CN108348611A - 使用pi3k抑制剂和mdm2抑制剂的联合疗法 - Google Patents
使用pi3k抑制剂和mdm2抑制剂的联合疗法 Download PDFInfo
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562211016P | 2015-08-28 | 2015-08-28 | |
| US62/211,016 | 2015-08-28 | ||
| PCT/IB2016/055075 WO2017037586A1 (en) | 2015-08-28 | 2016-08-25 | Combination therapy using pi3k inhbitor and mdm2 inhibitor |
Publications (1)
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|---|---|
| CN108348611A true CN108348611A (zh) | 2018-07-31 |
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| CN201680063787.3A Pending CN108348611A (zh) | 2015-08-28 | 2016-08-25 | 使用pi3k抑制剂和mdm2抑制剂的联合疗法 |
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| EP (1) | EP3341023A1 (enExample) |
| JP (1) | JP2018528949A (enExample) |
| CN (1) | CN108348611A (enExample) |
| WO (1) | WO2017037586A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108486041A (zh) * | 2018-03-28 | 2018-09-04 | 华南农业大学 | PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018522936A (ja) * | 2015-08-14 | 2018-08-16 | ノバルティス アーゲー | ぶどう膜黒色腫の処置のためのｍｄｍ２阻害剤 |
| CN118459413A (zh) * | 2017-09-26 | 2024-08-09 | 加利福尼亚大学董事会 | 用于治疗癌症的组合物和方法 |
| US20220331318A1 (en) * | 2019-09-16 | 2022-10-20 | Novartis Ag | Use of an mdm2 inhibitor for the treatment of myelofibrosis |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120129871A1 (en) * | 2010-11-19 | 2012-05-24 | Novartis Ag | Crystalline form of an inhibitor of MDM2/4 and p53 interaction |
| WO2013111105A1 (en) * | 2012-01-26 | 2013-08-01 | Novartis Ag | Imidazopyrrolidinone compounds |
| WO2015070224A2 (en) * | 2013-11-11 | 2015-05-14 | Amgen Inc. | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
| WO2015097622A1 (en) * | 2013-12-23 | 2015-07-02 | Novartis Ag | Pharmaceutical combinations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
-
2016
- 2016-08-25 JP JP2018510878A patent/JP2018528949A/ja active Pending
- 2016-08-25 CN CN201680063787.3A patent/CN108348611A/zh active Pending
- 2016-08-25 US US15/755,797 patent/US20180318275A1/en not_active Abandoned
- 2016-08-25 WO PCT/IB2016/055075 patent/WO2017037586A1/en not_active Ceased
- 2016-08-25 EP EP16763588.7A patent/EP3341023A1/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120129871A1 (en) * | 2010-11-19 | 2012-05-24 | Novartis Ag | Crystalline form of an inhibitor of MDM2/4 and p53 interaction |
| WO2013111105A1 (en) * | 2012-01-26 | 2013-08-01 | Novartis Ag | Imidazopyrrolidinone compounds |
| WO2015070224A2 (en) * | 2013-11-11 | 2015-05-14 | Amgen Inc. | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
| WO2015097622A1 (en) * | 2013-12-23 | 2015-07-02 | Novartis Ag | Pharmaceutical combinations |
Non-Patent Citations (1)
| Title |
|---|
| 郑杰: "《肿瘤的细胞和分子生物学》", 30 April 2014, 军事医学科学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108486041A (zh) * | 2018-03-28 | 2018-09-04 | 华南农业大学 | PI3K/Akt信号通路在鸡胚成纤维细胞内对马立克氏病毒增殖的应用及其检测方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018528949A (ja) | 2018-10-04 |
| US20180318275A1 (en) | 2018-11-08 |
| WO2017037586A1 (en) | 2017-03-09 |
| EP3341023A1 (en) | 2018-07-04 |
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