JP2014159478A5 - - Google Patents
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- JP2014159478A5 JP2014159478A5 JP2014111127A JP2014111127A JP2014159478A5 JP 2014159478 A5 JP2014159478 A5 JP 2014159478A5 JP 2014111127 A JP2014111127 A JP 2014111127A JP 2014111127 A JP2014111127 A JP 2014111127A JP 2014159478 A5 JP2014159478 A5 JP 2014159478A5
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65347905P | 2005-02-16 | 2005-02-16 | |
| US60/653,479 | 2005-02-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011264338A Division JP5852426B2 (ja) | 2005-02-16 | 2011-12-02 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016183644A Division JP6250764B2 (ja) | 2005-02-16 | 2016-09-21 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014159478A JP2014159478A (ja) | 2014-09-04 |
| JP2014159478A5 true JP2014159478A5 (enExample) | 2014-11-13 |
| JP6073833B2 JP6073833B2 (ja) | 2017-02-01 |
Family
ID=36917026
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556264A Expired - Fee Related JP5063366B2 (ja) | 2005-02-16 | 2006-02-16 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
| JP2011264338A Expired - Fee Related JP5852426B2 (ja) | 2005-02-16 | 2011-12-02 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
| JP2014111127A Expired - Fee Related JP6073833B2 (ja) | 2005-02-16 | 2014-05-29 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
| JP2016183644A Expired - Fee Related JP6250764B2 (ja) | 2005-02-16 | 2016-09-21 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556264A Expired - Fee Related JP5063366B2 (ja) | 2005-02-16 | 2006-02-16 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
| JP2011264338A Expired - Fee Related JP5852426B2 (ja) | 2005-02-16 | 2011-12-02 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016183644A Expired - Fee Related JP6250764B2 (ja) | 2005-02-16 | 2016-09-21 | ヘプシジンによる鉄代謝を制御するためのTGF−βスーパーファミリーの化合物の調節因子の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US7968091B2 (enExample) |
| EP (3) | EP2954903A1 (enExample) |
| JP (4) | JP5063366B2 (enExample) |
| CA (1) | CA2597925A1 (enExample) |
| ES (2) | ES2547866T3 (enExample) |
| HK (1) | HK1218875A1 (enExample) |
| WO (1) | WO2006088972A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2390425T3 (es) | 2000-12-22 | 2012-11-12 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Uso de moléculas de orientación repulsivas (RGM) y sus moduladores |
| CA2448382C (en) * | 2001-05-25 | 2013-02-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin as a regulator of iron homeostasis |
| EP3489257A1 (en) | 2004-07-23 | 2019-05-29 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| US7968091B2 (en) * | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| US20070099245A1 (en) * | 2005-09-29 | 2007-05-03 | Boris Gorovits | Assays for neutralizing antibodies |
| CN101277974A (zh) | 2005-09-30 | 2008-10-01 | 阿伯特有限及两合公司 | 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| EP2781222B1 (en) | 2005-11-23 | 2017-08-02 | Acceleron Pharma, Inc. | Activin-actriia antagonists in use for promoting bone growth |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| WO2008076437A2 (en) | 2006-12-18 | 2008-06-26 | Acceleron Pharma Inc. | Activin-actrii antagonists and uses for increasing red blood cell levels |
| CA2677007A1 (en) | 2007-02-01 | 2008-08-07 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
| TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| EP2481415B1 (en) | 2007-02-09 | 2019-09-11 | Acceleron Pharma Inc. | Pharmaceutical compositions comprising Activin-ActRIIA antagonists |
| WO2008124768A1 (en) * | 2007-04-09 | 2008-10-16 | The General Hospital Corporation | Hemojuvelin fusion proteins and uses thereof |
| JP2010539236A (ja) | 2007-09-18 | 2010-12-16 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIa拮抗薬およびFSH分泌を低減または阻害するための使用 |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| TWI626945B (zh) | 2008-08-14 | 2018-06-21 | 艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| EP2349332B1 (en) * | 2008-11-13 | 2019-10-23 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation bmp-6 |
| WO2010059861A1 (en) * | 2008-11-20 | 2010-05-27 | University Of Southern California | Compositions and methods to modulate hair growth |
| AU2010204985A1 (en) | 2009-01-13 | 2011-08-04 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| JP5912078B2 (ja) | 2009-06-08 | 2016-04-27 | アクセルロン ファーマ, インコーポレイテッド | 熱発生性脂肪細胞を増加させるための方法 |
| EP3290439B1 (en) | 2009-06-12 | 2020-09-02 | Acceleron Pharma Inc. | Truncated actriib-fc fusion proteins |
| EP3332796A1 (en) | 2009-11-17 | 2018-06-13 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| KR20120118002A (ko) * | 2009-12-08 | 2012-10-25 | 애보트 게엠베하 운트 콤파니 카게 | 망막 신경 섬유 층 변성의 치료에 사용하기 위한 rgm a 단백질에 대한 모노클로날 항체 |
| KR20130132824A (ko) | 2010-11-08 | 2013-12-05 | 악셀레론 파마 인코포레이티드 | Actriia 결합제 및 이의 용도 |
| CN107022032A (zh) * | 2011-01-19 | 2017-08-08 | 菲卢马克斯制药公司 | 用于调节铁稳态的组合物及其使用方法 |
| CN104144947B (zh) | 2011-12-14 | 2017-10-27 | 艾伯维德国有限责任两合公司 | 用于诊断和治疗铁相关病症的组合物和方法 |
| EP2791175A2 (en) | 2011-12-14 | 2014-10-22 | Abbvie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
| EP3369746A1 (en) | 2012-01-27 | 2018-09-05 | AbbVie Deutschland GmbH & Co KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
| RU2684216C2 (ru) * | 2012-11-01 | 2019-04-04 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа |
| US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
| AR093620A1 (es) | 2012-12-17 | 2015-06-10 | Lilly Co Eli | Anticuerpos bmp-6 |
| EP2976085A1 (en) * | 2013-03-21 | 2016-01-27 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression |
| JP6518656B2 (ja) * | 2013-06-13 | 2019-05-22 | バイオデシー, インコーポレイテッド | 標的生体実体を標的にする生化学実体候補をスクリーニングする方法 |
| MA40008A (fr) | 2014-06-13 | 2021-05-05 | Acceleron Pharma Inc | Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| TWI730949B (zh) | 2014-12-03 | 2021-06-21 | 美商西建公司 | 活化素-actrii拮抗劑及治療貧血之用途 |
| UY36449A (es) | 2014-12-19 | 2016-07-29 | Novartis Ag | Composiciones y métodos para anticuerpos dirigidos a bmp6 |
| EP3237906B8 (en) | 2014-12-23 | 2020-10-28 | Bluelight Therapeutics, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
| WO2016201077A1 (en) | 2015-06-12 | 2016-12-15 | Emory University | Growth and survival compositions for cells capable of producing antibodies and methods related thereto |
| CA2996996A1 (en) | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof |
| SG10202005377VA (en) * | 2015-10-23 | 2020-07-29 | Vifor Int Ag | Novel ferroportin inhibitors |
| US11458148B2 (en) | 2016-02-22 | 2022-10-04 | Brigham Young University | Method and compositions for the treatment of anemia through the inhibition of furin |
| CA3027651A1 (en) | 2016-06-15 | 2017-12-21 | Novartis Ag | Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6) |
| JP7231553B2 (ja) | 2017-03-02 | 2023-03-01 | ナショナル リサーチ カウンシル オブ カナダ | Tgf-b-受容体外部ドメイン融合分子及びその使用 |
| US11125757B2 (en) | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| CA3117695A1 (en) | 2018-10-26 | 2020-04-30 | Keros Therapeutics, Inc. | Crystal forms of an alk2 inhibitor |
| JP2022549506A (ja) * | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症および関連状態を処置するための方法 |
| WO2021062171A1 (en) * | 2019-09-27 | 2021-04-01 | Disc Medicine, Inc. | Methods for treating anemia of chronic disease |
| WO2021222875A1 (en) | 2020-04-30 | 2021-11-04 | Keros Therapeutics, Inc. | Methods of using alk2 inhibitors |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| WO2022098821A1 (en) * | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating lymphopenia |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| DK0414297T3 (da) | 1989-08-11 | 1997-07-07 | Genencor Int | Effektiv fremstilling af mutantproteaser |
| US5830847A (en) | 1992-10-30 | 1998-11-03 | Hsc Research & Development Limited Partnership | Soluble TGF-β-binding endoglin polypeptides and homodimers |
| JPH09500007A (ja) | 1993-04-19 | 1997-01-07 | スチュアート エイ コーフマン | 新規化合物生成に関するランダム化学 |
| BR9407947A (pt) | 1993-11-02 | 1996-11-26 | Affymax Tech Nv | Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv |
| AU6267098A (en) | 1997-02-05 | 1998-08-25 | Regents Of The University Of California, The | Morphogenic proteins |
| EP1396543A3 (en) | 1999-07-08 | 2004-03-31 | Research Association for Biotechnology | Primers for synthesizing full length cDNA clones and their use |
| CA2396719A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | 22 human secreted proteins |
| WO2002077006A1 (en) | 2001-03-23 | 2002-10-03 | Human Genome Sciences, Inc. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| US6800455B2 (en) | 2000-03-31 | 2004-10-05 | Scios Inc. | Secreted factors |
| CN1159063C (zh) | 2000-06-21 | 2004-07-28 | 中国医学科学院血液学研究所 | 骨形态发生蛋白(bmp)作为治疗急性再生障碍性贫血药物的应用 |
| ES2390425T3 (es) | 2000-12-22 | 2012-11-12 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Uso de moléculas de orientación repulsivas (RGM) y sus moduladores |
| CA2448382C (en) * | 2001-05-25 | 2013-02-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of hepcidin as a regulator of iron homeostasis |
| WO2003000461A1 (fr) | 2001-06-21 | 2003-01-03 | Meiyu-Giken Co., Ltd. | Procede de polissage de la surface d'extremite de connexion d'un connecteur a fibres optiques, structure optique et structure heterogene coaxiale de couches de materiau, et dispositif de polissage |
| WO2003004615A2 (en) | 2001-07-05 | 2003-01-16 | Incyte Genomics, Inc. | Secreted proteins |
| JP2003135075A (ja) | 2001-11-05 | 2003-05-13 | Research Association For Biotechnology | 新規な全長cDNA |
| AU2003234136A1 (en) | 2002-04-18 | 2003-11-03 | The General Hospital Corporation | Drg11-responsive (dragon) gene family |
| US7771952B2 (en) | 2002-06-26 | 2010-08-10 | Abott Laboratories | Modulators and modulation of the interaction between RGM and Neogenin |
| DE10230381A1 (de) * | 2002-07-05 | 2004-01-22 | Institut für Medizintechnologie Magdeburg GmbH, IMTM | Verwendung von Inhibitoren der Alanyl-Aminopeptidasen und diese umfassende pharmazeutischen Zubereitungen |
| GB0217786D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
| US20070166711A1 (en) | 2003-04-15 | 2007-07-19 | Samuels Mark E | Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof |
| US20070184052A1 (en) * | 2003-05-09 | 2007-08-09 | Lin Herbert Y | Soluble tgf-b type III receptor fusion proteins |
| US20060063208A1 (en) | 2004-08-02 | 2006-03-23 | Woolf Clifford J | DRG11-responsive (DRAGON) gene and uses thereof |
| US7968091B2 (en) * | 2005-02-16 | 2011-06-28 | The General Hospital Corporation | Methods and compositions to regulate iron metabolism |
| US7534764B2 (en) | 2005-06-29 | 2009-05-19 | The Regents Of The University Of California | Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin |
-
2006
- 2006-02-16 US US11/884,509 patent/US7968091B2/en active Active
- 2006-02-16 JP JP2007556264A patent/JP5063366B2/ja not_active Expired - Fee Related
- 2006-02-16 EP EP15173396.1A patent/EP2954903A1/en not_active Withdrawn
- 2006-02-16 WO PCT/US2006/005367 patent/WO2006088972A2/en not_active Ceased
- 2006-02-16 ES ES10196139.9T patent/ES2547866T3/es not_active Expired - Lifetime
- 2006-02-16 EP EP10196139.9A patent/EP2335719B1/en not_active Expired - Lifetime
- 2006-02-16 ES ES06735151T patent/ES2392096T3/es not_active Expired - Lifetime
- 2006-02-16 CA CA002597925A patent/CA2597925A1/en not_active Abandoned
- 2006-02-16 EP EP06735151A patent/EP1858541B1/en not_active Revoked
-
2011
- 2011-06-28 US US13/171,438 patent/US8293236B2/en not_active Expired - Fee Related
- 2011-12-02 JP JP2011264338A patent/JP5852426B2/ja not_active Expired - Fee Related
-
2012
- 2012-02-28 US US13/407,502 patent/US8637023B2/en not_active Expired - Fee Related
- 2012-10-18 US US13/654,623 patent/US8865168B2/en not_active Expired - Lifetime
-
2014
- 2014-05-29 JP JP2014111127A patent/JP6073833B2/ja not_active Expired - Fee Related
- 2014-07-16 US US14/332,716 patent/US9556251B2/en not_active Expired - Fee Related
-
2016
- 2016-06-16 HK HK16106934.8A patent/HK1218875A1/en unknown
- 2016-09-21 JP JP2016183644A patent/JP6250764B2/ja not_active Expired - Fee Related
- 2016-12-12 US US15/375,491 patent/US20170183411A1/en not_active Abandoned
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