ZA200903483B - Folate conjugates and corresponding metalchelate complexes for use in diagnosis imaging and radiotherapy - Google Patents
Folate conjugates and corresponding metalchelate complexes for use in diagnosis imaging and radiotherapyInfo
- Publication number
- ZA200903483B ZA200903483B ZA200903483A ZA200903483A ZA200903483B ZA 200903483 B ZA200903483 B ZA 200903483B ZA 200903483 A ZA200903483 A ZA 200903483A ZA 200903483 A ZA200903483 A ZA 200903483A ZA 200903483 B ZA200903483 B ZA 200903483B
- Authority
- ZA
- South Africa
- Prior art keywords
- metalchelate
- radiotherapy
- complexes
- diagnosis imaging
- folate conjugates
- Prior art date
Links
- 238000003745 diagnosis Methods 0.000 title 1
- 229940014144 folate Drugs 0.000 title 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 title 1
- 235000019152 folic acid Nutrition 0.000 title 1
- 239000011724 folic acid Substances 0.000 title 1
- 238000003384 imaging method Methods 0.000 title 1
- 238000001959 radiotherapy Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
- G01N23/2204—Specimen supports therefor; Sample conveying means therefore
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Radiation-Therapy Devices (AREA)
- Nuclear Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07105980 | 2007-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200903483B true ZA200903483B (en) | 2010-04-28 |
Family
ID=39683755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200903483A ZA200903483B (en) | 2007-04-11 | 2009-05-20 | Folate conjugates and corresponding metalchelate complexes for use in diagnosis imaging and radiotherapy |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20100143249A1 (enExample) |
| EP (1) | EP2146995A1 (enExample) |
| JP (2) | JP5710246B2 (enExample) |
| KR (2) | KR20150140415A (enExample) |
| CN (1) | CN101646672B (enExample) |
| AU (1) | AU2008237935B2 (enExample) |
| CA (1) | CA2670385C (enExample) |
| EA (1) | EA200901344A1 (enExample) |
| IL (1) | IL201250A0 (enExample) |
| WO (1) | WO2008125618A1 (enExample) |
| ZA (1) | ZA200903483B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008125618A1 (en) * | 2007-04-11 | 2008-10-23 | Merck Eprova Ag | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
| US8236284B1 (en) * | 2008-04-02 | 2012-08-07 | University Of Central Florida Research Foundation, Inc. | Multimodal, multifunctional polymer coated nanoparticles |
| FR2942227B1 (fr) * | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| WO2011084571A2 (en) | 2009-12-16 | 2011-07-14 | Mallinckrodt Inc. | Azide derivatives for phototherapy |
| EP2766364B1 (en) * | 2011-08-17 | 2024-07-31 | Merck & Cie | Folate conjugates of albumin-binding entities |
| PT2864329T (pt) | 2012-05-08 | 2019-01-10 | Merck & Cie | Análogos de folato/antifolato marcados com 18f |
| JP2018504422A (ja) * | 2015-02-06 | 2018-02-15 | センプラ ファーマシューティカルズ，インコーポレイテッド | ４−アジドブチルアミンおよびその調製方法 |
| JP7391847B2 (ja) | 2019-06-20 | 2023-12-05 | クワッド マイナーズ | ネットワークフォレンジックシステム及びこれを用いたネットワークフォレンジック方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093382A (en) * | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| US7875612B2 (en) * | 2001-04-24 | 2011-01-25 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| WO2003092742A1 (en) * | 2002-05-06 | 2003-11-13 | Endocyte, Inc. | Vitamin-targeted imaging agents |
| US8512675B2 (en) * | 2003-04-29 | 2013-08-20 | Mallinckrodt Llc | N and/or Nα derivatized, metal and organic protected L-histidine for coupling to biomolecules for highly efficient labeling with [M(OH2)3 (CO)3]+ by fac coordination |
| US9265746B2 (en) * | 2006-05-31 | 2016-02-23 | Merck & Cie | Method for cell-specific targeting |
| WO2008125618A1 (en) * | 2007-04-11 | 2008-10-23 | Merck Eprova Ag | Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy |
-
2008
- 2008-04-11 WO PCT/EP2008/054409 patent/WO2008125618A1/en not_active Ceased
- 2008-04-11 JP JP2010502521A patent/JP5710246B2/ja not_active Expired - Fee Related
- 2008-04-11 KR KR1020157034215A patent/KR20150140415A/ko not_active Withdrawn
- 2008-04-11 CA CA2670385A patent/CA2670385C/en not_active Expired - Fee Related
- 2008-04-11 CN CN200880002741.6A patent/CN101646672B/zh not_active Expired - Fee Related
- 2008-04-11 EP EP08736122A patent/EP2146995A1/en not_active Withdrawn
- 2008-04-11 US US12/595,147 patent/US20100143249A1/en not_active Abandoned
- 2008-04-11 KR KR1020097023300A patent/KR101605426B1/ko not_active Expired - Fee Related
- 2008-04-11 EA EA200901344A patent/EA200901344A1/ru unknown
- 2008-04-11 AU AU2008237935A patent/AU2008237935B2/en not_active Ceased
-
2009
- 2009-05-20 ZA ZA200903483A patent/ZA200903483B/xx unknown
- 2009-09-30 IL IL201250A patent/IL201250A0/en not_active IP Right Cessation
-
2014
- 2014-05-13 JP JP2014099667A patent/JP5876527B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-22 US US15/358,787 patent/US20170128599A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150140415A (ko) | 2015-12-15 |
| KR101605426B1 (ko) | 2016-03-22 |
| WO2008125618A1 (en) | 2008-10-23 |
| JP2010523626A (ja) | 2010-07-15 |
| IL201250A0 (en) | 2010-05-31 |
| JP2014193889A (ja) | 2014-10-09 |
| CA2670385A1 (en) | 2008-10-23 |
| EA200901344A1 (ru) | 2010-04-30 |
| CA2670385C (en) | 2016-01-12 |
| AU2008237935A1 (en) | 2008-10-23 |
| JP5710246B2 (ja) | 2015-04-30 |
| US20100143249A1 (en) | 2010-06-10 |
| CN101646672B (zh) | 2015-08-19 |
| JP5876527B2 (ja) | 2016-03-02 |
| AU2008237935B2 (en) | 2014-03-27 |
| EP2146995A1 (en) | 2010-01-27 |
| US20170128599A1 (en) | 2017-05-11 |
| KR20100016330A (ko) | 2010-02-12 |
| HK1138571A1 (zh) | 2010-08-27 |
| CN101646672A (zh) | 2010-02-10 |
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