JP2014166186A5 - - Google Patents
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- JP2014166186A5 JP2014166186A5 JP2014095688A JP2014095688A JP2014166186A5 JP 2014166186 A5 JP2014166186 A5 JP 2014166186A5 JP 2014095688 A JP2014095688 A JP 2014095688A JP 2014095688 A JP2014095688 A JP 2014095688A JP 2014166186 A5 JP2014166186 A5 JP 2014166186A5
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- 150000001875 compounds Chemical class 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 239000011230 binding agent Substances 0.000 claims 7
- 239000012636 effector Substances 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 102000011652 Formyl peptide receptors Human genes 0.000 claims 3
- 108010076288 Formyl peptide receptors Proteins 0.000 claims 3
- PRQROPMIIGLWRP-BZSNNMDCSA-N chemotactic peptide Chemical compound CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-BZSNNMDCSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000004463 Follicular Adenocarcinoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 208000019065 cervical carcinoma Diseases 0.000 claims 2
- 239000013043 chemical agent Substances 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 102000007863 pattern recognition receptors Human genes 0.000 claims 2
- 108010089193 pattern recognition receptors Proteins 0.000 claims 2
- 201000001514 prostate carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 2
- 208000019179 thyroid gland undifferentiated (anaplastic) carcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- NVHPXYIRNJFKTE-HAGHYFMRSA-N 2-[(2s,5r,8s,11s)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1CC1=CC=CC=C1 NVHPXYIRNJFKTE-HAGHYFMRSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 229930182818 D-methionine Natural products 0.000 claims 1
- 125000000296 D-methionine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])SC([H])([H])[H] 0.000 claims 1
- 108010033584 FROP-1 peptide Proteins 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000002771 cell marker Substances 0.000 claims 1
- 108010008021 cysteinyl-seryl-aspartyl-seryl-tryptophyl-histidyl-tyrosyl-tryptophyl-cysteine Proteins 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 108010046019 histidyl-glutamyl-tryptophyl-seryl-tyrosyl-leucyl-alanyl-prolyl-tyrosyl-prolyl-tryptophyl-phenylalanine Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 108010091705 seryl-tryptophyl-lysyl-leucyl-prolyl-prolyl-serine Proteins 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Claims (15)
- １つ以上のエフェクター部分および１つ以上のバインダー部分を含む合成化合物であって、該エフェクター部分は、リンカーを介して該バインダー部分と操作可能に連結され、
該エフェクター部分は少なくとも１つの病原体パターン認識受容体（ＰＲＲ）に対するリガンド、すなわち、（ｉ）ホルミルペプチド受容体（ＦＰＲ）または（ｉｉ）ＦＰＲファミリーのメンバーに対するリガンドであり、
該バインダー部分は腫瘍細胞のマーカーと結合し、
該バインダー部分は、５〜７５アミノ酸の長さを有する、ペプチド、マイクロプロテイン、またはペプチド模倣物である、化合物。 - 前記１つ以上のエフェクター部分は、Ｎ−ホルミルメチオニンペプチド；Ｎ−ホルミルＭｅｔ−Ｌｅｕ−Ｐｈｅ（ｆＭＬＦ）；Ｎ−ホルミル−ＭＭＹＡＬＦ（ｆＭＭＹＡＬＦ）；マンノース；フコース；Ｎ−アセチルガラクトサミン；ポリグアニル酸（ポリＧ）；Ｃ末端Ｄ−メチオニンの群から選択される１つ以上の部分であるかまたはその部分を含む、請求項１に記載の化合物。
- 前記１つ以上のエフェクター部分はＮ−ホルミルＭｅｔ−Ｌｅｕ−Ｐｈｅである、請求項１に記載の化合物。
- 少なくとも２つのバインダー部分を含む、請求項１〜３のいずれか一項に記載の化合物。
- 前記バインダーは以下のペプチド配列のいずれかを含む、請求項１〜４のいずれか一項に記載の化合物：ＣＧＬＩＩＱＫＮＥＣ；ＣＮＡＧＥＳＳＫＮＣ；Ｄｈｂ−ｐＬＤＩＫ；Ｄｈｂ−ｐＬＤＩ；ＷＩＦＰＷＩＱＬ；ＷＤＬＡＷＭＦＲＬＰＶＧ；ＶＶＩＳＹＳＭＰＤ；シクロ（ＲＧＤｆＫ）；ＲＧＤｆＫ；ＲＧＤＷＸＥ；ＧＧＨＧＲＶＬＷＰＤＧＷＦＳＬＶＧＩＳＰ；ＹＨＷＹＧＹＴＰＱＮＶＩ；ＧＹＴＰ；ＹＧＹＴＰＱ；ＷＹＧＹＴＰＱＮ；ＨＷＹＧＹＴＰＱＮＶ；ＴＡＣＨＱＨＶＲＭＶＲＰ；ＮＬＬＭＡＡＳ；ＤＵＰ−１；ＨＥＷＳＹＬＡＰＹＰＷＦ；ＨＴＦＥＰＧＶ；シクロ（ＳＲＥＳＰＨＰ）；ＳＲＥＳＰＨＰ；ＫＣＣＹＳＬ；ＬＴＶＸＰＷＹ；ＣＳＤＳＷＨＹＷＣ；ＣＳＤｘｘＨｘＷＣ；ＥＤＹＥＬＭＤＬＬＡＹＬ；シクロ（ＣＶＧＮＤＮＳＳＣ）；ＣＶＧＮＤＮＳＳＣ；ＴＴＰＲＤＡＹ；ＶＨＬＧＹＡＴ；ＣＳＮＲＤＡＲＲＣ；ＣＸＮＸＤＸＲ（Ｘ）／（Ｒ）Ｃ；ＳＷＫＬＰＰＳ；ＩＡＧＬＡＴＰＧＷＳＨＷＬＡＬ；ＡＷＹＰＬＰＰ；ＶＰＷＭＥＰＡＹＱＲＦＬ；ＥＰＡＹＱＲ；ＫＳＬＳＲＨＤＨＩＨＨＨ；ＴＮＳＬＰ；ＹＹＧＬＡＥＶＤＡＧＧＳ；ＭＱＬＰＬＡＴ；ＭＸＸＰ。
- 前記バインダーは、ＡＷＹＰＬＰＰまたはＭＱＬＰＬＡＴまたはＹＨＷＹＧＹＴＰＱＮＶＩＫである、請求項１〜５のいずれか一項に記載の化合物。
- 前記リンカーは、共有結合、エステル結合、アミド結合、ペプチド結合、またはエーテル結合である、請求項１〜６のいずれか一項に記載の化合物。
- 前記リンカーは合成または半合成ポリマーであり、かつ／または該リンカーは、オリゴペプチド、ポリエチレングリコール、またはポリリジンで構成される、請求項１〜７のいずれか一項に記載の化合物。
- 請求項１〜８のいずれか一項に記載の化合物を含有する医薬組成物。
- 腫瘍の治療用薬物の製造のための請求項１〜８のいずれか一項に記載の化合物の使用。
- 固形腫瘍；リンパ腫；非ホジキンリンパ腫；結腸直腸癌；前立腺癌；結腸癌；甲状腺癌；乳癌；膵臓癌、卵巣癌；濾胞性甲状腺癌腫；未分化甲状腺癌腫、乳癌腫、頸癌腫、前立腺癌腫；腫瘍性血管；肝癌；肝細胞癌；膀胱癌；胃癌の腹膜腫瘍；神経芽細胞腫；黒色腫の群から選択される腫瘍の治療のための請求項１０に記載の使用。
- さらに１つ以上の腫瘍の治療用薬物と組み合わせた、好ましくは、化学療法、モノクローナル抗体、抗体フラグメント、または抗体もしくは抗体フラグメントおよび化学的薬剤を含む融合分子と組み合わせた請求項１０または１１に記載の使用。
- 腫瘍の治療のための、請求項１〜８のいずれか一項に記載の化合物を含む組成物。
- 固形腫瘍；リンパ腫；非ホジキンリンパ腫；結腸直腸癌；前立腺癌；結腸癌；甲状腺癌；乳癌；膵臓癌、卵巣癌；濾胞性甲状腺癌腫；未分化甲状腺癌腫、乳癌腫、頸癌腫、前立腺癌腫；腫瘍性血管；肝癌；肝細胞癌；膀胱癌；胃癌の腹膜腫瘍；神経芽細胞腫；黒色腫の群から選択される腫瘍の治療のための請求項１３に記載の組成物。
- さらに１つ以上の腫瘍の治療用薬物と組み合わせた、化学療法、モノクローナル抗体、抗体フラグメント、または抗体もしくは抗体フラグメントおよび化学的薬剤を含む融合分子と組み合わせた、請求項１３または１４に記載の組成物。
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80629806P | 2006-06-30 | 2006-06-30 | |
| EP06013641 | 2006-06-30 | ||
| US60/806,298 | 2006-06-30 | ||
| EP06013641.3 | 2006-06-30 | ||
| EP06013640.5 | 2006-06-30 | ||
| EP06013640 | 2006-06-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517014A Division JP2009541398A (ja) | 2006-06-30 | 2007-07-02 | 医薬目的のための新規な多官能性化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114025A Division JP2017002039A (ja) | 2006-06-30 | 2016-06-08 | 医薬目的のための新規な多官能性化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014166186A JP2014166186A (ja) | 2014-09-11 |
| JP2014166186A5 true JP2014166186A5 (ja) | 2015-05-07 |
Family
ID=38353353
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517014A Pending JP2009541398A (ja) | 2006-06-30 | 2007-07-02 | 医薬目的のための新規な多官能性化合物 |
| JP2014095688A Withdrawn JP2014166186A (ja) | 2006-06-30 | 2014-05-07 | 医薬目的のための新規な多官能性化合物 |
| JP2016114025A Pending JP2017002039A (ja) | 2006-06-30 | 2016-06-08 | 医薬目的のための新規な多官能性化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517014A Pending JP2009541398A (ja) | 2006-06-30 | 2007-07-02 | 医薬目的のための新規な多官能性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114025A Pending JP2017002039A (ja) | 2006-06-30 | 2016-06-08 | 医薬目的のための新規な多官能性化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8470963B2 (ja) |
| EP (3) | EP2275142A3 (ja) |
| JP (3) | JP2009541398A (ja) |
| CN (1) | CN101528263B (ja) |
| WO (1) | WO2008000517A2 (ja) |
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| JP2012515144A (ja) * | 2009-01-14 | 2012-07-05 | エスカーウー アセット マネジメント ゲーエムベーハー | Ｎ−ホルミル−メチオニン残基および腫瘍標的化ペプチドを含む化合物 |
| WO2011034583A2 (en) | 2009-09-16 | 2011-03-24 | Duke University | Inhibition of endosomal toll-like receptor activation |
| WO2013142200A1 (en) * | 2012-03-22 | 2013-09-26 | The Curators Of The University Of Missouri | Peptide with gold binding and egfr receptor affinity and same attached to gold nanostructure |
| WO2015161094A1 (en) | 2014-04-16 | 2015-10-22 | Duke University | Electrospun cationic nanofibers and methods of making and using the same |
| GB201609083D0 (en) * | 2016-05-24 | 2016-07-06 | Syntab Therapeutics Gmbh | Synthetic compound |
| CA3066920A1 (en) * | 2017-06-16 | 2018-12-20 | Eli Lilly And Company | Engineered antibody compounds and conjugates thereof |
| WO2020018941A1 (en) * | 2018-07-19 | 2020-01-23 | The Regents Of The University Of California | Peptides for activation of cell signaling in osteoprogenitor cells |
| CN109055476B (zh) * | 2018-08-07 | 2021-07-09 | 河南大学 | 一种生物活性肽p11在治疗甲状腺癌的药物中效果分析方法 |
| CN109679981A (zh) * | 2019-02-21 | 2019-04-26 | 武汉大学 | 一种甲酰基肽定向进化噬菌体及其制备方法与应用 |
| CN111474370B (zh) * | 2020-04-22 | 2021-04-06 | 天津医科大学总医院 | 检测甲酰肽或甲酰肽受体-1配体含量的方法及应用 |
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2007
- 2007-07-02 EP EP10011976A patent/EP2275142A3/en not_active Withdrawn
- 2007-07-02 EP EP07764993.7A patent/EP2035041B1/en active Active
- 2007-07-02 CN CN200780024865XA patent/CN101528263B/zh active Active
- 2007-07-02 US US12/305,898 patent/US8470963B2/en active Active
- 2007-07-02 WO PCT/EP2007/005836 patent/WO2008000517A2/en active Application Filing
- 2007-07-02 JP JP2009517014A patent/JP2009541398A/ja active Pending
- 2007-07-02 EP EP20150389.3A patent/EP3669894A3/en not_active Withdrawn
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2014
- 2014-05-07 JP JP2014095688A patent/JP2014166186A/ja not_active Withdrawn
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2016
- 2016-06-08 JP JP2016114025A patent/JP2017002039A/ja active Pending
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