JP2014239686A5 - - Google Patents
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- JP2014239686A5 JP2014239686A5 JP2014144592A JP2014144592A JP2014239686A5 JP 2014239686 A5 JP2014239686 A5 JP 2014239686A5 JP 2014144592 A JP2014144592 A JP 2014144592A JP 2014144592 A JP2014144592 A JP 2014144592A JP 2014239686 A5 JP2014239686 A5 JP 2014239686A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- nucleotide sequence
- insect cell
- sequence
- parvovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 33
- 241000238631 Hexapoda Species 0.000 claims 32
- 239000002773 nucleotide Substances 0.000 claims 28
- 125000003729 nucleotide group Chemical group 0.000 claims 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 241000125945 Protoparvovirus Species 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 101100524319 Adeno-associated virus 2 (isolate Srivastava/1982) Rep52 gene Proteins 0.000 claims 4
- 235000018102 proteins Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 210000002845 virion Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 101100524324 Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 gene Proteins 0.000 claims 2
- 241000201370 Autographa californica nucleopolyhedrovirus Species 0.000 claims 2
- 108010056651 Hydroxymethylbilane synthase Proteins 0.000 claims 2
- 108010013563 Lipoprotein Lipase Proteins 0.000 claims 2
- 102100022119 Lipoprotein lipase Human genes 0.000 claims 2
- 102100034391 Porphobilinogen deaminase Human genes 0.000 claims 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 1
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 108090000565 Capsid Proteins Proteins 0.000 claims 1
- 102100023321 Ceruloplasmin Human genes 0.000 claims 1
- 102100022641 Coagulation factor IX Human genes 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 108700010070 Codon Usage Proteins 0.000 claims 1
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 108010076282 Factor IX Proteins 0.000 claims 1
- 102000016354 Glucuronosyltransferase Human genes 0.000 claims 1
- 108010092364 Glucuronosyltransferase Proteins 0.000 claims 1
- 101001104102 Homo sapiens X-linked retinitis pigmentosa GTPase regulator Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 241000256251 Spodoptera frugiperda Species 0.000 claims 1
- 108091081024 Start codon Proteins 0.000 claims 1
- XCCTYIAWTASOJW-XVFCMESISA-N Uridine-5'-Diphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-XVFCMESISA-N 0.000 claims 1
- 102100040092 X-linked retinitis pigmentosa GTPase regulator Human genes 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960004222 factor ix Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 108010011677 glyoxylate aminotransferase Proteins 0.000 claims 1
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000014621 translational initiation Effects 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95208107P | 2007-07-26 | 2007-07-26 | |
| US60/952,081 | 2007-07-26 | ||
| EP07113257 | 2007-07-26 | ||
| EP07113257.5 | 2007-07-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518140A Division JP5634262B2 (ja) | 2007-07-26 | 2008-07-25 | 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014239686A JP2014239686A (ja) | 2014-12-25 |
| JP2014239686A5 true JP2014239686A5 (OSRAM) | 2015-07-09 |
Family
ID=38753583
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518140A Active JP5634262B2 (ja) | 2007-07-26 | 2008-07-25 | 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター |
| JP2014144592A Pending JP2014239686A (ja) | 2007-07-26 | 2014-07-14 | 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010518140A Active JP5634262B2 (ja) | 2007-07-26 | 2008-07-25 | 差次的コドンバイアスを有する反復コード配列を含むバキュロウイルスベクター |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US8697417B2 (OSRAM) |
| EP (3) | EP2173888B1 (OSRAM) |
| JP (2) | JP5634262B2 (OSRAM) |
| KR (1) | KR101597695B1 (OSRAM) |
| CN (1) | CN101868547B (OSRAM) |
| AU (1) | AU2008279883B2 (OSRAM) |
| BR (1) | BRPI0814459B1 (OSRAM) |
| CA (1) | CA2694406C (OSRAM) |
| DK (2) | DK3093345T3 (OSRAM) |
| EA (1) | EA022169B1 (OSRAM) |
| ES (1) | ES2602585T3 (OSRAM) |
| HU (1) | HUE029744T2 (OSRAM) |
| IL (1) | IL203535A (OSRAM) |
| MX (1) | MX2010000944A (OSRAM) |
| NZ (1) | NZ582881A (OSRAM) |
| PL (2) | PL2173888T3 (OSRAM) |
| PT (1) | PT2173888T (OSRAM) |
| SI (2) | SI2173888T1 (OSRAM) |
| WO (1) | WO2009014445A2 (OSRAM) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0814459B1 (pt) * | 2007-07-26 | 2023-01-24 | Uniqure Ip B.V | Método para produzir um vírion parvoviral recombinante em uma célula de inseto, e, construção de ácido nucleico |
| GB0911870D0 (en) | 2009-07-08 | 2009-08-19 | Ucl Business Plc | Optimised coding sequence and promoter |
| WO2011112089A2 (en) | 2010-03-11 | 2011-09-15 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Mutated rep encoding sequences for use in aav production |
| WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
| IT1400425B1 (it) | 2010-06-08 | 2013-05-31 | Amsterdam Molecular Therapeutics Bv | Modified snrnas for use in therapy. |
| WO2012145509A2 (en) * | 2011-04-19 | 2012-10-26 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors, and viruses |
| GB201210357D0 (en) | 2012-06-12 | 2012-07-25 | Ucl Business Plc | Factor VIII sequences |
| CN105745326A (zh) | 2013-10-24 | 2016-07-06 | 优尼科Ip有限公司 | 用于基因治疗神经疾病的aav-5假型载体 |
| MX385339B (es) | 2014-03-10 | 2025-03-18 | Uniqure Ip Bv | Vectores aav mejorados adicionales producidos en células de insecto. |
| US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| SG11201703148TA (en) | 2014-11-05 | 2017-05-30 | Voyager Therapeutics Inc | Aadc polynucleotides for the treatment of parkinson's disease |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| MX2017006217A (es) | 2014-11-14 | 2018-05-02 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| US10597660B2 (en) | 2014-11-14 | 2020-03-24 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| PT3224376T (pt) | 2014-11-28 | 2019-10-25 | Uniqure Ip Bv | Impurezas de dna numa composição compreendendo um vírus parvoviral. |
| HK1245326A1 (zh) | 2014-12-12 | 2018-08-24 | Voyager Therapeutics, Inc. | 用於生产scaav的组合物和方法 |
| KR102636633B1 (ko) | 2014-12-24 | 2024-02-13 | 유니큐어 아이피 비.브이. | 헌팅턴 유전자 억제를 유도하는 RNAi |
| JP7496667B2 (ja) * | 2016-04-21 | 2024-06-07 | ビロベク，インコーポレイテッド | 昆虫細胞中でのａａｖ生成、方法およびその組成物 |
| EP3448987A4 (en) | 2016-04-29 | 2020-05-27 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| MX2018014152A (es) | 2016-05-18 | 2019-03-28 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la enfermedad de huntington. |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11584780B2 (en) * | 2016-07-26 | 2023-02-21 | Biomarin Pharmaceutical Inc. | Adeno-associated virus capsid proteins |
| EP4219724A3 (en) | 2016-08-23 | 2023-09-27 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| US11298041B2 (en) | 2016-08-30 | 2022-04-12 | The Regents Of The University Of California | Methods for biomedical targeting and delivery and devices and systems for practicing the same |
| AU2017378191A1 (en) | 2016-12-16 | 2019-07-04 | Uniqure Ip B.V. | Immunoadsorption |
| AU2018261790B2 (en) | 2017-05-05 | 2024-10-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| AU2018261003A1 (en) | 2017-05-05 | 2019-11-14 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's Disease |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| PL3652326T3 (pl) | 2017-07-10 | 2025-02-24 | Uniqure Ip B.V. | Środki i sposoby terapii genowej aav u ludzi |
| JP7229989B2 (ja) | 2017-07-17 | 2023-02-28 | ボイジャー セラピューティクス インコーポレイテッド | 軌道アレイガイドシステム |
| JP7221275B2 (ja) | 2017-08-03 | 2023-02-13 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖを送達するための組成物および方法 |
| CA3075656A1 (en) | 2017-09-29 | 2019-04-04 | Voyager Therapeutics, Inc. | Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery |
| WO2019079240A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| WO2019129859A1 (en) | 2017-12-29 | 2019-07-04 | Uniqure Ip B.V. | Modified viral vectors and methods of making and using the same |
| JP7389040B2 (ja) | 2018-01-17 | 2023-11-29 | メイラジーティーエックス・ユーケー・ザ・セカンド・リミテッド | 遺伝子治療のための修飾ｒＡＡＶキャプシドタンパク質 |
| GB201800903D0 (en) | 2018-01-19 | 2018-03-07 | Oxford Genetics Ltd | Vectors |
| EP3794126A1 (en) | 2018-05-15 | 2021-03-24 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of parkinson's disease |
| US20210230632A1 (en) | 2018-05-15 | 2021-07-29 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| WO2019241486A1 (en) | 2018-06-13 | 2019-12-19 | Voyager Therapeutics, Inc. | Engineered 5' untranslated regions (5' utr) for aav production |
| JP7565218B2 (ja) | 2018-07-02 | 2024-10-10 | ボイジャー セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症および脊髄に関連する障害の治療 |
| EP3826719A1 (en) | 2018-07-24 | 2021-06-02 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| EP3850098A1 (en) | 2018-09-12 | 2021-07-21 | uniQure IP B.V. | Rnai induced c9orf72 suppression for the treatment of als/ftd |
| WO2020061418A1 (en) * | 2018-09-20 | 2020-03-26 | Tallgrass Biologics L.L.C. | Treatment and control of colony collapse disorder |
| CN109295172A (zh) * | 2018-09-26 | 2019-02-01 | 浙江海洋大学 | 大黄鱼清道夫受体家族基因的密码子偏好性分析方法 |
| AU2019346655B2 (en) | 2018-09-28 | 2025-03-13 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| US20210348242A1 (en) | 2018-10-04 | 2021-11-11 | Voyager Therapeutics, Inc. | Methods for measuring the titer and potency of viral vector particles |
| EP3861107A1 (en) | 2018-10-05 | 2021-08-11 | Voyager Therapeutics, Inc. | Engineered nucleic acid constructs encoding aav production proteins |
| WO2020077165A1 (en) | 2018-10-12 | 2020-04-16 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| AU2019360937A1 (en) | 2018-10-15 | 2021-05-20 | Voyager Therapeutics, Inc. | Expression vectors for large-scale production of rAAV in the baculovirus/Sf9 system |
| WO2020104480A1 (en) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| AU2019385598A1 (en) | 2018-11-19 | 2021-06-03 | Uniqure Ip B.V. | RNAi induced reduction of ataxin-3 for the treatment of Spinocerebellar ataxia type 3 |
| EP3883582A1 (en) | 2018-11-19 | 2021-09-29 | uniQure IP B.V. | Method and means to deliver mirna to target cells |
| EP3884067A1 (en) | 2018-11-19 | 2021-09-29 | uniQure IP B.V. | A companion diagnostic to monitor the effects of gene therapy |
| CN113631225A (zh) | 2019-01-18 | 2021-11-09 | 沃雅戈治疗公司 | 用于生产aav颗粒的方法和系统 |
| EP3962536A1 (en) | 2019-04-29 | 2022-03-09 | Voyager Therapeutics, Inc. | Systems and methods for producing baculoviral infected insect cells (biics) in bioreactors |
| SI3999119T1 (sl) | 2019-07-15 | 2025-03-31 | Meiragtx Uk Ii Limited | Modificirani aav kapsidni proteini za zdravljenje artritičnih bolezni |
| WO2021030125A1 (en) | 2019-08-09 | 2021-02-18 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
| WO2021041375A1 (en) * | 2019-08-26 | 2021-03-04 | Rootpath Genomics, Inc. | Compositions and methods for producing adeno-associated viral vectors |
| TW202122582A (zh) | 2019-08-26 | 2021-06-16 | 美商航海家醫療公司 | 病毒蛋白之控制表現 |
| EP4031148A1 (en) | 2019-09-16 | 2022-07-27 | uniQure IP B.V. | Targeting misspliced transcripts in genetic disorders |
| CN114981442A (zh) * | 2019-12-04 | 2022-08-30 | 桑格摩生物治疗股份有限公司 | 用于生产重组aav的新颖组合物及方法 |
| BR112022016596A2 (pt) | 2020-02-21 | 2022-11-16 | Akouos Inc | Composições e métodos para o tratamento de debilitação auditiva não associada à idade em um indivíduo humano |
| WO2021195491A2 (en) * | 2020-03-26 | 2021-09-30 | Asklepios Biopharmaceutical, Inc. | Inducible promoter for viral vector production |
| KR20220161297A (ko) * | 2020-04-02 | 2022-12-06 | 유니큐어 바이오파마 비.브이. | 신규 세포주 |
| AU2021250656A1 (en) | 2020-04-02 | 2022-09-15 | Uniqure Biopharma B.V. | Dual bifunctional vectors for AAV production |
| JP2023521347A (ja) | 2020-04-07 | 2023-05-24 | ユニキュアー アイピー ビー．ブイ． | アンジオポエチン様３（ａｎｇｐｔｌ３）をサイレンシングするための遺伝子構築物及びその使用 |
| CN116249712A (zh) | 2020-04-15 | 2023-06-09 | 沃雅戈治疗公司 | Tau结合化合物 |
| KR20230093241A (ko) | 2020-07-27 | 2023-06-27 | 보이저 테라퓨틱스, 인크. | 글루코실세라미데이스 베타 결핍증과 관련된 신경 장애의 치료를 위한 조성물 및 방법 |
| WO2022026410A2 (en) | 2020-07-27 | 2022-02-03 | Voyager Therapeutics, Inc | Compositions and methods for the treatment of niemann-pick type c1 disease |
| WO2022032153A1 (en) | 2020-08-06 | 2022-02-10 | Voyager Therapeutics, Inc. | Cell culture medium for use in producing gene therapy products in bioreactors |
| EP4301768A2 (en) | 2021-03-03 | 2024-01-10 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| US20240141378A1 (en) | 2021-03-03 | 2024-05-02 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| CN115427561B (zh) | 2021-03-09 | 2024-06-04 | 辉大(上海)生物科技有限公司 | 工程化CRISPR/Cas13系统及其用途 |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| EP4347849A1 (en) | 2021-06-02 | 2024-04-10 | uniQure biopharma B.V. | Adeno-associated virus vectors modified to bind high-density lipoprotein |
| AU2022286647A1 (en) | 2021-06-02 | 2023-11-30 | Uniqure Biopharma B.V. | Insect cell production of parvoviral vectors with modified capsid proteins |
| EP4359525A1 (en) | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Gene constructs for silencing alpha-synuclein and uses thereof |
| WO2022268811A1 (en) | 2021-06-21 | 2022-12-29 | Uniqure Biopharma B.V. | Improved lysis procedures |
| WO2023283962A1 (en) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Modified aav capsid for gene therapy and methods thereof |
| KR20240021951A (ko) * | 2021-07-28 | 2024-02-19 | 바이오마린 파머수티컬 인크. | 대규모 아데노-관련 바이러스 생산 시스템 |
| WO2023025920A1 (en) | 2021-08-26 | 2023-03-02 | Uniqure Biopharma B.V. | Insect cell-produced high potency aav vectors with cns-tropism |
| WO2023091949A2 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency |
| US20250346920A1 (en) | 2022-01-25 | 2025-11-13 | Voyager Therapeutics, Inc. | Baculovirus expression system |
| CN114703203B (zh) * | 2022-02-11 | 2024-08-06 | 上海渤因生物科技有限公司 | 杆状病毒载体及其用途 |
| WO2023198662A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Novel systems for nucleic acid regulation |
| US20250297252A1 (en) | 2022-04-12 | 2025-09-25 | Uniqure Biopharma B.V. | Nucleic acid regulation of SNCA |
| CN119032174A (zh) | 2022-04-12 | 2024-11-26 | 优尼科生物制药有限公司 | ApoE的核酸调节 |
| EP4508214A1 (en) | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of c9orf72 |
| WO2023240236A1 (en) | 2022-06-10 | 2023-12-14 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of spinal muscular atrophy related disorders |
| WO2024054983A1 (en) | 2022-09-08 | 2024-03-14 | Voyager Therapeutics, Inc. | Controlled expression of viral proteins |
| WO2024143440A1 (ja) | 2022-12-28 | 2024-07-04 | 富士フイルム株式会社 | アデノ随伴ウイルスの製造方法、およびベクターのセット |
| AU2023427408A1 (en) | 2023-02-02 | 2025-09-04 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency |
| AU2024256392A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Gene delivery vehicles comprising rna and antibodies |
| AU2024258047A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Novel neurotropic adeno-associated virus capsids with detargeting of peripheral organs |
| AU2024258816A1 (en) | 2023-04-18 | 2025-10-23 | Uniqure Biopharma B.V. | Generation of adeno-associated virus capsid libraries for insect cells |
| WO2024226761A2 (en) | 2023-04-26 | 2024-10-31 | Voyager Therapeutics, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| WO2024261220A1 (en) | 2023-06-23 | 2024-12-26 | Uniqure Biopharma B.V. | Novel fragile x constructs |
| WO2025049993A1 (en) | 2023-08-31 | 2025-03-06 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2025051805A1 (en) | 2023-09-04 | 2025-03-13 | Uniqure Biopharma B.V. | Novel neurotropic recombinant adeno-associated virus particles |
| WO2025078606A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Further novel systems for nucleic acid regulation |
| WO2025078598A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Novel nucleic acid regulation of huntingtin gene |
| WO2025078602A1 (en) | 2023-10-11 | 2025-04-17 | Uniqure Biopharma B.V. | Nucleic acid regulation of msh3 in repeat expansion disorders |
| WO2025114524A1 (en) | 2023-11-30 | 2025-06-05 | Uniqure Biopharma B.V. | Formulations for viral drug products |
| WO2025171227A1 (en) | 2024-02-08 | 2025-08-14 | Dyno Therapeutics, Inc. | Capsid polypeptides and methods of use thereof |
| WO2025219443A1 (en) | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US5871974A (en) * | 1990-09-28 | 1999-02-16 | Ixsys Inc. | Surface expression libraries of heteromeric receptors |
| NZ308772A (en) * | 1995-05-17 | 1999-04-29 | Du Pont | Recombinant baculovirus insecticides |
| FR2774699B1 (fr) | 1997-11-17 | 2003-10-03 | Rhone Poulenc Rorer Sa | Methode de reduction des evenements de recombinaison homologue |
| AU6490699A (en) | 1998-09-24 | 2000-04-10 | Ultrasonus Ab | A mixing method and a mixing chamber |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| PT1200117E (pt) | 1999-06-24 | 2008-11-26 | Univ British Columbia | Tratamento à base de variantes da lipoproteína lipase |
| WO2001014539A2 (en) * | 1999-08-20 | 2001-03-01 | Johns Hopkins University School Of Medicine | Methods and compositions for the construction and use of fusion libraries |
| JP2003526377A (ja) * | 2000-03-14 | 2003-09-09 | ニユーロロジクス・インコーポレーテツド | キメラキャプシドベクターの製造 |
| US20030129203A1 (en) * | 2001-08-27 | 2003-07-10 | Nautilus Biotech S.A. | Mutant recombinant adeno-associated viruses |
| EP1572893B1 (en) | 2001-11-09 | 2009-01-07 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES | Production of adeno-associated virus in insect cells |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| CA2369985A1 (en) * | 2002-01-18 | 2003-07-18 | Duke University | Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach |
| AU2003219760A1 (en) * | 2002-02-14 | 2003-09-04 | Novavax, Inc. | Optimization of gene sequences of virus-like particles for expression in insect cells |
| WO2003074714A1 (en) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Baculovirus expression system |
| DE10260805A1 (de) | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
| US20070275449A1 (en) * | 2003-10-15 | 2007-11-29 | Vector Gene Technology Company Ltd. | Method for Large-Scale Production, Isolation, Purification and the Uses of Multi-Type Recombinant Adeno-Associated Virus Vectors |
| US20060166363A1 (en) * | 2004-01-27 | 2006-07-27 | Sergei Zolotukhin | Modified baculovirus expression system for production of pseudotyped rAAV vector |
| BRPI0513081A (pt) | 2004-08-03 | 2008-04-22 | Geneart Ag | método para modular a expressão gênica pela alteração do conteúdo de cpg, sistema de expressão, medicamento que o compreende e respectivos usos |
| EP1945779B1 (en) * | 2005-10-20 | 2013-03-06 | UniQure IP B.V. | Improved aav vectors produced in insect cells |
| US20090191597A1 (en) * | 2006-01-20 | 2009-07-30 | Asklepios Biopharmaceutical, Inc. | Enhanced production of infectious parvovirus vectors in insect cells |
| CN101506369B (zh) | 2006-06-21 | 2014-02-12 | 尤尼克尔生物制药股份有限公司 | 具有经修饰的用于在昆虫细胞中产生aav的aav-rep78翻译起始密码子的载体 |
| BRPI0814459B1 (pt) * | 2007-07-26 | 2023-01-24 | Uniqure Ip B.V | Método para produzir um vírion parvoviral recombinante em uma célula de inseto, e, construção de ácido nucleico |
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