JP2018528949A5 - - Google Patents
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- JP2018528949A5 JP2018528949A5 JP2018510878A JP2018510878A JP2018528949A5 JP 2018528949 A5 JP2018528949 A5 JP 2018528949A5 JP 2018510878 A JP2018510878 A JP 2018510878A JP 2018510878 A JP2018510878 A JP 2018510878A JP 2018528949 A5 JP2018528949 A5 JP 2018528949A5
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- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical combination
- combination according
- pharmaceutical
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims description 36
- 201000011510 cancer Diseases 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 22
- 229940083338 MDM2 inhibitor Drugs 0.000 claims description 21
- 239000012819 MDM2-Inhibitor Substances 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 14
- 206010009944 Colon cancer Diseases 0.000 claims description 13
- 206010039491 Sarcoma Diseases 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 11
- 239000012664 BCL-2-inhibitor Substances 0.000 claims description 10
- 229940123711 Bcl2 inhibitor Drugs 0.000 claims description 10
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims description 10
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims description 10
- 230000035772 mutation Effects 0.000 claims description 10
- 206010006187 Breast cancer Diseases 0.000 claims description 9
- 208000026310 Breast neoplasm Diseases 0.000 claims description 9
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 9
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims description 9
- 206010024627 liposarcoma Diseases 0.000 claims description 9
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 9
- 210000002784 stomach Anatomy 0.000 claims description 8
- -1 tetrocalcin A Chemical compound 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- QBKSWRVVCFFDOT-UHFFFAOYSA-N gossypol Chemical compound CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 QBKSWRVVCFFDOT-UHFFFAOYSA-N 0.000 claims description 6
- 201000001441 melanoma Diseases 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 210000004291 uterus Anatomy 0.000 claims description 6
- 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims description 5
- 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims description 5
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 5
- 206010069755 K-ras gene mutation Diseases 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 5
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- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 4
- 206010004146 Basal cell carcinoma Diseases 0.000 claims description 4
- 206010005949 Bone cancer Diseases 0.000 claims description 4
- 208000018084 Bone neoplasm Diseases 0.000 claims description 4
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims description 4
- 208000012609 Cowden disease Diseases 0.000 claims description 4
- 201000002847 Cowden syndrome Diseases 0.000 claims description 4
- 208000032612 Glial tumor Diseases 0.000 claims description 4
- 206010018338 Glioma Diseases 0.000 claims description 4
- 208000017604 Hodgkin disease Diseases 0.000 claims description 4
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims description 4
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 4
- 206010025323 Lymphomas Diseases 0.000 claims description 4
- 206010027476 Metastases Diseases 0.000 claims description 4
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims description 4
- 208000034578 Multiple myelomas Diseases 0.000 claims description 4
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 4
- 208000034179 Neoplasms, Glandular and Epithelial Diseases 0.000 claims description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 4
- 208000017733 acquired polycythemia vera Diseases 0.000 claims description 4
- 208000009621 actinic keratosis Diseases 0.000 claims description 4
- 210000004100 adrenal gland Anatomy 0.000 claims description 4
- 210000003445 biliary tract Anatomy 0.000 claims description 4
- 210000004556 brain Anatomy 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims description 4
- 210000000621 bronchi Anatomy 0.000 claims description 4
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 4
- 210000001072 colon Anatomy 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 210000004696 endometrium Anatomy 0.000 claims description 4
- 208000010932 epithelial neoplasm Diseases 0.000 claims description 4
- 210000003238 esophagus Anatomy 0.000 claims description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 4
- 208000005017 glioblastoma Diseases 0.000 claims description 4
- 210000003128 head Anatomy 0.000 claims description 4
- 210000003494 hepatocyte Anatomy 0.000 claims description 4
- 210000003228 intrahepatic bile duct Anatomy 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 4
- 210000000244 kidney pelvis Anatomy 0.000 claims description 4
- 210000000867 larynx Anatomy 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 210000004185 liver Anatomy 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- 206010028537 myelofibrosis Diseases 0.000 claims description 4
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims description 4
- 210000003739 neck Anatomy 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 201000008968 osteosarcoma Diseases 0.000 claims description 4
- 210000000496 pancreas Anatomy 0.000 claims description 4
- 210000003800 pharynx Anatomy 0.000 claims description 4
- 208000037244 polycythemia vera Diseases 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 210000000664 rectum Anatomy 0.000 claims description 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 4
- 201000010700 sporadic breast cancer Diseases 0.000 claims description 4
- 210000001685 thyroid gland Anatomy 0.000 claims description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 4
- 210000003932 urinary bladder Anatomy 0.000 claims description 4
- 229930182536 Antimycin Natural products 0.000 claims description 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 3
- 108010079882 Bax protein (53-86) Proteins 0.000 claims description 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 3
- QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 claims description 3
- NIOHNDKHQHVLKA-UHFFFAOYSA-N acetic acid;7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde Chemical compound CC(O)=O.CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 NIOHNDKHQHVLKA-UHFFFAOYSA-N 0.000 claims description 3
- CQIUKKVOEOPUDV-IYSWYEEDSA-N antimycin Chemical compound OC1=C(C(O)=O)C(=O)C(C)=C2[C@H](C)[C@@H](C)OC=C21 CQIUKKVOEOPUDV-IYSWYEEDSA-N 0.000 claims description 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 3
- SXJDCULZDFWMJC-DGCLKSJQSA-N ethyl (4s)-2-amino-6-bromo-4-[(1s)-1-cyano-2-ethoxy-2-oxoethyl]-4h-chromene-3-carboxylate Chemical compound C1=C(Br)C=C2[C@H]([C@@H](C#N)C(=O)OCC)C(C(=O)OCC)=C(N)OC2=C1 SXJDCULZDFWMJC-DGCLKSJQSA-N 0.000 claims description 3
- 229930000755 gossypol Natural products 0.000 claims description 3
- 229950005277 gossypol Drugs 0.000 claims description 3
- 229960000435 oblimersen Drugs 0.000 claims description 3
- MIMNFCVQODTQDP-NDLVEFNKSA-N oblimersen Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(S)(=O)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)CO)[C@@H](O)C1 MIMNFCVQODTQDP-NDLVEFNKSA-N 0.000 claims description 3
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 claims description 2
- 208000025113 myeloid leukemia Diseases 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims description 2
- 210000000813 small intestine Anatomy 0.000 claims description 2
- 210000001215 vagina Anatomy 0.000 claims description 2
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 229950004847 navitoclax Drugs 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 4
- 210000003679 cervix uteri Anatomy 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 3
- 208000003747 lymphoid leukemia Diseases 0.000 description 3
- 206010061692 Benign muscle neoplasm Diseases 0.000 description 2
- 208000032027 Essential Thrombocythemia Diseases 0.000 description 2
- 201000004458 Myoma Diseases 0.000 description 2
- 208000018596 benign neoplasm of small intestine Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- 201000002314 small intestine cancer Diseases 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211016P | 2015-08-28 | 2015-08-28 | |
| US62/211,016 | 2015-08-28 | ||
| PCT/IB2016/055075 WO2017037586A1 (en) | 2015-08-28 | 2016-08-25 | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018528949A JP2018528949A (ja) | 2018-10-04 |
| JP2018528949A5 true JP2018528949A5 (enExample) | 2019-10-03 |
Family
ID=56896742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510878A Pending JP2018528949A (ja) | 2015-08-28 | 2016-08-25 | Ｐｉ３ｋ阻害剤およびｍｄｍ２阻害剤を使用する組み合わせ療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20180318275A1 (enExample) |
| EP (1) | EP3341023A1 (enExample) |
| JP (1) | JP2018528949A (enExample) |
| CN (1) | CN108348611A (enExample) |
| WO (1) | WO2017037586A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180037975A (ko) * | 2015-08-14 | 2018-04-13 | 노파르티스 아게 | 포도막 흑색종을 치료하기 위한 mdm2 억제제 |
| US20200290978A1 (en) * | 2017-09-26 | 2020-09-17 | The Regents Of The University Of California | Compositions and methods for treating cancer |
| CN108486041A (zh) * | 2018-03-28 | 2018-09-04 | 华南农业大学 | PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法 |
| WO2021053489A1 (en) * | 2019-09-16 | 2021-03-25 | Novartis Ag | Use of an mdm2 inhibitor for the treatment of myelofibrosis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| CU24130B1 (es) * | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| JO3357B1 (ar) * | 2012-01-26 | 2019-03-13 | Novartis Ag | مركبات إيميدازوبيروليدينون |
| EA202092456A3 (ru) * | 2013-11-11 | 2021-09-30 | Эмджен Инк. | Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака |
| CA2931073C (en) * | 2013-12-23 | 2021-10-26 | Novartis Ag | Pharmaceutical combinations |
-
2016
- 2016-08-25 CN CN201680063787.3A patent/CN108348611A/zh active Pending
- 2016-08-25 EP EP16763588.7A patent/EP3341023A1/en not_active Withdrawn
- 2016-08-25 WO PCT/IB2016/055075 patent/WO2017037586A1/en not_active Ceased
- 2016-08-25 US US15/755,797 patent/US20180318275A1/en not_active Abandoned
- 2016-08-25 JP JP2018510878A patent/JP2018528949A/ja active Pending