JP2013545759A5 - - Google Patents
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- JP2013545759A5 JP2013545759A5 JP2013540063A JP2013540063A JP2013545759A5 JP 2013545759 A5 JP2013545759 A5 JP 2013545759A5 JP 2013540063 A JP2013540063 A JP 2013540063A JP 2013540063 A JP2013540063 A JP 2013540063A JP 2013545759 A5 JP2013545759 A5 JP 2013545759A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- ldh
- ldh5
- ldh4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 206010028980 Neoplasm Diseases 0.000 claims 18
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 15
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 14
- 108010088350 Lactate Dehydrogenase 5 Proteins 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 12
- 206010021143 Hypoxia Diseases 0.000 claims 11
- 108010029485 Protein Isoforms Proteins 0.000 claims 9
- 102000001708 Protein Isoforms Human genes 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 9
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 102100031357 L-lactate dehydrogenase C chain Human genes 0.000 claims 5
- 101150050566 LDHC gene Proteins 0.000 claims 5
- 230000007954 hypoxia Effects 0.000 claims 5
- 230000001146 hypoxic effect Effects 0.000 claims 5
- 101150035055 ldh3 gene Proteins 0.000 claims 5
- 101001090713 Homo sapiens L-lactate dehydrogenase A chain Proteins 0.000 claims 4
- 102100034671 L-lactate dehydrogenase A chain Human genes 0.000 claims 4
- 108010087599 lactate dehydrogenase 1 Proteins 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- -1 LDH4 Proteins 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 101001051207 Homo sapiens L-lactate dehydrogenase B chain Proteins 0.000 claims 2
- 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 claims 2
- 102000004207 Neuropilin-1 Human genes 0.000 claims 2
- 108090000772 Neuropilin-1 Proteins 0.000 claims 2
- 102000052812 Ornithine decarboxylases Human genes 0.000 claims 2
- 108700005126 Ornithine decarboxylases Proteins 0.000 claims 2
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 2
- 108091006296 SLC2A1 Proteins 0.000 claims 2
- 108091006299 SLC2A2 Proteins 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 230000001023 pro-angiogenic effect Effects 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- WVWOOAYQYLJEFD-UHFFFAOYSA-N 1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol Chemical compound C1=CN=C([N+]([O-])=O)N1CC(O)CN1CCCCC1 WVWOOAYQYLJEFD-UHFFFAOYSA-N 0.000 claims 1
- 102100030907 Aryl hydrocarbon receptor nuclear translocator Human genes 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000021309 Germ cell tumor Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000793115 Homo sapiens Aryl hydrocarbon receptor nuclear translocator Proteins 0.000 claims 1
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 208000015021 Meningeal Neoplasms Diseases 0.000 claims 1
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000003019 Neurofibromatosis 1 Diseases 0.000 claims 1
- 208000024834 Neurofibromatosis type 1 Diseases 0.000 claims 1
- 208000005890 Neuroma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010061332 Paraganglion neoplasm Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 201000005188 adrenal gland cancer Diseases 0.000 claims 1
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000003567 ascitic fluid Anatomy 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000014541 detection of hypoxia Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000000416 exudates and transudate Anatomy 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 208000021622 familial nonmedullary thyroid carcinoma Diseases 0.000 claims 1
- 210000003608 fece Anatomy 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 201000008822 gestational choriocarcinoma Diseases 0.000 claims 1
- 208000002409 gliosarcoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 230000009033 hematopoietic malignancy Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 208000029824 high grade glioma Diseases 0.000 claims 1
- 201000006866 hypopharynx cancer Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 101150095787 ldh2 gene Proteins 0.000 claims 1
- 101150100271 ldhb gene Proteins 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004880 lymph fluid Anatomy 0.000 claims 1
- 201000005831 male reproductive organ cancer Diseases 0.000 claims 1
- 201000011614 malignant glioma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000022006 malignant tumor of meninges Diseases 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 208000021039 metastatic melanoma Diseases 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000003731 mucosal melanoma Diseases 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 201000006958 oropharynx cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000007312 paraganglioma Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 229950010456 pimonidazole Drugs 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000003804 salivary gland carcinoma Diseases 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 210000001625 seminal vesicle Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000004500 stellate cell Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 201000010653 vesiculitis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41510410P | 2010-11-18 | 2010-11-18 | |
| US61/415,104 | 2010-11-18 | ||
| PCT/US2011/061453 WO2012068491A1 (en) | 2010-11-18 | 2011-11-18 | Preselection of subjects for therapeutic treatment with elesclomol based on hypoxic status |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013545759A JP2013545759A (ja) | 2013-12-26 |
| JP2013545759A5 true JP2013545759A5 (enExample) | 2015-01-15 |
Family
ID=45217701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540063A Pending JP2013545759A (ja) | 2010-11-18 | 2011-11-18 | 低酸素状態に基づくエレスクロモールによる治療に適した被験体の事前選択 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20120128580A1 (enExample) |
| EP (1) | EP2640372A1 (enExample) |
| JP (1) | JP2013545759A (enExample) |
| WO (1) | WO2012068491A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130149392A1 (en) * | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
| WO2020102303A1 (en) * | 2018-11-14 | 2020-05-22 | The Broad Institute, Inc. | Use of disulfiram and other compounds to treat cancers with loss of chromosome 16q and/or low expression of metallothionein proteins |
| WO2021162478A1 (ko) * | 2020-02-14 | 2021-08-19 | 사회복지법인 삼성생명공익재단 | 게니핀 및 엘레스클로몰을 포함하는 암 예방 또는 치료용 약학적 조성물 |
| CN112618527B (zh) * | 2021-01-20 | 2021-11-09 | 上海交通大学医学院附属第九人民医院 | 一种小分子在制备突变型葡萄膜黑色素瘤药物中的应用 |
| WO2023276768A1 (ja) * | 2021-06-29 | 2023-01-05 | 国立大学法人京都大学 | 低酸素バイオマーカー及びその利用 |
| AU2022370861A1 (en) * | 2021-10-21 | 2024-06-06 | Edison Oncology | Compositions and methods for treatment of hyperproliferative, inflammatory, and immunological diseases, and infections |
| CN115581775B (zh) * | 2022-09-26 | 2025-09-30 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | 一种用于治疗骨肉瘤的复合纳米药剂及其制备方法 |
| CN118453879B (zh) * | 2024-05-23 | 2025-10-03 | 大连医科大学附属第二医院 | 恩杂鲁胺与铜离子载体联合在制备前列腺癌治疗药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250255A (en) | 1977-07-11 | 1981-02-10 | Eastman Kodak Company | Assay method for isoenzyme activity |
| US6242208B1 (en) | 1988-07-15 | 2001-06-05 | International Reagents Corporation | LDH1 assay |
| CN1993318B (zh) | 2004-06-23 | 2012-10-03 | Synta医药公司 | 用于治疗癌症的双（硫代-酰肼酰胺）盐 |
| EP1731617A1 (de) | 2005-06-06 | 2006-12-13 | DSM IP Assets B.V. | Rückführung lysierter Biomasse als Nährmedium bei der fermentativen Herstellung von Riboflavin |
| SE530596C2 (sv) | 2006-10-13 | 2008-07-15 | Mathias Karlsson | Metod att fastställa syrebrist i blod från skalpen under förlossning |
| EP2099933A4 (en) | 2006-11-21 | 2010-03-24 | Beth Israel Hospital | HYPOXIA-ASSOCIATED GENES AND PROTEINS FOR THE TREATMENT AND DIAGNOSIS OF PREGNANCY-RELATED COMPLICATIONS |
| JP2011506467A (ja) * | 2007-12-14 | 2011-03-03 | サイクローン・ファーマシューティカルズ・インコーポレイテッド | 抗悪性腫瘍性熱ショックアポトーシス活性化因子（ｈｓａａ）と組み合わせられたアルファチモシンペプチドによる黒色腫の処置の方法 |
| US8815945B2 (en) * | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
-
2011
- 2011-11-18 US US13/300,231 patent/US20120128580A1/en not_active Abandoned
- 2011-11-18 JP JP2013540063A patent/JP2013545759A/ja active Pending
- 2011-11-18 WO PCT/US2011/061453 patent/WO2012068491A1/en not_active Ceased
- 2011-11-18 EP EP11793609.6A patent/EP2640372A1/en not_active Withdrawn
-
2013
- 2013-12-27 US US14/141,883 patent/US20140113972A1/en not_active Abandoned
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