JP2014193889A5 - - Google Patents
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- Publication number
- JP2014193889A5 JP2014193889A5 JP2014099667A JP2014099667A JP2014193889A5 JP 2014193889 A5 JP2014193889 A5 JP 2014193889A5 JP 2014099667 A JP2014099667 A JP 2014099667A JP 2014099667 A JP2014099667 A JP 2014099667A JP 2014193889 A5 JP2014193889 A5 JP 2014193889A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- substituted
- hal
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 50
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 48
- 150000001875 compounds Chemical class 0.000 claims 43
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 40
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 39
- 229910052799 carbon Inorganic materials 0.000 claims 30
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 28
- 125000000623 heterocyclic group Chemical group 0.000 claims 22
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 20
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 20
- -1 C1-C12 alkanoyl Chemical group 0.000 claims 20
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 20
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 14
- 235000019152 folic acid Nutrition 0.000 claims 14
- 239000011724 folic acid Substances 0.000 claims 14
- 229960000304 folic acid Drugs 0.000 claims 14
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims 10
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 10
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims 10
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 150000001345 alkine derivatives Chemical class 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 238000002059 diagnostic imaging Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000006736 Huisgen cycloaddition reaction Methods 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 102000006815 folate receptor Human genes 0.000 claims 2
- 108020005243 folate receptor Proteins 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- JOAQINSXLLMRCV-UHFFFAOYSA-N 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid Chemical compound C1=NC2=NC(N)=NC(O)=C2N=C1CNC1=CC=C(C(O)=O)C=C1 JOAQINSXLLMRCV-UHFFFAOYSA-N 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002224 folic acids Chemical class 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07105980 | 2007-04-11 | ||
| EP07105980.2 | 2007-04-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502521A Division JP5710246B2 (ja) | 2007-04-11 | 2008-04-11 | 診断用画像及び放射線治療用の葉酸複合体及び対応する金属キレート錯体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014193889A JP2014193889A (ja) | 2014-10-09 |
| JP2014193889A5 true JP2014193889A5 (enExample) | 2015-03-19 |
| JP5876527B2 JP5876527B2 (ja) | 2016-03-02 |
Family
ID=39683755
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502521A Expired - Fee Related JP5710246B2 (ja) | 2007-04-11 | 2008-04-11 | 診断用画像及び放射線治療用の葉酸複合体及び対応する金属キレート錯体 |
| JP2014099667A Expired - Fee Related JP5876527B2 (ja) | 2007-04-11 | 2014-05-13 | 診断用画像及び放射線治療用の葉酸複合体及び対応する金属キレート錯体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502521A Expired - Fee Related JP5710246B2 (ja) | 2007-04-11 | 2008-04-11 | 診断用画像及び放射線治療用の葉酸複合体及び対応する金属キレート錯体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20100143249A1 (enExample) |
| EP (1) | EP2146995A1 (enExample) |
| JP (2) | JP5710246B2 (enExample) |
| KR (2) | KR20150140415A (enExample) |
| CN (1) | CN101646672B (enExample) |
| AU (1) | AU2008237935B2 (enExample) |
| CA (1) | CA2670385C (enExample) |
| EA (1) | EA200901344A1 (enExample) |
| IL (1) | IL201250A0 (enExample) |
| WO (1) | WO2008125618A1 (enExample) |
| ZA (1) | ZA200903483B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008237935B2 (en) * | 2007-04-11 | 2014-03-27 | Merck & Cie | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
| US8236284B1 (en) * | 2008-04-02 | 2012-08-07 | University Of Central Florida Research Foundation, Inc. | Multimodal, multifunctional polymer coated nanoparticles |
| FR2942227B1 (fr) * | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| WO2011084571A2 (en) | 2009-12-16 | 2011-07-14 | Mallinckrodt Inc. | Azide derivatives for phototherapy |
| PL2766364T3 (pl) * | 2011-08-17 | 2024-12-16 | Merck & Cie Kmg | Koniugaty folianowe jednostek wiążących albuminę |
| CN104379585B (zh) | 2012-05-08 | 2018-07-06 | 默克及其合伙人公司 | 18f-标记的叶酸/抗叶酸剂类似物 |
| WO2016127023A1 (en) * | 2015-02-06 | 2016-08-11 | Cempra Pharmaceuticals, Inc. | 4-azidobutylamines and processes for preparing |
| JP7391847B2 (ja) | 2019-06-20 | 2023-12-05 | クワッド マイナーズ | ネットワークフォレンジックシステム及びこれを用いたネットワークフォレンジック方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093382A (en) * | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| ATE427948T1 (de) * | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| CN101648028B (zh) * | 2002-05-06 | 2012-11-21 | 恩多塞特公司 | 维生素-定向的显象剂 |
| CN100507563C (zh) * | 2003-04-29 | 2009-07-01 | 苏黎世大学 | 借助通过fac配位作用高效标记[M(OH2)3(CO)3]+而用于偶联生物分子的Nε和/或Nα衍生化的、金属和有机保护的L-组氨酸 |
| US9265746B2 (en) * | 2006-05-31 | 2016-02-23 | Merck & Cie | Method for cell-specific targeting |
| AU2008237935B2 (en) * | 2007-04-11 | 2014-03-27 | Merck & Cie | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
-
2008
- 2008-04-11 AU AU2008237935A patent/AU2008237935B2/en not_active Ceased
- 2008-04-11 EP EP08736122A patent/EP2146995A1/en not_active Withdrawn
- 2008-04-11 EA EA200901344A patent/EA200901344A1/ru unknown
- 2008-04-11 WO PCT/EP2008/054409 patent/WO2008125618A1/en not_active Ceased
- 2008-04-11 US US12/595,147 patent/US20100143249A1/en not_active Abandoned
- 2008-04-11 KR KR1020157034215A patent/KR20150140415A/ko not_active Withdrawn
- 2008-04-11 CA CA2670385A patent/CA2670385C/en not_active Expired - Fee Related
- 2008-04-11 JP JP2010502521A patent/JP5710246B2/ja not_active Expired - Fee Related
- 2008-04-11 KR KR1020097023300A patent/KR101605426B1/ko not_active Expired - Fee Related
- 2008-04-11 CN CN200880002741.6A patent/CN101646672B/zh not_active Expired - Fee Related
-
2009
- 2009-05-20 ZA ZA200903483A patent/ZA200903483B/xx unknown
- 2009-09-30 IL IL201250A patent/IL201250A0/en not_active IP Right Cessation
-
2014
- 2014-05-13 JP JP2014099667A patent/JP5876527B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-22 US US15/358,787 patent/US20170128599A1/en not_active Abandoned
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