JP2014144962A5 - - Google Patents
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- Publication number
- JP2014144962A5 JP2014144962A5 JP2014048595A JP2014048595A JP2014144962A5 JP 2014144962 A5 JP2014144962 A5 JP 2014144962A5 JP 2014048595 A JP2014048595 A JP 2014048595A JP 2014048595 A JP2014048595 A JP 2014048595A JP 2014144962 A5 JP2014144962 A5 JP 2014144962A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- nucleoside analog
- valine ester
- cancer
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SDXHMABNCMMVLJ-UHFFFAOYSA-N 2-[2-(6-aminopurin-9-yl)ethyl]propane-1,3-diol Chemical compound NC1=NC=NC2=C1N=CN2CCC(CO)CO SDXHMABNCMMVLJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002777 nucleoside Substances 0.000 claims 76
- -1 valine ester Chemical class 0.000 claims 73
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 65
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 63
- 239000004474 valine Substances 0.000 claims 63
- 229940127073 nucleoside analogue Drugs 0.000 claims 43
- 206010028980 Neoplasm Diseases 0.000 claims 29
- 102100034343 Integrase Human genes 0.000 claims 28
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 28
- 108010017842 Telomerase Proteins 0.000 claims 27
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 claims 27
- 239000003112 inhibitor Substances 0.000 claims 27
- 201000011510 cancer Diseases 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 22
- 241000700605 Viruses Species 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 238000011282 treatment Methods 0.000 claims 18
- 238000002560 therapeutic procedure Methods 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 239000002246 antineoplastic agent Substances 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 9
- 238000011319 anticancer therapy Methods 0.000 claims 9
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 9
- 229960004562 carboplatin Drugs 0.000 claims 9
- 239000003937 drug carrier Substances 0.000 claims 9
- 150000003680 valines Chemical class 0.000 claims 9
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 8
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims 8
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
- 229960004397 cyclophosphamide Drugs 0.000 claims 8
- 108020004414 DNA Proteins 0.000 claims 7
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 7
- 241001631646 Papillomaviridae Species 0.000 claims 7
- 241001505332 Polyomavirus sp. Species 0.000 claims 7
- 230000001028 anti-proliverative effect Effects 0.000 claims 7
- 208000006454 hepatitis Diseases 0.000 claims 7
- 231100000283 hepatitis Toxicity 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 241000701161 unidentified adenovirus Species 0.000 claims 7
- 241001529453 unidentified herpesvirus Species 0.000 claims 7
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 6
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 6
- 125000002015 acyclic group Chemical group 0.000 claims 6
- 229960004117 capecitabine Drugs 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 231100000024 genotoxic Toxicity 0.000 claims 5
- 230000001738 genotoxic effect Effects 0.000 claims 5
- 230000003287 optical effect Effects 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 230000001093 anti-cancer Effects 0.000 claims 4
- 238000002512 chemotherapy Methods 0.000 claims 4
- 229960004316 cisplatin Drugs 0.000 claims 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 4
- 229960004679 doxorubicin Drugs 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 238000001959 radiotherapy Methods 0.000 claims 4
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 229960004150 aciclovir Drugs 0.000 claims 3
- 230000006907 apoptotic process Effects 0.000 claims 3
- 229940127093 camptothecin Drugs 0.000 claims 3
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 229960002656 didanosine Drugs 0.000 claims 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 229960001592 paclitaxel Drugs 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- RMLUKZWYIKEASN-UHFFFAOYSA-M sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate Chemical group [Na+].O=C1[N-]C(N)=NC2=C1N=CN2COCCO RMLUKZWYIKEASN-UHFFFAOYSA-M 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 229960002949 fluorouracil Drugs 0.000 claims 2
- 229960002963 ganciclovir Drugs 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 238000002428 photodynamic therapy Methods 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000001235 sensitizing effect Effects 0.000 claims 2
- JJICLMJFIKGAAU-UHFFFAOYSA-M sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate Chemical group [Na+].NC1=NC([O-])=C2N=CN(COC(CO)CO)C2=N1 JJICLMJFIKGAAU-UHFFFAOYSA-M 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 238000007910 systemic administration Methods 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
- KILTZVMZCMTFFU-UHFFFAOYSA-N 1-[4-hydroxy-3-(hydroxymethyl)butyl]-5-methylpyrimidine-2,4-dione Chemical compound CC1=CN(CCC(CO)CO)C(=O)NC1=O KILTZVMZCMTFFU-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- RPZDLTVHZJHPAW-BAJZRUMYSA-N 9-[(2r,3r,5s)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound O1[C@H](CO)C[C@@H](O)[C@@H]1N1C(NC=NC2=O)=C2N=C1 RPZDLTVHZJHPAW-BAJZRUMYSA-N 0.000 claims 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
- 230000005778 DNA damage Effects 0.000 claims 1
- 231100000277 DNA damage Toxicity 0.000 claims 1
- 238000011346 DNA-damaging therapy Methods 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 claims 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical group N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940124650 anti-cancer therapies Drugs 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 229960002092 busulfan Drugs 0.000 claims 1
- 229960005243 carmustine Drugs 0.000 claims 1
- 230000032823 cell division Effects 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 229960004630 chlorambucil Drugs 0.000 claims 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 1
- 229960003901 dacarbazine Drugs 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 229960000908 idarubicin Drugs 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 230000006882 induction of apoptosis Effects 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 229960002247 lomustine Drugs 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229960004961 mechlorethamine Drugs 0.000 claims 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
- 229960001924 melphalan Drugs 0.000 claims 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
- 229960004857 mitomycin Drugs 0.000 claims 1
- 229960001156 mitoxantrone Drugs 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 108091035539 telomere Proteins 0.000 claims 1
- 102000055501 telomere Human genes 0.000 claims 1
- 210000003411 telomere Anatomy 0.000 claims 1
- 229960004964 temozolomide Drugs 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
- 0 CC(C(N1)=O)=CN(CCC(C*)CO)C1=O Chemical compound CC(C(N1)=O)=CN(CCC(C*)CO)C1=O 0.000 description 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78255906P | 2006-03-14 | 2006-03-14 | |
| US60/782,559 | 2006-03-14 | ||
| US80169306P | 2006-05-18 | 2006-05-18 | |
| USPCT/US2006/019488 | 2006-05-18 | ||
| PCT/US2006/019488 WO2006125166A2 (en) | 2005-05-18 | 2006-05-18 | Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer |
| US60/801,693 | 2006-05-18 | ||
| US86051806P | 2006-11-21 | 2006-11-21 | |
| US60/860,518 | 2006-11-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500483A Division JP5571947B2 (ja) | 2006-03-14 | 2007-03-14 | 癌およびその他の疾患の予防および治療 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016081985A Division JP2016175917A (ja) | 2006-03-14 | 2016-04-15 | 癌およびその他の疾患の予防および治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014144962A JP2014144962A (ja) | 2014-08-14 |
| JP2014144962A5 true JP2014144962A5 (enExample) | 2014-09-25 |
Family
ID=38510093
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500483A Expired - Fee Related JP5571947B2 (ja) | 2006-03-14 | 2007-03-14 | 癌およびその他の疾患の予防および治療 |
| JP2014048595A Pending JP2014144962A (ja) | 2006-03-14 | 2014-03-12 | 癌およびその他の疾患の予防および治療 |
| JP2016081985A Pending JP2016175917A (ja) | 2006-03-14 | 2016-04-15 | 癌およびその他の疾患の予防および治療 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500483A Expired - Fee Related JP5571947B2 (ja) | 2006-03-14 | 2007-03-14 | 癌およびその他の疾患の予防および治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016081985A Pending JP2016175917A (ja) | 2006-03-14 | 2016-04-15 | 癌およびその他の疾患の予防および治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090203636A1 (enExample) |
| EP (1) | EP2001488A4 (enExample) |
| JP (3) | JP5571947B2 (enExample) |
| CA (1) | CA2644297A1 (enExample) |
| WO (1) | WO2007106561A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5571947B2 (ja) * | 2006-03-14 | 2014-08-13 | アルト ソリューションズ インコーポレーテッド | 癌およびその他の疾患の予防および治療 |
| JP2012061053A (ja) * | 2010-09-14 | 2012-03-29 | Yuuki Kitaoka | 投薬装置、投薬装置の作動方法及び投薬方法 |
| US10420761B2 (en) | 2013-03-15 | 2019-09-24 | University Of Florida Research Foundation, Inc. | Allosteric inhibitors of thymidylate synthase |
| US10835524B2 (en) | 2015-06-24 | 2020-11-17 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of pancreatic cancer and uses thereof |
| US20200217837A1 (en) * | 2016-07-15 | 2020-07-09 | Northwestern University | Chromatin protective therapeutics and chromatin heterogeneity |
| WO2018143911A1 (en) * | 2017-01-31 | 2018-08-09 | Kimberly-Clark Worldwide, Inc. | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same |
| WO2019246376A1 (en) * | 2018-06-20 | 2019-12-26 | Chernova Olga B | Prevention of primary and treatment-resistant cancer by inhibitors of endogenous reverse transcriptase |
| EP3940075A1 (en) * | 2020-07-17 | 2022-01-19 | Istituto Nazionale Di Genetica Molecolare-INGM | Inhibitors of line1 and uses thereof |
| WO2023141534A1 (en) * | 2022-01-19 | 2023-07-27 | Northwestern University | Agents that target telomerase reverse transcriptase (tert) for treating cancer and sensitizing cancer cells to genotoxic therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
| US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
| US4347360A (en) * | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
| DE3665260D1 (en) * | 1985-05-07 | 1989-10-05 | Teijin Ltd | Antitumor agent |
| JPS61254526A (ja) * | 1985-05-07 | 1986-11-12 | Teijin Ltd | 経口投与用抗腫瘍剤 |
| EP0659209A1 (en) * | 1991-07-26 | 1995-06-28 | The University Of Rochester | Cancer therapy utilizing malignant cells |
| JP4651942B2 (ja) * | 2001-12-20 | 2011-03-16 | フアーマセツト・インコーポレイテッド | Ｅｂｖ及びｋｈｓｖ感染並びにそれに伴う異常細胞増殖の治療 |
| US20050113324A1 (en) * | 2003-01-15 | 2005-05-26 | Bondarev Igor E. | Modulation of line-1 reverse transcriptase |
| US20050026902A1 (en) * | 2003-01-31 | 2005-02-03 | Timothy Maziasz | Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents |
| CN104997783A (zh) * | 2005-03-25 | 2015-10-28 | Alt解决方案公司 | 端粒酶阳性细胞中端粒长度的调节和癌症治疗 |
| EP1885370A4 (en) * | 2005-05-18 | 2012-07-25 | Alt Solutions Inc | PHARMACOLOGICAL MODULATION OF THE TELOMER LENGTH OF CANCER CELLS FOR THE PREVENTION AND TREATMENT OF CANCER |
| JP5571947B2 (ja) * | 2006-03-14 | 2014-08-13 | アルト ソリューションズ インコーポレーテッド | 癌およびその他の疾患の予防および治療 |
-
2007
- 2007-03-14 JP JP2009500483A patent/JP5571947B2/ja not_active Expired - Fee Related
- 2007-03-14 WO PCT/US2007/006538 patent/WO2007106561A2/en not_active Ceased
- 2007-03-14 EP EP07753185A patent/EP2001488A4/en not_active Withdrawn
- 2007-03-14 US US12/225,199 patent/US20090203636A1/en not_active Abandoned
- 2007-03-14 CA CA002644297A patent/CA2644297A1/en not_active Abandoned
-
2014
- 2014-03-12 JP JP2014048595A patent/JP2014144962A/ja active Pending
-
2016
- 2016-04-15 JP JP2016081985A patent/JP2016175917A/ja active Pending
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