CN101646672B - 用于诊断成像和放射治疗的叶酸轭合物和相应的金属螯合物络合物 - Google Patents

用于诊断成像和放射治疗的叶酸轭合物和相应的金属螯合物络合物 Download PDF

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Publication number
CN101646672B
CN101646672B CN200880002741.6A CN200880002741A CN101646672B CN 101646672 B CN101646672 B CN 101646672B CN 200880002741 A CN200880002741 A CN 200880002741A CN 101646672 B CN101646672 B CN 101646672B
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independently
complex
compound
another
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CN101646672A (zh
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R·莫泽
R·施布利
C·M·穆勒
V·格罗恩
U·米歇尔
C·斯帕尔
T·L·曼德
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Merck And Seay Partnership
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Merck Eprova AG
Eprova AG
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Radiation-Therapy Devices (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nuclear Medicine (AREA)
CN200880002741.6A 2007-04-11 2008-04-11 用于诊断成像和放射治疗的叶酸轭合物和相应的金属螯合物络合物 Expired - Fee Related CN101646672B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07105980 2007-04-11
EP07105980.2 2007-04-11
PCT/EP2008/054409 WO2008125618A1 (en) 2007-04-11 2008-04-11 Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy

Publications (2)

Publication Number Publication Date
CN101646672A CN101646672A (zh) 2010-02-10
CN101646672B true CN101646672B (zh) 2015-08-19

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CN200880002741.6A Expired - Fee Related CN101646672B (zh) 2007-04-11 2008-04-11 用于诊断成像和放射治疗的叶酸轭合物和相应的金属螯合物络合物

Country Status (11)

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US (2) US20100143249A1 (enExample)
EP (1) EP2146995A1 (enExample)
JP (2) JP5710246B2 (enExample)
KR (2) KR101605426B1 (enExample)
CN (1) CN101646672B (enExample)
AU (1) AU2008237935B2 (enExample)
CA (1) CA2670385C (enExample)
EA (1) EA200901344A1 (enExample)
IL (1) IL201250A0 (enExample)
WO (1) WO2008125618A1 (enExample)
ZA (1) ZA200903483B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100143249A1 (en) * 2007-04-11 2010-06-10 Merck Eprova Ag Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy
US8236284B1 (en) * 2008-04-02 2012-08-07 University Of Central Florida Research Foundation, Inc. Multimodal, multifunctional polymer coated nanoparticles
FR2942227B1 (fr) * 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
WO2011084571A2 (en) 2009-12-16 2011-07-14 Mallinckrodt Inc. Azide derivatives for phototherapy
DK2766364T3 (da) * 2011-08-17 2024-09-30 Merck & Cie Folatkonjugater af albumin-bindende enheder
AU2013258027B2 (en) 2012-05-08 2017-11-30 Merck & Cie 18F-labelled follate/antifolate analogues
CN107207418A (zh) * 2015-02-06 2017-09-26 森普拉制药公司 4‑叠氮基丁胺和制备方法
JP7391847B2 (ja) 2019-06-20 2023-12-05 クワッド マイナーズ ネットワークフォレンジックシステム及びこれを用いたネットワークフォレンジック方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059640A2 (en) * 1998-05-16 1999-11-25 Bracco International B.V. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
CN1662263A (zh) * 2002-05-06 2005-08-31 恩多塞特公司 维生素－定向的显象剂
US20070280880A1 (en) * 2006-05-31 2007-12-06 Rudolf Moser Method for cell-specific targeting

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1389209B1 (en) 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
WO2004097406A2 (en) * 2003-04-29 2004-11-11 Universität Zürich Nϵ AND/OR Nα DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH [M(OH2)3(CO)3]+ BY FAC COORDINATION
US20100143249A1 (en) * 2007-04-11 2010-06-10 Merck Eprova Ag Folate-conjugates and corresponding metal-chelate complexes for use in diagnostic imaging and radiotherapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059640A2 (en) * 1998-05-16 1999-11-25 Bracco International B.V. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
CN1662263A (zh) * 2002-05-06 2005-08-31 恩多塞特公司 维生素－定向的显象剂
US20070280880A1 (en) * 2006-05-31 2007-12-06 Rudolf Moser Method for cell-specific targeting

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KE C-Y等.The folate receptor as a molecular target for tumor-selective radionuclide delivery.《NUCLEAR MEDICINE AND BIOLOGY》.2003,第30卷(第8期),811-817. *
Thomas L.MINDT 等.Click to chelate: synthesis and installation of metal chelates into biomolecules in a single ste.《J. AM. CHEM. SOC.》.2006,第128卷15096-15097. *

Also Published As

Publication number Publication date
CA2670385C (en) 2016-01-12
ZA200903483B (en) 2010-04-28
JP5876527B2 (ja) 2016-03-02
US20170128599A1 (en) 2017-05-11
HK1138571A1 (zh) 2010-08-27
WO2008125618A1 (en) 2008-10-23
US20100143249A1 (en) 2010-06-10
KR20150140415A (ko) 2015-12-15
AU2008237935B2 (en) 2014-03-27
KR20100016330A (ko) 2010-02-12
KR101605426B1 (ko) 2016-03-22
AU2008237935A1 (en) 2008-10-23
CA2670385A1 (en) 2008-10-23
EA200901344A1 (ru) 2010-04-30
EP2146995A1 (en) 2010-01-27
IL201250A0 (en) 2010-05-31
JP2014193889A (ja) 2014-10-09
JP5710246B2 (ja) 2015-04-30
JP2010523626A (ja) 2010-07-15
CN101646672A (zh) 2010-02-10

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