JP2014221117A5 - - Google Patents

Download PDF

Info

Publication number
JP2014221117A5
JP2014221117A5 JP2013101609A JP2013101609A JP2014221117A5 JP 2014221117 A5 JP2014221117 A5 JP 2014221117A5 JP 2013101609 A JP2013101609 A JP 2013101609A JP 2013101609 A JP2013101609 A JP 2013101609A JP 2014221117 A5 JP2014221117 A5 JP 2014221117A5
Authority
JP
Japan
Prior art keywords
calculated
intensity
time
fluorescence intensity
depth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013101609A
Other languages
English (en)
Other versions
JP2014221117A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP2013101609A priority Critical patent/JP2014221117A/ja
Priority claimed from JP2013101609A external-priority patent/JP2014221117A/ja
Priority to EP14798487.6A priority patent/EP2997999A4/en
Priority to KR1020157035195A priority patent/KR20160015254A/ko
Priority to US14/891,244 priority patent/US20160113573A1/en
Priority to PCT/JP2014/062566 priority patent/WO2014185372A1/ja
Priority to CN201480027739.XA priority patent/CN105263576A/zh
Publication of JP2014221117A publication Critical patent/JP2014221117A/ja
Publication of JP2014221117A5 publication Critical patent/JP2014221117A5/ja
Pending legal-status Critical Current

Links

Description

Δｔ（秒）が経過した場合（ステップＳ２：Ｙｅｓ）、予め設定された測定時間間隔が経過したものとして、ステップＳ３で、蛍光検出部１２で検知されたその時点の蛍光の強度を算出し、不図示のメモリに保存する。
次いで、ステップＳ４で、ステップＳ３で算出された蛍光強度をグラフにプロットしたときの蛍光強度波形が、定常状態に達したかを判定する。
この判定は、前回の蛍光強度との差が、所定の値以上である場合には、定常状態に達していないものと、所定の値より小さい場合には、定常状態に達したものと判定する。
蛍光強度波形が、定常状態に達していない場合（ステップＳ４：Ｎｏ）、ステップＳ５で、補正推定治療深度ｄｎｅｃを算出する。補正推定治療深度ｄｎｅｃの算出は、次の手順で行う。
まず、不図示のタイマから、光照射開始時からその時点までの時間を示す光照射時間を取得し、その時点の戻り励起光検出部１３で検知されたその時点の戻り励起光の強度を算出すると共に、ステップＳ３で算出された蛍光強度を用いて、次の式（１）により、ＰＢＩの算出を行う。
以下、実施例により、本発明を更に具体的に説明する。
本例では、心筋における経カテーテル的細胞外光線力学的治療において上記式（１）で算出されたＰＢＩと実測ネクローシス深度Ｄｎｅｃとの関係を調査し、上記式（２）で算出される推定治療深度ｄｎｅｃによる実測ネクローシス深度Ｄｎｅｃの推定の可能性を検討した。
本実施例では、イヌ（体重：１２．４±０．８ｋｇ，Ｎ＝１６）を肋間開胸し心臓を露出し、ＰＤＴ薬剤タラポルフィンナトリウムを２．５，５．０ｍｇ／ｋｇ静脈投与した。
２．５ｍｇ／ｋｇ投与の場合の血漿中の平均薬剤濃度は、１５．８５μｇ／ｍｌ（Ｓ．Ｄ．：２．００）、５．０ｍｇ／ｋｇ投与の場合の血漿中の平均薬剤濃度は、３６．１６μｇ／ｍｌ（Ｓ．Ｄ．：７．９９）であった。
投薬から１５分後に心室筋に対してレーザカテーテル３０より光照射を行い、各条件での蛍光強度、戻り励起光強度を測定した。このときの照射光の波長は、６６３±２ｎｍ、スポット径は、１．４ｍｍ、照射強度は、５，１０，２０Ｗ／ｃｍ２，照射時間は、５，１０，２０秒とした。
JP2013101609A 2013-05-13 2013-05-13 治療進行度モニタ装置及びその方法 Pending JP2014221117A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2013101609A JP2014221117A (ja) 2013-05-13 2013-05-13 治療進行度モニタ装置及びその方法
EP14798487.6A EP2997999A4 (en) 2013-05-13 2014-05-12 DEVICE AND METHOD FOR MONITORING THE THERAPY PROGRESS GRADE
KR1020157035195A KR20160015254A (ko) 2013-05-13 2014-05-12 치료 진행도 모니터링 장치 및 그의 방법
US14/891,244 US20160113573A1 (en) 2013-05-13 2014-05-12 Therapy-progress-level monitoring device and method
PCT/JP2014/062566 WO2014185372A1 (ja) 2013-05-13 2014-05-12 治療進行度モニタ装置及びその方法
CN201480027739.XA CN105263576A (zh) 2013-05-13 2014-05-12 治疗进度监视装置及其方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013101609A JP2014221117A (ja) 2013-05-13 2013-05-13 治療進行度モニタ装置及びその方法

Publications (2)

Publication Number Publication Date
JP2014221117A JP2014221117A (ja) 2014-11-27
JP2014221117A5 true JP2014221117A5 (ja) 2016-07-07

Family

ID=51898350

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013101609A Pending JP2014221117A (ja) 2013-05-13 2013-05-13 治療進行度モニタ装置及びその方法

Country Status (6)

Country Link
US (1) US20160113573A1 (ja)
EP (1) EP2997999A4 (ja)
JP (1) JP2014221117A (ja)
KR (1) KR20160015254A (ja)
CN (1) CN105263576A (ja)
WO (1) WO2014185372A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015089489A (ja) * 2013-11-07 2015-05-11 株式会社アライ・メッドフォトン研究所 医療用具及び光線治療装置
WO2016158195A1 (ja) * 2015-03-31 2016-10-06 ソニー株式会社 光照射方法、光照射装置、光照射システム、光線力学診断用又は光線力学治療用装置システム、腫瘍部位特定システム及び腫瘍治療システム
JP6583819B2 (ja) * 2015-10-23 2019-10-02 国立大学法人大阪大学 一重項酸素累積濃度のシミュレーション法
JP7024781B2 (ja) 2017-03-24 2022-02-24 日本ゼオン株式会社 バインダー組成物の保管方法
CN109549615A (zh) * 2018-11-29 2019-04-02 深圳信息职业技术学院 氧饱和度内窥镜监控光动力治疗效果的装置和方法
JP7435611B2 (ja) * 2019-08-27 2024-02-21 株式会社島津製作所 治療支援装置、治療光制御方法
CN111166470B (zh) * 2019-10-15 2021-06-18 东北大学 一种深度可分辨的目标探测及消融系统
WO2022038806A1 (ja) * 2020-08-19 2022-02-24 株式会社島津製作所 治療支援システムおよび治療支援装置
JP7476755B2 (ja) 2020-10-19 2024-05-01 株式会社島津製作所 治療支援装置
CN116685376A (zh) 2021-04-15 2023-09-01 奥林巴斯株式会社 光治疗装置、光治疗方法及光治疗程序

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576173A (en) * 1982-06-28 1986-03-18 The Johns Hopkins University Electro-optical device and method for monitoring instanteous singlet oxygen concentration produced during photoradiation using a CW excitation source
US4592361A (en) * 1982-06-28 1986-06-03 The Johns Hopkins University Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing
EP0568596A1 (en) * 1991-01-24 1993-11-10 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
JPH0680671A (ja) 1992-09-03 1994-03-22 Toyo Hatsuka Kogyo Kk ポルフィリン二量体とその用途
US7236815B2 (en) * 1995-03-14 2007-06-26 The Board Of Regents Of The University Of Texas System Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US7328059B2 (en) * 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
JP2961074B2 (ja) 1995-09-06 1999-10-12 明治製菓株式会社 光化学療法用の新生血管閉塞剤
US6135965A (en) * 1996-12-02 2000-10-24 Board Of Regents, The University Of Texas System Spectroscopic detection of cervical pre-cancer using radial basis function networks
US6406845B1 (en) * 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6128525A (en) 1997-07-29 2000-10-03 Zeng; Haishan Apparatus and method to monitor photodynamic therapy (PDT)
IL135831A0 (en) * 1997-10-30 2001-05-20 Esc Medical Systems Ltd System and method for endoscopically applying and monitoring photodynamic therapy and photodynamic diagnosis
US6051437A (en) * 1998-05-04 2000-04-18 American Research Corporation Of Virginia Optical chemical sensor based on multilayer self-assembled thin film sensors for aquaculture process control
US6362888B1 (en) * 1999-12-23 2002-03-26 Lj Laboratories, L.L.C. Spectrometer assembly
US20010047136A1 (en) * 2000-01-21 2001-11-29 Domanik Richard A. In-vivo tissue inspection and sampling
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
US7110118B2 (en) * 2000-12-19 2006-09-19 Trustees Of Boston University Spectral imaging for vertical sectioning
US7328060B2 (en) * 2002-02-12 2008-02-05 Science & Engineering Associates, Inc. Cancer detection and adaptive dose optimization treatment system
US7135033B2 (en) * 2002-05-23 2006-11-14 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US20040106163A1 (en) * 2002-11-12 2004-06-03 Workman Jerome James Non-invasive measurement of analytes
EP2066403B1 (en) * 2006-08-15 2010-05-12 Spectracure AB System and method for controlling and adjusting interstitial photodynamic light therapy parameters
US8961580B2 (en) 2006-11-30 2015-02-24 Keio University Abnormal electrical conduction blocking apparatus using photodynamic therapy (PDT)
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US8480662B2 (en) * 2007-08-22 2013-07-09 Cardiac Pacemakers, Inc. Systems and devices for photoablation
KR101061004B1 (ko) * 2008-12-10 2011-09-01 한국전기연구원 광역학 치료 및 광 검출을 위한 장치
JP5719159B2 (ja) * 2010-03-15 2015-05-13 ソニー株式会社 評価装置
JP5635282B2 (ja) * 2010-03-15 2014-12-03 ソニー株式会社 判別装置
JP5736116B2 (ja) * 2010-03-15 2015-06-17 ソニー株式会社 算出装置
US20110238137A1 (en) * 2010-03-25 2011-09-29 Fujifilm Corporation Medical apparatus for photodynamic therapy and method for controlling therapeutic light
WO2012076631A1 (en) * 2010-12-07 2012-06-14 Spectracure Ab System and method for interstitial photodynamic light therapy in combination with photosensitizers
US20120209125A1 (en) * 2011-02-10 2012-08-16 Physical Sciences, Inc. Singlet Oxygen Production and Dosimetry for Photodynamic Therapy
DE102011007546A1 (de) * 2011-04-15 2012-10-18 Humboldt-Universität Zu Berlin Messvorrichtung für eine Messung einer Singulettsauerstoff-Lumineszenz
US20130053699A1 (en) * 2011-08-30 2013-02-28 National Applied Research Laboratories Instrument Technology Research Center Apparatus and method for performing photodynamic diagnosis and photodynamic therapy
US9010935B2 (en) * 2011-11-22 2015-04-21 California Institute Of Technology Systems and methods for noninvasive analysis of retinal health and function
JP6015501B2 (ja) * 2012-06-01 2016-10-26 ソニー株式会社 歯用装置及び医療用装置

Similar Documents

Publication Publication Date Title
JP2014221117A5 (ja)
De Lima et al. Low‐level laser therapy restores the oxidative stress balance in acute lung injury induced by gut ischemia and reperfusion
WO2014185372A1 (ja) 治療進行度モニタ装置及びその方法
JP2015510891A5 (ja)
JP2015516375A5 (ja)
WO2014172376A3 (en) Markers of tumor cell response to anti-cancer therapy
JP2016533366A5 (ja)
JP2018533013A5 (ja)
Abdul‐Ghani et al. Remote ischemic preconditioning triggers changes in autonomic nervous system activity: implications for cardioprotection
JP2016527202A5 (ja)
Kennedy et al. Assessment of the duration of infusion on the tolerability and repeat dose pharmacokinetics of F901318 in healthy volunteers
Kotzki et al. Effect of continuous vs pulsed iontophoresis of treprostinil on skin blood flow
Lu et al. Additive beneficial effects of amlodipine and atorvastatin in reversing advanced cardiac hypertrophy in elderly spontaneously hypertensive rats
KR20140022052A (ko) 심근 경색 후 환자에서의 심부전 및 부정맥 치료를 위한 ａ２ｂ 아데노신 수용체 안타고니스트의 용도
JP2018528238A5 (ja)
Egawa et al. Effects of tadalafil to prevent thickening of pulmonary artery in monocrotaline-induced pulmonary hypertension rats: compared with echocardiographic findings: pp. 13.485
Viggiano et al. Exposure reduction by optimization of the imaging toolchain in pulmonary vein isolation
JP2015500295A5 (ja)
TSE et al. Blood pressure response to transition from supine to standing posture using an orthostatic response algorithm
Martynov et al. True resistance and pseudoresistance to aspirin
Savelieva If inhibition with ivabradine: electrophysiological effects and cardiac safety
Reddy Management of infantile hemangiomas
Sachdeva et al. Direct Thrombin Inhibitors versus Warfarin in Non-Valvular Atrial Fibrillation
Ubbink et al. Novel technique to monitor effect of transfusion on mitochondrial oxygenation
Gazzola et al. Airway smooth muscle tone increases airway responsiveness in young healthy adults