28 2000-02-29 Novo Nordisk As Novel trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5985306A (en) 1996-10-28 1999-11-16 Novo Nordisk A/S (+)-enantiomers of cis-3,4-chroman derivatives useful in prevention or treatment of estrogen diseases or syndromes
ZA979644B (en) 1996-10-28 1998-04-28 Novo Nordisk As Heterocyclic compounds, compositions and uses.
CA2269974A1 (en) 1996-10-28 1998-05-07 Paul Stanley Bury Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2270057A1 (en) 1996-10-28 1998-05-07 Novo Nordisk A/S Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5958967A (en) 1996-10-28 1999-09-28 Novo Nordisk A/S Cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US6316494B1 (en) 1996-10-28 2001-11-13 Novo Nordisk A/S cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
CA2270113A1 (en) 1996-10-28 1998-05-07 Poul Jacobsen Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
JP2001502703A (ja) 1996-10-28 2001-02-27 ノボ ノルディスク アクティーゼルスカブ (−)―3,4―トランス―ジアリールクロマンの調製方法
AU4772297A (en) 1996-10-28 1998-05-22 Novo Nordisk A/S Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
US5919817A (en) 1996-10-28 1999-07-06 Novo Nordisk A/S Cis-3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
AU4772397A (en) 1996-10-28 1998-05-22 Novo Nordisk A/S Novel (cis)-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ES2191170T3 (es) 1996-10-28 2003-09-01 Novo Nordisk As Nuevos (-)-enantiomeros de derivados de cis-3,4-cromano utiles en la prevencion y tratamiento de sindromes o enfermedades relacionadas con el estrogeno.
US5994390A (en) 1996-10-28 1999-11-30 Novo Nordisk Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes
ATE225782T1 (de) 1996-12-13 2002-10-15 Chugai Pharmaceutical Co Ltd Benzopyranderivate
WO1998032437A1 (en) 1997-01-29 1998-07-30 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibiting one or more psychiatric disorders
ZA98681B (en) 1997-01-29 1998-07-29 Novo Nordisk As Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for inhibition senescense-associated motor impairment
AU5550298A (en) 1997-01-29 1998-08-25 Novo Nordisk A/S Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical compositionfor increasing libido in post-menopausal women
US5874418A (en) 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
AUPP112497A0 (en) 1997-12-24 1998-01-22 Novogen Research Pty Ltd Compositions and method for protecting skin from UV induced immunosupression and skin damage
WO1999049862A1 (en) 1998-03-30 1999-10-07 The University Of Mississippi Isoflavones for treating giardiasis and malaria
WO1999055898A1 (en) 1998-04-28 1999-11-04 Novo Nordisk A/S Enzymatic resolvation for obtaining a (-)-3,4-trans-diarylchroman
FR2778404B1 (fr) 1998-05-06 2000-06-30 Hoechst Marion Roussel Inc Derives du dihydro ou tetrahydronaphtalene, et les compositions pharmaceutiques les renfermant
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
KR20000001793A (ko) 1998-06-13 2000-01-15 이경하 신규한 벤조피란 또는 티오벤조피란 유도체
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
FR2789685B1 (fr) 1999-02-15 2001-05-04 Univ Lille Sciences Tech Procede de fabrication de polymeres solubles et insolubles a base de cyclodextrine(s) et/ou de derives de cyclodextrine(s) et polymeres solubles a base de cyclodextrine(s) et/ou de derives de cyclodextrine(s)
AUPP868599A0 (en) 1999-02-15 1999-03-11 Novogen Research Pty Ltd Production of isoflavone derivatives
AUPQ008299A0 (en) 1999-04-30 1999-05-27 G.J. Consultants Pty Ltd Isoflavone metabolites
WO2001007031A1 (en) 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same
AUPQ266199A0 (en) 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
US6528042B1 (en) 1999-10-08 2003-03-04 Galileo Laboratories, Inc. Compositions of flavonoids for use as cytoprotectants and methods of making and using them
AU7896100A (en) 1999-10-14 2001-04-23 Endorecherche Inc. Selective estrogen receptor modulators in the treatment or reduction of the riskof acquiring hypertension, cardiovascular diseases, and insulin resistance
EP1241165A4 (en) 1999-12-13 2003-03-19 Chugai Pharmaceutical Co Ltd OPTICALLY ACTIVE CHROMAN AND THIOCHROME DERIVATIVES
US6479467B1 (en) 1999-12-16 2002-11-12 Eastman Chemical Company Cyclodextrin ethers
EP1251855A1 (en) 2000-01-28 2002-10-30 Endorecherche, Inc. Selective estrogen receptor modulators in combination with estrogens
AU2001255709A1 (en) 2000-05-11 2001-11-20 Eastman Chemical Company Acylated cyclodextrin guest inclusion complexes
FI20001593A7 (fi) 2000-07-03 2002-01-04 Orion Yhtymo Oyj Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia
CN1250505C (zh) 2000-08-31 2006-04-12 科学工业研究院 制备1-丙基-2,4,5-三甲氧基苯的改进方法
WO2002055562A2 (en) 2001-01-11 2002-07-18 Eastman Chem Co Cyclodextrin sulfonates, guest inclusion complexes, methods of making the same and related materials
WO2002059113A1 (en) 2001-01-24 2002-08-01 Chiesi Farmaceutici S.P.A. 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
US7026304B2 (en) 2001-02-14 2006-04-11 Akzo Nobel N.V. 2-alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
EP1417169A2 (en) 2001-08-11 2004-05-12 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
CN1668287B (zh) 2001-09-06 2012-03-28 赛诺克思公司 3-脱氧类黄酮在制备抑制t淋巴细胞活性的药物中的用途
AUPR846401A0 (en) 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
WO2003063859A1 (en) 2002-01-14 2003-08-07 Nordic Bioscience A/S Suppression of cartilage degradation via the estrogen receptor
EP1503751A4 (en) 2002-04-09 2007-08-01 Novogen Res Pty Ltd THERAPEUTIC PROCESSES AND COMPOSITIONS WITH ISOFLAV-3-EN AND ISOFLAVAN STRUCTURES
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
BR0315198A (pt) 2002-10-09 2005-08-30 Insert Therapeutics Inc Materiais e composições à base de ciclodextrina e usos relacionados aos mesmos
CA2546643A1 (en) 2003-11-18 2005-06-02 Novogen Research Pty Ltd Isoflavonoid prodrugs, compositions thereof and therapeutic methods involving same
CN101123958A (zh) 2003-11-19 2008-02-13 诺沃根研究股份有限公司 联合放射疗法与化学疗法的组合物和方法
DE102004002787A1 (de) 2004-01-19 2005-08-11 Merck Patent Gmbh Flavonoid-Komplexe
ES2377073T3 (es) 2004-09-21 2012-03-22 Marshall Edwards, Inc. Derivados de cromano sustituidos, medicamentos y utilización en terapia
CN101056868B (zh) 2004-09-21 2012-05-02 马休爱德华兹股份有限公司 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用
EP2436680B1 (en) 2004-09-21 2016-05-18 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
JP4976649B2 (ja) 2004-09-21 2012-07-18 マーシャル エドワーズ,インク. 化合物
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
CA2668008A1 (en) 2006-10-30 2008-05-08 Novogen Research Pty Ltd Prevention and reversal of chemotherapy-induced peripheral neuropathy
EP2120925A4 (en) 2007-03-16 2010-04-07 Novogen Res Pty Ltd METHOD FOR INTRODUCING AUTOPHAGIA
CA2738328A1 (en) 2008-08-29 2010-03-04 Novogen Research Pty Ltd Immunomodulating activities
CN102596196A (zh) 2008-10-22 2012-07-18 诺沃根研究控股有限公司 用于诱导程序性细胞死亡的方法
CA2641541A1 (en) 2008-10-22 2010-04-22 Novogen Research Pty Ltd. Methods for inducing programmed cell death
WO2012061409A1 (en) 2010-11-01 2012-05-10 Marshall Edwards, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US20120251630A1 (en) * 2011-03-29 2012-10-04 Marshall Edwards, Inc. Remission therapy of cancer with isoflavonoids
US20140093498A1 (en) 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents
ES2643407T3 (es) 2014-02-07 2017-11-22 Novogen Ltd. Compuestos de benzopirano funcionalizados y uso de los mismos
PT3253208T (pt) * 2015-02-02 2021-06-17 The Spanish National Cancer Res Centre Terapêuticas de combinação para utilização no tratamento do cancro da mama

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